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ACSL5, a prognostic factor in acute myeloid leukemia, modulates the activity of Wnt/-catenin signaling

《医学前沿(英文)》 2023年 第17卷 第4期   页码 685-698 doi: 10.1007/s11684-022-0942-1

摘要: Acyl-CoA synthetase long chain family member 5 (ACSL5), is a member of the acyl-CoA synthetases (ACSs) family that activates long chain fatty acids by catalyzing the synthesis of fatty acyl-CoAs. The dysregulation of ACSL5 has been reported in some cancers, such as glioma and colon cancers. However, little is known about the role of ACSL5 in acute myeloid leukemia (AML). We found that the expression of ACSL5 was higher in bone marrow cells from AML patients compared with that from healthy donors. ACSL5 level could serve as an independent prognostic predictor of the overall survival of AML patients. In AML cells, the ACSL5 knockdown inhibited cell growth both in vitro and in vivo. Mechanistically, the knockdown of ACSL5 suppressed the activation of the Wnt/β-catenin pathway by suppressing the palmitoylation modification of Wnt3a. Additionally, triacsin c, a pan-ACS family inhibitor, inhibited cell growth and robustly induced cell apoptosis when combined with ABT-199, the FDA approved BCL-2 inhibitor for AML therapy. Our results indicate that ACSL5 is a potential prognosis marker for AML and a promising pharmacological target for the treatment of molecularly stratified AML.

关键词: acute myeloid leukemia     acyl-CoA synthetase long chain family member 5     Wnt3a     palmitoylation     ABT-199    

Keratin 5-Cre-driven deletion of

Jun Yang, Lianqing Wang, Yingzhi Huang, Keqiang Liu, Chaoxia Lu, Nuo Si, Rongrong Wang, Yaping Liu, Xue Zhang

《医学前沿(英文)》 2020年 第14卷 第3期   页码 305-317 doi: 10.1007/s11684-019-0722-8

摘要: Familial acne inversa (AI) is an autoinflammatory disorder that affects hair follicles and is caused by loss-of-function mutations in -secretase component genes. We and other researchers showed that ( ) is the most frequently mutated gene in familial AI. In this study, we generated a keratin 5-Cre-driven epidermis-specific conditional knockout mutant in mice. We determined that this mutant recapitulated the major phenotypes of AI, including hyperkeratosis of hair follicles and inflammation. In mice, the IL-36a expression level markedly increased starting from postnatal day 0 (P0), and this increase occurred much earlier than those of TNF- , IL-23A, IL-1 and TLR4. RNA-Seq analysis indicated that Sprr2d, a member of the small proline-rich protein 2 family, in the skin tissues of the mice was also upregulated on P0. Quantitative reverse-transcription polymerase chain reaction showed that other genes had a similar expression pattern. Our findings suggested that IL-36a might be a key inflammatory cytokine in the pathophysiology of AI and involved in the malfunction of the skin barrier in the pathogenesis of AI.

关键词: acne inversa mouse model     interleukin 1 family     member 6     small proline rich protein 2D     key inflammatory cytokine    

Responses of bacterial strains isolated from drinking water environments to N-acyl-L-homoserine lactones

Zhuoying WU, Qing WANG, Feng GUO, Shenghua ZHANG, Qipei JIANG, Xin YU

《环境科学与工程前沿(英文)》 2014年 第8卷 第2期   页码 205-214 doi: 10.1007/s11783-013-0492-5

摘要: Often as a result of biofilm formation, drinking water distribution systems (DWDS) are regularly faced with the problem of microbial contamination. Quorum sensing (QS) systems play a marked role in the regulation of microbial biofilm formation; thus, inhibition of QS systems may provide a promising approach to biofilm formation control in DWDS. In the present study, 22 bacterial strains were isolated from drinking water-related environments. The following properties of the strains were investigated: bacterial biofilm formation capacity, QS signal molecule N-acyl-L-homoserine lactones (AHLs) production ability, and responses to AHLs and AHL analogs, 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) and 2(5H)-furanone. Four AHLs were added to developed biofilms at dosages ranging from 0.1?nmol·L to 100 nmol·L . As a result, the biofilm growth of more than 1/4 of the isolates, which included AHL producers and non-producers, were significantly promoted. Further, the biofilm biomasses were closely associated with respective AHLs concentrations. These results provided evidence to support the idea that AHLs play a definitive role in biofilm formation in many of the studied bacteria. Meanwhile, two AHLs analogs demonstrated unexpectedly minimal negative effects on biofilm formation. This suggested that, in order to find an applicable QS inhibition approach for biofilm control in DWDS, the testing and analysis of more analogs is needed.

