检索范围:
排序: 展示方式:
Jiao HU,Xiufan LIU
《农业科学与工程前沿(英文)》 2016年 第3卷 第1期 页码 11-24 doi: 10.15302/J-FASE-2016092
关键词: avian influenza virus H9N2 H5N1 novel viruses public health
Zhuoying WU, Qing WANG, Feng GUO, Shenghua ZHANG, Qipei JIANG, Xin YU
《环境科学与工程前沿(英文)》 2014年 第8卷 第2期 页码 205-214 doi: 10.1007/s11783-013-0492-5
关键词: drinking water distribution systems (DWDS) biofilm quorum sensing (QS) N-acyl-L-homoserine lactones (AHLs) (dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) 2(5H)-furanone
Pathogenesis of pandemic H1N1 2009 influenza virus infection and the implication on management
Kelvin Kai-Wang TO FRCPath, Iris Wai-Sum LI FRCP, Ivan Fan-Ngai HUNG FRCP, Vincent Chi-Chung CHENG FRCPath, Kwok-Yung YUEN MD,
《医学前沿(英文)》 2010年 第4卷 第2期 页码 147-156 doi: 10.1007/s11684-010-0030-9
关键词: influenza A virus H1N1 subtype pandemic pathogenesis virulence factors immunity management antiviral
从H1N1血凝素序列提取的沙门氏菌传递的COBRA-HA1抗原对甲型流感亚型产生广谱保护作用 Article
Ram Prasad Aganja, Amal Senevirathne, Chandran Sivasankar, John Hwa Lee
《工程(英文)》 2024年 第32卷 第1期 页码 42-57 doi: 10.1016/j.eng.2023.08.001
A universal vaccine is in high demand to address the uncertainties of antigenic drift and the reduced effectiveness of current influenza vaccines. In this study, a strategy called computationally optimized broadly reactive antigen (COBRA) was used to generate a consensus sequence of the hemagglutinin globular head portion (HA1) of influenza virus samples collected from 1918 to 2021 to trace evolutionary changes and incorporate them into the designed constructs. Constructs carrying different HA1 regions were delivered into eukaryotic cells by Salmonella-mediated bactofection using a Semliki Forest virus RdRp-dependent eukaryotic expression system, pJHL204. Recombinant protein expression was confirmed by Western blot and immunofluorescence assays. Mice immunized with the designed constructs produced a humoral response, with a significant increase in immunoglobulin G (IgG) levels, and a cell-mediated immune response, including a 1.5-fold increase in CD4+ and CD8+ T cells. Specifically, constructs #1 and #5 increased the production of interferon-γ (IFN-γ) producing CD4+ and CD8+ T cells, skewing the response toward the T helper type 1 cell (Th1) pathway. Additionally, interleukin-4 (IL-4)-producing T cells were upregulated 4-fold. Protective efficacy was demonstrated, with up to 4-fold higher production of neutralizing antibodies and a hemagglutination inhibition titer > 40 against the selected viral strains. The designed constructs conferred a broadly protective immune response, resulting in a notable reduction in viral titer and minimal inflammation in the lungs of mice challenged with the influenza A/PR8/34, A/Brisbane/59/2007, A/California/07/2009, KBPV VR-92, and NCCP 43021 strains. This discovery revolutionizes influenza vaccine design and delivery; Salmonella-mediated COBRA-HA1 is a highly effective in vivo antigen presentation strategy. This approach can effectively combat seasonal H1N1 influenza strains and potential pandemic outbreaks.
关键词: COBRA Influenza A Salmonella Vaccine Broad spectral protection
《环境科学与工程前沿(英文)》 2022年 第16卷 第10期 doi: 10.1007/s11783-022-1557-0
● A series of Cu-ZSM-5 catalysts were tested for DMF selective catalytic oxidation.
关键词: N N-Dimethylformamide Selective catalytic oxidation Cu-ZSM-5 CuO particle size
Yongli WANG, Shuyuan MA, Xiaodong Lü, Chuang XIE
《化学科学与工程前沿(英文)》 2012年 第6卷 第4期 页码 423-431 doi: 10.1007/s11705-012-1211-7
关键词:
5-(difluoromethoxy)-2-mercapto-1
面向5G n260应用的低成本基片集成空腔波导高次模背腔缝隙天线阵
齐紫航1,2,3,李秀萍1,2,3,朱华1,2,3
《信息与电子工程前沿(英文)》 2021年 第22卷 第4期 页码 609-614 doi: 10.1631/FITEE.2000503
Nonlinear dynamic analysis for elastic robotic arms
H. KORAYEM, H. N. RAHIMI
《机械工程前沿(英文)》 2011年 第6卷 第2期 页码 219-228 doi: 10.1007/s11465-011-0218-y
The aim of the paper is to analyze the nonlinear dynamics of robotic arms with elastic links and joints. The main contribution of the paper is the comparative assessment of assumed modes and finite element methods as more convenient approaches for computing the nonlinear dynamic of robotic systems. Numerical simulations comprising both methods are carried out and results are discussed. Hence, advantages and disadvantages of each method are illustrated. Then, adding the joint flexibility to the system is dealt with and the obtained model is demonstrated. Finally, a brief description of the optimal motion generation is presented and the simulation is carried out to investigate the role of robot dynamic modeling in the control of robots.
