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PD-1/PD-L1 blockade in cervical cancer: current studies and perspectives

Yumeng Wang, Guiling Li

Frontiers of Medicine 2019, Volume 13, Issue 4,   Pages 438-450 doi: 10.1007/s11684-018-0674-4

Abstract: Checkpoint blockades targeting the PD-1/PD-L1 axis have achieved effective clinical responses with acceptableIn this review, we summarize recent advances in our understanding of the PD-1/PD-L1 signaling pathway, including the expression patterns of PD-1/PD-L1 and potential PD-1/PD-L1-related therapeutic strategies

Keywords： PD-1     PD-L1     immune checkpoint blockade antibody     immunotherapy     cervical cancer    

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Metabolic interventions combined with CTLA-4 and PD-1/PD-L1 blockade for the treatment of tumors: mechanisms

Frontiers of Medicine   Pages 805-822 doi: 10.1007/s11684-023-1025-7

Abstract: To date, immune checkpoint inhibitors (ICIs) of CTLA-4 and PD-1/PD-L1 represent the main class of immunotherapyBlockade of CTLA-4 and PD-1/PD-L1 has shown remarkable efficacy in several specific types of cancers,the generalized mechanism of targeting cancer metabolism at three crucial immune checkpoints (CTLA-4, PD-1, and PD-L1) to influence ICB therapy and propose potential combined immunotherapeutic strategies co-targeting

Keywords： CTLA-4     PD-1     PD-L1     immune checkpoint blockade (ICB)     metabolic reprogramming     combined tumor therapeutic    

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Activation of phagocytosis by immune checkpoint blockade

Chia-Wei Li, Yun-Ju Lai, Jennifer L. Hsu, Mien-Chie Hung

Frontiers of Medicine 2018, Volume 12, Issue 4,   Pages 473-480 doi: 10.1007/s11684-018-0657-5

Abstract: On the basis of a recently discovered programmed death protein 1 (PD-1) in TAMs, we discuss the potential

Keywords： CD47     PD-1     PD-L1     immunotherapy     TAM     phagocytosis     macrophage    

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Molecular classification and precision therapy of cancer: immune checkpoint inhibitors

Yingyan Yu

Frontiers of Medicine 2018, Volume 12, Issue 2,   Pages 229-235 doi: 10.1007/s11684-017-0581-0

Abstract: refractory Hodgkin lymphoma, and urothelial carcinoma, all of which carry positive programmed death-1/programmed death-ligand 1 biomarkers.

Keywords： molecular classification     precision medicine     pembrolizumab     PD-1/PD-L1     MSI-H    

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Application of StrucGP in medical immunology: site-specific -glycoproteomic analysis of macrophages

Frontiers of Medicine 2023, Volume 17, Issue 2,   Pages 304-316 doi: 10.1007/s11684-022-0964-8

Abstract: In this work, we used THP-1-derived macrophages as examples to show the vast potential of a N-bisected GlcNAc, core fucosylated, and sialylated glycans (e.g., HexNAc4Hex5Fuc1Neu5Ac1, N4H5F1S1) were increased in M1 andIn addition, a high level of glycosylated PD-L1 was observed in M1 macrophages, and the LacNAc moietywas detected at Asn-192 and Asn-200 of PD-L1, and Asn-200 contained Lewis epitopes.

Keywords： macrophage     glycoproteome     glycopeptides     N-glycan structures     PD-L1    

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High-Affinity Decoy PD-1 Mutant Screened from an Epitope-Specific Cell Library Article

Hao Liu, Chunxia Qiao, Naijing Hu, Zhihong Wang, Jing Wang, Jiannan Feng, Beifen Shen, Yuanfang Ma, Longlong Luo

Engineering 2021, Volume 7, Issue 11,   Pages 1557-1565 doi: 10.1016/j.eng.2020.11.011

Abstract: The PD-1/PD-L1 pathway inhibits T cell activation in the micro-environment, making it anWild-type (WT) PD-1 ectodomain has been shown to have difficulty blocking PD-1/PD-L1 mixture formation-1 binds to PD-L1 or PD-L2.Based on the theoretical binding analysis of PD-1 and its ligands (i.e., PD-L1 and PD-L2) or antibodyIt exhibited an inhibitory effect against PD-1 to prevent it from forming mixtures with PD-L1, which

Keywords： Decoy PD-1     PD-L1     Mammalian cell library     Epitope-oriented    

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Monitoring checkpoint inhibitors: predictive biomarkers in immunotherapy

Min Zhang, Jingwen Yang, Wenjing Hua, Zhong Li, Zenghui Xu, Qijun Qian

Frontiers of Medicine 2019, Volume 13, Issue 1,   Pages 32-44 doi: 10.1007/s11684-018-0678-0

Abstract:

Immunotherapy has become the fourth cancer therapy after surgery, chemotherapy, and radiotherapy. In particular, immune checkpoint inhibitors are proved to be unprecedentedly in increasing the overall survival rates of patients with refractory cancers, such as advanced melanoma, non-small cell lung cancer, and renal cell carcinoma. However, inhibitor therapies are only effective in a small proportion of patients with problems, such as side effects and high costs. Therefore, doctors urgently need reliable predictive biomarkers for checkpoint inhibitor therapies to choose the optimal therapies. Here, we review the biomarkers that can serve as potential predictors of the outcomes of immune checkpoint inhibitor treatment, including tumor-specific profiles and tumor microenvironment evaluation and other factors.

