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Integrated management of cardiac failure: the cardiac failure clinic

Daniel LOISANCE

Frontiers of Medicine 2011, Volume 5, Issue 1,   Pages 20-25 doi: 10.1007/s11684-011-0106-1

Abstract:

The prevalence of the risk factors and the risk of cardiac failure are both increasing in China.The wide range of clinical presentations of cardiac failure (acute or chronic) and of therapeutic approachesintegration within the same structure of the various experts involved in the diagnosis and the treatment of cardiacIn these centers, collaboration should replace competition between the medical and the surgical cardiac

Keywords： cardiac failure     cardiac transplantation     mechanical circulatory support    

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Distinct mononuclear diploid cardiac subpopulation with minimal cell–cell communications persists in

Frontiers of Medicine   Pages 939-956 doi: 10.1007/s11684-023-0987-9

Abstract: To this end, 12 645 cardiac cells were generated from embryonic day 17.5 and postnatal days 2 and 8 miceThree cardiac developmental paths were identified: two switching to cardiomyocytes (CM) maturation withThese findings could improve the understanding of MNDCM heterogeneity and cardiac development, thus providingnew clues for approaches to effective cardiac regeneration.

Keywords： mononuclear diploid cardiomyocytes     cell–cell communication     cardiac fibroblast     single-cell RNA sequencing     cardiac regeneration    

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Association of cardiac disease with the risk of post-lung transplantation mortality in Chinese recipients

Frontiers of Medicine 2023, Volume 17, Issue 1,   Pages 58-67 doi: 10.1007/s11684-022-0937-y

Abstract: Kaplan–Meier estimates showed that recipients with cardiac abnormalities had a significantly increasedAfter adjusting for potential confounders, cardiac abnormality was shown to be independently associated

Keywords： cardiac disease     mortality     aged population     lung transplantation    

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Management of mantle cell leukemia with cardiac involvement leading to cardiogenic shock

Muhammad Furqan,Yamei Chen,Akintunde Akinleye,Judy Sarungbam,Alan Gass,Karen Seiter,Delong Liu

Frontiers of Medicine 2014, Volume 8, Issue 2,   Pages 254-258 doi: 10.1007/s11684-014-0319-1

Abstract: Here we report a case of cardiac involvement by mantle cell leukemia leading to cardiogenic shock which

Keywords： mantle cell lymphoma     bendamustine     cardiogenic shock    

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Effects of RNA interference targeting angiotensin 1a receptor on blood pressure and cardiac hypertrophy

ZHANG Jingqun, SUN Honglei, MA Yexin, WANG Daowen

Frontiers of Medicine 2008, Volume 2, Issue 1,   Pages 19-24 doi: 10.1007/s11684-008-0005-2

Abstract: the effects of RNA interference (RNAi) targeting angiotensin 1a receptor (AT1a) on blood pressure and cardiactargeting AT1a receptor inhibits the development of renovascular hypertension and the accompanying cardiac

Keywords： therapy     Sprague     administration     cardiac hypertrophy     valsartan    

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Proteins moonlighting in tumor metabolism and epigenetics

Lei Lv, Qunying Lei

Frontiers of Medicine 2021, Volume 15, Issue 3,   Pages 383-403 doi: 10.1007/s11684-020-0818-1

Abstract: The signal−moonlighting protein−metabolism axis facilitates the adaptation of tumor cells under varying

Keywords： moonlighting function     tumor metabolism     epigenetics    

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Changes in Lipoprotein Lipase in the Heart Following Diabetes Onset Review

Chae Syng Lee, Yajie Zhai, Brian Rodrigues

Engineering 2023, Volume 20, Issue 1,   Pages 19-25 doi: 10.1016/j.eng.2022.06.013

Abstract:

Due to its constant pumping and contraction, the heart requires a substantial amount of energy, with fatty acids (FAs) providing a major part of its adenosine triphosphate (ATP). However, the heart is incapable of making this substrate and attains its FAs from multiple sources, including the action of lipoprotein lipase (LPL). LPL is produced in cardiomyocytes and subsequently secreted to its heparan sulfate proteoglycan (HSPG) binding sites on the plasma membrane. To then move LPL to the endothelial cell (EC) lumen, glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1 (GPIHBP1) attaches to interstitial LPL and transfers it to the vascular lumen, where the LPL is ready to perform its function of breaking down circulating triglycerides (TG) into FAs. The endo-β-glucuronidase heparanase (Hpa) is unique in that it is the only known mammalian enzyme to cleave heparan sulfate (HS), thereby promoting the abovementioned release of LPL from the cardiomyocyte HSPG. In diabetes, it has been suggested that changes in how the heart generates energy are responsible for the development of diabetic cardiomyopathy (DCM). Following moderate diabetes, with the reduction in glucose utilization, the heart increases its LPL activity at the vascular lumen due to an increase in Hpa action. Although this adaptation might be beneficial to compensate for the underutilization of glucose by the heart, it is toxic over the long term, as harmful lipid metabolite accumulation, along with augmented FA oxidation and thus oxidative stress, leads to cell death. This coincides with the loss of a cardioprotective growth factor—namely, vascular endothelial growth factor B (VEGFB). This review discusses interconnections between Hpa, LPL, and VEGFB and their potential implications in DCM. Given that mechanism-based therapeutic care for DCM is unavailable, understanding the pathology of this cardiomyopathy, along with the contribution of LPL, will help us advance its clinical management.

