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Improved dissolution and anti-inflammatory effect of ibuprofen by solid dispersion
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《医学前沿(英文)》 2012年 第6卷 第2期 页码 195-203 doi: 10.1007/s11684-012-0189-3
The purpose of this study was to improve the dissolution rate and anti-inflammatory effect of ibuprofen by a solid dispersion (SD) method. Initial screening was developed based on drug solubility in carriers in the liquid state to select a suitable water-soluble carrier system for the preparation of SDs. The dissolution of ibuprofen in urea was higher than in PEG4000 or mannitol. Thus, urea was selected as the carrier for the preparation of SDs. SDs were characterized in terms of dissolution, differential scanning calorimetry (DSC), X-ray diffraction (XRD), scanning electron microscopy (SEM), and Fourier transform infrared (FTIR) spectroscopy. Solid dispersion-based (SDBT) and conventional (CT) tablets were prepared by the wet granulation method. The anti-inflammatory effect of SDBT was evaluated using the mouse ear edema test with xylene. In vitro release results indicated that the ibuprofen dissolution rate was improved by the SD. SD characterization results suggested that ibuprofen partly precipitates in crystalline and amorphous forms after SD preparation and that ibuprofen and urea do not interact. SDBT displayed more significant anti-inflammatory effects than CT. The dissolution rate and anti-inflammatory effect of ibuprofen were significantly enhanced by the ibuprofen-urea SD.
关键词: ibuprofen solid dispersion physical mixture dissolution anti-inflammatory effect
Yan ZHAO, Wenjing LU, Jiajun CHEN, Xiangfeng ZHANG, Hongtao WANG
《环境科学与工程前沿(英文)》 2014年 第8卷 第2期 页码 151-161 doi: 10.1007/s11783-013-0607-z
关键词: lignocellulosic waste hydrothermal conversion separate dissolution asynchronous hydrolysis mechanism
《环境科学与工程前沿(英文)》 2022年 第16卷 第12期 doi: 10.1007/s11783-022-1586-8
● nZVI, S-nZVI, and nFeS were systematically compared for Cd(II) removal.
关键词: Nano zero valent iron Sulfided zero valent iron FeS Cd(II) immobilization Fe dissolution
Lin Yang, Wenpeng Li, Junheng Guo, Wei Li, Baoguo Wang, Minqing Zhang, Jinli Zhang
《化学科学与工程前沿(英文)》 2021年 第15卷 第2期 页码 384-398 doi: 10.1007/s11705-020-1928-7
关键词: jet-flow high shear mixer solid particle dissolution power consumption characteristics CFD Simulation
Crystal modification of rifapentine using different solvents
Kun ZHOU, Jun LI, Jianhong LUO, Dongsheng ZHENG,
《化学科学与工程前沿(英文)》 2010年 第4卷 第1期 页码 65-69 doi: 10.1007/s11705-009-0302-6
关键词: identical scanning calorimetry different comparative dissolution structure modification
Oral product input to the GI tract: GIS an oral product performance technology
Gordon L. Amidon, Yasuhiro Tsume
《化学科学与工程前沿(英文)》 2017年 第11卷 第4期 页码 516-520 doi: 10.1007/s11705-017-1658-7
关键词: GIS in vivo predictive dissolution ketoconazole BCS subclassification supersaturation
Modeling of specific structure crystallization coupling with dissolution
Yuanhui JI, Hongliang QIAN, Chang LIU, Xiaohua LU, Xin FENG, Xiaoyan JI,
《化学科学与工程前沿(英文)》 2010年 第4卷 第1期 页码 52-56 doi: 10.1007/s11705-009-0301-7
关键词: structure crystallization activity coefficient reference KCl dissolution
Dissolution and enzymatic hydrolysis of casein micelles studied by dynamic light scattering
LIU Rui, QI Wei, SU Rongxin, ZHANG Yubin, JIN Fengmin, HE Zhimin
《化学科学与工程前沿(英文)》 2007年 第1卷 第2期 页码 123-127 doi: 10.1007/s11705-007-0023-7
《化学科学与工程前沿(英文)》 2023年 第17卷 第12期 页码 2050-2060 doi: 10.1007/s11705-023-2343-7
关键词: LiMn2O4 lithium extraction surface coating cyclic stability Mn dissolution
标题 作者 时间 类型 操作
Research progress on hydrothermal dissolution and hydrolysis of lignocellulose and lignocellulosic waste
Yan ZHAO, Wenjing LU, Jiajun CHEN, Xiangfeng ZHANG, Hongtao WANG
期刊论文
Cadmium removal mechanistic comparison of three Fe-based nanomaterials: Water-chemistry and roles of Fe dissolution
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Effects of rotor and stator geometry on dissolution process and power consumption in jet-flow high shear
Lin Yang, Wenpeng Li, Junheng Guo, Wei Li, Baoguo Wang, Minqing Zhang, Jinli Zhang
期刊论文
Crystal modification of rifapentine using different solvents
Kun ZHOU, Jun LI, Jianhong LUO, Dongsheng ZHENG,
期刊论文
Oral product input to the GI tract: GIS an oral product performance technology
Gordon L. Amidon, Yasuhiro Tsume
期刊论文
Modeling of specific structure crystallization coupling with dissolution
Yuanhui JI, Hongliang QIAN, Chang LIU, Xiaohua LU, Xin FENG, Xiaoyan JI,
期刊论文
Dissolution and enzymatic hydrolysis of casein micelles studied by dynamic light scattering
LIU Rui, QI Wei, SU Rongxin, ZHANG Yubin, JIN Fengmin, HE Zhimin
期刊论文