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AML1-ETO driven acute leukemia: insights into pathogenesis and potential therapeutic approaches

Megan A. Hatlen, Lan Wang, Stephen D. Nimer

Frontiers of Medicine 2012, Volume 6, Issue 3,   Pages 248-262 doi: 10.1007/s11684-012-0206-6

Abstract:

The AML1-ETO fusion transcription factor is generated by the t(8;21) translocation, which is presentBoth human and mouse models of AML have demonstrated that AML1-ETO is insufficient for leukemogenesispathogenetic insights that have been gained from identifying the various events that can cooperate with AML1-ETO to induce AML in vivo.We also discuss potential therapeutic strategies for t(8;21) positive AML that involve targeting the

Keywords： AML1-ETO     mouse model     leukemia     t(8     21)     pathway hits     mutation     hematopoiesis     Kasumi-1     CD34+    

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Homoharringtonine synergy with oridonin in treatment of t(8; 21) acute myeloid leukemia

Weina Zhang, Ying Lu, Tao Zhen, Xinjie Chen, Ming Zhang, Ping Liu, Xiangqin Weng, Bing Chen, Yueying Wang

Frontiers of Medicine 2019, Volume 13, Issue 3,   Pages 388-397 doi: 10.1007/s11684-018-0624-1

Abstract: Collaboration of c-KIT mutations with AML1–ETO (AE) has been demonstrated to induce t(8; 21) acute myeloidleukemia (AML).therapies designed to eliminate AE and c-KIT oncoproteins may facilitate effective treatment of t(8; 21) AMLfeatures activity against tumor cells harboring c-KIT mutations, whereas oridonin can induce t(8; 21) AMLHHT increased intracellular oridonin concentration by modulating the expressions of MRP1 and MDR1, thus

Keywords： AML1–ETO     c-KIT     homoharringtonine     oridonin     t(8     21) AML     synergistic effect    

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Venetoclax and low-dose cytarabine induced complete remission in a patient with high-risk acute myeloid leukemia: a case report

Bingshan Liu, Roshni Narurkar, Madhura Hanmantgad, Wahib Zafar, Yongping Song, Delong Liu

Frontiers of Medicine 2018, Volume 12, Issue 5,   Pages 593-599 doi: 10.1007/s11684-018-0635-y

Abstract: combination therapies have not resulted in considerable progress in the treatment of acute myeloid leukemia (AMLElderly patients with AML and poor risk factors have grave prognosis.Midostaurin has been recently approved for the treatment of FLT-3-mutated AML.Here, we present a case of a male patient with poor performance status and who developed AML followingThe patient with high risk AML achieved complete response to the combined treatment regimen of low-dose

Keywords： venetoclax     cytarabine     AML     leukemia    

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Analysis of GM（1，1）Model and Its Application in Fire Risk Prediction

Chen Zijin,Wang Fuliang,Lu Shouxiang

Strategic Study of CAE 2007, Volume 9, Issue 5,   Pages 91-94

Abstract:

Theoretical analysis of grey prediction model GM(1, 1) is present inMonotonicity of predicted value and its variation tendency predicted by GM(1, 1)model is proved.the monotonicity of predicted value and its variation tendency,  applicability criterion of GM(1,1) is brought forward.

Keywords： fire forecast     GM(1     1)     rate of the fire injured    

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Metabolic interventions combined with CTLA-4 and PD-1/PD-L1 blockade for the treatment of tumors: mechanisms

Frontiers of Medicine 2023, Volume 17, Issue 5,   Pages 805-822 doi: 10.1007/s11684-023-1025-7

Abstract: To date, immune checkpoint inhibitors (ICIs) of CTLA-4 and PD-1/PD-L1 represent the main class of immunotherapyBlockade of CTLA-4 and PD-1/PD-L1 has shown remarkable efficacy in several specific types of cancers,generalized mechanism of targeting cancer metabolism at three crucial immune checkpoints (CTLA-4, PD-1,and PD-L1) to influence ICB therapy and propose potential combined immunotherapeutic strategies co-targeting

Keywords： CTLA-4     PD-1     PD-L1     immune checkpoint blockade (ICB)     metabolic reprogramming     combined tumor therapeutic    

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geological recognition breakthrough in Liaodong zone, which leading to the discovery of the large oilfield JX1-recognition breakthrough in Liaodong zone, which leading to the discovery of the large oilfield JX1-1

Deng Yunhua

Strategic Study of CAE 2011, Volume 13, Issue 10,   Pages 13-18

Abstract: According to this guidance, such giant oilfield JX1-1 was discovered with 150 million reserves in the

