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Comparison of human nasal epithelial cells grown as explant outgrowth cultures or dissociated tissue cultures

null

《医学前沿(英文)》 2013年 第7卷 第4期   页码 486-491 doi: 10.1007/s11684-013-0287-x

摘要:

The purpose of this study was to compare cell growth characteristics, ciliated cell differentiation, and function of human nasal epithelial cells established as explant outgrowth cultures or dissociated tissue cultures. Human nasal mucosa of the uncinate process was obtained by endoscopy and epithelial cell cultures were established by explant outgrowth or dissociated tissue culture methods. Epithelial cell growth characteristics were observed by inverted phase contrast microscopy. Ciliated cell differentiation was detected by β-tubulin IV and ZO-1 immunocytochemistry. Basal and ATP-stimulated ciliary beat frequency (CBF) was measured using a high-speed digital microscopic imaging system. Both the explant and dissociated tissue cultures established as monolayers with tight junctions and differentiated cell composition, with both types of cultures comprising ciliated and non-ciliated epithelial cells. Fibroblasts were also frequently found in explant cultures but rarely seen in dissociated tissue cultures. In both culture systems, the highest ciliated cell density appeared at 7th–10th culture day and declined with time, with the lifespan of ciliated cells ranging from 14 to 21 days. Overall, 10% of the cells in explant cultures and 20% of the cells in the dissociated tissue cultures were ciliated. These two cultures demonstrated similar ciliary beat frequency values at baseline (7.78±1.99 Hz and 7.91±2.52 Hz, respectively) and reacted equivalently following stimulation with 100 μM ATP. The results of this study indicate that both the explant outgrowth and dissociated tissue culture techniques are suitable for growing well-differentiated nasal ciliated and non-ciliated cells, which have growth characteristics and ciliary activity similar to those of nasal epithelial cells in vivo.

关键词: ciliated cells     ciliary beat frequency     dissociated tissue culture     explant culture     nasal epithelial cells    

Solid-state transformer-based new traction drive system and control

Jianghua FENG, Jing SHANG, Zhixue ZHANG, Huadong LIU, Zihao HUANG

《机械工程前沿(英文)》 2018年 第13卷 第3期   页码 411-426 doi: 10.1007/s11465-018-0467-0

摘要:

A new type of traction drive system consisting of solid-state traction transformer (SSTT), inverter unit, auxiliary inverter, traction motor and other key components is built in order to suit the demand of developing the next-generation electric traction system which will be efficient and lightweight, with high power density. For the purpose of reducing system volume and weight and improving efficiency and grid-side power quality, an efficient SSTT optimized topology combining high-voltage cascaded rectifiers with high-power high-frequency LLC resonant converter is proposed. On this basis, an integrated control strategy built upon synchronous rotating reference frame is presented to achieve unified control over fundamental active, reactive and harmonic components. The carrier-interleaving phase shift modulation strategy is proposed to improve the harmonic performance of cascaded rectifiers. In view of the secondary pulsating existing in a single-phase system, the mathematical model of secondary power transfer is built, and the mechanism of pulsating voltage resulting in beat frequency of LLC resonant converter is revealed, so as to design optimum matching of system parameters. Simulation and experimental results have verified that the traction system and control scheme mentioned in this paper are reasonable and superior and that they meet the future application requirements for rail transit.

关键词: solid-state traction transformer     high-voltage cascaded rectifier     LLC resonant converter     synchronous rotating reference frame     carrier-interleaving phase shift control     secondary pulsating voltage     beat frequency    

用于并网逆变器的改进三矢量无差拍模型预测直接功率控制策略 None

Chen-wen CHENG, Heng NIAN, Long-qi LI

《信息与电子工程前沿(英文)》 2018年 第19卷 第11期   页码 1420-1431 doi: 10.1631/FITEE.1601874

摘要: 用于并网逆变器的传统模型预测直接功率控制,在每个控制周期只使用一个逆变器电压矢量,导致并网电流和功率出现大量谐波分量,降低电能质量。为提高稳态性能,预测控制需要很高的采样频率,同时由于计算复杂,预测算法需要较长执行时间,二者存在矛盾。为解决这个问题,提出一种新的无差拍模型预测直接功率控制策略,在每个控制周期使用2个有效电压矢量和1个零电压矢量。采用三矢量策略保证开关频率恒定,提高电流和功率质量。不同于传统三矢量模型预测直接功率控制策略,该方法根据功率误差而非电网电压矢量位置选择三个矢量,保证矢量计算时间始终为正。同时,无需迭代计算,有利于在数字信号处理芯片上执行算法。最后,搭建1 kW逆变器实验平台,验证了该方法的有效性。

