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A comparison of the biological activities of ethyl acetate fractions from the stems and leaves of
Zhaolei WANG, Kai JIANG, Qinchao DING, Shujun LIU, Xiaobing DOU, Bin DING
《农业科学与工程前沿(英文)》 2020年 第7卷 第4期 页码 505-512 doi: 10.15302/J-FASE-2019271
Pursh (PCP) is a popular traditional medicinal plant in China, widely used for the treatment of a variety of liver diseases. Although it has been long recognized that the main active elements of PCP are contained in ethyl acetate fraction (EAF), little is known so far in terms of the relative effectiveness of EAF derived from the stems versus leaves of this plant. In the current study, we prepared EAF by reflux extraction and sequential extraction from the stems (SEAF) and leaves (LEAF) of PCP and tested their hepatoprotective efficacies. The extract rates and flavonoid contents of LEAF were higher than those of SEAF. EAFs (>50 μg·mL ) prevented lipid accumulation in cells and protected against lipotoxicity injury when the concentration exceeded 25 μg·mL . More than 95% free radicals released by 2,2-diphenyl-1-picrylhydrazyl (DPPH) were eliminated by 25 μg·mL SEAF and 50 μg·mL LEAF, respectively. Further, EAFs (25 μg·mL ) also showed protective antioxidant effects, with the activity of LEAF being significantly higher than that of SEAF. EAFs (10 mg·mL ) also showed similar unspecific bacteriostatic activity. In comparison with SEAF, LEAF contained more flavonoids and had a higher anti-oxidation capability and for these reasons we suggest it should be better for clinical use.
关键词: antibacterial anti-oxidation lipid accumulation lipotoxicity Penthorum chinense Pursh
《农业科学与工程前沿(英文)》 2023年 第10卷 第2期 页码 306-332 doi: 10.15302/J-FASE-2023488
● Using visual analysis to predict the trend of natural product pest resistance.
关键词: anti-pest activity crop protection insect pest natural product visual analysis
《医学前沿(英文)》 2023年 第17卷 第4期 页码 729-746 doi: 10.1007/s11684-022-0978-2
关键词: hepatocellular carcinoma YAP1 Akkermansia muciniphila anti-PD-1 dihydroartemisinin bile acid
A modular cable-driven humanoid arm with anti-parallelogram mechanisms and Bowden cables
《机械工程前沿(英文)》 2023年 第18卷 第1期 doi: 10.1007/s11465-022-0722-2
关键词: modular robotic arm anti-parallelogram mechanism Bowden cable humanoid arm lightweight joint design
Anti-biofouling strategies for implantable biosensors of continuous glucose monitoring systems
《化学科学与工程前沿(英文)》 2023年 第17卷 第12期 页码 1866-1878 doi: 10.1007/s11705-023-2340-x
关键词: implantable glucose biosensor anti-biofouling continuous glucose monitoring immune responses
《化学科学与工程前沿(英文)》 2023年 第17卷 第7期 页码 966-975 doi: 10.1007/s11705-022-2244-1
关键词: alkali lignin red light carbon dots hypochlorite encryption and anti-counterfeiting
SUN Mingxiao, WANG Yao, CHI Jiamin
《医学前沿(英文)》 2008年 第2卷 第2期 页码 174-177 doi: 10.1007/s11684-008-0032-z
Preparation of reverse osmosis membrane with high permselectivity and anti-biofouling properties for
《环境科学与工程前沿(英文)》 2022年 第16卷 第7期 doi: 10.1007/s11783-021-1497-0
• Nanoparticle incorporation and anti-biofouling grafting were integrated.
关键词: Anti-biofouling grafting Nanoparticle incorporation Sterilization rates Water flux Water flux recovery
Small-molecule anti-COVID-19 drugs and a focus on China’s homegrown mindeudesivir (VV116)
《医学前沿(英文)》 doi: 10.1007/s11684-023-1037-3
Phenolic compounds removal by wet air oxidation based processes
Linbi Zhou, Hongbin Cao, Claude Descorme, Yongbing Xie
《环境科学与工程前沿(英文)》 2018年 第12卷 第1期 doi: 10.1007/s11783-017-0970-2
关键词: Wet air oxidation Catalytic wet air oxidation Phenolic compounds Heterogeneous catalysts Mechanism
Improved dissolution and anti-inflammatory effect of ibuprofen by solid dispersion
null
《医学前沿(英文)》 2012年 第6卷 第2期 页码 195-203 doi: 10.1007/s11684-012-0189-3
The purpose of this study was to improve the dissolution rate and anti-inflammatory effect of ibuprofen by a solid dispersion (SD) method. Initial screening was developed based on drug solubility in carriers in the liquid state to select a suitable water-soluble carrier system for the preparation of SDs. The dissolution of ibuprofen in urea was higher than in PEG4000 or mannitol. Thus, urea was selected as the carrier for the preparation of SDs. SDs were characterized in terms of dissolution, differential scanning calorimetry (DSC), X-ray diffraction (XRD), scanning electron microscopy (SEM), and Fourier transform infrared (FTIR) spectroscopy. Solid dispersion-based (SDBT) and conventional (CT) tablets were prepared by the wet granulation method. The anti-inflammatory effect of SDBT was evaluated using the mouse ear edema test with xylene. In vitro release results indicated that the ibuprofen dissolution rate was improved by the SD. SD characterization results suggested that ibuprofen partly precipitates in crystalline and amorphous forms after SD preparation and that ibuprofen and urea do not interact. SDBT displayed more significant anti-inflammatory effects than CT. The dissolution rate and anti-inflammatory effect of ibuprofen were significantly enhanced by the ibuprofen-urea SD.
