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Chengwei JING, Qin FU, Xiaojun XU
《医学前沿(英文)》 2009年 第3卷 第1期 页码 45-48 doi: 10.1007/s11684-009-0019-4
关键词: central cord syndrome decompression surgical titanium mesh
Primary spinal epidural non-Hodgkin’s lymphoma presented with spinal cord compression syndrome
Chunquan CAI MD, PhD, Qingjiang ZHANG BM, Changhong SHEN MD, PhD,
《医学前沿(英文)》 2009年 第3卷 第4期 页码 499-502 doi: 10.1007/s11684-009-0075-9
关键词: non-Hodgkin’ s lymphoma primary spinal cord compression syndrome epidural space
null
《医学前沿(英文)》 2015年 第9卷 第1期 页码 20-29 doi: 10.1007/s11684-014-0371-x
Ischemic stroke is a focal cerebral insult that often leads to many adverse neurological complications severely affecting the quality of life. The prevalence of stroke is increasing throughout the world, while the efficacy of current pharmacological therapies remains unclear. As a neuroregenerative therapy, the implantation of human umbilical cord mesenchymal stem cells (hUC-MSCs) has shown great possibility to restore function after stroke. This review article provides an update role of hUC-MSCs implantation in the treatment of ischemic stroke. With the unique “immunosuppressive and immunoprivilege” property, hUC-MSCs are advised to be an important candidate for allogeneic cell treatment. Nevertheless, most of the treatments are still at primary stage and not clinically feasible at the current time. Several uncertain problems, such as culture conditions, allograft rejection, and potential tumorigenicity, are the choke points in this cellular therapy. More preclinical researches and clinical studies are needed before hUC-MSCs implantation can be used as a routinely applied clinical therapy.
关键词: cellular therapy transplantation human umbilical cord mesenchymal stem cells ischemic stroke
null
《医学前沿(英文)》 2012年 第6卷 第1期 页码 41-47 doi: 10.1007/s11684-012-0175-9
Umbilical cord mesenchymal stem cells (MSCs) are a unique, accessible, and non-controversial source of early stem cells that can be readily manipulated. As the most common pluripotent cell, bone marrow-derived MSCs display limitations with the progress of stem cell therapy. By contrast, umbilical cord-derived cells, which have plentiful resources, are more accessible. However, several uncertain aspects, such as the effect of donor selection or culture conditions, long-term therapeutic effects, product consistency, and potential tumorigenicity, are the bottleneck in this clinical therapy. MSCs are predicted to undergo an unprecedented development in clinical treatment when a generally acknowledged criterion emerges. In the current paper, we highlight the application of umbilical cord-derived MSCs in skin therapies based on our previous studies, as well as the achievements of our peers in this field. This paper focuses on the strategies, challenges, and potential of this novel therapy.
关键词: umbilical cord mesenchymal stem cells cutaneous regeneration
Bin Yu, Xiaosong Gu
《医学前沿(英文)》 2019年 第13卷 第2期 页码 131-137 doi: 10.1007/s11684-018-0642-z
关键词: spinal cord injury biomaterial extrinsic barrier intrinsic regeneration capacity
《工程管理前沿(英文)》 doi: 10.1007/s42524-024-4019-5
关键词: last-mile delivery crowdshipping public transport-based crowdshipping integrated passenger and freight transportation impact assessment
null
《医学前沿(英文)》 2013年 第7卷 第3期 页码 345-353 doi: 10.1007/s11684-013-0282-2
Human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) possess various advantageous properties, including self-renewal, extended proliferation potential, multi-lineage differentiation potential and capacity for differentiating into sweat gland-like cells in certain conditions. However, little is known about the effect of clinical-grade culture conditions on these properties and on the differentiative potential of hUC-MSCs. In this study, we sought to investigate the properties of hUC-MSCs expanded with animal serum free culture media (ASFCM) in order to determine their potential for differentiation into sweat gland-like cells. We found that primary cultures of hUC-MSCs could be established with ASFCM. Moreover, cells cultured in ASFCM showed vigorous proliferation comparable to those of cells grown in classical culture conditions containing fetal bovine serum (FBS). Morphology of hUC-MSCs cultured in ASFCM was comparable to those of cells grown under classical culture conditions, and hUC-MSCs grown in both of the two culture conditions tested showed the typical antigen profile of MSCs—positive for CD29, CD44, CD90, and CD105, and negative for CD34 and CD45, as expected. Chromosomal aberration assay revealed that the cells were stable after long-term culture under both culture conditions. Like normal cultured MSCs, hUC-MSCs induced under ASFCM conditions exhibited expression of the same markers (CEA, CK14 and CK19) and developmental genes (EDA and EDAR) that are characteristic of normal sweat gland cells. Taken together, our findings indicate that the classical culture medium used to differentiate hUC-MSCs into sweat gland-like cells can be replaced safely by ASFCM for clinical purposes.