Keywords： Bohai Liaodong zone     JX1-1     geological recognition     large oilfield    

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Federated unsupervised representation learning Research Article

Fengda ZHANG, Kun KUANG, Long CHEN, Zhaoyang YOU, Tao SHEN, Jun XIAO, Yin ZHANG, Chao WU, Fei WU, Yueting ZHUANG, Xiaolin LI,fdzhang@zju.edu.cn,kunkuang@zju.edu.cn

Frontiers of Information Technology & Electronic Engineering 2023, Volume 24, Issue 8,   Pages 1181-1193 doi: 10.1631/FITEE.2200268

Abstract: FURL poses two new challenges: (1) data distribution shift (non-independent and identically distributed

Keywords： Federated learning     Unsupervised learning     Representation learning     Contrastive learning    

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Non-equidistant GM(1,1) power model and its application in engineering

Wang Zhengxin,Dang Yaoguo,Liu Sifeng

Strategic Study of CAE 2012, Volume 14, Issue 7,   Pages 98-102

Abstract: text-align: justify;">Aiming at the problem of modeling for non-equidistant sequence, the non-equidistant GM(1,1The results showed that the form of non equidistant GM(1,1) power model was more flexible than the traditionalBoth non equidistant GM(1,1) model and Grey Verhulst model were the special cases of non equidistantGM(1,1) power model.shows modeling accuracy in traditional modeling, which was significantly improved by non equidistant GM(1,1

Keywords： grey system     non-equidistant sequence     GM(1     1) power model     parameter optimization    

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Band-gap tunable (GaxIn1−x)2O3 layer Research Articles

Fabi Zhang, Jinyu Sun, Haiou Li, Juan Zhou, Rong Wang, Tangyou Sun, Tao Fu, Gongli Xiao, Qi Li, Xingpeng Liu, Xiuyun Zhang, Daoyou Guo, Xianghu Wang, Zujun Qin,zhangfabi@outlook.com,qinzj@guet.edu.cn

Frontiers of Information Technology & Electronic Engineering 2021, Volume 22, Issue 10,   Pages 1370-1378 doi: 10.1631/FITEE.2000330

Abstract: Multicomponent oxide (GaIn)O films are prepared on (0001) sapphire substrates to realize a tunable band-gap by technology followed by thermal annealing. The optical properties and band structure evolution over the whole range of compositions in ternary compounds (GaIn)O are investigated in detail. The X-ray diffraction spectra clearly indicate that (GaIn)O films with Ga content varying from 0.11 to 0.55 have both cubic and monoclinic structures, and that for films with Ga content higher than 0.74, only the monoclinic structure appears. The transmittance of all films is greater than 86% in the visible range with sharp absorption edges and clear fringes. In addition, a blue shift of ultraviolet absorption edges from 380 to 250 nm is noted with increasing Ga content, indicating increasing band-gap energy from 3.61 to 4.64 eV. The experimental results lay a foundation for the application of transparent conductive compound (GaIn)O thin films in photoelectric and photovoltaic industry, especially in display, light-emitting diode, and solar cell applications.

Keywords： (GaxIn1−x)2O3薄膜；带隙可调谐；磁控溅射    

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Realizing complex beams via amplitude-phase digital coding metasurfaces and semidefinite relaxation optimization Research Article

武军伟1,2,3,华琼1,徐辉1,杨汉卿1,汪正兴1,程强1,崔铁军1,2,3

Frontiers of Information Technology & Electronic Engineering 2023, Volume 24, Issue 12,   Pages 1708-1716 doi: 10.1631/FITEE.2300146

Abstract: Complex beams play important roles in wireless communications, radar, and satellites, and have attracted great interest in recent years. In light of this background, we present a fast and efficient approach to realize complex beams by using (SDR) optimization and amplitude-phase digital coding metasurfaces. As the application examples of this approach, complex beam patterns with cosecant, flat-top, and double shapes are designed and verified using full-wave simulations and experimental measurements. The results show excellent main lobes and low-level side lobes and demonstrate the effectiveness of the approach. Compared with previous works, this approach can solve the complex beam-forming problem more rapidly and effectively. Therefore, the approach will be of great significance in the design of beam-forming systems in wireless applications.

