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Netrin-1 works with UNC5B to regulate angiogenesis in diabetic kidney disease

Xiaojing Jiao, Dong Zhang, Quan Hong, Lei Yan, Qiuxia Han, Fengmin Shao, Guangyan Cai, Xiangmei Chen, Hanyu Zhu

《医学前沿（英文）》 2020年第14卷第3期页码 293-304 doi: 10.1007/s11684-019-0715-7

摘要： Netrin-1, an axon guidance factor, and its receptor UNC5B play important roles in axonal development and angiogenesis. This study examined netrin-1 and UNC5B expression in kidneys with diabetic kidney disease (DKD) and investigated their roles in angiogenesis. Netrin-1 and UNC5B were upregulated in streptozotocin-induced DKD Wistar rats, and their expression was compared with that in healthy controls. However, exogenous netrin-1 in UNC5B-depleted human renal glomerular endothelial cells (HRGECs) inhibited cell migration and tubulogenesis. This effect was likely associated with SRC pathway deactivation. Netrin-1 treatment also eliminated the pro-angiogenic effects of exogenous VEGF-165 on UNC5B-silenced HRGECs. These results indicate that UNC5B antagonizes netrin-1 and that UNC5B upregulation contributes partly to enhancing angiogenesis in DKD. Therefore, introducing exogenous netrin-1 and depleting endogenous UNC5B are potential strategies for reducing the incidence of early angiogenesis and mitigating kidney injury in DKD.

关键词： netrin-1 VEGF-165 UNC5B angiogenesis diabetic kidney disease

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多天线非正交多址接入技术：综述 Regular Papers

Fei-yan TIAN, Xiao-ming CHEN

《信息与电子工程前沿（英文）》 2019年第20卷第12期页码 1665-1697 doi: 10.1631/FITEE.1900405

摘要：在第5代及未来无线通信网络中，非正交多址接入技术为实现大规模万物互联提供了可行方案。然而，严重的共道干扰和较高的实施复杂度阻碍了其在实际系统中的应用。

关键词：非正交多址接入；多天线技术；B5G；物联网

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MicroRNA-148b promotes proliferation of hair follicle cells by targeting

Wanbao YANG,Qinqun LI,Bo SU,Mei YU

《农业科学与工程前沿（英文）》 2016年第3卷第1期页码 72-80 doi: 10.15302/J-FASE-2016089

摘要： MicroRNAs (miRNAs), small non-coding RNAs, are involved in many aspects of biological processes. Previous studies have indicated that miRNAs are important for hair follicle development and growth. In our study, we found by qRT-PCR that miR-148b was significantly upregulated in sheep wool follicle bulbs in anagen phase compared with the telogen phase of the hair follicle cycle. Overexpression of miR-148b promoted proliferation of both HHDPC and HHGMC. By using the TOPFlash system we demonstrated that miR-148b could activate Wnt/β-catenin pathway and , , and were consistently upregulated accordingly. Furthermore, transcript factor nuclear factor of activated T cells type 5 ( ) and were predicted to be the target of miR-148b and this was substantiated using a Dual-Luciferase reporter system. Subsequently was further identified as the target of miR-148b using western blotting. These results were considered to indicate that miR-148b could activate the Wnt/β-catenin signal pathway by targeting to promote the proliferation of human hair follicle cells.

关键词： miR-148b hair follicle proliferation NFAT5 Wnt10b

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5G成效未达预期

Mitch Leslie

《工程（英文）》 2023年第29卷第10期页码 5-7 doi: 10.1016/j.eng.2023.08.003

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基于 5G技术的教育信息化应用研究

卢向群,孙禹

《中国工程科学》 2019年第21卷第6期页码 120-128 doi: 10.15302/J-SSCAE-2019.06.020

摘要：

教育信息化日益普及，智慧学习空间不断出现，学生对学习内容的个性化、便捷化、多样化需求也日益凸显，而第五代移动通信（ 5G）技术以其大带宽、本文重点探索 5G技术的教育信息化应用，在梳理教育信息化主要特征的基础上，分析了我国教育网络面临的技术挑战，从教学、教研、教育管理三方面着手，论证提出相应的 5G应用场景，形成 5G教育信息化总体视图。面向 2035年， 5G的技术普及与应用拓展，将不断丰富教育场景的内涵，推动教育场景的变革，成为我国教育信息化创新的原生动力。

关键词：教育信息技术教育信息化 5G 技术应用场景

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5G应用下的MIMO阵列天线去耦方法综述 Review Articles