关键词: 并网逆变器;模型预测控制;直接功率控制;三矢量;恒定开关频率;功率误差    

A frequency error estimation for isogeometric analysis of Kirchhoff–Love cylindrical shells

《结构与土木工程前沿(英文)》 doi: 10.1007/s11709-023-0006-x

摘要: A frequency error estimation is presented for the isogeometric free vibration analysis of Kirchhoff–Love cylindrical shells using both quadratic and cubic basis functions. By analyzing the discrete isogeometric equations with the aid of harmonic wave assumption, the frequency error measures are rationally derived for the quadratic and cubic formulations for Kirchhoff–Love cylindrical shells. In particular, the governing relationship of the continuum frequency for Kirchhoff–Love cylindrical shells is naturally embedded into the frequency error measures without the need of explicit frequency expressions, which usually are not trivial for the shell problems. In accordance with these theoretical findings, the 2nd and 4th orders of frequency accuracy are attained for the isogeometric schemes using quadratic and cubic basis functions, respectively. Numerical results not only thoroughly verify the theoretical convergence rates of frequency solutions, but also manifest an excellent magnitude match between numerical and theoretical frequency errors for the isogeometric free vibration analysis of Kirchhoff–Love cylindrical shells.

关键词: isogeometric analysis     Kirchhoff–Love cylindrical shell     free vibration     frequency error     convergence    

Calculation of collision frequency function for aerosol particles in free molecule regime in presence

Xiaowei LUO, Yannick BENICHOU, Suyuan YU

《能源前沿(英文)》 2013年 第7卷 第4期   页码 506-510 doi: 10.1007/s11708-013-0275-5

摘要: The collision frequency function for aerosol particles has already been calculated for the free molecule regime and for the continuum range. The present work, taking into account the influence of internal force fields such as magnetic force, electric force and molecular forces, created by particles themselves, recalculated the collision frequency in the case of particles much smaller than the mean free path of the gas (free molecule regime). Attractive forces increase naturally the collision frequency, while repulsive forces decrease it. The calculation was performed for all types of central forces deriving from a potential, including Coulomb forces and Van der Waals forces.

关键词: aerosol particles     collision frequency function     coagulation    

Experimental study of structural damage identification based on modal parameters and decay ratio of acceleration signals

Zhigen WU, Guohua LIU, Zihua ZHANG

《结构与土木工程前沿(英文)》 2011年 第5卷 第1期   页码 112-120 doi: 10.1007/s11709-010-0069-3

摘要: A novel damage assessment method based on the decay ratio of acceleration signals (DRAS) was proposed. Two experimental tests were used to show the efficiency. Three beams were gradually damaged, and then the changes of dynamic parameters were monitored from initial to failure state. In addition, a new method was compared with the linear modal-based damage assessment using wavelet transform (WT). The results clearly show that DRAS increases in linear elasticity state and microcrack propagation state, while DRAS decreases in macrocrack propagation state. Preliminary analysis was developed considering the beat phenomenon in the nonlinear state to explain the turn point of DRAS. With better sensibility of damage than modal parameters, probably DRAS is a promising damage indicator in damage assessment.