Keywords： Antenna beams     Amplitude-phase coding metasurface     Far-field synthesis     Semidefinite relaxation    

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Visual knowledge guided intelligent generation of Chinese seal carving Research Article

Kejun ZHANG, Rui ZHANG, Yehang YIN, Yifei LI, Wenqi WU, Lingyun SUN, Fei WU, Huanghuang DENG, Yunhe PAN

Frontiers of Information Technology & Electronic Engineering 2022, Volume 23, Issue 10,   Pages 1479-1493 doi: 10.1631/FITEE.2100094

Abstract:

We digitally reproduce the process of resource collaboration, design creation, and visual presentation of Chinese art. We develop an intelligent art-generation system (Zhejiang University Intelligent System, http://www.next.zju.edu.cn/seal/; the website of the search and layout system is http://www.next.zju.edu.cn/seal/search_app/) to deal with the difficulty in using a visual knowledge guided approach. The knowledge base in this study is the Qiushi Database, which consists of open datasets of images of seal characters and seal stamps. We propose a seal character generation method based on visual knowledge, guided by the database and expertise. Furthermore, to create the layout of the seal, we propose a deformation algorithm to adjust the seal characters and calculate layout parameters from the database and knowledge to achieve an intelligent structure. Experimental results show that this method and system can effectively deal with the difficulties in the generation of seal carving. Our work provides theoretical and applied references for the rebirth and innovation of art.

Keywords： Seal-carving     Intelligent generation     Deep learning     Parametric modeling     Computational art    

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Soluble triggering receptor expressed on myeloid cell-1 (sTREM-1): a potential biomarker for the diagnosis

Changlin Cao, Jingxian Gu, Jingyao Zhang

Frontiers of Medicine 2017, Volume 11, Issue 2,   Pages 169-177 doi: 10.1007/s11684-017-0505-z

Abstract: An example of these biomarkers is triggering receptor expressed on myeloid cell-1 (TREM-1), which isTREM-1 amplifies inflammation by activating the TREM-1/DAP12 pathway.Soluble TREM-1 (sTREM-1) is a special form of TREM-1 that can be directly tested in human body fluidsand well-known biomarker for infectious diseases. sTREM-1 level can be potentially used for the earlyTherefore, sTREM-1 is a feasible biomarker for the targeted therapy and rapid and early diagnosis of

Keywords： soluble triggering receptor expressed on myeloid cells-1     infectious diseases     diagnosis and prognosis    

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PD-1/PD-L1 blockade in cervical cancer: current studies and perspectives

Yumeng Wang, Guiling Li

Frontiers of Medicine 2019, Volume 13, Issue 4,   Pages 438-450 doi: 10.1007/s11684-018-0674-4

Abstract: Checkpoint blockades targeting the PD-1/PD-L1 axis have achieved effective clinical responses with acceptableIn this review, we summarize recent advances in our understanding of the PD-1/PD-L1 signaling pathway, including the expression patterns of PD-1/PD-L1 and potential PD-1/PD-L1-related therapeutic strategies

Keywords： PD-1     PD-L1     immune checkpoint blockade antibody     immunotherapy     cervical cancer    

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Optimal replication strategy for mitigating burst traffic in information-centric satellite networks: a focus on remote sensing image transmission Research Article

Ziyang XING, Xiaoqiang DI, Hui QI, Jing CHEN, Jinhui CAO, Jinyao LIU, Xusheng LI, Zichu ZHANG, Yuchen ZHU, Lei CHEN, Kai HUANG, Xinghan HUO

Frontiers of Information Technology & Electronic Engineering 2024, Volume 25, Issue 6,   Pages 791-808 doi: 10.1631/FITEE.2400025

Abstract: s play a crucial role in remote sensing applications, particularly in the transmission of remote sensing images. However, the occurrence of poses significant challenges in meeting the increased bandwidth demands. Traditional networks are ill-equipped to handle such bursts due to their pre-deployed content. In this paper, we propose an optimal replication strategy for mitigating in s, specifically focusing on the transmission of remote sensing images. Our strategy involves selecting the most optimal replication delivery satellite node when multiple users subscribe to the same remote sensing content within a short time, effectively reducing network transmission data and preventing throughput degradation caused by expansion. We formulate the process as a multi-objective optimization problem and apply Markov decision processes to determine the optimal value for reduction. To address these challenges, we leverage techniques. Additionally, we use s with subdivision and data identification methods to enable rapid retrieval and encoding of remote sensing images. Through software-based simulations using a low Earth orbit satellite constellation, we validate the effectiveness of our proposed strategy, achieving a significant 17% reduction in the average delivery delay. This paper offers valuable insights into efficient in satellite networks, specifically targeting the transmission of remote sensing images, and presents a promising approach to mitigate challenges in information-centric environments.