Keywords： Cardiac metabolism     Lipoprotein lipase     Heparanase     Vascular endothelial growth factor     Diabetic cardiomyopathy    

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Chronic inhibition of cyclic guanosine monophosphate-specific phosphodiesterase 5 prevented cardiac fibrosis

Wei Gong,Mengwen Yan,Junxiong Chen,Sandip Chaugai,Chen Chen,Daowen Wang

Frontiers of Medicine 2014, Volume 8, Issue 4,   Pages 445-455 doi: 10.1007/s11684-014-0378-3

Abstract: The purpose of this study was to investigate the effects of PDE5 inhibitor on cardiac fibrosis.In control mice, 4 weeks of TAC induced significant cardiac dysfunction, cardiac fibrosis, and cardiacSildenafil treatment markedly prevented TAC-induced cardiac dysfunction, cardiac fibrosis and cardiacIn isolated cardiac fibroblasts, sildenafil blocked TGF-β1-induced cardiac fibroblast transformationthrough CREB activation in cardiac fibroblasts.

Keywords： PDE5     cardiac fibrosis     TGF-β     CREB    

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Acetyl salicylic acid attenuates cardiac hypertrophy through Wnt signaling

Samuel Chege Gitau,Xuelian Li,Dandan Zhao,Zhenfeng Guo,Haihai Liang,Ming Qian,Lifang Lv,Tianshi Li,Bozhi Xu,Zhiguo Wang,Yong Zhang,Chaoqian Xu,Yanjie Lu,Zhiming Du,Hongli Shan,Baofeng Yang

Frontiers of Medicine 2015, Volume 9, Issue 4,   Pages 444-456 doi: 10.1007/s11684-015-0421-z

Abstract: Changes in the cardiac structure and function were assessed through echocardiography and transmission

Keywords： aspirin     Akt     cardiac hypertrophy     GSK-3β     Wnt/β-catenin    

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Vanadium metabolism investigation using substance flow and scenario analysis

Fangfang ZHANG, Huiquan LI, Bo CHEN, Xue GUAN, Yi ZHANG

Frontiers of Environmental Science & Engineering 2014, Volume 8, Issue 2,   Pages 256-266 doi: 10.1007/s11783-013-0585-1

Abstract: Vanadium is a vital strategic resource, and vanadium metabolism is an important part of the nationalThis study conducts accounting and scenario analysis on the life cycle of vanadium metabolism in ChinaA scenario analysis was conducted to analyze the future developmental trend of vanadium metabolism in

Keywords： metabolism     vanadium industry     substance flow analysis     scenario analysis    

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Insulin resistance and the metabolism of branched-chain amino acids

Jingyi Lu, Guoxiang Xie, Weiping Jia, Wei Jia

Frontiers of Medicine 2013, Volume 7, Issue 1,   Pages 53-59 doi: 10.1007/s11684-013-0255-5

Abstract: particularly responsive to the inhibitory insulin action on amino acid release by skeletal muscle and their metabolism

Keywords： branched-chain amino acids     leucine     isoleucine     valine     insulin resistance    

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Research progress on FASN and MGLL in the regulation of abnormal lipid metabolism and the relationship

Jingyue Zhang, Yawen Song, Qianqian Shi, Li Fu

Frontiers of Medicine 2021, Volume 15, Issue 5,   Pages 649-656 doi: 10.1007/s11684-021-0830-0

Abstract: Tumorigenesis involves metabolic reprogramming and abnormal lipid metabolism, which is manifested byBoth enzymes play an important role in lipid metabolism and are associated with tumor-related signalingarticle introduces the structures and functions of FASN and MGLL, their relationship with abnormal lipid metabolism

Keywords： FASN     MGLL     lipid metabolism     tumor invasion     metastasis    

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PAK1 is a novel cardiac protective signaling molecule

Yunbo Ke,Xin Wang,Xu Yu Jin,R. John Solaro,Ming Lei

Frontiers of Medicine 2014, Volume 8, Issue 4,   Pages 399-403 doi: 10.1007/s11684-014-0380-9

Abstract:

We review here the novel cardiac protective effects of the multifunctional enzyme, p21-activated kinasereview, we assemble an overview of the recent findings on PAK1 signaling in the heart, particularly its cardiacWe present a model for PAK1 signaling that provides a mechanism for specifically affecting cardiac cellularWe discuss the anti-adrenergic and antihypertrophic cardiac protective effects of PAK1, as well as its

