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Histone variants: critical determinants in tumour heterogeneity

Tao Wang, Florent Chuffart, Ekaterina Bourova-Flin, Jin Wang, Jianqing Mi, Sophie Rousseaux, Saadi Khochbin

Frontiers of Medicine 2019, Volume 13, Issue 3, Pages 289-297 doi: 10.1007/s11684-018-0667-3

Abstract: Malignant cell transformation could be considered as a series of cell reprogramming events driven by oncogenic transcription factors and upstream signalling pathways. Chromatin plasticity and dynamics are critical determinants in the control of cell reprograming. An increase in chromatin dynamics could therefore constitute an essential step in driving oncogenesis and in generating tumour cell heterogeneity, which is indispensable for the selection of aggressive properties, including the ability of cells to disseminate and acquire resistance to treatments. Histone supply and dosage, as well as histone variants, are the best-known regulators of chromatin dynamics. By facilitating cell reprogramming, histone under-dosage and histone variants should also be crucial in cell transformation and tumour metastasis. Here we summarize and discuss our knowledge of the role of histone supply and histone variants in chromatin dynamics and their ability to enhance oncogenic cell reprogramming and tumour heterogeneity.

Keywords： cancer-testis TH2B TH2A H1T H1.0 H1F0 linker histones

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Preface of special issue of the 10 th International Conference on CO 2 Utilization

Changjun LIU,

Frontiers of Chemical Science and Engineering 2010, Volume 4, Issue 2, Pages 109-109 doi: 10.1007/s11705-009-0258-6

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Detection of maternal serum thromboxane B2 in different durations of pregnancy and prediction of preeclampsia

Geqing XIA MD, Zehua WANG MD, Li ZOU MD, Chaoying WU MS, Yu HU MD,

Frontiers of Medicine 2010, Volume 4, Issue 2, Pages 235-240 doi: 10.1007/s11684-010-0002-0

Abstract: This study was aimed to detect maternal serum levels of thromboxane B2 (TXB2) in different durationsof pregnancy and explore the predictive value of TXB2 for preeclampsia.Maternal serum levels of TXB2 were measured by enzyme-linked immunoassay.of pregnancy, the levels of maternal serum TXB2 in the 180 cases gradually ascended as seen throughHigher levels of maternal serum TXB2 were detected a long time before clinical symptoms appeared.

Keywords： thromboxane B2 preeclampsia

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Fenton oxidation of 2,4- and 2,6-dinitrotoluene and acetone inhibition

HE Yiliang, ZHAO Bin, HUGHES Joseph B., HAN Sung Soo

Frontiers of Environmental Science & Engineering 2008, Volume 2, Issue 3, Pages 326-332 doi: 10.1007/s11783-008-0038-4

Abstract: The performances and kinetic parameters of Fenton oxidation of 2,4- and 2,6-dinitrotoluene (DNT) in water-acetone- and 2,6-DNT.- and 2,6-DNT completely, mainly due to the competition of hydroxyl radicals.Fenton oxidation of 2,4- and 2,6-DNT fit well with the first-order kinetics and the presence of acetone-DNT primary degradation was proposed: 2,4-DNT → 2,4-dinitro-benzaldehyde → 2,4-dinitrobenzoic acid →

Keywords： presence 2 4-DNT competition laboratory scavenger

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Study of recombinant human IFN-α-2b bacilli Calmette–Guerin activated killer cells and against bladder

FAN Xiaodong, HAN Ruifa

Frontiers of Medicine 2007, Volume 1, Issue 4, Pages 377-380 doi: 10.1007/s11684-007-0073-8

Abstract: Therefore, current studies aim at developing recombinant BCG (rBCG) strains secreting Th1-like cytokinesRecombinant IFN--2b-BCG, wild-type BCG (wBCG), wild-type BCG and IFN--2b were coincubated with PBMCs

