检索范围:
排序: 展示方式:
Prohibitin regulates mTOR pathway via interaction with FKBP8
Jiahui Zhang, Yanan Yin, Jiahui Wang, Jingjing Zhang, Hua Liu, Weiwei Feng, Wen Yang, Bruce Zetter, Yingjie Xu
《医学前沿(英文)》 2021年 第15卷 第3期 页码 448-459 doi: 10.1007/s11684-020-0805-6
Zeolitic imidazolate framework-8 (ZIF-8) for drug delivery: A critical review
Simin Feng, Xiaoli Zhang, Dunyun Shi, Zheng Wang
《化学科学与工程前沿(英文)》 2021年 第15卷 第2期 页码 221-237 doi: 10.1007/s11705-020-1927-8
关键词: zeolitic imidazolate framework-8 (ZIF-8) synthesis methods applications drug delivery
Role of salivary matrix metalloproteinase-8 (MMP-8) in chronic periodontitis diagnosis
null
《医学前沿(英文)》 2015年 第9卷 第1期 页码 72-76 doi: 10.1007/s11684-014-0347-x
Periodontitis is an inflammatory disease of the periodontium. Any imbalance between the matrix metalloproteinases (MMPs) secreted by neutrophils and tissue inhibitors initiates the destruction of collagen in gum tissue, leading to chronic periodontitis. This study aimed to correlate salivary levels of MMP-8 and periodontal parameters of chronic periodontitis to establish MMP-8 as a noninvasive marker for the early diagnosis of chronic periodontitis. The study involved 40 subjects visiting the periodontic OPD of Dr. Ziauddin Ahmad Dental College and Hospital, located in Aligarh, U.P., India, from 2011 to 2012. The subjects were divided into two groups: group I consisted of 20 periodontally healthy subjects (controls) while group II consisted of 20 patients with chronic periodontitis. Chronic periodontitis was assessed on the basis of several periodontal parameters, including pocket probing depth (PPD), clinical attachment level (CAL), gingival index (GI), and plaque index (PI). Around 3 ml of unstimulated and whole expectorated saliva was collected for MMP-8 estimation by ELISA using Quantikine human total MMP-8 immunoassay kits. Data were analyzed using STATISTICA (Windows version 6) software. Salivary MMP-8 levels of groups I and II were 190.91±143.89 ng/ml and 348.26±202.1 ng/ml, respectively. The MMP-8 levels and periodontal status (PPD, CAL, GI, and PI) of groups I and II showed positive and significant correlations (for PPD, r = 0.63, P<0.001; for CAL, r = 0.54, P<0.001; for GI, r = 0.49, P<0.001; and for PI, r = 0.63, P<0.001). The results of this study demonstrate elevated concentrations of MMP-8 in individuals with chronic periodontitis.
关键词: matrix metalloproteinase-8 chronic periodontitis pocket probing depth clinical attachment level gingival index plaque index
Protective efficacy of vaccination with NcMIC3 and NcMIC8 against
Taotao ZHANG, Xiao ZHANG, Qun LIU, Jianhai XU, Jing LIU
《农业科学与工程前沿(英文)》 2019年 第6卷 第2期 页码 188-196 doi: 10.15302/J-FASE-2019253
Microneme proteins (MICs) are important for Apicomplexan parasite invasion due to their adhesion to host cells. Several studies have indicated that MIC3 and MIC8 are important adhesion factors and potential vaccine candidates against neosporosis. In this study, we evaluated the protective efficacy of recombinant proteins and DNA vaccines of NcMIC3 and NcMIC8. BALB/c mice were immunized with rNcMIC3, rNcMIC8, pcDNA3.1-NcMIC3 and pcDNA3.1-NcMIC8 respectively, and challenged with tachyzoites. The immune responses were evaluated through cytokine, antibody measurements and the parasite burden in the mice brain tissues. Serological analysis showed that recombinant protein vaccines induced higher levels of immunoglobulin G (IgG) than other groups. The percentage of IgG1 and IgG2a in the recombinant protein groups was higher than the other groups, and with a predominance of IgG1 over IgG2a, suggesting that recombinant protein vaccines elicited a Th2-type immune response, while DNA vaccines mainly produce a Th1-type immune response. In addition, mice immunized with rNcMIC3 and rNcMIC8 a had lower parasite burden in brain tissue compared with the other groups. These results demonstrate that rNcMIC3 and rNcMIC8 could induce humoral and Th2-type immune response, leading to a considerable level of resistance against neosporosis.