关键词: drinking water distribution systems (DWDS)     biofilm     quorum sensing (QS)     N-acyl-L-homoserine lactones (AHLs)     (dichloromethyl)-5-hydroxy-2(5H)-furanone (MX)     2(5H)-furanone    

Benzene alkylation with long chain olefins catalyzed by ionic liquids: a review

QIAO Congzhen, CAI Yonghong, GUO Quanhui

《化学科学与工程前沿(英文)》 2008年 第2卷 第3期   页码 346-352 doi: 10.1007/s11705-008-0045-9

摘要: The introduction of ionic liquids to alkylation process gives a choice for “green production” in the petrochemical and detergent industry. A lot of papers and patents have been published using chloroaluminate ionic liquid as a novel catalyst for alkylation with high reactivity and easy separation from reactants. These included the acidity, characterization, determination and catalysis technologies in batch and continuous operation mode for different scales. According to published data and several results of pilot alkylation,including the authors’ experience,the prospect of chloroaluminate ionic liquids for commercials was also discussed. It has been pointed out that there still are many difficulties and challenges to be overcome for commercial application of the ionic liquid catalyst.

关键词: different     petrochemical     characterization     introduction     chloroaluminate    

Continuous reaction performances of benzene alkylation with long chain olefins catalyzed by ionic liquid

QIAO Congzhen, LI Chengyue

《化学科学与工程前沿(英文)》 2008年 第2卷 第1期   页码 69-73 doi: 10.1007/s11705-008-0014-3

摘要: Based on a compulsive mixing-reacting-separating-recycling small experimental setup,the continuous reaction performances of benzene alkylation with long chain olefins catalyzed by [BMIM]Cl-AlCl ionic liquid were investigated. Three different situations including normal continuous operation mode (reagent materials), sidetrack feeding from different axial positions along the static mixing reactor (reagent materials) and normal continuous alkylation using industrial paraffin and olefins materials were examined. Even under the relatively hypecritical reaction conditions, the single pass conversion of pure 1-dodecene could reach to nearly 100.0%, and the selectivity of 2-phenyl isomer was higher than 37.7%. Although the positions along the reactor for sidetrack feeding were different, the 100.0% single pass conversion of 1-dodecene was also attained before the outlet of the reactor. The refined industrial olefins as raw material could meet with the requirements of continuous alkylation. The influences of impurities such as di-olefins and non-benzene aromatics on the catalytic activity and stability should be studied further.

关键词: stability     different     hypecritical     compulsive mixing-reacting-separating-recycling     non-benzene    

中国进入空间能力的现状与展望

龙乐豪,王小军,果琳丽

《中国工程科学》 2006年 第8卷 第11期   页码 25-28

摘要:

总结了国外航天运输系统的现状及发展趋势;对比分析了我国长征系列运载火箭的现状和差距;提出了增强我国进入空间能力的五个发展方向,即改进现役运载火箭、研制新一代运载火箭系列、发展快速机动发射小型运载火箭、具备载人登月及深空运输能力、探索重复使用运输技术。

关键词: 航天     长征火箭家族     载人登月     重复使用运载器    

Long-term correction of hemorrhagic diathesis in hemophilia A mice by an AAV-delivered hybrid FVIII composedof the human heavy chain and the rat light chain