Keywords： Urology powerful 2b-BCG Tianjin institute wild-type

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Anti-β glycoprotein I antibodies in complex with β2 glycoprotein I induce platelet activation via tworeceptors: apolipoprotein E receptor 2' and glycoprotein I bα

Wenjing Zhang,Fei Gao,Donghe Lu,Na Sun,Xiaoxue Yin,Meili Jin,Yanhong Liu

Frontiers of Medicine 2016, Volume 10, Issue 1, Pages 76-84 doi: 10.1007/s11684-015-0426-7

Abstract: ba (GP I bα) in platelet activation induced by the anti-β₂GP I /β_{2b/ III a activation and P-selectin expression andthromboxane B₂ production as well as p38 mitogen-activated protein kinase phosphorylationactivate platelets, and this activation was inhibited by either the anti-GP I bα antibody or theactivation via GP I bα and apoER2', which may then contribute to the prothrombotic tendency}

Keywords： anti-β2GP I /β2GP I complex platelet GP I bα apoER2' thrombosis

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Neutralization against SARS-CoV-2 Delta/Omicron variants and B cell response after inactivated vaccination

Frontiers of Medicine 2023, Volume 17, Issue 4, Pages 747-757 doi: 10.1007/s11684-022-0954-x

Abstract: Emerging SARS-CoV-2 variants have made COVID-19 convalescents susceptible to re-infection and have raisedefficacy of inactivated vaccination in neutralization against emerging variants and antigen-specific B, and 18.5 (Visit 3) months after SARS-CoV-2 infection.Similarly, the responses of SARS-CoV-2 RBD-specific B cells and memory B cells were boosted by the secondvariants and memory B cell responses.

Keywords： COVID-19 convalescent SARS-CoV-2 inactivated vaccination neutralizing antibody B cell response

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The 9th China Engineering Management Forum Guangzhou Consensus

Frontiers of Engineering Management 2015, Volume 2, Issue 2, Pages 105-107 doi: 10.15302/J-FEM-2015019

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Relationship between Th17 cells and allograft rejection

Zhikun ZHENG MM, Jinsong LI MD, Ke JIANG MD,

Frontiers of Medicine 2009, Volume 3, Issue 4, Pages 491-494 doi: 10.1007/s11684-009-0066-x

Abstract: As a different subset from the Thl and Th2 cells, Th17 cells play an important role in the developmentAs our knowledge on Th17 family members is rapidly growing and changing, it will be important to specifyHerein, we review the key features of Th17 cells and discuss their potential relevance to transplantation

Keywords： TH17 cells regulation allograft rejection

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2015 International Summit Forum on Engineering Science and Technology Development Strategy, the 205thChina Engineering Science and Technology Forum, and the 9th China Engineering Management Forum Held

China Engineering Management Forum Organization Committee

Frontiers of Engineering Management 2015, Volume 2, Issue 2, Pages 195-197 doi: 10.15302/J-FEM-2015032

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Inhibition of protein kinase B by Palmitate in the insulin signaling of HepG2 cells and the preventive

XIA Yanzhi, WAN Xuedong, DUAN Qiuhong, HE Shansu, WANG Ximing

Frontiers of Medicine 2007, Volume 1, Issue 2, Pages 200-206 doi: 10.1007/s11684-007-0038-y

Abstract: of free fatty acids (FFAs) may contribute to insulin resistance (IR) that is characteristic of type 2

Keywords： palmitate characteristic study plasma resistance

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Aldolase B attenuates clear cell renal cell carcinoma progression by inhibiting CtBP2

Frontiers of Medicine 2023, Volume 17, Issue 3, Pages 503-517 doi: 10.1007/s11684-022-0947-9

Abstract: Aldolase B (ALDOB), a glycolytic enzyme, is uniformly depleted in clear cell renal cell carcinoma (ccRCCWe showed that the corepressor C-terminal-binding protein 2 (CtBP2) is a novel ALDOB-interacting proteinThe CtBP2-to-ALDOB expression ratio in clinical samples was correlated with the expression of CtBP2 targetALDOB inhibited CtBP2-mediated repression of multiple cell cycle inhibitor, proapoptotic, and epithelial4-methylthio 2-oxobutyric acid.