Keywords： p21-activated kinase 1 (PAK1)     heart    

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Anaerobic ammonia oxidizing bacteria: ecological distribution, metabolism, and microbial interactions

Dawen Gao, Xiaolong Wang, Hong Liang, Qihang Wei, Yuan Dou, Longwei Li

Frontiers of Environmental Science & Engineering 2018, Volume 12, Issue 3, doi: 10.1007/s11783-018-1035-x

Abstract: Anammox (ANaerobic AMMonia OXidation) is a newly discovered pathway in the nitrogen cycle. This discovery has increased our knowledge of the global nitrogen cycle and triggered intense interest for anammox-based applications. Anammox bacteria are almost ubiquitous in the suboxic zones of almost all types of natural ecosystems and contribute significant to the global total nitrogen loss. In this paper, their ecological distributions and contributions to the nitrogen loss in marine, wetland, terrestrial ecosystems, and even extreme environments were reviewed. The unique metabolic mechanism of anammox bacteria was well described, including the particular cellular structures and genome compositions, which indicate the special evolutionary status of anammox bacteria. Finally, the ecological interactions among anammox bacteria and other organisms were discussed based on substrate availability and spatial organizations. This review attempts to summarize the fundamental understanding of anammox, provide an up-to-date summary of the knowledge of the overall anammox status, and propose future prospects for anammox. Based on novel findings, the metagenome has become a powerful tool for the genomic analysis of communities containing anammox bacteria; the metabolic diversity and biogeochemistry in the global nitrogen budget require more comprehensive studies.

Keywords： Anammox     Metabolism     Metagenome     Ecological distribution     Microbial interactions    

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Metabolism and immunity in breast cancer

Deyu Zhang, Xiaojie Xu, Qinong Ye

Frontiers of Medicine 2021, Volume 15, Issue 2,   Pages 178-207 doi: 10.1007/s11684-020-0793-6

Abstract: Breast cancer cells generate energy through increased glucose metabolism.Lipid metabolism contributes to biological signal pathways and forms cell membranes except energy generationHere, we review the recent findings related to abnormal metabolism and immune characteristics, regulatory

Keywords： breast cancer     metabolism     immunity     cancer stem cells    

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Title Author Date Type Operation

Integrated management of cardiac failure: the cardiac failure clinic

Daniel LOISANCE

Journal Article

Distinct mononuclear diploid cardiac subpopulation with minimal cell–cell communications persists in

Journal Article

Association of cardiac disease with the risk of post-lung transplantation mortality in Chinese recipients

Journal Article

Management of mantle cell leukemia with cardiac involvement leading to cardiogenic shock

Muhammad Furqan,Yamei Chen,Akintunde Akinleye,Judy Sarungbam,Alan Gass,Karen Seiter,Delong Liu

Journal Article

Effects of RNA interference targeting angiotensin 1a receptor on blood pressure and cardiac hypertrophy

ZHANG Jingqun, SUN Honglei, MA Yexin, WANG Daowen

Journal Article

Proteins moonlighting in tumor metabolism and epigenetics

Lei Lv, Qunying Lei

Journal Article

Changes in Lipoprotein Lipase in the Heart Following Diabetes Onset

Chae Syng Lee, Yajie Zhai, Brian Rodrigues

Journal Article

Chronic inhibition of cyclic guanosine monophosphate-specific phosphodiesterase 5 prevented cardiac fibrosis

Wei Gong,Mengwen Yan,Junxiong Chen,Sandip Chaugai,Chen Chen,Daowen Wang

Journal Article

Acetyl salicylic acid attenuates cardiac hypertrophy through Wnt signaling

Samuel Chege Gitau,Xuelian Li,Dandan Zhao,Zhenfeng Guo,Haihai Liang,Ming Qian,Lifang Lv,Tianshi Li,Bozhi Xu,Zhiguo Wang,Yong Zhang,Chaoqian Xu,Yanjie Lu,Zhiming Du,Hongli Shan,Baofeng Yang

Journal Article

Vanadium metabolism investigation using substance flow and scenario analysis

Fangfang ZHANG, Huiquan LI, Bo CHEN, Xue GUAN, Yi ZHANG

Journal Article

Insulin resistance and the metabolism of branched-chain amino acids

Jingyi Lu, Guoxiang Xie, Weiping Jia, Wei Jia

Journal Article

Research progress on FASN and MGLL in the regulation of abnormal lipid metabolism and the relationship

Jingyue Zhang, Yawen Song, Qianqian Shi, Li Fu

Journal Article

PAK1 is a novel cardiac protective signaling molecule

Yunbo Ke,Xin Wang,Xu Yu Jin,R. John Solaro,Ming Lei

Journal Article

Anaerobic ammonia oxidizing bacteria: ecological distribution, metabolism, and microbial interactions

Dawen Gao, Xiaolong Wang, Hong Liang, Qihang Wei, Yuan Dou, Longwei Li

Journal Article

Metabolism and immunity in breast cancer

Deyu Zhang, Xiaojie Xu, Qinong Ye

Journal Article