关键词: damage assessment     decay ratio of acceleration signals (DRAS)     wavelet transform (WT)     modal analysis     reinforced concrete beam     beat phenomenon    

Fuel variability effect on flickering frequency of diffusion flames

Jizhao LI, Yang ZHANG

《能源前沿(英文)》 2009年 第3卷 第2期   页码 134-140 doi: 10.1007/s11708-009-0034-9

摘要: It is known that fuel variability of different gas suppliers may cause combustion instability in a gas turbine combustor. Mechanisms that control the time scale of the heat release oscillations and acoustic pressure perturbations are both physical and chemical in nature, and thus can be influenced by changes in fuel composition. The intent of this study is to investigate the fuel variability on the flickering frequency of diffusion flames in the hope of understanding some of the fundamental aspects of fuel variability effect on the dynamics of combustion. Experiments were conducted at atmospheric pressure with a matrix of methane and propane blends. An optical fibre system was applied to capture simultaneously the flame flickering at two different light frequencies (430 nm and 516 nm), which provided a means of comparing the chemistry change. It was found that the low frequency oscillation of flow and flame structures depended only weakly on the exit velocities of the fuel, while ambient conditions had a significant effect on flickering frequencies and spectrum. The results of using CH and C H as test fuels at different flow rates showed very little variations, with peak frequencies at 11-13 Hz. When the jet flame was not disturbed, harmonics to at least the third mode were obtained in most of these cases. However, the cases which included CH /C H splits of 90/10, 85/15 and 80/20 by volume showed that unstable flickering frequencies and flame harmonics were not observed. When a mixture of methane/propane at a ratio of 1:1 was used the peak flickering frequency was around 6 Hz, and slight disturbance in the environment would cause the harmonics to disappear. Mechanisms thought to produce changes in the dynamic response and frequency harmonics were discussed.

关键词: fuel variability     flickering frequency     diffusion flames     dynamics of combustion    

Capacity limitation of nuclear units in grid based on analysis of frequency regulation

Yiping DAI, Pan JIANG, Lin GAO, Weimin KAN, Xiaoqing XIAO, Ge JIN

《能源前沿(英文)》 2012年 第6卷 第2期   页码 148-154 doi: 10.1007/s11708-012-0174-1

摘要: The increasing capacity of nuclear units in power grid poses threat to system stability and security. Load disturbance may cause overspeed of the units and trigger the overspeed protection controller (OPC). Repeating actions of valves have a strong impact on the security of the equipment and may result in a collapse of the power system. Based on the analysis of frequency regulation, mathematic models for nuclear units in the grid are established in this paper to simulate the dynamic process when load disturbance occurs. The critical action of the OPC is proposed as the constraint of safe operation for the units. The relationship between different styles of frequency regulation and the allowable capacity of the nuclear units in the grid is discussed. This research can help to estimate the capacity limitation of nuclear units in the grid.

关键词: nuclear units capacity     overspeed     primary frequency control (PFC)     second frequency control (SFC)    

Oscillation frequency of simplified arterial tubes

Hui AN, Fan HE, Lingxia XING, Xiaoyang LI

《机械工程前沿(英文)》 2009年 第4卷 第3期   页码 300-304 doi: 10.1007/s11465-009-0038-5

摘要: To construct the spatial kinetic equation of an arterial tube and obtain its radial natural frequency, a linear-elastic and small deformation condition is assumed. The theoretical analysis is first presented and the finite element method is then used to numerically simulate the spatial kinematics. The results show that the first-order frequency is 15.8 Hz and the obtained exact analytical solutions agree well with numerical solutions, which proves that the theoretical analysis and numerical simulation are both correct.

关键词: spatial kinematics     natural frequency     finite element method    

Parameter identification of interconnected power system frequency after trip-out of high voltage transmission

Xuzhan ZHOU,Shanshan LIU,Mingkun WANG,Yiping DAI,Yaohua TANG

《能源前沿(英文)》 2014年 第8卷 第3期   页码 386-393 doi: 10.1007/s11708-014-0323-9

摘要: Accurate modeling and parameters of high voltage (HV) grid are critical for stability research of system frequency. In this paper, simulation modeling of the system frequency was conducted of an interconnected power system with HV transmission lines in China. Based on recorded tripping data of the HV transmission lines, system parameters were identified by using genetic algorithm (GA). The favorable agreement between simulation results and recorded data verifies the validity of gird models and the accuracy of system parameters. The results of this paper can provide reference for the stability research of HV power grid.