关键词: ibuprofen solid dispersion physical mixture dissolution anti-inflammatory effect
Mobile CRISPR-Cas9 based anti-phage system in E. coli
《化学科学与工程前沿(英文)》 2022年 第16卷 第8期 页码 1281-1289 doi: 10.1007/s11705-022-2141-7
关键词: phage infections anti-phage CRISPR-Cas9 conjugative transfer synthetic biology
彭家庭
《中国工程科学》 1999年 第1卷 第2期 页码 19-23
从近来的局部战争陆基防空雷达面临的任务出发,简要阐述了近来出现的各种目标的特点以及防空雷达所处的作战环境与电子对抗环境。分析了陆基中低空防空系统在现代防空中的作用和地位。陆基中低空防空系统在现在的防空中是可以发挥它的重要作用的,尤其是在对付巡航导弹、武装直升机、低空飞机(含隐身飞机)、反辐射导弹等目标时,该系统是属于比较优选的武器;归纳了对陆基中低空防空雷达的新的要求,主要是强的抗干扰性能,好的低空特性,满足武器系统需要的探测小目标的能力,快速的搜捕截获目标的能力等;同时也简要分析了这些要求在陆基中低空防空雷达中的技术可实现性。
null
《医学前沿(英文)》 2016年 第10卷 第1期 页码 76-84 doi: 10.1007/s11684-015-0426-7
Anti-β2 glycoprotein I (anti-β2GP I ) antibodies are important contributors to thrombosis, especially in patients with antiphospholipid syndrome (APS). However, the mechanism by which anti-β2GP I antibodies are involved in the pathogenesis of thrombosis is not fully understood. In this report, we investigated the role of anti-β2GP I antibodies in complexes with β2GP I as mediators of platelet activation, which can serve as a potential source contributing to thrombosis. We examined the involvement of the apolipoprotein E receptor 2' (apoER2') and glycoprotein I ba (GP I bα) in platelet activation induced by the anti-β2GP I /β2GP I complex. The interaction between the anti-β2GP I /β2GP I complex and platelets was examined using in vitro methods, in which the Fc portion of the antibody was immobilized using protein A coated onto a microtiter plate. Platelet activation was assessed by measuring GP II b/ III a activation and P-selectin expression and thromboxane B2 production as well as p38 mitogen-activated protein kinase phosphorylation. Our results revealed that the anti-β2GP I /β2GP I complex was able to activate platelets, and this activation was inhibited by either the anti-GP I bα antibody or the apoER2' inhibitor. Results showed that the anti-β2GP I /β2GP I complex induced platelet activation via GP I bα and apoER2', which may then contribute to the prothrombotic tendency in APS patients.
关键词: anti-β2GP I /β2GP I complex platelet GP I bα apoER2' thrombosis
β-Cyclodextrin promoted oxidation of primary amines to nitriles in water
Dongpo SHI, Hongbing JI, Zhong LI
《化学科学与工程前沿(英文)》 2009年 第3卷 第2期 页码 196-200 doi: 10.1007/s11705-009-0051-6
标题 作者 时间 类型 操作
A comparison of the biological activities of ethyl acetate fractions from the stems and leaves of
Zhaolei WANG, Kai JIANG, Qinchao DING, Shujun LIU, Xiaobing DOU, Bin DING
期刊论文
QUANTITATIVE STUDY ON ANTI-PEST ACTIVITY OF NATURAL PRODUCTS BASED ON VISUALIZATION FRAMEWORK OF KNOWLEDGE
期刊论文
Dihydroartemisinin increased the abundance of by YAP1 depression that sensitizes hepatocellular carcinoma to anti-PD
期刊论文
Lignin-derived dual-function red light carbon dots for hypochlorite detection and anti-counterfeiting
期刊论文
Modulatory effect on dyslipidemia and anti-atherosclerotic function of in newly diagnosed type 2 diabetes
SUN Mingxiao, WANG Yao, CHI Jiamin
期刊论文
Preparation of reverse osmosis membrane with high permselectivity and anti-biofouling properties for
期刊论文
Phenolic compounds removal by wet air oxidation based processes
Linbi Zhou, Hongbin Cao, Claude Descorme, Yongbing Xie
期刊论文
Anti-β glycoprotein I antibodies in complex with β2 glycoprotein I induce platelet activation via two
null
期刊论文