8英寸绝缘栅双极型晶体管 (IGBT) 关键技术研究 Article
刘国友,丁荣军,罗海辉
《工程(英文)》 2015年 第1卷 第3期 页码 361-366 doi: 10.15302/J-ENG-2015043
基于8英寸绝缘栅双极型晶体管 (IGBT) 生产线的建设,重点解决了8英寸IGBT先进工艺技术、第四代高压双扩散金属氧化物半导体 (DMOS+) IGBT技术和第五代沟槽栅IGBT技术等关键技术问题,实现了高压IGBT芯片制造从6英寸到8英寸的技术突破,自主开发的1600 A/1.7 kV与1500 A/3.3 kV IGBT模块已经被成功制造并通过考核,现已应用于轨道交通牵引系统。
关键词: 绝缘栅双极型晶体管 (IGBT) 高功率密度 沟槽栅 8英寸 轨道交通
《医学前沿(英文)》 2022年 第16卷 第6期 页码 909-918 doi: 10.1007/s11684-021-0890-1
关键词: acute promyelocytic leukemia intracranial hemorrhage cytokines biomarker
《医学前沿(英文)》 2022年 第16卷 第3期 页码 403-415 doi: 10.1007/s11684-021-0858-1
关键词: myeloproliferative neoplasms IRF4 IRF8 hydroxyurea essential thrombocythemia
Alireza Hadi, Javad Karimi-Sabet, Abolfazl Dastbaz
《化学科学与工程前沿(英文)》 2020年 第14卷 第4期 页码 579-594 doi: 10.1007/s11705-018-1770-3
关键词: metal organic frameworks zeolitic imidazolate frameworks ZIF-8 response surface methodology Box Behnken design CO adsorption
Gene therapy for hemophilia B mice with scAAV8-LP1-hFIX
null
《医学前沿(英文)》 2016年 第10卷 第2期 页码 212-218 doi: 10.1007/s11684-016-0438-y
Hemophilia B is a hemorrhagic disease caused by the deficiency of clotting factor IX (FIX). Gene therapy might be the ultimate strategy for the disease. However, two main problems that should be solved in gene therapy for hemophilia B are immunity and safety. Self-complementary adeno-associated virus serotype 8 (scAAV8), a non-human primate AAV featuring low immunogenicity and high transfection efficiency in liver cells, might be a potential vector for hemophilia B gene therapy. A strong liver-specific promoter-1 (LP1) was inserted and mutant human FIX Arg338Ala was introduced into plasmid scAAV8-LP1 to develop an optimized AAV8 vector that expresses human clotting factor FIX (hFIX). The efficiency of scAAV8-LP1-hFIX administered through normal systemic injection or hydrodynamic injection was compared. A high expression was achieved using hydrodynamic injection, and the peak hFIX expression levels in the 5×1011 and 1×1011 virus genome (vg) cohorts were 31.94% and 25.02% of normal level, respectively, at 60 days post-injection. From the perspective of long-term (200 days) expression, both injection methods presented promising results with the concentration value maintained above 4% of normal plasma. The results were further verified by enzyme-linked immunosorbent assay and activated partial thromboplastin time. Our study provides a potential gene therapy method for hemophilia B.
关键词: hemophilia B AAV8 hFIX gene therapy
《化学科学与工程前沿(英文)》 2022年 第16卷 第1期 页码 103-111 doi: 10.1007/s11705-021-2064-8
关键词: UDP-glucuronosyltransferase 1A8 fluorescent probe subtype selectivity fluorescence imaging
Single and joint effects of HHCB and cadmium on zebrafish (
Lei ZHANG, Jing AN, Qixing ZHOU
《环境科学与工程前沿(英文)》 2012年 第6卷 第3期 页码 360-372 doi: 10.1007/s11783-011-0353-z
关键词: 1 3 4 6 7 8-hexahydro-4 6 6 7 8 8-hexamethylcyclopenta-gamma-2-benzopyran (HHCB) cadmium (Cd) antioxidant biomarker feculent water containing bedloads
乔映宾
《中国工程科学》 1999年 第1卷 第1期 页码 73-77
文章介绍了SKI系列C8芳烃异构化催化剂研究工作的进展。阐述了催化剂研制开发的创新思路以及该催化剂的优异性能。该催化剂可使贫对二甲苯或贫对、邻二甲苯的混合C8芳烃异构为接近热力学平衡的C8芳烃,C8芳烃的选择性大于97%,使用寿命可达5年以上。并介绍了该催化剂在引进的七套C8芳烃异构化工业装置上取代了进口催化剂,将该科技成果转化为现实的生产力所取得的成绩。
Influence of retinoic acid on TBX1 expression in myocardial cells induced by Shh and Fgf8
Miao LIU, Xiaoyan WU, Jiawei XU, Runming JIN
《医学前沿(英文)》 2009年 第3卷 第1期 页码 61-66 doi: 10.1007/s11684-009-0007-8
李秀娟,王祖强,刘宪伟
《中国工程科学》 2006年 第8卷 第12期 页码 89-91
采用自顶向下的设计方法,设计了8位MCU IP核。该8位MCU IP核可简化为两大部分,通过精心设计,时序整齐,译码电路单元结构简单,层次化数据通道模型结构规整。
标题 作者 时间 类型 操作
Prohibitin regulates mTOR pathway via interaction with FKBP8
Jiahui Zhang, Yanan Yin, Jiahui Wang, Jingjing Zhang, Hua Liu, Weiwei Feng, Wen Yang, Bruce Zetter, Yingjie Xu
期刊论文
Zeolitic imidazolate framework-8 (ZIF-8) for drug delivery: A critical review
Simin Feng, Xiaoli Zhang, Dunyun Shi, Zheng Wang
期刊论文
Protective efficacy of vaccination with NcMIC3 and NcMIC8 against
Taotao ZHANG, Xiao ZHANG, Qun LIU, Jianhai XU, Jing LIU
期刊论文
Predictive values of plasma TNFα and IL-8 for intracranial hemorrhage in patients with acute promyelocytic
期刊论文
IRF4 and IRF8 expression are associated with clinical phenotype and clinico-hematological response to
期刊论文
Parametric study on the mixed solvent synthesis of ZIF-8 nano- and micro-particles for CO adsorption:
Alireza Hadi, Javad Karimi-Sabet, Abolfazl Dastbaz
期刊论文
A highly selective fluorescent probe for real-time imaging of UDP-glucuronosyltransferase 1A8 in living
期刊论文
Influence of retinoic acid on TBX1 expression in myocardial cells induced by Shh and Fgf8
Miao LIU, Xiaoyan WU, Jiawei XU, Runming JIN
期刊论文