[ 1 ] Larsson DGJ. Pollution from drug manufacturing: review and perspectives. Philos Trans R Soc Lond B Biol Sci 2014;369(1656):20130571. 链接1

[ 2 ] Berendonk TU, Manaia CM, Merlin C, Fatta-Kassinos D, Cytryn E, Walsh F, et al. Tackling antibiotic resistance: the environmental framework. Nat Rev Microbiol 2015;13(5):310‒7. 链接1

[ 3 ] Larsson DGJ, Flach CF. Antibiotic resistance in the environment. Nat Rev Microbiol 2022;20(5):257‒69. 链接1

[ 4 ] Bewick MWM. Use of antibiotic fermentation wastes as fertilizers for tomatoes. J Agric Sci 1979;92(3):669‒74. 链接1

[ 5 ] Zhang Q, Ying G, Pan C, Liu Y, Zhao J. Comprehensive evaluation of antibiotics emission and fate in the river basins of China: source analysis, multimedia modeling, and linkage to bacterial resistance. Environ Sci Technol 2015;49(11):6772‒82. 链接1

[ 6 ] Ding Y, Zhang W, Gu C, Xagoraraki I, Li H. Determination of pharmaceuticals in biosolids using accelerated solvent extraction and liquid chromatography/tandem mass spectrometry. J Chromatogr A 2011;1218(1):10‒6. 链接1

[ 7 ] Carvalho RN, Ceriani L, Ippolito A, Lettieri T. Development of the 1st Watch List under the Environmental Quality Standards Directive. Report. Luxembourg: Publications Office of the European Union. 2015. Report No.: EUR 27142 EN.

[ 8 ] Bengtsson-Palme J, Larsson DGJ. Concentrations of antibiotics predicted to select for resistant bacteria: proposed limits for environmental regulation. Environ Int 2016;86:140‒9. 链接1

[ 9 ] Tang M, Gu Y, Wei D, Tian Z, Tian Y, Yang M, et al. Enhanced hydrolysis of fermentative antibiotics in production wastewater: hydrolysis potential prediction and engineering application. Chem Eng J 2020;391:123626. 链接1

[10] He Y, Tian Z, Yi Q, Zhang Yu, Yang M. Impact of oxytetracycline on anaerobic wastewater treatment and mitigation using enhanced hydrolysis pretreatment. Water Res 2020;187:116408. 链接1

[11] Tang M, Li F, Yang M, Zhang Y. Degradation of kanamycin from production wastewater with high-concentration organic matrices by hydrothermal treatment. J Environ Sci (China) 2020;97:11‒8. 链接1

[12] Yi Q, Zhang Y, Gao Y, Tian Z, Yang M. Anaerobic treatment of antibiotic production wastewater pretreated with enhanced hydrolysis: simultaneous reduction of COD and ARGs. Water Res 2017;110:211‒7. 链接1

[13] Yousefifar A, Baroutian S, Farid MM, Gapes DJ, Young BR. Fundamental mechanisms and reactions in non-catalytic subcritical hydrothermal processes: a review. Water Res 2017;123:607‒22. 链接1

[14] Cai C, Hua Yu, Li H, Li L, Dai L, Liu H, et al. Hydrothermal treatment of erythromycin fermentation residue: harmless performance and bioresource properties. Resour Conserv Recycling 2020;161:104952. 链接1

[15] Zhang Y, Liu H, Dai X, Cai C, Wang J, Wang M, et al. Impact of application of heat-activated persulfate oxidation treated erythromycin fermentation residue as a soil amendment: soil chemical properties and antibiotic resistance. Sci Total Environ 2020;736:139668. 链接1

[16] Luan X, Han Z, Shen Y, Yang M, Zhang Y. Assessing the effect of treated erythromycin fermentation residue on antibiotic resistome in soybean planting soil: in situ field study. Sci Total Environ 2021;779:146329. 链接1

[17] Topp E, Renaud J, Sumarah M, Sabourin L. Reduced persistence of themacrolide antibiotics erythromycin, clarithromycin and azithromycin in agricultural soil following several years of exposure in the field. Sci Total Environ 2016;562:136‒44. 链接1