Xiao-xi ZHANG, Ai-di REN, Ying LIU

《信息与电子工程前沿（英文）》 2020年第21卷第1期页码 62-71 doi: 10.1631/FITEE.1900466

摘要：提出一种面向微纳卫星的自主汽化管理液氨推进系统。相比常规冷气或液化气推进系统，提出多路平行筛孔式汽化装置和对应汽化控制方法。所提方案有效解决了液氨高汽化潜热和不易完全汽化的问题，从而发挥液氨推进剂高贮存密度和高比冲性能优势。此外，重点分析自主汽化管理液氨推进系统的工作流程及其涉及的物理化学过程和数学模型。综合考虑推力表现和能源效率，提出最优系统推力控制策略。地面测试表明，自主汽化管理液氨推进系统总重1.8 kg（包含0.34 kg液氨推进剂），比冲达到100 s，系统功耗在10 W以下。自主汽化管理液氨推进系统具有高比冲、低功耗、可实现性强、推力输出均一稳定等特点，适合微纳卫星在轨应用。

关键词： MIMO阵列；5G手机；去耦方法

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lncR-GAS5 upregulates the splicing factor to impair endothelial autophagy, leading to atherogenesis

《医学前沿（英文）》 2023年第17卷第2期页码 317-329 doi: 10.1007/s11684-022-0931-4

摘要： Long noncoding RNAs (lncRNAs) play a critical role in the regulation of atherosclerosis. Here, we investigated the role of the lncRNA growth arrest-specific 5 (lncR-GAS5) in atherogenesis. We found that the enforced expression of lncR-GAS5 contributed to the development of atherosclerosis, which presented as increased plaque size and reduced collagen content. Moreover, impaired autophagy was observed, as shown by a decreased LC3II/LC3I protein ratio and an elevated P62 level in lncR-GAS5-overexpressing human aortic endothelial cells. By contrast, lncR-GAS5 knockdown promoted autophagy. Moreover, serine/arginine-rich splicing factor 10 (SRSF10) knockdown increased the LC3II/LC3I ratio and decreased the P62 level, thus enhancing the formation of autophagic vacuoles, autolysosomes, and autophagosomes. Mechanistically, lncR-GAS5 regulated the downstream splicing factor SRSF10 to impair autophagy in the endothelium, which was reversed by the knockdown of SRSF10. Further results revealed that overexpression of the lncR-GAS5-targeted gene miR-193-5p promoted autophagy and autophagic vacuole accumulation by repressing its direct target gene, SRSF10. Notably, miR-193-5p overexpression decreased plaque size and increased collagen content. Altogether, these findings demonstrate that lncR-GAS5 partially contributes to atherogenesis and plaque instability by impairing endothelial autophagy. In conclusion, lncR-GAS5 overexpression arrested endothelial autophagy through the miR-193-5p/SRSF10 signaling pathway. Thus, miR-193-5p/SRSF10 may serve as a novel treatment target for atherosclerosis.

关键词： lncR-GAS5 miR-193-5p splicing factor SRSF10 autophagy atherogenesis

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2020普遍通信与5G技术国际会议(UC5G 2020)

会议日期： 2020年03月26日

会议地点：上海

主办单位： APISE

Boehmite-supported CuO as a catalyst for catalytic transfer hydrogenation of 5-hydroxymethylfurfural

《化学科学与工程前沿（英文）》 2023年第17卷第4期页码 415-424 doi: 10.1007/s11705-022-2225-4

摘要： 2,5-bis(hydroxymethyl)furan (BHMF) is an important monomer of polyester. Its oxygen-containing rigid ring structure and symmetrical diol functional group establish it as an alternative to petroleum-based monomer with unique advantages for the prodution of the degradable bio-based polyester materials. Herein, we prepared a boehmite-supported copper-oxide catalyst for the selective hydrogenation of 5-hydroxymethylfurfural into BHMF via catalytic transfer hydrogenation (CTH). Further, ethanol successfully replaced conventional high-pressure hydrogen as the hydrogen donor, with up to 96.9% BHMF selectivity achieved under suitable conditions. Through characterization and factor investigations, it was noted that CuO is crucial for high BHMF selectivity. Furthermore, kinetic studies revealed a higher by-product activation energy compared to that of BHMF, which explained the influence of reaction temperature on product distribution. To establish the catalyst structure-activity correlation, a possible mechanism was proposed. The copper-oxide catalyst deactivated following CTH because ethanol reduced the CuO, which consequently decreased the active sites. Finally, calcination of the catalyst in air recovered its activity. These results will have a positive impact on hydrogenation processes in the biomass industry.