关键词: high voltage (HV) grid     frequency stability parameter identification     primary frequency regulation (PFR)    

Dependence of error sensitivity of frequency on bias voltage in force-balanced micro accelerometer

Lili CHEN, Wu ZHOU

《机械工程前沿(英文)》 2013年 第8卷 第2期   页码 146-149 doi: 10.1007/s11465-013-0260-z

摘要:

To predict more precisely the frequency of force-balanced micro accelerometer with different bias voltages, the effects of bias voltages on error sensitivity of frequency is studied. The resonance frequency of accelerometer under closed loop control is derived according to its operation principle, and its error sensitivity is derived and analyzed under over etching structure according to the characteristics of Deep Reaction Ion Etching (DRIE). Based on the theoretical results, micro accelerometer is fabricated and tested to study the influences of AC bias voltage and DC bias voltage on sensitivity, respectively. Experimental results indicate that the relative errors between test data and theory data are less than 7%, and the fluctuating value of error sensitivity under the range of voltage adjustment is less than 0.01 μm . It is concluded that the error sensitivity with designed parameters of structure, circuit and process error can be used to predict the frequency of accelerometer with no need to consider the influence of bias voltage.

关键词: Micro-Electro-Mechanical Systems (MEMS)     micro accelerometer     force-balanced micro accelerometer     frequency     error sensitivity    

Potential unreliability of ALK variant allele frequency in the efficacy prediction of targeted therapy

《医学前沿(英文)》 2023年 第17卷 第3期   页码 493-502 doi: 10.1007/s11684-022-0946-x

摘要: Anaplastic lymphoma kinase (ALK) is the most common fusion gene involved in non-small cell lung cancer (NSCLC), and remarkable response has been achieved with the use of ALK tyrosine kinase inhibitors (ALK-TKIs). However, the clinical efficacy is highly variable. Pre-existing intratumoral heterogeneity (ITH) has been proven to contribute to the poor treatment response and the resistance to targeted therapies. In this work, we investigated whether the variant allele frequencies (VAFs) of ALK fusions can help assess ITH and predict targeted therapy efficacy. Through the application of next-generation sequencing (NGS), 7.2% (326/4548) of patients were detected to be ALK positive. On the basis of the adjusted VAF (adjVAF, VAF normalization for tumor purity) of four different threshold values (adjVAF < 50%, 40%, 30%, or 20%), the association of ALK subclonality with crizotinib efficacy was assessed. Nonetheless, no statistical association was observed between median progression-free survival (PFS) and ALK subclonality assessed by adjVAF, and a poor correlation of adjVAF with PFS was found among the 85 patients who received first-line crizotinib. Results suggest that the ALK VAF determined by hybrid capture-based NGS is probably unreliable for ITH assessment and targeted therapy efficacy prediction in NSCLC.

关键词: ALK fusion     next-generation sequencing     fluorescence in situ hybridization     immunohistochemistry     variant allele frequency     intratumoral heterogeneity     targeted therapy    

Remote calibration system for frequency based on in-place benchmark

Xiaobin HONG, Guixiong LIU, Zhuokui WU, Xipeng DU,

《机械工程前沿(英文)》 2010年 第5卷 第3期   页码 316-321 doi: 10.1007/s11465-010-0021-1

摘要: According to the deficiencies of remote calibration mode based on material object reference, a new model of a remote calibration system for frequency based on in-place benchmark is introduced, which is made of a calibration subsystem on the spot and a remote management subsystem. The key technology of some key problems for the remote calibration system is particularly discussed, including the time and frequency benchmark receiving module based on global positioning system (GPS), frequency comparison based on a phase method, frequency division based on dual high-frequency phase locked loop (PLL), and remote calibration based on the web. The results show that the system possesses some characteristics, such as high precision, good versatility, and no limitation of time and place.

关键词: remote calibration     in-place benchmark     frequency comparison     global position system (GPS)    

Research progress in pathogenic genes of hereditary non-syndromic mid-frequency deafness

null

《医学前沿(英文)》 2016年 第10卷 第2期   页码 137-142 doi: 10.1007/s11684-016-0449-8

摘要:

Hearing impairment is considered as the most prevalent impairment worldwide. Almost 600 million people in the world suffer from mild or moderate hearing impairment, an estimated 10% of the human population. Genetic factors play an important role in the pathogenesis of this disorder. Hereditary hearing loss is divided into syndromic hearing loss (associated with other anomalies) and non-syndromic hearing loss (not associated with other anomalies). Approximately 80% of genetic deafness is non-syndromic. On the basis of the frequency of hearing loss, hereditary non-syndromic hearing loss can be divided into high-, mid-, low-, and total-frequency hearing loss. An audiometric finding of mid-frequency sensorineural hearing loss, or a “bowl-shaped” audiogram, is uncommon. Up to now, merely 7 loci have been linked to mid-frequency hearing loss. Only four genetic mid-frequency deafness genes, namely, DFNA10 (EYA4), DFNA8/12 (TECTA), DFNA13 (COL11A2), DFNA44 (CCDC50), have been reported to date. This review summarizes the research progress of the four genes to draw attention to mid-frequency deafness genes.

