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垂直双扩散MOS场效应晶体管 1

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Effect of Ca

Qi WANG, Hongzhi JIANG, Shengli CHEN, Mingmin ZHANG, Mingxing DING, Esheng KONG, Guangying HUANG

《医学前沿（英文）》 2009年第3卷第1期页码 96-99 doi: 10.1007/s11684-009-0014-9

摘要： The aim of this paper was to explore the relationship between energy metabolism and the meridian phenomenon. The manner of change of oxygen partial pressure in acupoints and no-acupoints of the urinary bladder meridian of goats was observed with a needle-type tissue oxygen tension sensor after the acupuncture effect was blocked by Ca complexation with ethylenediamine tetraacetic acid (EDTA)-Na . The results showed that: (1) the concentration of calcium ion in urinary bladder meridian acupoints was higher than that in no-acupoints ( <0.01 or <0.05); (2) the tissue oxygen tension in urinary bladder meridian acupoints was higher than that in no-acupoints ( <0.01); (3) the oxygen partial pressure in acupoints decreased significantly after injection with EDTA-Na , compared with injection of either normal sodium or nothing ( <0.01); (4) the oxygen partial pressure in acupoints was higher than that in no-acupoints after EDTA-Na injection ( <0.01). Acupuncture could reduce oxygen partial pressure in acupoints by regulating microcirculation and increasing metabolic levels.

关键词： oxygen partial pressure biosensor calcium channels acupoint

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Biomimetic Macrophage–Fe3O4@PLGA Particle-Triggered Intelligent Catalysis for Killing Multidrug-Resistant Escherichia coli

Jieni Fu,Xiangmei Liu,Zhaoyang Li,Yufeng Zheng,Yu Zhang,Hui Jiang,Yanqin Liang,Shengli Zhu,Zhenduo Cui

《工程（英文）》 doi: 10.1016/j.eng.2023.05.022

摘要： Infections with multidrug-resistant (MRD) Gram-negative bacteria, such as MRD Escherichia coli (E. coli), remain a challenge due to the lack of safe antibiotics and high fatality rates under anti-infection therapies. This work presents a form of biomimetic intelligent catalysis inspired by the selective biocatalytic property of macrophages, consisting of an intelligent controlling center (a living macrophage, MΦ) and a Fenton reaction catalyst (Fe₃O₄@poly(lactic-co-glycolic acid) (PLGA) nanoparticles) for killing MDR E. coli without harming normal cells. The MΦ–Fe₃O₄@PLGA particles (i.e., the intelligent catalysis particles) exhibit selective biocatalysis activity toward MDR E. coli by producing H₂O₂ and lipid droplets (LDs). This process activates the lipid metabolism and glycan biosynthesis and metabolism pathways based on the result of RNA sequencing data analysis. The H₂O₂ further reacts with Fe₃O₄@PLGA to form highly toxic hydroxyl radicals (•OH), while the LDs contain antimicrobial peptides and can target MDR E. coli. The highly toxic •OH and antimicrobial peptides are shown to combat with MDR E. coli, such that the antibacterial efficiency of the MΦ–Fe₃O₄@PLGA particles against MDR E. coli is 99.29% ± 0.31% in vitro. More importantly, after several passages, the intelligent catalysis function of the MΦ–Fe₃O₄@PLGA particles is well maintained. Hence, the concept of biomimetic intelligent catalysts displays potential for treating diseases other than infections.

关键词： Multidrug-resistant Escherichia coli Macrophage–Fe3O4@PLGA particles Biomimetic intelligent catalysis

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大直径泥水盾构系统管理与典型故障分析

李小岗,李胜利,牛学臣

《中国工程科学》 2010年第12卷第12期页码 51-55

摘要：

通过对北京地下直径线大直径泥水盾构机典型故障的分析，提出了相应的处理办法和预防措施。同时通过对油样分析，有预见性地对盾构机进行维护保养，客观上使盾构机完好率得到了保证。并在施工过程中引入了“零库存”和工厂化管理等一套科学的设备管理理念及方法，提高了盾构机完好率，保证了盾构机的正常施工。

