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《工程(英文)》 >> 2022年 第9卷 第2期 doi: 10.1016/j.eng.2021.06.020

用于器官芯片的工程化血管系统

a State Key Laboratory of Fluid Power and Mechatronic Systems, Zhejiang University, Hangzhou 310058, China
b School of Mechanical Engineering, Zhejiang University, Hangzhou 310058, China
c The Affiliated Stomatologic Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China
d School of Materials Science and Engineering, Tongji University, Shanghai 201804, China

收稿日期: 2020-12-11 修回日期: 2021-06-10 录用日期: 2021-06-20 发布日期: 2021-08-19

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摘要

器官芯片技术是一种很有前途的三维(3D)动态培养方法,可确保准确高效的细胞培养,在临床前试验中具有替代动物模型的巨大潜力。血管系统是人体内最丰富的器官,在氧气交换和物质传递中起着至关重要的作用,是组织器官生存的决定性因素。因此,必须将血管系统集成到器官芯片中,以重建组织和器官微环境及其生理功能。本文讨论了血管与新兴器官芯片技术之间的协同作用,为复现生理学和疾病特征提供了更好的可能性。此外,回顾了血管化的器官芯片制造过程的不同步骤,包括使用不同生物制造策略的结构制造和组织构建。最后,概述了这项技术在器官和肿瘤培养这个有极具吸引力且快速发展的领域的适用性。

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