[18] Lau CHF, Tien YC, Stedtfeld RD, Topp E. Impacts of multi-year field exposure of agricultural soil to macrolide antibiotics on the abundance of antibiotic resistance genes and selected mobile genetic elements. Sci Total Environ 2020;727:138520. 链接1

[19] Chow LKM, Ghaly TM, Gillings MR. A survey of sub-inhibitory concentrations of antibiotics in the environment. J Environ Sci 2021;99:21‒7. 链接1

[20] Andersson DI, Hughes D. Microbiological effects of sublethal levels of antibiotics. Nat Rev Microbiol 2014;12(7):465‒78. 链接1

[21] Jørgensen KM, Wassermann T, Jensen PØ, Hengzuang W, Molin S, Høiby N, et al. Sublethal ciprofloxacin treatment leads to rapid development of high-level ciprofloxacin resistance during long-term experimental evolution of Pseudomonas aeruginosa. Antimicrob Agents Chemother 2013;57(9):4215‒21. 链接1

[22] Andersson DI, Hughes D. Evolution of antibiotic resistance at non-lethal drug concentrations. Drug Resist Updat 2012;15(3):162‒72. 链接1

[23] Xie W, Yuan S, Xu M, Yang X, Shen Q, Zhang W, et al. Long-term effects of manure and chemical fertilizers on soil antibiotic resistome. Soil Biol Biochem 2018;122:111‒9. 链接1

[24] Wang Y, Li S, Zhang F, Lu Y, Yang B, Zhang F, et al. Study of matrix effects for liquid chromatography-electrospray ionization tandem mass spectrometric analysis of 4 aminoglycosides residues in milk. J Chromatogr A 2016;‍1437:8‒14.

[25] Fouhy F, Clooney AG, Stanton C, Claesson MJ, Cotter PD. 16S rRNA gene sequencing of mock microbial populations—impact of DNA extraction method, primer choice and sequencing platform. BMC Microbiol 2016;16:123. 链接1

[26] Yan L, Yang M, Guo H, Yang L, Wu J, Li R, et al. Single-cell RNA-Seq profiling of human preimplantation embryos and embryonic stem cells. Nat Struct Mol Biol 2013;20(9):1131‒9. 链接1

[27] Yin X, Jiang XT, Chai B, Li L, Yang Y, Cole JR, et al. ARGs-OAP v2.0 with an expanded SARG database and Hidden Markov Models for enhancement characterization and quantification of antibiotic resistance genes in environmental metagenomes. Bioinformatics 2018;34(13):2263‒70. 链接1

[28] Ju F, Beck K, Yin X, Maccagnan A, McArdell CS, Singer HP, et al. Wastewater treatment plant resistomes are shaped by bacterial composition, genetic exchange, and upregulated expression in the effluent microbiomes. ISME J 2019;13(2):346‒60. 链接1

[29] Angly FE, Dennis PG, Skarshewski A, Vanwonterghem I, Hugenholtz P, Tyson GW. CopyRighter: a rapid tool for improving the accuracy of microbial community profiles through lineage-specific gene copy number correction. Microbiome 2014;2:11. 链接1

[30] Yang Y, Jiang X, Chai B, Ma L, Li B, Zhang A, et al. ARGs-OAP: online analysis pipeline for antibiotic resistance genes detection from metagenomic data using an integrated structured ARG-database. Bioinformatics 2016;32(15):2346‒51. 链接1

[31] Pärnänen K, Karkman A, Hultman J, Lyra C, Bengtsson-Palme J, Larsson DGJ, et al. Maternal gut and breast milk microbiota affect infant gut antibiotic resistome and mobile genetic elements. Nat Commun 2018;9:3891. 链接1

[32] Patro R, Duggal G, Love MI, Irizarry RA, Kingsford C. Salmon provides fast and bias-aware quantification of transcript expression. Nat Methods 2017;14(4):417‒9. 链接1

[33] Li D, Liu CM, Luo R, Sadakane K, Lam TW. MEGAHIT: an ultra-fast single-node solution for large and complex metagenomics assembly via succinct de Bruijn graph. Bioinformatics 2015;31(10):1674‒6. 链接1

[34] Uritskiy GV, DiRuggiero J, Taylor J. MetaWRAP—a flexible pipeline for genome-resolved metagenomic data analysis. Microbiome 2018;6:158. 链接1