关键词: umbilical cord mesenchymal stem cells sweat gland preclinical
Atypical manifestations of acute coronary syndrome — throat discomfort: a multi-center observational
《医学前沿(英文)》 2022年 第16卷 第4期 页码 651-658 doi: 10.1007/s11684-021-0859-0
关键词: acute coronary syndrome (ACS) throat discomfort (TD) throat pain cardiology departments non-cardiologic physicians
Hassan YOUSEFI, Alireza TAGHAVI KANI, Iradj MAHMOUDZADEH KANI
《结构与土木工程前沿(英文)》 2019年 第13卷 第2期 页码 429-455 doi: 10.1007/s11709-018-0483-5
关键词: central high resolution schemes RBFs higher order accuracy generalized thermoelasticity multiresolution-based adaptation
Degradation of refractory organics in concentrated leachate by the Fenton process: Central composite
Senem Yazici Guvenc, Gamze Varank
《环境科学与工程前沿(英文)》 2021年 第15卷 第1期 doi: 10.1007/s11783-020-1294-1
关键词: Concentrated leachate Fenton oxidation Central composite design Biodegradability Inert COD
Development of a multi-component drug from turmeric using central composite design
Xiaohang ZHANG,Shengnan HAN,Yan LI,Jianlan JIANG
《化学科学与工程前沿(英文)》 2014年 第8卷 第3期 页码 362-368 doi: 10.1007/s11705-014-1439-5
关键词: multi-component drug development central composite design turmeric curcuminoids
Prevalence of vitamin D deficiency in girls with idiopathic central precocious puberty
null
《医学前沿(英文)》 2018年 第12卷 第2期 页码 174-181 doi: 10.1007/s11684-017-0544-5
The relationship between vitamin D deficiency and idiopathic central precocious puberty (ICPP) has been recently documented. In this study, 280 girls diagnosed with ICPP and 188 normal puberty control girls of similar ages were enrolled and retrospectively studied. The ICPP group had significantly lower serum 25-hydroxyvitamin D (25[OH]D) levels than the control group. Furthermore, a nonlinear relationship was found between serum 25[OH]D and ICPP, and a cut-off point for serum 25[OH]D was found at 31.8 ng/ml for ICPP with and without adjusting the different confounding factors. Girls with serum 25[OH]D≥31.8 ng/ml had a lower odds ratio (unadjusted: OR 0.36, 95% CI 0.15 to 0.83, <0.05; height and weight adjusted: OR 0.44, 95% CI 0.18 to 1.08, = 0.072; BMI adjusted: OR 0.36, 95% CI 0.16 to 0.84, <0.05). The ICPP subjects with 25[OH]D deficiency had a higher body mass index (BMI) than the subjects from the two other subgroups. Correlation analysis showed that vitamin D level is correlated with BMI and some metabolic parameters in the ICPP group. Our study suggested that vitamin D status may be associated with ICPP risk and may have a threshold effect on ICPP.
关键词: idiopathic central precocious puberty threshold effects vitamin D status
《医学前沿(英文)》 doi: 10.1007/s11684-024-1073-7
关键词: acupuncture functional gastrointestinal disorders irritable bowel syndrome clinical trial
Developmental expression of CAPON and Dexras1 in spinal cord of rats
LI Xin, CHENG Chun, CHEN Mengling, GAO Shangfeng, ZHAO Jian, NIU Shuqiong, SHEN Aiguo
《医学前沿(英文)》 2008年 第2卷 第1期 页码 75-81 doi: 10.1007/s11684-008-0014-1
关键词: CAPON ISH differentiation postnatal different subcellular
标题 作者 时间 类型 操作
Anterior cervical surgery methods for central cord syndrome without radiographic spinal fracture-dislocation
Chengwei JING, Qin FU, Xiaojun XU
期刊论文
Primary spinal epidural non-Hodgkin’s lymphoma presented with spinal cord compression syndrome
Chunquan CAI MD, PhD, Qingjiang ZHANG BM, Changhong SHEN MD, PhD,
期刊论文
Implantation of human umbilical cord mesenchymal stem cells for ischemic stroke: perspectives and challenges
null
期刊论文
Umbilical cord-derived mesenchymal stem cells: strategies, challenges, and potential for cutaneous regeneration
null
期刊论文
and genetic enhancement of intrinsic growth capacities to promote CNS axon regeneration after spinal cord
Bin Yu, Xiaosong Gu
期刊论文
Assessing the potential impacts of public transport-based crowdshipping: A case study in a central district
期刊论文
Capacity of human umbilical cord-derived mesenchymal stem cells to differentiate into sweat gland-like
null
期刊论文
Atypical manifestations of acute coronary syndrome — throat discomfort: a multi-center observational
期刊论文
Multiscale RBF-based central high resolution schemes for simulation of generalized thermoelasticity problems
Hassan YOUSEFI, Alireza TAGHAVI KANI, Iradj MAHMOUDZADEH KANI
期刊论文
Degradation of refractory organics in concentrated leachate by the Fenton process: Central composite
Senem Yazici Guvenc, Gamze Varank
期刊论文
Development of a multi-component drug from turmeric using central composite design
Xiaohang ZHANG,Shengnan HAN,Yan LI,Jianlan JIANG
期刊论文
Efficacy of acupuncture in refractory irritable bowel syndrome patients: a randomized controlled trial
期刊论文