关键词: hereditary non-syndromic hearing loss     mid-frequency hearing loss     deafness genes    

Time-domain and frequency-domain approaches to identification of bridge flutter derivatives

Zhengqing CHEN

《结构与土木工程前沿(英文)》 2009年 第3卷 第2期   页码 173-179 doi: 10.1007/s11709-009-0034-1

摘要: Flutter derivatives are essential for flutter analysis of long-span bridges, and they are generally identified from the vibration testing data of a sectional model suspended in a wind tunnel. Making use of the forced vibration testing data of three sectional models, namely, a thin-plate model, a nearly streamlined model, and a bluff-body model, a comparative study was made to identify the flutter derivatives of each model by using a time-domain method and a frequency-domain method. It was shown that all the flutter derivatives of the thin-plate model identified with the frequency-domain method and time-domain method, respectively, agree very well. Moreover, some of the flutter derivatives of each of the other two models identified with the two methods deviate to some extent. More precisely, the frequency-domain method usually results in smooth curves of the flutter derivatives. The formulation of time-domain method makes the identification results of flutter derivatives relatively sensitive to the signal phase lag between vibration state vector and aerodynamic forces and also prone to be disturbed by noise and nonlinearity.

关键词: long-span bridges     wind-induced vibration     flutter derivatives     forced vibration test     time-domain method     frequency-domain method    

标题 作者 时间 类型 操作

Comparison of human nasal epithelial cells grown as explant outgrowth cultures or dissociated tissue cultures

null

期刊论文

Solid-state transformer-based new traction drive system and control

Jianghua FENG, Jing SHANG, Zhixue ZHANG, Huadong LIU, Zihao HUANG

期刊论文

用于并网逆变器的改进三矢量无差拍模型预测直接功率控制策略

Chen-wen CHENG, Heng NIAN, Long-qi LI

期刊论文

A frequency error estimation for isogeometric analysis of Kirchhoff–Love cylindrical shells

期刊论文

Calculation of collision frequency function for aerosol particles in free molecule regime in presence

Xiaowei LUO, Yannick BENICHOU, Suyuan YU

期刊论文

Experimental study of structural damage identification based on modal parameters and decay ratio of acceleration signals

Zhigen WU, Guohua LIU, Zihua ZHANG

期刊论文

Fuel variability effect on flickering frequency of diffusion flames

Jizhao LI, Yang ZHANG

期刊论文

Capacity limitation of nuclear units in grid based on analysis of frequency regulation

Yiping DAI, Pan JIANG, Lin GAO, Weimin KAN, Xiaoqing XIAO, Ge JIN

期刊论文

Oscillation frequency of simplified arterial tubes

Hui AN, Fan HE, Lingxia XING, Xiaoyang LI

期刊论文

Parameter identification of interconnected power system frequency after trip-out of high voltage transmission

Xuzhan ZHOU,Shanshan LIU,Mingkun WANG,Yiping DAI,Yaohua TANG

期刊论文

Dependence of error sensitivity of frequency on bias voltage in force-balanced micro accelerometer

Lili CHEN, Wu ZHOU

期刊论文

Potential unreliability of ALK variant allele frequency in the efficacy prediction of targeted therapy

期刊论文

Remote calibration system for frequency based on in-place benchmark

Xiaobin HONG, Guixiong LIU, Zhuokui WU, Xipeng DU,

期刊论文

Research progress in pathogenic genes of hereditary non-syndromic mid-frequency deafness

null

期刊论文

Time-domain and frequency-domain approaches to identification of bridge flutter derivatives

Zhengqing CHEN

期刊论文