Keywords： immune checkpoint     companion diagnosis     PD-L1     tumor mutation burden     immune score    

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mTOR-targeted cancer therapy: great target but disappointing clinical outcomes, why?

Shi-Yong Sun

Frontiers of Medicine 2021, Volume 15, Issue 2,   Pages 221-231 doi: 10.1007/s11684-020-0812-7

Abstract: metabolism, survival, and immune response by forming two important complexes, namely, mTOR complex 1(mTORC1) and complex 2 (mTORC2). mTOR signaling is often dysregulated in cancers and has been consideredmade to develop efficacious mTOR inhibitors, particularly mTOR kinase inhibitors, which suppress mTORC1findings on the essential role of GSK3 in mediating cancer cell response to mTOR inhibitors and mTORC1inhibition-induced upregulation of PD-L1 in cancer cells may provide some explanations.

Keywords： mTOR     cancer therapy     resistance     GSK3     protein degradation     E3 ubiquitin ligase     PD-L1    

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Selective hydrogenation of acetylene over Pd/CeO

L. Jang

Frontiers of Chemical Science and Engineering 2020, Volume 14, Issue 6,   Pages 929-936 doi: 10.1007/s11705-019-1912-2

Abstract: Five hundred ppm Pd/CeO catalyst was prepared and evaluated in selective hydrogenation of acetylenePd/CeO catalyst could be activated by the feed gas during reactions and the catalyst without reductionThis could be ascribed to the formation of Pd Ce O or Pd-O-Ce surface species based on the X-ray diffraction

Keywords： selective hydrogenation     acetylene     Pd/CeO2     strong interaction    

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Dihydroartemisinin increased the abundance of by YAP1 depression that sensitizes hepatocellular carcinomato anti-PD-1 immunotherapy

Frontiers of Medicine 2023, Volume 17, Issue 4,   Pages 729-746 doi: 10.1007/s11684-022-0978-2

Abstract: The effect of anti-programmed cell death 1 (anti-PD-1) immunotherapy is limited in patients with hepatocellularHere, anti-PD-1 treatment decreased A. muciniphila abundance in the colon, but increased YAP1Yap1 knockout enhanced anti-PD-1 efficacy.anti-PD-1 efficacy in liver tumors.anti-PD-1 therapy.

Keywords： hepatocellular carcinoma     YAP1     Akkermansia muciniphila     anti-PD-1     dihydroartemisinin     bile acid    

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A perspective on the promoting effect of Ir and Au on Pd toward the ethanol oxidation reaction in alkaline

WEI, L. X. LUO, F. LI, J. L. ZHANG

Frontiers in Energy 2018, Volume 12, Issue 4,   Pages 501-508 doi: 10.1007/s11708-018-0586-7

Abstract: is less active relative to Pd Ir/C and Pd/C while the stabilizing effect of Au leads to both a higherAu Ir/C than those on Pd Ir/C.On the other hand, the tri-metallic Pd Ir@(1/3Au)/C electrocatalyst with a near surface alloy architecturedelivers a much higher activity with an improvement up to 50.4% compared to Pd Ir/C.It is speculated that for the tri-metallic Pd Ir@(1/3Au)/C electrocatalyst, certain Au atoms are well

Keywords： fuel cells     catalysts     ethanol oxidation     alkaline media     solid solution alloy     near surface alloy    

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Molecular dynamics simulations of initial Pd and PdO nanocluster growth in a magnetron gas aggregation

Pascal Brault, William Chamorro-Coral, Sotheara Chuon, Amaël Caillard, Jean-Marc Bauchire, Stève Baranton

Frontiers of Chemical Science and Engineering 2019, Volume 13, Issue 2,   Pages 324-329 doi: 10.1007/s11705-019-1792-5

Abstract: Molecular dynamics simulations are carried out for describing growth of Pd and PdO nanoclusters using

Keywords： molecular dynamics     cluster growth     plasma sputtering     nanocatalyst    

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Investigation of the preparation methodologies of Pd-Cu single atom alloy catalysts for selective hydrogenation

-L. Jang

Frontiers of Chemical Science and Engineering 2015, Volume 9, Issue 4,   Pages 442-449 doi: 10.1007/s11705-015-1547-x