《医学前沿(英文)》 2022年 第16卷 第4期   页码 584-595 doi: 10.1007/s11684-021-0844-7

摘要: Conventional therapies for hemophilia A (HA) are prophylactic or on-demand intravenous FVIII infusions. However, they are expensive and inconvenient to perform. Thus, better strategies for HA treatment must be developed. In this study, a recombinant FVIII cDNA encoding a human/rat hybrid FVIII with an enhanced procoagulant potential for adeno-associated virus (AAV)-delivered gene therapy was developed. Plasmids containing human FVIII heavy chain (hHC), human light chain (hLC), and rat light chain (rLC) were transfected into cells and hydrodynamically injected into HA mice. Purified AAV viruses were intravenously injected into HA mice at two doses. Results showed that the hHC+ rLC protein had a higher activity than the hHC+ hLC protein at comparable expression levels. The specific activity of hHC+ rLC was about 4- to 8-fold higher than that of their counterparts. Hydrodynamic injection experiments obtained consistent results. Notably, the HA mice undergoing the AAV-delivered hHC+ rLC treatment exhibited a visibly higher activity than those treated with hHC+ hLC, and the therapeutic effects lasted for up to 40 weeks. In conclusion, the application of the hybrid FVIII (hHC+ rLC) via an AAV-delivered gene therapy substantially improved the hemorrhagic diathesis of the HA mice. These data might be of help to the development of optimized FVIII expression cassette for HA gene therapy.

关键词: hemophilia A     adeno-associated virus (AAV)     human/rat hybrid factor VIII     gene therapy     dual chain strategy    

The Integration Model of Closed-Loop Supply Chain Resource Allocation Considering Remanufacturing

Xiao-qiu Shi,Yan-yan Li,Wei Long

《工程管理前沿(英文)》 2016年 第3卷 第2期   页码 132-135 doi: 10.15302/J-FEM-2016026

摘要: Logistics resource planning is an integration model of materials requirement planning and distribution resource planning which is a resource allocation technology. It is a technology of satisfying both production material supply and resource allocation optimization which is based on inventory management. For the remanufacturing supply chain, recycling and rebuilding of products form a reverse materials movement loop which challenges the traditional logistics resource planning system. For the characteristics of reverse logistics of remanufacturing supply chain, we propose a closed-loop supply chain resource allocation model based on autonomous multi-entity. We focus on integration resource allocation model of materials requirement planning and distribution resource planning considering remanufacturing.

关键词: remanufacturing     supply chain     reverse logistics     resource allocation     integration model    

Synthesis of ordered cerium-doped cubic mesoporous silica using long-chain ionic liquid as template

YUE Hongxia, ZHAO Hongmei, LIU Longjiang, WANG Siping, Ruan Qiong, WANG Tongwen

《化学科学与工程前沿(英文)》 2008年 第2卷 第2期   页码 135-139 doi: 10.1007/s11705-008-0031-2

摘要: The long-chain ionic liquid 1-hexadecyl-3-methylimidazolium chloride (CmimCl) was used as a template to prepare cerium-doped MCM-48 materials in basic medium by a hydrothermal synthesis procedure. The effect of the amount of Ce salt and CmimCl/Si on the synthesis were discussed in detail. This mesoporous material exhibits a pore architecture which is cubic 3 gyroid and possesses a large surface area and a narrow pore distribution. Cerium in calcined porous framework exists in the form of well-dispersed tetrahedral coordination. The CmimCl shows a high tendency toward self-aggregation that allows the formation of the cerium-doped gyroid mesostructure by using the appropriate amount of Ce salt.

关键词: mesoporous     CmimCl/Si     tendency     mesostructure     synthesis procedure    

Optimal dome design considering member-related design constraints

Tugrul TALASLIOGLU

《结构与土木工程前沿(英文)》 2019年 第13卷 第5期   页码 1150-1170 doi: 10.1007/s11709-019-0543-5

摘要: This study proposes to optimize the design of geometrically nonlinear dome structures. A new Multi-objective Optimization Algorithm named Pareto Archived Genetic Algorithm (PAGA), which has an ability of integrating the nonlinear structural analysis with the provisions of American Petroleum Institute specification is employed to optimize the design of ellipse and sphere-shaped dome configurations. Thus, it is possible to investigate how the qualities of optimal designations vary considering the shape, size, and topology-related design variables. Furthermore, the computing efficiency of PAGA is evaluated considering six multi-objective optimization algorithms and eight quality measuring indicators. It is shown that PAGA has a capability of both exploring an increased number of pareto solutions and predicting a pareto front with a higher convergence degree. Moreover, the inclusion of shape-related design variables leads to a decrease in both the weights of dome structures and their load-carrying capacities. However, the designer easily determines the most requested optimal design through the archiving feature of PAGA. Thus, it is also demonstrated that the proposed optimal design procedure increases the correctness degree in the evaluation of optimal dome designs through the tradeoff analysis. Consequently, PAGA is recommended as an optimization tool for the design optimization of geometrically nonlinear dome structures.

