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MicroRNA-148b promotes proliferation of hair follicle cells by targeting
Wanbao YANG,Qinqun LI,Bo SU,Mei YU
《农业科学与工程前沿(英文)》 2016年 第3卷 第1期 页码 72-80 doi: 10.15302/J-FASE-2016089
Role of Wnt and Notch signaling in regulating hair cell regeneration in the cochlea
null
《医学前沿(英文)》 2016年 第10卷 第3期 页码 237-249 doi: 10.1007/s11684-016-0464-9
Sensory hair cells in the inner ear are responsible for sound recognition. Damage to hair cells in adult mammals causes permanent hearing impairment because these cells cannot regenerate. By contrast, newborn mammals possess limited regenerative capacity because of the active participation of various signaling pathways, including Wnt and Notch signaling. The Wnt and Notch pathways are highly sophisticated and conserved signaling pathways that control multiple cellular events necessary for the formation of sensory hair cells. Both signaling pathways allow resident supporting cells to regenerate hair cells in the neonatal cochlea. In this regard, Wnt and Notch signaling has gained increased research attention in hair cell regeneration. This review presents the current understanding of the Wnt and Notch signaling pathways in the auditory portion of the inner ear and discusses the possibilities of controlling these pathways with the hair cell fate determiner Atoh1 to regulate hair cell regeneration in the mammalian cochlea.
关键词: inner ear cochlea hair cell regeneration Wnt Notch signaling pathways
Acetyl salicylic acid attenuates cardiac hypertrophy through Wnt signaling
null
《医学前沿(英文)》 2015年 第9卷 第4期 页码 444-456 doi: 10.1007/s11684-015-0421-z
Ventricular hypertrophy is a powerful and independent predictor of cardiovascular morbid events. The vascular properties of low-dose acetyl salicylic acid (aspirin) provide cardiovascular benefits through the irreversible inhibition of platelet cyclooxygenase 1; however, the possible anti-hypertrophic properties and potential mechanism of aspirin have not been investigated in detail. In this study, healthy wild-type male mice were randomly divided into three groups and subjected to transverse aortic constriction (TAC) or sham operation. The TAC-operated mice were treated with the human equivalent of low-dose aspirin (10 mg·kg−1·d−1); the remaining mice received an equal amount of phosphate buffered saline with 0.65% ethanol, which was used as a vehicle. A cardiomyocyte hypertrophy model induced by angiotensin II (10 nmol·L−1) was treated with the human equivalent of low (10 or 100 µmol·L−1) and high (1000 µmol·L−1) aspirin concentrations in plasma. Changes in the cardiac structure and function were assessed through echocardiography and transmission electron microscopy. Gene expression was determined through RT-PCR and western blot analysis. Results indicated that aspirin treatment abrogated the increased thickness of the left ventricular anterior and posterior walls, the swelling of mitochondria, and the increased surface area in in vivo and in vitro hypertrophy models. Aspirin also normalized the upregulated hypertrophic biomarkers, β-myosin heavy chain (β-MHC), atrial natriuretic peptide (ANP), and b-type natriuretic peptide (BNP). Aspirin efficiently reversed the upregulation of β-catenin and P-Akt expression and the TAC- or ANG II-induced downregulation of GSK-3β. Therefore, low-dose aspirin possesses significant anti-hypertrophic properties at clinically relevant concentrations for anti-thrombotic therapy. The downregulation of β-catenin and Akt may be the underlying signaling mechanism of the effects of aspirin.