Abstract: Galvanic replacement, co-impregnation and sequential impregnation have been employed to prepare Pd-Cubimetallic catalysts with less than 1 wt-% Cu and ca. 0.03 wt-% Pd for selective hydrogenation of acetylenefield-scanning transmission electron microscopy (HAADF-STEM) and H chemisorption results confirmed that Pd-Cu

Keywords： H2 pulse chemisorption     palladium-copper bimetallic catalyst     single atom alloy     acetylene hydrogenation     HAADF-STEM    

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Preparation and investigation of Pd doped Cu catalysts for selective hydrogenation of acetylene

-L. Jang, Jong K. Keum, Karren More, Changjun Liu, Xiaoliang Yan

Frontiers of Chemical Science and Engineering 2020, Volume 14, Issue 4,   Pages 522-533 doi: 10.1007/s11705-019-1822-3

Abstract: A series of PdCu bimetallic catalysts with low Cu and Pd loadings and different Cu: Pd atomic ratiosby conventionally sequential impregnation (CSI) and modified sequential impregnation (MSI) of Cu and PdIn addition, for the catalysts prepared by MSI, Pd atoms can form PdCu alloy on the surface of metalparticles, however, for the catalysts prepared by CSI, Pd tends to migrate and exist below the surfaceMoreover, even Pd loading is super low,<0.045 wt-% in this study, by through adjusting Cu loading to

Keywords： copper     palladium     catalysts     acetylene     selective hydrogenation    

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Synthesis, physicochemical characterizations and catalytic performance of Pd/carbon-zeolite and Pd/carbon-CeO

Zeinab JAMALZADEH, Mohammad HAGHIGHI, Nazli ASGARI

Frontiers of Environmental Science & Engineering 2013, Volume 7, Issue 3,   Pages 365-381 doi: 10.1007/s11783-013-0520-5

Abstract: In this work, xylene removal from waste gas streams was investigated via catalytic oxidation over Pd/carbon-zeolite and Pd/carbon-CeO nanocatalysts.

Keywords： Pd/carbon-CeO2     Pd/carbon-zeolite     pine cone     ZnCl2     catalytic oxidation     xylene    

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Title Author Date Type Operation

PD-1/PD-L1 blockade in cervical cancer: current studies and perspectives

Yumeng Wang, Guiling Li

Journal Article

Metabolic interventions combined with CTLA-4 and PD-1/PD-L1 blockade for the treatment of tumors: mechanisms

Journal Article

Activation of phagocytosis by immune checkpoint blockade

Chia-Wei Li, Yun-Ju Lai, Jennifer L. Hsu, Mien-Chie Hung

Journal Article

Molecular classification and precision therapy of cancer: immune checkpoint inhibitors

Yingyan Yu

Journal Article

Application of StrucGP in medical immunology: site-specific -glycoproteomic analysis of macrophages

Journal Article

High-Affinity Decoy PD-1 Mutant Screened from an Epitope-Specific Cell Library

Hao Liu, Chunxia Qiao, Naijing Hu, Zhihong Wang, Jing Wang, Jiannan Feng, Beifen Shen, Yuanfang Ma, Longlong Luo

Journal Article

Monitoring checkpoint inhibitors: predictive biomarkers in immunotherapy

Min Zhang, Jingwen Yang, Wenjing Hua, Zhong Li, Zenghui Xu, Qijun Qian

Journal Article

mTOR-targeted cancer therapy: great target but disappointing clinical outcomes, why?

Shi-Yong Sun

Journal Article

Selective hydrogenation of acetylene over Pd/CeO

L. Jang

Journal Article

Dihydroartemisinin increased the abundance of by YAP1 depression that sensitizes hepatocellular carcinomato anti-PD-1 immunotherapy

Journal Article

A perspective on the promoting effect of Ir and Au on Pd toward the ethanol oxidation reaction in alkaline

WEI, L. X. LUO, F. LI, J. L. ZHANG

Journal Article

Molecular dynamics simulations of initial Pd and PdO nanocluster growth in a magnetron gas aggregation

Pascal Brault, William Chamorro-Coral, Sotheara Chuon, Amaël Caillard, Jean-Marc Bauchire, Stève Baranton

Journal Article

Investigation of the preparation methodologies of Pd-Cu single atom alloy catalysts for selective hydrogenation

-L. Jang

Journal Article

Preparation and investigation of Pd doped Cu catalysts for selective hydrogenation of acetylene

-L. Jang, Jong K. Keum, Karren More, Changjun Liu, Xiaoliang Yan

Journal Article

Synthesis, physicochemical characterizations and catalytic performance of Pd/carbon-zeolite and Pd/carbon-CeO

Zeinab JAMALZADEH, Mohammad HAGHIGHI, Nazli ASGARI

Journal Article