关键词: dome structure     geometric nonlinearity     multi-objective optimization     API RP2A-LRFD    

Epidemiological study of a von Hippel-Lindau family in northwest China

null

《医学前沿(英文)》 2013年 第7卷 第3期   页码 378-385 doi: 10.1007/s11684-013-0276-0

摘要:

von Hippel-Lindau (VHL) disease is a rare, inherited neoplastic disease characterized by hemangioblastomas (HBL) of the central nervous system (CNS), retinal angiomas, renal cell carcinomas (RCC), pancreatic endocrine tumors (PETs), pheochromocytomas, paragangliomas, and visceral cysts. We encountered a large VHL family in northwest China and conducted a systematic screening of the family members based on their epidemiological and clinical characteristics. A self-designed questionnaire was used to collect the general sociodemographic and health information of the family members. For the preliminary family screening, physical examination and abdomen B ultrasonography were performed. The suspected patients were subjected to cranial computerized tomography and fundus examination. The clinical data of the patients with confirmed VHL disease were collected from hospital records. A total of 63 lineal descendants in six generations were observed in the family (generations O, A, B, C, D, E), including 9 dead suspected cases (6 males, 3 females) and 10 living cases (2 males, 8 females). Among the 10 living cases, 4, 2, 1, 3, 4, 8, and 2 manifested HBLs of the CNS, PETs, RCC, pancreatic cysts, renal cysts, pheochromocytomas (4 hemi and 4 bilateral), and paragangliomas, respectively. Data showed that the morbidity of VHL disease in generation C was lower than that in generation B, but the age of onset was younger. This study is the first to report VHL disease in northwest China and VHL-associated PET cases in Chinese. Therefore, follow-up checkups of the family should be focused on younger generations. Proper family screening protocols should be followed for the treatment of patients with VHL disease.

关键词: von Hippel-Lindau disease     epidemiology     family screening     pancreatic endocrine tumor    

普列克底物蛋白同源物样结构域家族A成员1蛋白——导致代谢疾病的多方面细胞存活因素 Review

Tamana Yousof, Jae Hyun Byun, Jack Chen, Richard C. Austin

《工程(英文)》 2023年 第20卷 第1期   页码 9-18 doi: 10.1016/j.eng.2022.05.014

摘要:

普列克底物蛋白同源物样结构域家族A成员1(PHLDA1)是多作用的胞内蛋白,属于进化上保守的普列克底物蛋白同源相关结构域家族。最初,PHLDA1的小鼠同源基因——T 细胞死亡相关51 基因(TDAG51)——因其在T细胞杂交瘤中活化诱导的细胞凋亡中的作用而被发现。近年来,由于PHLDA与肥胖症、脂肪性肝病、糖尿病、动脉硬化和癌症有关,因此受到越来越多的关注。越来越多的证据也证实,PHLDA1在内质网应激信号通路中作为细胞凋亡、自噬和增殖的关键介质发挥作用。本文综述了PHLDA1基因及蛋白调控、定位和功能方面的现有知识。本文重点介绍了PHLDA1促凋亡和抗凋亡,进而导致代谢性疾病的作用。

关键词: 内质网应激     代谢     凋亡     细胞存活     普列克底物蛋白同源物样结构域家族A成员1(PHLDA1)    

95式5.8mm班用枪族的研制

朵英贤

《中国工程科学》 1999年 第1卷 第2期   页码 57-61

摘要:

主要叙述我国轻武器行业两代工程技术人员在基础很薄弱的情况下,团结合作,用科学和严密的方法,在很短的时间内研制出高水平的步兵班用枪族,使中国步兵枪械达到世界先进水平,受到军方高度评价。该枪族已于1997年元月正式装备驻港部队,并将陆续装备全军。

关键词: 班用枪族     自动步枪     班用机枪     突击步枪    

A CO and CO

Guoxing Chen, Marc Widenmeyer, Binjie Tang, Louise Kaeswurm, Ling Wang, Armin Feldhoff, Anke Weidenkaff