Keywords： Information-centric satellite network     Burst traffic     Content delivery     Federated reinforcement learning     Mixed-integer linear programming model     Bloom filter     Dynamic network    

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Molecular characterization of two suppressor of cytokine signaling 1 genes (

Xue XU,Jiannan ZHANG,Juan LI,Yajun WANG

Frontiers of Agricultural Science and Engineering 2015, Volume 2, Issue 1,   Pages 73-83 doi: 10.15302/J-FASE-2015044

Abstract: Suppressor of cytokine signaling 1 (SOCS1) protein can inhibit the signal transduction triggered by someamino acid protein, which shares high amino acid sequence identity (64%–67%) with human and mouse SOCS1.and cSOCS1a.and SOCS1b proteins can negatively regulate GH/PRL signaling.Taken together, these data suggest that both cSOCS1a and cSOCS1b may function as negative regulators

Keywords： chicken     SOCS1a     SOCS1b     growth hormone     prolactin    

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Title Author Date Type Operation

AML1-ETO driven acute leukemia: insights into pathogenesis and potential therapeutic approaches

Megan A. Hatlen, Lan Wang, Stephen D. Nimer

Journal Article

Homoharringtonine synergy with oridonin in treatment of t(8; 21) acute myeloid leukemia

Weina Zhang, Ying Lu, Tao Zhen, Xinjie Chen, Ming Zhang, Ping Liu, Xiangqin Weng, Bing Chen, Yueying Wang

Journal Article

Venetoclax and low-dose cytarabine induced complete remission in a patient with high-risk acute myeloid leukemia: a case report

Bingshan Liu, Roshni Narurkar, Madhura Hanmantgad, Wahib Zafar, Yongping Song, Delong Liu

Journal Article

Analysis of GM（1，1）Model and Its Application in Fire Risk Prediction

Chen Zijin,Wang Fuliang,Lu Shouxiang

Journal Article

Metabolic interventions combined with CTLA-4 and PD-1/PD-L1 blockade for the treatment of tumors: mechanisms

Journal Article

geological recognition breakthrough in Liaodong zone, which leading to the discovery of the large oilfield JX1-recognition breakthrough in Liaodong zone, which leading to the discovery of the large oilfield JX1-1

Deng Yunhua

Journal Article

Federated unsupervised representation learning

Fengda ZHANG, Kun KUANG, Long CHEN, Zhaoyang YOU, Tao SHEN, Jun XIAO, Yin ZHANG, Chao WU, Fei WU, Yueting ZHUANG, Xiaolin LI,fdzhang@zju.edu.cn,kunkuang@zju.edu.cn

Journal Article

Non-equidistant GM(1,1) power model and its application in engineering

Wang Zhengxin,Dang Yaoguo,Liu Sifeng

Journal Article

Band-gap tunable (GaxIn1−x)2O3 layer

Fabi Zhang, Jinyu Sun, Haiou Li, Juan Zhou, Rong Wang, Tangyou Sun, Tao Fu, Gongli Xiao, Qi Li, Xingpeng Liu, Xiuyun Zhang, Daoyou Guo, Xianghu Wang, Zujun Qin,zhangfabi@outlook.com,qinzj@guet.edu.cn

Journal Article

Realizing complex beams via amplitude-phase digital coding metasurfaces and semidefinite relaxation optimization

武军伟1,2,3,华琼1,徐辉1,杨汉卿1,汪正兴1,程强1,崔铁军1,2,3

Journal Article

Visual knowledge guided intelligent generation of Chinese seal carving

Kejun ZHANG, Rui ZHANG, Yehang YIN, Yifei LI, Wenqi WU, Lingyun SUN, Fei WU, Huanghuang DENG, Yunhe PAN

Journal Article

Soluble triggering receptor expressed on myeloid cell-1 (sTREM-1): a potential biomarker for the diagnosis

Changlin Cao, Jingxian Gu, Jingyao Zhang

Journal Article

PD-1/PD-L1 blockade in cervical cancer: current studies and perspectives

Yumeng Wang, Guiling Li

Journal Article

Optimal replication strategy for mitigating burst traffic in information-centric satellite networks: a focus on remote sensing image transmission

Ziyang XING, Xiaoqiang DI, Hui QI, Jing CHEN, Jinhui CAO, Jinyao LIU, Xusheng LI, Zichu ZHANG, Yuchen ZHU, Lei CHEN, Kai HUANG, Xinghan HUO

Journal Article

Molecular characterization of two suppressor of cytokine signaling 1 genes (

Xue XU,Jiannan ZHANG,Juan LI,Yajun WANG

Journal Article