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Fanghe LI BM , Chunyan ZHANG MS , Jinghua LIU MS , Xiaoyan ZHANG MS , Bing YAN , Bo ZHANG MS , Yongguo HUANG MS , Jingsong GONG BM , Yan CHEN BM ,
《医学前沿(英文)》 2009年 第3卷 第3期 页码 277-283 doi: 10.1007/s11684-009-0047-0
关键词: hepatitis B virus gene variation hepatitis B surface antigen immune escape enzyme-linked immunosorbent assay
FAN Xiaodong, HAN Ruifa
《医学前沿(英文)》 2007年 第1卷 第4期 页码 377-380 doi: 10.1007/s11684-007-0073-8
LI Yongfeng, REN Nanqi, LI Jianzheng, LI Peng, YANG Chuanping
《能源前沿(英文)》 2007年 第1卷 第4期 页码 403-407 doi: 10.1007/s11708-007-0058-2
关键词: fermented biohydrogen high important identification biohydrogen
Junguo HE, Guangming ZHANG, Haifeng LU,
《环境科学与工程前沿(英文)》 2010年 第4卷 第3期 页码 334-339 doi: 10.1007/s11783-010-0239-5
关键词: purple nonsulfur bacteria (PNSB) Rhodobacter sphaeroides Z08 soybean wastewater cost effective
New practice in semaglutide on type-2 diabetes and obesity: clinical evidence and expectation
《医学前沿(英文)》 2022年 第16卷 第1期 页码 17-24 doi: 10.1007/s11684-021-0873-2
董玉琛
《中国工程科学》 2001年 第3卷 第1期 页码 1-5
作物种质资源学科是20世纪发展起来的,瓦维洛夫的世界考察收集及其材料的表型多样性地理分布研究,奠定了作物种质资源学科的基础。自1958年美国建成世界第一座现代化种子库后,至今全世界的种质库已达1300多个,保存种质600×104份(另一文献为2500×104份)。现在的种质库分为长期、中期和短期三种,并在研究液态氮保存。无性繁殖作物采用种质圃或试管苗保存。由于育种工作对种质资源要求日益迫切,以及分子生物技术的发展,使作物种质资源研究进入了以评价鉴定为主的时代。应用分子遗传图谱不仅能鉴定质量性状,而且能发掘数量性状基因。中国原产的作物种质资源得到了较好的收集,1986年建成国家作物种质库(长期库),其中已存人各种作物的种质资源31×104份。并建有西宁复份保存库,22个中期库,30个国家种质圃和2个试管苗库。对保存的材料大多数进行了农艺性状、抗病虫害、抗逆性和品质初步鉴定,并建成了中国作物种质资源信息系统。随着生物技术的加速发展,应用高新技术千方百计在种质资源中发掘新基因将是21世纪作物种质资源学科发展的热点。因此,要妥善保护现有种质资源,不再使任何基因流失;并从国外引进新作物、新基因,以促进农业改制和作物生产的发展;大力从地方品种中,特别是野生种中发掘新基因,促进农业持续发展。
Personalized medicine of type 2 diabetes
null
《医学前沿(英文)》 2013年 第7卷 第1期 页码 1-3 doi: 10.1007/s11684-013-0241-y
Immunological and virological characteristics of human immunodeficiency virus type 1 superinfection:
null
《医学前沿(英文)》 2017年 第11卷 第4期 页码 480-489 doi: 10.1007/s11684-017-0594-8
Superinfection is frequently detected among individuals infected by human immunodeficiency virus type I (HIV-1). Superinfection occurs at similar frequencies at acute and chronic infection stages but less frequently than primary infection. This observation indicates that the immune responses elicited by natural HIV-1 infection may play a role in curb of superinfection; however, these responses are not sufficiently strong to completely prevent superinfection. Thus, a successful HIV-1 vaccine likely needs to induce more potent and broader immune responses than those elicited by primary infection. On the other hand, potent and broad neutralization responses are more often detected after superinfection than during monoinfection. This suggests that broadly neutralizing antibodies are more likely induced by sequential immunization of multiple different immunogens than with only one form of envelope glycoprotein immunogens. Understanding why the protection from superinfection by immunity induced by primary infection is insufficient and if superinfection can lead to cross-reactive immune responses will be highly informative for HIV-1 vaccine design.
关键词: human immunodeficiency virus type I superinfection incidence immune response
Metabolomics in human type 2 diabetes research
null
《医学前沿(英文)》 2013年 第7卷 第1期 页码 4-13 doi: 10.1007/s11684-013-0248-4
The high prevalence of diabetes and diabetic complications has caused a huge burden on the modern society. Although scientific advances have led to effective strategies for preventing and treating diabetes over the past several decades, little progress has been made toward curing the disease or even getting it under control, from a public health and overall societal standpoint. There is still a lack of reliable biomarkers indicative of metabolic alterations associated with diabetes and different drug responses, highlighting the need for the development of early diagnostic and prognostic markers for diabetes and diabetic complications. The emergence of metabolomics has allowed researchers to systemically measure the small molecule metabolites, which are sensitive to the changes of both environmental and genetic factors and therefore, could be regarded as the link between genotypes and phenotypes. During the last decade, the progression made in metabolomics has provided insightful information on disease development and disease onset prediction. Recent studies using metabolomics approach coupled with statistical tools to predict incident diabetes revealed a number of metabolites that are significantly altered, including branched-chain and aromatic amino acids, such as isoleucine, leucine, valine, tyrosine and phenylalanine, as diagnostic or highly-significant predictors of future diabetes. This review summarizes the current findings of metabolomic studies in human investigations with the most common form of diabetes, type 2 diabetes.