[35] Wu YW, Simmons BA, Singer SW. MaxBin 2.0: an automated binning algorithm to recover genomes from multiple metagenomic datasets. Bioinformatics 2016;32(4):605‒7. 链接1

[36] Parks DH, Rinke C, Chuvochina M, Chaumeil PA, Woodcroft BJ, Evans PN, et al. Recovery of nearly 8000 metagenome-assembled genomes substantially expands the tree of life. Nat Microbiol 2017;2(11):1533‒42. 链接1

[37] Chaumeil PA, Mussig AJ, Hugenholtz P, Parks DH. GTDB-Tk: a toolkit to classify genomes with the Genome Taxonomy Database. Bioinformatics 2019;36:1925‒7. 链接1

[38] Alcock BP, Raphenya AR, Lau TTY, Tsang KK, Bouchard M, Edalatmand A, et al. CARD 2020: antibiotic resistome surveillance with the comprehensive antibiotic resistance database. Nucleic Acids Res 2020;48(D1):D517‒25.

[39] Seemann T. Prokka: rapid prokaryotic genome annotation. Bioinformatics 2014;30(14):2068‒9. 链接1

[40] Yuan L, Wang Y, Zhang L, Palomo A, Zhou J, Smets BF, et al. Pathogenic and indigenous denitrifying bacteria are transcriptionally active and key multi-antibiotic-resistant players in wastewater treatment plants. Environ Sci Technol 2021;55(15):10862‒74. 链接1

[41] Rice EW, Wang P, Smith AL, Stadler LB. Determining hosts of antibiotic resistance genes: a review of methodological advances. Environ Sci Technol Lett 2020;7(5):282‒91. 链接1

[42] Anderson MJ. A new method for non-parametric multivariate analysis of variance. Austral Ecol 2001;26(1):32‒46. 链接1

[43] Segata N, Izard J, Waldron L, Gevers D, Miropolsky L, Garrett WS, et al. Metagenomic biomarker discovery and explanation. Genome Biol 2011;12(6):R60. 链接1

[44] Peres-Neto PR, Jackson DA. How well do multivariate data sets match? The advantages of a Procrustean superimposition approach over the Mantel test. Oecologia 2001;129(2):169‒78. 链接1

[45] Smouse PE, Long JC, Sokal RR. Multiple-regression and correlation extensions of the mantel test of matrix correspondence. Syst Zool 1986;35(4):627‒32. 链接1

[46] Byrne BM. Structural equation modeling with amos: basic concepts, applications, and programming. Mahwah: Lawrence Erlbaum Associates Publishers; 2001.

[47] Schermelleh-Engel K, Moosbrugger H, Müller H. Evaluating the fit of structural equation models: tests of significance and descriptive goodness-of-fit measures. Methods Psychol Res Online 2003;8:23‒74. 链接1

[48] Senta I, Kostanjevecki P, Krizman-Matasic I, Terzic S, Ahel M. Occurrence and behavior of macrolide antibiotics in municipal wastewater treatment: possible importance of metabolites, synthesis byproducts, and transformation products. Environ Sci Technol 2019;53(13):7463‒72. 链接1

[49] Muurinen J, Stedtfeld R, Karkman A, Pärnänen K, Tiedje J, Virta M. Influence of manure application on the environmental resistome under finnish agricultural practice with restricted antibiotic use. Environ Sci Technol 2017;‍51(11):5989‒99. 链接1

[50] Bengtsson-Palme J, Larsson DGJ. Antibiotic resistance genes in the environment: prioritizing risks. Nat Rev Microbiol 2015;13(6):396. 链接1

[51] Roberts MC, Sutcliffe J, Courvalin P, Jensen LB, Rood J, Seppala H. Nomenclature for macrolide and macrolide‍‒‍lincosamide‍‒‍streptogramin B resistance determinants. Antimicrob Agents Chemother 1999;43(12):2823‒30. 链接1

[52] Saribas Z, Tunckanat F, Pinar A. Prevalence of erm genes encoding macrolide-lincosamide-streptogramin (MLS) resistance among clinical isolates of Staphylococcus aureus in a Turkish university hospital. Clin Microbiol Infect 2006;12(8):797‒9. 链接1

