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《工程(英文)》 >> 2017年 第3卷 第1期 doi: 10.1016/J.ENG.2017.01.020

微生物组分析技术的发展趋势:从单细胞功能成像到菌群大数据

a Single-Cell Center, CAS Key Laboratory of Biofuels, Shandong Key Laboratory of Energy Genetics, Qingdao Institute of BioEnergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao, Shandong 266101, China
b Center for Microbiome Innovation, Department of Pediatrics, Department of Computer Science and Engineering, University of California San Diego, CA 92093, USA
c Department of Engineering Science, University of Oxford, Oxford OX1 3PJ, UK
d State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
e University of Chinese Academy of Sciences, Beijing 100049, China

录用日期: 2017-02-01 发布日期: 2017-02-28

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摘要

方法学创新一直是微生物组学研究的核心驱动力。我们认为在未来五到十年,微生物组的方法学体系在研究理念与技术平台方面将发生三大变革:①从监测菌群“结构”变化向监测菌群“功能/状态”变化的变革;②从细胞“群体”分析精度向细胞“个体”分析精度的转变;③从“数据分析”向“数据科学”的跨越。在这里我们针对实现上述三大方法学变革需要克服的关键科学或技术挑战,重点介绍了部分中国微生物组分析方法学研究团队及其国际合作伙伴的最新工作进展。我们相信中国微生物组计划应把握住当前这一重要机遇,通过在微生物组分析方法学前沿开展富有雄心、远见、创意与竞争力的交叉合作研究,为国际微生物组计划贡献一系列“中国制造”的新方法、新工具和新仪器。

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