关键词：盾构故障诊断管理技术

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液体射流技术在油田开发中的新应用

吴太平,李生莉

《中国工程科学》 2004年第6卷第10期页码 75-78

摘要：

介绍了利用液体射流原理的4项油田开发新技术——负压法地层解堵技术、不动管柱降压排酸技术、油井井口降压掺水技术、污水沉降罐底部负压排污泥技术——的原理、特点、适应范围、现场应用效果等；通过现场200多井(套)次证明，采用液体射流对地层解堵效果明显，不会对储层造成伤害；采用液体射流排残酸，排酸迅速、彻底；采用液体射流法在井口掺热水，可降低井口回压，改善油井工况，提高泵效；采用液体射流法排放污水沉降罐底部沉积污泥，能提高排泥效果，改善污水处理质量；液体射流新技术工艺简单，操作方便，成本低廉，在油田生产中具有较好的应用前景。

关键词：液体射流油田应用

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肿瘤诊疗新方法与新技术

王红阳, 杨胜利

《工程（英文）》 2021年第7卷第10期页码 1343-1344 doi: 10.1016/j.eng.2021.08.002

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A post-GWAS replication study confirming the association of

Shaohua YANG,Chao QI,Yan XIE,Xiaogang CUI,Yahui GAO,Jianping JIANG,Li JIANG,Shengli ZHANG,Qin ZHANG,Dongxiao

《农业科学与工程前沿（英文）》 2014年第1卷第4期页码 321-330 doi: 10.15302/J-FASE-2014037

摘要： Genome-wide association studies with an Illumina Bovine50K chip have detected 105 SNPs associated with one or multiple milk production traits in the Chinese Holstein population. Of these, 38 significant SNPs detected with high confidence by both L1-TDT and MMRA methods were selected to further mine potential key genes affecting milk yield and milk composition. By blasting the flanking sequences of these 38 SNPs with the bovine genome sequence combined with comparative genomics analysis, 26 genes were found to contain or be near to such SNPs. Among them, the gene is merely 87 bp away from the significant SNP, Hapmap30383-BTC-005848. Hence, we report herein genotype-phenotype associations to further validate the genetic effects of the gene. By pooled DNA sequencing of 14 unrelated Holstein sires, a total of 18 with seven novel SNPs were identified. Among them, nine SNPs were in the 5′ regulatory region, one in exon 6 and the other in the 3′ UTR and 3′ regulatory region. A total of nine of these identified SNPs were successfully genotyped and analyzed by mass spectrometry for association with five milk production traits in an independent resource population. The results showed that these SNPs were statistically significant for more than two traits [ <(0.0001-0.0267)]. In addition, mRNA expression analyses revealed that was ubiquitous in eight different tissues, with a relatively higher expression level in the mammary gland than in other tissues. These findings, therefore, provide strong evidence for association of variants with milk yield and milk composition traits and may be applied in Chinese Holstein breeding programs.

关键词： GWAS functional annotation Chinese Holstein milk production traits C14H8orf33 gene single nucleotide polymorphisms association study

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中药现代化与国际化探索

张伯礼, 杨胜利, 果德安

《工程（英文）》 2019年第5卷第1期页码 1-2 doi: 10.1016/j.eng.2019.01.002

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大型农业生态工程的数学模型

卞有生,王天喜,陈正龙,崔斌

《中国工程科学》 2002年第4卷第7期页码 17-22

摘要：

文章在对胜利油田生态农场系统结构分析的基础上，根据农场规划目标，建立了由投入产出模型和线性规划模型相结合的经济发展数学模型。应用该模型指导农场的经济建设，取得了极好的效果，证明所建立的模型是正确的。

关键词：农业生态工程数学模型胜利油田

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桥面铺装对钢桥面板疲劳应力幅的影响

吴冲,刘海燕,张胜利,崔冰,丁文俊

《中国工程科学》 2010年第12卷第7期页码 39-42

摘要：

钢桥面板厚度小，铺装层的相对刚度较大，钢桥面板疲劳设计时，应该考虑铺装层与钢桥面板的共同作用。假设桥面铺装与顶板没有相对滑移，采用有限元方法探讨了桥面铺装弹性模量和厚度对正交异性钢桥面板疲劳应力幅的影响。

关键词：桥梁钢桥面板桥面铺装疲劳应力幅

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Visbreaking of heavy petroleum oil catalyzed by SO/ZrO solid super-acid doped with Ni or Sn