[53] Whitehead TR, Cotta MA. Sequence analyses of a broad host-range plasmid containing ermT from a tylosin-resistant Lactobacillus sp. isolated from swine feces. Curr Microbiol 2001;43(1):17‒20. 链接1

[54] Tsai JC, Hsueh PR, Chen HJ, Tseng SP, Chen PY, Teng LJ. The erm(T) gene is flanked by IS1216V in inducible erythromycin-resistant Streptococcus gallolyticus subsp. pasteurianus. Antimicrob Agents Chemother 2005;‍49(10):4347‒50. 链接1

[55] Bethke JH, Davidovich A, Cheng L, Lopatkin AJ, Song W, Thaden JT, et al. Environmental and genetic determinants of plasmid mobility in pathogenic Escherichia coli. Sci Adv 2020;6(4):eaax3173. 链接1

[56] Kobayashi N, Nishino K, Yamaguchi A. Novel macrolide-specific ABC-type efflux transporter in Escherichia coli. J Bacteriol 2001;183(19):5639‒44. 链接1

[57] Greene NP, Kaplan E, Crow A, Koronakis V. Antibiotic resistance mediated by the macb abc transporter family: a structural and functional perspective. Front Microbiol 2018;9:950. 链接1

[58] Heß S, Gallert C. Growth behavior of E. coli, Enterococcus and Staphylococcus species in the presence and absence of sub-inhibitory antibiotic concentrations: consequences for interpretation of culture-based data. Microb Ecol 2016;72(4):898‒908. 链接1

[59] Gullberg E, Cao S, Berg OG, Ilbäck C, Sandegren L, Hughes D, et al. Selection of resistant bacteria at very low antibiotic concentrations. PLoS Pathog 2011;7(7):e1002158. 链接1

[60] Hall JPJ, Wright RCT, Harrison E, Muddiman KJ, Wood AJ, Paterson S, et al. Plasmid fitness costs are caused by specific genetic conflicts enabling resolution by compensatory mutation. PLoS Biol 2021;19(10):e3001225. 链接1

[61] Zhang J, Sui Q, Tong J, Zhong H, Wang Y, Chen M, et al. Soil types influence the fate of antibiotic-resistant bacteria and antibiotic resistance genes following the land application of sludge composts. Environ Int 2018;118:34‒43. 链接1

[62] Udikovic-Kolic N, Wichmann F, Broderick NA, Handelsman J. Bloom of resident antibiotic-resistant bacteria in soil following manure fertilization. Proc Natl Acad Sci USA 2014;111(42):15202‒7. 链接1

[63] Yang Y, Li B, Ju F, Zhang T. Exploring variation of antibiotic resistance genes in activated sludge over a four-year period through a metagenomic approach. Environ Sci Technol 2013;47(18):10197‒205. 链接1

[64] Garner E, Chen C, Xia K, Bowers J, Engelthaler DM, McLain J, et al. Metagenomic characterization of antibiotic resistance genes in full-scale reclaimed water distribution systems and corresponding potable systems. Environ Sci Technol 2018;52(11):6113‒25. 链接1

[65] Rutgersson C, Ebmeyer S, Lassen SB, Karkman A, Fick J, Kristiansson E, et al. Long-term application of Swedish sewage sludge on farmland does not cause clear changes in the soil bacterial resistome. Environ Int 2020;137:105339. 链接1

[66] Department for Environment Food & Rural Affairs. Fertiliser manual (RB209). 8th ed. Norwich: The Stationery Office (TSO); 2010. 链接1

[67] Wang F, Harindintwali JD, Yuan Z, Wang M, Wang F, Li S, et al. Technologies and perspectives for achieving carbon neutrality. Innovation 2021;2(4):100180. 链接1

[68] Tang M, Dou X, Tian Z, Yang M, Zhang Y. Enhanced hydrolysis of streptomycin from production wastewater using CaO/MgO solid base catalysts. Chem Eng J 2019;355:586‒93. 链接1

[69] Lang Q, Zhang B, Liu Z, Chen Z, Xia Y, Li D, et al. Co-hydrothermal carbonization of corn stalk and swine manure: combustion behavior of hydrochar by thermogravimetric analysis. Bioresour Technol 2019;271:75‒83. 链接1