关键词: robotic arms elastic link elastic joint nonlinear dynamics optimal control
Research progress on human infection with avian influenza H7N9
Xiaoxin Wu, Lanlan Xiao, Lanjuan Li
《医学前沿(英文)》 2020年 第14卷 第1期 页码 8-20 doi: 10.1007/s11684-020-0739-z
Baodong Song, Yongqiang Li, Gang Cao, Zhenhai Sun, Xu Han
《化学科学与工程前沿(英文)》 2017年 第11卷 第4期 页码 564-574 doi: 10.1007/s11705-017-1654-y
关键词: MTG nano-scale H-ZSM-5 steam treatment gasoline selectivity to gasoline
grown TiN/N-TiO composite for enhanced photocatalytic H evolution activity
《能源前沿(英文)》 2021年 第15卷 第3期 页码 721-731 doi: 10.1007/s11708-021-0766-8
关键词: photocatalytic H2 evolution TiN/N-TiO2 composite plasmonic effect in-situ nitridation
《环境科学与工程前沿(英文)》 2022年 第16卷 第8期 doi: 10.1007/s11783-022-1522-y
• Simultaneous C & N removal in Methammox occurs at wide C:N ratio.
关键词: Methanogens Biological Nitrogen Removal (BNR) Simultaneous Methammox C:N ratio
Probes and nano-delivery systems targeting NAD(P)H:quinone oxidoreductase 1: a mini-review
《化学科学与工程前沿(英文)》 2023年 第17卷 第2期 页码 123-138 doi: 10.1007/s11705-022-2194-7
关键词: NAD(P)H:quinone oxidoreductase 1 cancer therapy target probe nanosystem
Compiling of comprehensive data of human infections with novel influenza A (H7N9) virus
null
《医学前沿(英文)》 2013年 第7卷 第3期 页码 275-276 doi: 10.1007/s11684-013-0285-z
Catalytic activity of manganese oxide supported on alumina in the synthesis of quinoxalines
., H. Kathyayini, N. Nagaraju
《化学科学与工程前沿(英文)》 2013年 第7卷 第4期 页码 415-421 doi: 10.1007/s11705-013-1360-3
关键词: alumina manganese oxide deposited on alumina quinoxaline synthesis
标题 作者 时间 类型 操作
Endemicity of H9N2 and H5N1 avian influenza viruses in poultry in China poses a serious threat to poultry
Jiao HU,Xiufan LIU
期刊论文
Responses of bacterial strains isolated from drinking water environments to N-acyl-L-homoserine lactones
Zhuoying WU, Qing WANG, Feng GUO, Shenghua ZHANG, Qipei JIANG, Xin YU
期刊论文
Pathogenesis of pandemic H1N1 2009 influenza virus infection and the implication on management
Kelvin Kai-Wang TO FRCPath, Iris Wai-Sum LI FRCP, Ivan Fan-Ngai HUNG FRCP, Vincent Chi-Chung CHENG FRCPath, Kwok-Yung YUEN MD,
期刊论文
从H1N1血凝素序列提取的沙门氏菌传递的COBRA-HA1抗原对甲型流感亚型产生广谱保护作用
Ram Prasad Aganja, Amal Senevirathne, Chandran Sivasankar, John Hwa Lee
期刊论文
Effect of Cu-ZSM-5 catalysts with different CuO particle size on selective catalytic oxidation of N,N-Dimethylformamide
期刊论文
Control of the agglomeration of crystals in the reactive crystallization of 5-(difluoromethoxy)-2-mercaptoof the agglomeration of crystals in the reactive crystallization of 5-(difluoromethoxy)-2-mercapto-1
Yongli WANG, Shuyuan MA, Xiaodong Lü, Chuang XIE
期刊论文
Research progress on human infection with avian influenza H7N9
Xiaoxin Wu, Lanlan Xiao, Lanjuan Li
期刊论文
The effect of doping and steam treatment on the catalytic activities of nano-scale H-ZSM-5 in the methanol
Baodong Song, Yongqiang Li, Gang Cao, Zhenhai Sun, Xu Han
期刊论文
Enhancing the efficiency of nitrogen removing bacterial population to a wide range of C:N ratio (1.5:1 to 14:1) for simultaneous C & N removal
期刊论文