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The feasibility of coating by cooling crystallization on ibuprofen naked tablets
Fatima Mameri, Ouahiba Koutchoukali, Mohamed Bouhelassa, Anne Hartwig, Leila Nemdili, Joachim Ulrich
《化学科学与工程前沿(英文)》 2017年 第11卷 第2期 页码 211-219 doi: 10.1007/s11705-017-1619-1
关键词: coating solution crystallization ibuprofen tablets sucrose
Improved dissolution and anti-inflammatory effect of ibuprofen by solid dispersion
null
《医学前沿(英文)》 2012年 第6卷 第2期 页码 195-203 doi: 10.1007/s11684-012-0189-3
The purpose of this study was to improve the dissolution rate and anti-inflammatory effect of ibuprofen by a solid dispersion (SD) method. Initial screening was developed based on drug solubility in carriers in the liquid state to select a suitable water-soluble carrier system for the preparation of SDs. The dissolution of ibuprofen in urea was higher than in PEG4000 or mannitol. Thus, urea was selected as the carrier for the preparation of SDs. SDs were characterized in terms of dissolution, differential scanning calorimetry (DSC), X-ray diffraction (XRD), scanning electron microscopy (SEM), and Fourier transform infrared (FTIR) spectroscopy. Solid dispersion-based (SDBT) and conventional (CT) tablets were prepared by the wet granulation method. The anti-inflammatory effect of SDBT was evaluated using the mouse ear edema test with xylene. In vitro release results indicated that the ibuprofen dissolution rate was improved by the SD. SD characterization results suggested that ibuprofen partly precipitates in crystalline and amorphous forms after SD preparation and that ibuprofen and urea do not interact. SDBT displayed more significant anti-inflammatory effects than CT. The dissolution rate and anti-inflammatory effect of ibuprofen were significantly enhanced by the ibuprofen-urea SD.
关键词: ibuprofen solid dispersion physical mixture dissolution anti-inflammatory effect
Isolation and application of an ibuprofen-degrading bacterium to a biological aerated filter for the
Bingjie Xu, Gang Xue, Xing Yang
《环境科学与工程前沿(英文)》 2018年 第12卷 第5期 doi: 10.1007/s11783-018-1080-5
• An ibuprofen-degrading strain, Serratia marcescens BL1, was isolated and identified. • The effects of various factors on ibuprofen degradation by BL1 were evaluated. • Strain BL1 was applied to a laboratory-scale biological aerated filter system. • Strain BL1 was stable in both static tests and in the biological aerated filter system.
关键词: Ibuprofen Biological aerated filter Degrading bacterium Serratia marcescens
Preparation of ibuprofen/lipid composite microparticles by supercritical fluid technique
WANG Xia, CHEN Hui, GUO Yanni, SU Yuzhong, WANG Hongtao, LI Jun
《化学科学与工程前沿(英文)》 2008年 第2卷 第4期 页码 361-367 doi: 10.1007/s11705-008-0066-4
标题 作者 时间 类型 操作
The feasibility of coating by cooling crystallization on ibuprofen naked tablets
Fatima Mameri, Ouahiba Koutchoukali, Mohamed Bouhelassa, Anne Hartwig, Leila Nemdili, Joachim Ulrich
期刊论文
Isolation and application of an ibuprofen-degrading bacterium to a biological aerated filter for the
Bingjie Xu, Gang Xue, Xing Yang
期刊论文