《化学科学与工程前沿(英文)》 2020年 第14卷 第3期   页码 405-414 doi: 10.1007/s11705-019-1886-0

摘要: A series of novel dense mixed conducting ceramic membranes based on K NiF -type (La Ca ) (Ni Cu )O was successfully prepared through a sol-gel route. Their chemical compatibility, oxygen permeability, CO and CO tolerance, and long-term CO resistance regarding phase composition and crystal structure at different atmospheres were studied. The results show that higher Ca contents in the material lead to the formation of CaCO . A constant oxygen permeation flux of about 0.63 mL·min ·cm at 1173 K through a 0.65 mm thick membrane was measured for (La Ca ) (Ni Cu )O , using either helium or pure CO as sweep gas. Steady oxygen fluxes with no sign of deterioration of this membrane were observed with increasing CO concentration. The membrane showed excellent chemical stability towards CO for more than 1360 h and phase stability in presence of CO for 4 h at high temperature. In addition, this membrane did not deteriorate in a high-energy CO plasma. The present work demonstrates that this (La Ca ) (Ni Cu )O membrane is a promising chemically robust candidate for oxygen separation applications.

关键词: K2NiF4 structure     oxygen permeation membrane     CO2 and CO resistances     CO2 plasma resistance     long-term robustness    

Identification of novel mutations in and in a family with craniofacial microsomia: evidence of digenic

《医学前沿(英文)》   页码 1006-1009 doi: 10.1007/s11684-023-1000-3

摘要: Identification of novel mutations in and in a family with craniofacial microsomia: evidence of digenic inheritance

关键词: family craniofacial microsomia     Identification novel mutations    

标题 作者 时间 类型 操作

ACSL5, a prognostic factor in acute myeloid leukemia, modulates the activity of Wnt/-catenin signaling

期刊论文

Keratin 5-Cre-driven deletion of

Jun Yang, Lianqing Wang, Yingzhi Huang, Keqiang Liu, Chaoxia Lu, Nuo Si, Rongrong Wang, Yaping Liu, Xue Zhang

期刊论文

Responses of bacterial strains isolated from drinking water environments to N-acyl-L-homoserine lactones

Zhuoying WU, Qing WANG, Feng GUO, Shenghua ZHANG, Qipei JIANG, Xin YU

期刊论文

Benzene alkylation with long chain olefins catalyzed by ionic liquids: a review

QIAO Congzhen, CAI Yonghong, GUO Quanhui

期刊论文

Continuous reaction performances of benzene alkylation with long chain olefins catalyzed by ionic liquid

QIAO Congzhen, LI Chengyue

期刊论文

中国进入空间能力的现状与展望

龙乐豪,王小军,果琳丽

期刊论文

Long-term correction of hemorrhagic diathesis in hemophilia A mice by an AAV-delivered hybrid FVIII composedof the human heavy chain and the rat light chain

期刊论文

The Integration Model of Closed-Loop Supply Chain Resource Allocation Considering Remanufacturing

Xiao-qiu Shi,Yan-yan Li,Wei Long

期刊论文

Synthesis of ordered cerium-doped cubic mesoporous silica using long-chain ionic liquid as template

YUE Hongxia, ZHAO Hongmei, LIU Longjiang, WANG Siping, Ruan Qiong, WANG Tongwen

期刊论文

Optimal dome design considering member-related design constraints

Tugrul TALASLIOGLU

期刊论文

Epidemiological study of a von Hippel-Lindau family in northwest China

null

期刊论文

普列克底物蛋白同源物样结构域家族A成员1蛋白——导致代谢疾病的多方面细胞存活因素

Tamana Yousof, Jae Hyun Byun, Jack Chen, Richard C. Austin

期刊论文

95式5.8mm班用枪族的研制

朵英贤

期刊论文

A CO and CO

Guoxing Chen, Marc Widenmeyer, Binjie Tang, Louise Kaeswurm, Ling Wang, Armin Feldhoff, Anke Weidenkaff

期刊论文

Identification of novel mutations in and in a family with craniofacial microsomia: evidence of digenic

期刊论文