JING Ping, LI Qingbiao, HAN Mei, SUN Daohua, JIA Lishan, FANG Weiping

《化学科学与工程前沿（英文）》 2008年第2卷第2期页码 186-190 doi: 10.1007/s11705-008-0035-y

摘要： SO/ZrO solid super-acid catalysts (SZ) doped with Ni or Sn (Ni/SZ, Sn/SZ) were prepared for catalytic visbreaking of heavy petroleum oil from Shengli oil field. The visbreaking reactions were carried out at 240°C and 3–4 MPa for 24 h using a heavy petroleum oil to catalyst mass ratio of 100 : 0.05. The effect of water content on viscosity of heavy petroleum oil was also investigated. Both catalysts can promote thermolysis of heavy petroleum oil and the viscosity was reduced from 0.319 Pa·s to 0.135 Pa·s for Ni/SZ and 0.163 Pa·s for (Sn/SZ) with visbreaking rates of 57.7% and 48.9%, respectively. After visbreaking, the saturated hydrocarbon content increased while aromatics, resin, asphaltene, sulfur and nitrogen content decreased. The presence of water was disadvantageous to visbreaking of heavy petroleum oil.

关键词： thermolysis Shengli asphaltene SO/ZrO presence

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一种时空权重和边缘自适应的扫描格式转换

丁勇,陆生礼,时龙兴

《中国工程科学》 2007年第9卷第10期页码 49-54

摘要：

为实现隔行扫描到逐行扫描的视频扫描格式转换，提出了一种时空权重和边缘自适应的去隔行算法，主要包括运动估计、小角度边缘搜索、时空权重计算、自适应插值等。该算法通过4场相邻像素的最大灰度变化与运动阈值比较实现对当前像素的运动估计，采用自适应搜索半径和并行搜索树的方法实现小角度边缘检测，并且增加对半像素边缘的考虑实现最小6°边缘的检测，最后通过时空权重自适应的插值算法实现去隔行处理，取得很好的处理效果。

关键词：扫描格式转换运动估计边缘搜索时空权重自适应插值去隔行

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新型PB-PSOI器件表面电场和温度分布模型研究

孙伟锋,高珊,陆生礼,陈军宁

《中国工程科学》 2009年第11卷第11期页码 82-87

摘要：

根据泊松方程和热扩散方程提出了新型PB-PSOI 器件漂移区的二维表面电场分布模型和温度分布模型，模型计算结果与Medici模拟结果相一致。根据所提出的模型，重点研究了埋氧化层厚度及长度对漂移区表面电场分布和温度分布的影响，最后给出了PB-PSOI 器件的埋氧化层厚度和长度的优化设计方法。

关键词： PB-PSOI 表面电场温度分布埋氧化层

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新型国家药品服务体系建设的构想

王健,袁春平,王浩,张志荣,张强,陈桂良,刘昌孝,侯惠民,杨胜利

《中国工程科学》 2017年第19卷第2期页码 62-67 doi: 10.15302/J-SSCAE-2017.02.010

摘要：

我国现有药品服务体系可初步满足医疗卫生的基本需求，但在研发、生产、销售及使用的各领域中均存在一些突出问题。本研究通过文献检索、数据查询、专家咨询及专题讨论，对我国药品服务体系的现状进行调研，找准存在的问题，并提出建设新型国家药品服务体系的构想，旨在为我国人民提供质量优良、疗效可靠、价格合理、使用方便的药品，保障临床用药的有效性、安全性、可及性及合理性；同时，促进制药产业结构转型发展，推动我国从制药大国向制药强国的转变。

关键词：药品服务体系制药产业监管发展战略

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高压VDMOS的一种高精度静态物理模型

鲍嘉明,孙伟锋,赵野,陆生礼

《中国工程科学》 2008年第10卷第2期页码 72-78

摘要：

提出了高压VDMOS的一种高精度静态物理模型(HASPM)。在该模型中，基于更为合理的假设而使得用解析方法求得了双扩散沟道区中的电场和电压；通过深入研究VDMOS 内部的物理特性，给出了一个关于漂移区电场的微分方程，并在整个漂移区都用解析方法求解了该微分方程，由此求得了漂移区的电压降。计算结果表明，该模型在漏端电流接近饱和处的稳定性有较大提高，具有较高的计算精度，特别是在栅电压与漏电压都比较大的情况下，其计算精度有较大程度的提高。

关键词：垂直双扩散MOS场效应晶体管静态物理模型解析方法