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Developing macromolecular therapeutics: the future drug-of-choice

Huining HE, Victor C. YANG, Weibing DONG, Junbo GONG, Jingkang WANG,

《化学科学与工程前沿（英文）》 2010年第4卷第1期页码 10-17 doi: 10.1007/s11705-009-0291-5

摘要： Macromolecular drugs including peptides, proteins, antibodies, polysaccharides and nucleic acids have been widely used for therapy of major diseases such as carcinoma and AIDS as well as cardiovascular and neurodegenerative disorders among other medical conditions. Due to their unmatched properties of high selectivity and efficiency, macromolecular drugs have been recognized as the drug-of-choice of the future. Since worldwide progress on macromolecular therapeutics still remains in the infant stage and is therefore wide open for equal-ground competition, R&D related to macromolecular drugs should be considered as the main point of focus in China in setting up its strategic plans in pharmaceutical development. In this article, research strategies and drug delivery approaches that should be adopted to enhance the therapeutic effects of macromolecular drugs are reviewed. In addition, comments concerning how to implement such strategies to excel from competition in this challenging research field, such as the design of innovative and highly effective delivery systems of macromolecular drugs with self-owned intellectual property rights, are provided.

关键词： worldwide challenging effective macromolecular self-owned intellectual

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国际固体氧化物燃料电池堆及系统

苏巴辛格尔

《中国工程科学》 2013年第15卷第2期页码 7-14

摘要：

为了实现固体氧化物燃料电池（SOFC）的广泛应用，世界上许多公司正在致力于SOFC的开发、制造和商业化研究。本文回顾和讨论了SOFC领域的相关发展现状。

关键词： SOFC SOFC电池堆管式电池热电联供辅助动力单元

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全球水产生物安保战略及其国外经验的启示

董宣,梁艳,黄倢

《中国工程科学》 2016年第18卷第3期页码 110-114 doi: 10.15302/J-SSCAE-2016.03.019

摘要：

本文介绍了全球水产生物安保战略的国际组织框架，阐述了联合国粮食及农业组织（FAO）、世界动物卫生组织（OIE）和国际水产兽医生物安保联盟对全球生物安保战略所提出的建议，举例说明了美国、泰国、印度尼西亚对虾种业生物安保的实践经验，为我国水产养殖业的健康可持续发展提供了借鉴。

关键词：生物安保水产养殖水产种业全球战略虾病

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Implementation and performance evaluation of advance metering infrastructure for Borneo-Wide Power Grid

Mujahid TABASSUM,Manas K. HALDAR,Duaa Fatima S. KHAN

《能源前沿（英文）》 2020年第14卷第1期页码 192-211 doi: 10.1007/s11708-016-0438-2

摘要： In this paper, a supervisory computer network for Borneo-Wide Power Grid system have been proposed and implemented, which includes a renewable power generation and advanced metering infrastructure. An Internet-based communication network running on multiprotocol label switching (MPLS) has been implemented for a smart power grid, with the addition of the renewable energy monitoring system. The centralized supervisory control and data acquisition systems (SCADA) are replaced by a wide area monitoring system(WAMS) comprising of a phasor measurement unit (PMU). The implemented communication network used advanced metering infrastructure that operates on worldwide interoperability for microwave access (WiMAX), wireless fidelity (Wi-Fi) and low power Wi-Fi, which are proposed for the distribution systems of Sarawak Energy. The proposed wide area network (WAN) is simulated using OPNET Modeler and the results are compared with the existing WAN used by Sarawak Energy.

关键词： renewable energy multiprotocol label switching (MPLS) power grid phasor measurement unit (PMU) supervisory control and data acquisition systems (SCADA) wide area monitoring system (WAMS) worldwide interoperability for microwave access (WiMAX) synchronous digital hierarchy (SDH)

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Real drive cycles analysis by ordered power methodology applied to fuel consumption, CO

Pol Masclans Abelló, Vicente Medina Iglesias, M. Antonia de los Santos López, Jesús Álvarez-Flórez

《环境科学与工程前沿（英文）》 2021年第15卷第1期 doi: 10.1007/s11783-020-1296-z

摘要： Abstract • New method named CAbOP is presented based on ordering data according to power. • Three emission models are used and their emission results compared. • Emissions data are analyzed in real driving cycles under CAbOP criteria. • Methodology to collect data and reconstruct lost data in real urban driving cycles. In this work three fuel consumption and exhaust emission models, ADVISOR, VT-MICRO and the European Environmental Agency Emission factors, have been used to obtain fuel consumption (FC) and exhaust emissions. These models have been used at micro-scale, using the two signal treatment methods presented. The manuscript presents: 1) a methodology to collect data in real urban driving cycles, 2) an estimation of FC and tailpipe emissions using some available models in literature, and 3) a novel analysis of the results based on delivered wheel power. The results include Fuel Consumption (FC), CO2, NOx and PM10 emissions, which are derived from the three simulators. In the first part of the paper we present a new procedure for incomplete drive cycle data treatment, which is necessary for real drive cycle acquisition in high density cities. Then the models are used to obtain second by second FC and exhaust emissions. Finally, a new methodology named Cycle Analysis by Ordered Power (CAbOP) is presented and used to compare the results. This method consists in the re-ordering of time dependant data, considering the wheel mechanical power domain instead of the standard time domain. This new strategy allows the 5 situations in drive cycles to be clearly visualized: hard breaking zone, slowdowns, idle or stop zone, sustained speed zone and acceleration zone. The complete methodology is applied in two real drive cycles surveyed in Barcelona (Spain) and the results are compared with a standardized WLTC urban cycle.

关键词： Cycle Analysis by Ordered Power (CAbOP) Micro and macro models Real drive cycle NO_x/PM₁₀/CO₂ emissions Wheel mechanical power domain Worldwide Harmonized Light-Duty Vehicles Test Cycle (WLTC)