Keywords： ALDOB kidney cancer cell proliferation

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Special Issue for the 14th Global Chinese Chemical Engineering Symposium

Frontiers of Chemical Science and Engineering 2023, Volume 17, Issue 10, Pages 1321-1322 doi: 10.1007/s11705-023-2351-7

Abstract: Special Issue for the 14th Global Chinese Chemical Engineering Symposium

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A Novel Human Antibody, HF, against HER2/erb-B2 Obtained by a Computer-Aided Antibody Design Method Article

Chunxia Qiao, Ming Lv, Xinying Li, Xiaoling Lang, Shouqin Lv, Mian Long, Yan Li, Shusheng Geng, Zhou Lin, Beifen Shen , Jiannan Feng

Engineering 2021, Volume 7, Issue 11, Pages 1566-1576 doi: 10.1016/j.eng.2020.10.024

Abstract: display method (in vitro) or by transgenic mice (in vivo); other methods include BBased on the complex structure of human epidermal growth factor receptor 2 (HER2)/Herceptin, we firstdesigned six short peptides targeting the potential epitope of HER2 recognized by Herceptin.complementarity determining regions in a suitable immunoglobulin frame, giving birth to a novel anti-HER2

Keywords： HER2/erb-B2 Human antibody Computer-aided design

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Challenge of global climate change: Prospects for a new energy paradigm

Michael B. MCELROY

Frontiers of Environmental Science & Engineering 2010, Volume 4, Issue 1, Pages 2-11 doi: 10.1007/s11783-010-0005-8

Abstract: Perspectives on the challenge posed by potential future climate change are presented including a discussion of prospects for carbon capture followed either by sequestration or reuse including opportunities for alternatives to the use of oil in the transportation sector. The potential for wind energy as an alternative to fossil fuel energy as a source of electricity is outlined including the related opportunities for cost effective curtailment of future growth in emissions of CO.

Keywords： climate change carbon capture wind ethanol CO₂ radiative forcing

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Title Author Date Type Operation

Histone variants: critical determinants in tumour heterogeneity

Tao Wang, Florent Chuffart, Ekaterina Bourova-Flin, Jin Wang, Jianqing Mi, Sophie Rousseaux, Saadi Khochbin

Journal Article

Preface of special issue of the 10 th International Conference on CO 2 Utilization

Changjun LIU,

Journal Article

Detection of maternal serum thromboxane B2 in different durations of pregnancy and prediction of preeclampsia

Geqing XIA MD, Zehua WANG MD, Li ZOU MD, Chaoying WU MS, Yu HU MD,

Journal Article

Fenton oxidation of 2,4- and 2,6-dinitrotoluene and acetone inhibition

HE Yiliang, ZHAO Bin, HUGHES Joseph B., HAN Sung Soo

Journal Article

Study of recombinant human IFN-α-2b bacilli Calmette–Guerin activated killer cells and against bladder

FAN Xiaodong, HAN Ruifa

Journal Article

Anti-β glycoprotein I antibodies in complex with β2 glycoprotein I induce platelet activation via tworeceptors: apolipoprotein E receptor 2' and glycoprotein I bα

Wenjing Zhang,Fei Gao,Donghe Lu,Na Sun,Xiaoxue Yin,Meili Jin,Yanhong Liu

Journal Article

Neutralization against SARS-CoV-2 Delta/Omicron variants and B cell response after inactivated vaccination

Journal Article

The 9th China Engineering Management Forum Guangzhou Consensus

Journal Article

Relationship between Th17 cells and allograft rejection

Zhikun ZHENG MM, Jinsong LI MD, Ke JIANG MD,

Journal Article

China Engineering Management Forum Organization Committee

Journal Article

Inhibition of protein kinase B by Palmitate in the insulin signaling of HepG2 cells and the preventive