关键词： biomass 5-hydroxymethylfurfural 2 5-bis(hydroxymethyl)furan transfer hydrogenation catalysis

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一场潜在的5G干扰风暴

Chris Palmer

《工程（英文）》 2019年第5卷第5期页码 815-816 doi: 10.1016/j.eng.2019.08.007

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2020年5G移动通信与信息科学国际学术会议（MCIS-5G2020）

会议日期： 2020年06月26日

会议地点：广东广州

5G综述及中国的进展 None

Shan-zhi CHEN, Shao-li KANG

《信息与电子工程前沿（英文）》 2018年第19卷第3期页码 309-321 doi: 10.1631/FITEE.1800070

摘要： 5G技术、标准和产业化从20012年开始高速发展，是全球经济新的驱动力。本文全面介绍了5G，包括愿景、要求、演进、关键技术、标准化、频谱分配、技术试验、产业化进展和5G主要贡献者。同时指出，中国企业作为5G主要技术和标准的贡献者，正处于“5G引领”过程中。最后介绍了5G最新进展和作者关于5G的再思考。

关键词： 5G；IMT-2020；关键技术；标准；现场试验

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Management innovation of Chang’e-5 project

《工程管理前沿（英文）》 2021年第8卷第4期页码 620-626 doi: 10.1007/s42524-021-0165-1

关键词： lunar exploration sample return systems engineering project management

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Sodium butyrate activates HMGCS2 to promote ketone body production through SIRT5-mediated desuccinylation

《医学前沿（英文）》 2023年第17卷第2期页码 339-351 doi: 10.1007/s11684-022-0943-0

摘要： Ketone bodies have beneficial metabolic activities, and the induction of plasma ketone bodies is a health promotion strategy. Dietary supplementation of sodium butyrate (SB) is an effective approach in the induction of plasma ketone bodies. However, the cellular and molecular mechanisms are unknown. In this study, SB was found to enhance the catalytic activity of 3-hydroxy-3-methylglutaryl-CoA synthase 2 (HMGCS2), a rate-limiting enzyme in ketogenesis, to promote ketone body production in hepatocytes. SB administrated by gavage or intraperitoneal injection significantly induced blood β-hydroxybutyrate (BHB) in mice. BHB production was induced in the primary hepatocytes by SB. Protein succinylation was altered by SB in the liver tissues with down-regulation in 58 proteins and up-regulation in 26 proteins in the proteomics analysis. However, the alteration was mostly observed in mitochondrial proteins with 41% down- and 65% up-regulation, respectively. Succinylation status of HMGCS2 protein was altered by a reduction at two sites (K221 and K358) without a change in the protein level. The SB effect was significantly reduced by a SIRT5 inhibitor and in Sirt5-KO mice. The data suggests that SB activated HMGCS2 through SIRT5-mediated desuccinylation for ketone body production by the liver. The effect was not associated with an elevation in NAD⁺/NADH ratio according to our metabolomics analysis. The data provide a novel molecular mechanism for SB activity in the induction of ketone body production.

关键词： sodium butyrate succinylation HMGCS2 ketogenesis SIRT5

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Catalytic hydrogenation of insoluble organic matter of CS/Acetone from coal over mesoporous HZSM-5 supported

《化学科学与工程前沿（英文）》 2022年第16卷第10期页码 1505-1513 doi: 10.1007/s11705-022-2164-0

摘要： Four supported catalysts, nickel and ruthenium on a HZSM-5 support, were prepared by equal volume impregnation and in-situ decomposition of carbonyl nickel. The properties of catalysts were investigated by catalytic hydro-conversion of 2,2′-dinaphthyl ether as the model compound and extraction residue of Naomaohu lignite as the sample under an initial H₂ pressure of 5 MPa and temperature at 150 °C. According to the catalytic hydro-conversion results of the model compound, Ni−Ru/HZSM-5 exhibited the best catalytic performance. It not only activated H₂ into H···H, but also further heterolytically split H···H into immobile H^‒ attached on the acidic centers of Ni−Ru/HZSM-5 and relatively mobile H⁺. Catalytic hydro-conversion of the extraction residue from Naomaohu lignite was further examined over the optimized catalyst, Ni−Ru/HZSM-5. Detailed molecular compositions of products from the extraction residue with and without hydrogenation were characterized by Fourier transform infrared spectroscopy and gas chromatography/mass spectrometry. The analytical results showed that the oxygen-containing functional groups in products of hydrogenated extraction residue were obviously reduced after the catalytic treatment. The relative content of oxygenates in the product with catalytic treatment was 18.57% lower than that in the product without catalytic treatment.

关键词： HZSM-5 Ni-based catalyst catalytic hydrogenation coal model compound