关键词: metabolomics type 2 diabetes metabolic pathway mass spectrometry nuclear magnetic resonance (NMR)
《结构与土木工程前沿(英文)》 2021年 第15卷 第4期 页码 1071-1071 doi: 10.1007/s11709-021-0736-6
The mechanisms linking adiposopathy to type 2 diabetes
null
《医学前沿(英文)》 2013年 第7卷 第4期 页码 433-444 doi: 10.1007/s11684-013-0288-9
Obesity is defined as excessive accumulation of body fat in proportion to body size. When obesity occurs, the functions of adipose tissue may be deregulated, which is termed as adiposopathy. Adiposopathy is an independent risk factor for many diseases, including diabetes and cardiovascular diseases. In overweight or obese subjects with adiposopathy, hyperlipidemia exerts lipotoxicity in pancreatic islet and liver and induces pancreatic β cell dysfunction and liver insulin resistance, which are the decisive factors causing type 2 diabetes. Moreover, adipokines have been shown to play important roles in the regulation of glucose homeostasis. When adiposopathy occurs, abnormal changes in the serum adipokine profile correlate with the development and progression of pancreatic β cell dysfunction and insulin resistance in peripheral tissue. The current paper briefly discusses the latest findings regarding the effects of adiposopathy-related lipotoxicity and cytokine toxicity on the development of type 2 diabetes.
Mechanical performance analysis and stiffness test of a new type of suspension bridge
《结构与土木工程前沿(英文)》 2021年 第15卷 第5期 页码 1160-1180 doi: 10.1007/s11709-021-0760-6
关键词: new type of suspension bridge stiffness test mechanical performance railway bridge space truss
Targeted therapy of desmoid-type fibromatosis: mechanism, current situation, and future prospects
Zhen Wang, Jianhui Wu, Xiuyun Tian, Chunyi Hao
《医学前沿(英文)》 2019年 第13卷 第4期 页码 427-437 doi: 10.1007/s11684-018-0672-6
关键词: targeted therapy desmoid-type fibromatosis tyrosine kinase inhibitor γ-secretase inhibitor
Development of an axial-type fan with an optimization method
Chong-hyun CHO, Soo-yong CHO, Chaesil KIM,
《能源前沿(英文)》 2009年 第3卷 第4期 页码 414-422 doi: 10.1007/s11708-009-0038-5
关键词: axial-type fan gradient method free-vortex method design variable total pressure static pressure operating flowrate
Qing YE, Donghui LI, Jun ZHAO, Jiansheng ZHAO, Tianfang KANG, Shuiyuan CHENG
《环境科学与工程前沿(英文)》 2011年 第5卷 第4期 页码 497-504 doi: 10.1007/s11783-011-0256-z
关键词: 13X-type zeolite CO oxidation gold solution pH calcination temperature
标题 作者 时间 类型 操作
Preparation, identification, and clinical application of anti-HBs monoclonal antibody that binds both wild-type
Fanghe LI BM , Chunyan ZHANG MS , Jinghua LIU MS , Xiaoyan ZHANG MS , Bing YAN , Bo ZHANG MS , Yongguo HUANG MS , Jingsong GONG BM , Yan CHEN BM ,
期刊论文
Study of recombinant human IFN-α-2b bacilli Calmette–Guerin activated killer cells and against bladder cancer cell in vitro
FAN Xiaodong, HAN Ruifa
期刊论文
Molecular characterization and fermentative hydrogen production of a wild anaerobe in clostridium genus
LI Yongfeng, REN Nanqi, LI Jianzheng, LI Peng, YANG Chuanping
期刊论文
Treatment of soybean wastewater by a wild strain Rhodobacter sphaeroides and to produce protein under
Junguo HE, Guangming ZHANG, Haifeng LU,
期刊论文
Immunological and virological characteristics of human immunodeficiency virus type 1 superinfection:
null
期刊论文
Correction to: Effect of wood dust type on mechanical properties, wear behavior, biodegradability, and
期刊论文
Targeted therapy of desmoid-type fibromatosis: mechanism, current situation, and future prospects
Zhen Wang, Jianhui Wu, Xiuyun Tian, Chunyi Hao
期刊论文
Development of an axial-type fan with an optimization method
Chong-hyun CHO, Soo-yong CHO, Chaesil KIM,
期刊论文