《医学前沿(英文)》 2023年 第17卷 第4期 页码 685-698 doi: 10.1007/s11684-022-0942-1
关键词: acute myeloid leukemia acyl-CoA synthetase long chain family member 5 Wnt3a palmitoylation ABT-199
Unidirectional and stage-dependent roles of Notch1 in Wnt-responsive Lgr5
Hui Jiang, Shan Zeng, Wenli Ni, Yan Chen, Wenyan Li
《医学前沿(英文)》 2019年 第13卷 第6期 页码 705-712 doi: 10.1007/s11684-019-0703-y
PM10 emissions from industrial coal-fired chain-grate boilers
Xinghua Li, Junzan Han, Lei Duan
《环境科学与工程前沿(英文)》 2017年 第11卷 第6期 doi: 10.1007/s11783-017-0966-y
关键词: coal-fired chain-grate boiler PM10 size distribution particulate emission control devices size-dependent collection efficiency
《医学前沿(英文)》 2022年 第16卷 第6期 页码 873-882 doi: 10.1007/s11684-022-0925-2
关键词: Salmonella VNP20009 tumstatin B16F10 melanoma apoptosis angiogenesis
Dynein axonemal heavy chain 10 deficiency causes primary ciliary dyskinesia in humans and mice
《医学前沿(英文)》 页码 957-971 doi: 10.1007/s11684-023-0988-8
关键词: DNAH10 mice motile cilia mutation primary ciliary dyskinesia
《医学前沿(英文)》 2022年 第16卷 第4期 页码 596-609 doi: 10.1007/s11684-021-0868-z
关键词: innate immune checkpoint Siglec10 kidney renal clear cell carcinoma
The most influential “Top 10 Events” in carbon neutrality and climate change in 2022
《能源前沿(英文)》 2023年 第17卷 第1期 页码 1-4 doi: 10.1007/s11708-023-0869-5
Effect of IL-10 on formation of foam cell induced by ox-LDL
WANG Fei, DAI Yalei, XU Ting, XU Bo, WANG Kaifeng
《医学前沿(英文)》 2008年 第2卷 第3期 页码 298-302 doi: 10.1007/s11684-008-0057-3
关键词: inflammatory presence interleukin-10 dose-dependent ox-LDL
Preface of special issue of the 10 th International Conference on CO 2 Utilization
Changjun LIU,
《化学科学与工程前沿(英文)》 2010年 第4卷 第2期 页码 109-109 doi: 10.1007/s11705-009-0258-6
《医学前沿(英文)》 2022年 第16卷 第6期 页码 969-974 doi: 10.1007/s11684-021-0912-z
关键词: severe malaria nigeria malaria mortality PfPR2-10 intermediate malaria transmission
Wnt/β-catenin signaling pathway and its role in hepatocellular carcinoma
ZHANG Xufeng, YU Liang, LU Yi
《医学前沿(英文)》 2008年 第2卷 第3期 页码 216-228 doi: 10.1007/s11684-008-0042-x
关键词: interacting complicated understanding embryogenesis activation organism development
《农业科学与工程前沿(英文)》 2022年 第9卷 第2期 页码 309-311 doi: 10.15302/J-FASE-2022440
标题 作者 时间 类型 操作
MicroRNA-148b promotes proliferation of hair follicle cells by targeting
Wanbao YANG,Qinqun LI,Bo SU,Mei YU
期刊论文
ACSL5, a prognostic factor in acute myeloid leukemia, modulates the activity of Wnt/-catenin signaling
期刊论文
Unidirectional and stage-dependent roles of Notch1 in Wnt-responsive Lgr5
Hui Jiang, Shan Zeng, Wenli Ni, Yan Chen, Wenyan Li
期刊论文
Bacteria-mediated tumor-targeted delivery of tumstatin (54-132) significantly suppresses tumor growth in mouse model by inhibiting angiogenesis and promoting apoptosis
期刊论文
Innate immune checkpoint Siglec10 in cancers: mining of comprehensive omics data and validation in patient
期刊论文
Effect of IL-10 on formation of foam cell induced by ox-LDL
WANG Fei, DAI Yalei, XU Ting, XU Bo, WANG Kaifeng
期刊论文
Preface of special issue of the 10 th International Conference on CO 2 Utilization
Changjun LIU,
期刊论文
Cross-sectional prevalence and pattern of non-anaemia severe malaria among 2–10 year olds in Sokoto in
期刊论文
Wnt/β-catenin signaling pathway and its role in hepatocellular carcinoma
ZHANG Xufeng, YU Liang, LU Yi
期刊论文