资源类型

期刊论文 289

年份

2023 29

2022 22

2021 20

2020 23

2019 11

2018 22

2017 16

2016 7

2015 25

2014 13

2013 7

2012 5

2011 9

2010 12

2009 7

2008 14

2007 17

2006 5

2005 2

2004 3

展开 ︾

关键词

农业面源污染 2

大气污染 2

1)幂模型 1

2R-1C模型；嵌入式系统；参数估计；非迭代方法；二次型 1

3D细胞容器 1

Beclin-1 1

GIS 1

GM(1 1

MOF基催化剂 1

PP 1

SARS-CoV-2干扰 1

SIMPLEC算法 1

SPSS 1

WPC 1

circRNA 1

square-twist折纸 1

三点弯曲梁 1

三酰甘油 1

上行非正交多址；Generalized Welch界等式；多级接收功率；序列分组 1

展开 ︾

检索范围：

排序： 展示方式：

Primary spinal epidural non-Hodgkin’s lymphoma presented with spinal cord compression syndrome

Chunquan CAI MD, PhD, Qingjiang ZHANG BM, Changhong SHEN MD, PhD,

《医学前沿（英文）》 2009年 第3卷 第4期   页码 499-502 doi: 10.1007/s11684-009-0075-9

摘要： The spinal epidural space is an uncommon presenting site in primary non-Hodgkin’s lymphomas, especially for children. A boy suffered spinal cord compression syndrome caused by primary spinal epidural non-Hodgkin’s lymphoma. Thoracolumbar magnetic resonance imaging (MRI) demonstrated an intraspinal mass. An operation was performed with gross total tumor removal. Histological examination revealed a non-Hodgkin’s B-cell lymphoma. Bone marrow aspiration was negative for lymphoma involvement. No other therapies (chemotherapy and/or radiotherapy) were performed according to the parents’ opinion. The patient died approximately one year after the operation due to brain metastases. The clinical course and imaging features were discussed with a review of literatures.

关键词： non-Hodgkin’     s lymphoma     primary     spinal cord compression syndrome     epidural space    

HTML PDF 收藏

Different sites of extranodal involvement may affect the survival of patients with relapsed or refractory non-Hodgkin

Lili Zhou, Ping Li, Shiguang Ye, Xiaochen Tang, Junbang Wang, Jie Liu, Aibin Liang

《医学前沿（英文）》 2020年 第14卷 第6期   页码 786-791 doi: 10.1007/s11684-020-0751-3

摘要： Factors associated with complete and durable remissions after anti-CD19 chimeric antigen receptor T (CAR-T) cell immunotherapy for relapsed or refractory non-Hodgkin lymphoma (r/r NHL) have not been well characterized. In this study, we found that the different sites of extranodal involvement may affect response, overall survival (OS), and progression-free survival (PFS) in patients with r/r NHL treated with anti-CD19 CAR-T cells. In a cohort of 32 treated patients, 12 (37.5%) and 8 (25%) patients exhibited soft tissue lymphoma and bone marrow (BM) infiltrations, respectively, and 13 (41%) patients exhibited infiltration at other sites. The factors that may affect prognosis were identified through multivariable analysis. As an independent risk factor, soft tissue infiltration was the only factor significantly correlated with adverse prognosis ( <0.05), whereas other factors did not reach statistical significance. Furthermore, the site of extranodal tumor infiltration significantly and negatively affected OS and PFS in patients with r/r NHL treated with anti-CD19 CAR-T cell therapy. PFS and OS in patients with BM involvement were not significantly different from those of patients with lymph node involvement alone. Thus, anti-CD19 CAR-T cell therapy may improve the prognosis of patients with BM infiltration.

关键词： anti-CD19 chimeric antigen receptor T cell     soft tissue     bone marrow     relapsed or refractory non-Hodgkin lymphoma    

HTML PDF 收藏

thyroid-stimulating hormone during radiotherapy to prevent primary hypothyroidism in medulloblastoma/PNET and Hodgkin

Maura Massimino, Marta Podda, Lorenza Gandola, Emanuele Pignoli, Ettore Seregni, Carlo Morosi, Filippo Spreafico, Andrea Ferrari, Emilia Pecori, Monica Terenziani

《医学前沿（英文）》 2021年 第15卷 第1期   页码 101-107 doi: 10.1007/s11684-020-0752-2

摘要： Primary hypothyroidism commonly occurs after radiotherapy (RT), and coincides with increased circulating thyroid-stimulating hormone (TSH) levels. We tested therefore the protective effect of suppressing TSH with L-thyroxine during RT for medulloblastoma/PNET and Hodgkin lymphoma (HL) in a prospective cohort study. From 1998 to 2001, a total of 37 euthyroid children with medulloblastoma/PNET plus 14 with HL, scheduled for craniospinal irradiation and mediastinum/neck radiotherapy, respectively, underwent thyroid ultrasound and free triiodothyronine (FT3), free thyroxine (FT4), and TSH evaluation at the beginning and end of craniospinal iiradiation. From 14 days before and up to the end of radiotherapy, patients were administered L-thyroxine checking every 3 days TSH to ensure a value<0.3 μIU/mL. During follow-up, blood tests and ultrasound were repeated; primary hypothyroidism was considered an increased TSH level greater than normal range. Twenty-two/37 patients with medulloblastoma/PNET and all the 14 patients with HL were alive after a median 231 months from radiotherapy with 7/22 and 8/14 having correctly reached TSH levels ˂ 0.3 μIU/mL and well matched for other variables. Twenty years on, hypothyroidism-free survival rates differed significantly, being 60%±15% and 15.6%±8.2% in TSH-suppressed vs. not-TSH suppressed patients, respectively ( =0.001). These findings suggest that hypothyroidism could be durably prevented in two populations at risk of late RT sequelae, but it should be confirmed in a larger cohort.

关键词： iatrogenic primary hypothyroidism     late effects of radiotherapy     long-term follow-up     medulloblastoma     Hodgkin lymphoma    

HTML PDF 收藏

Bevacizumab in combination with pemetrexed and platinum for elderly patients with advanced non-squamousnon-small-cell lung cancer: a retrospective analysis

《医学前沿（英文）》 2022年 第16卷 第4期   页码 610-617 doi: 10.1007/s11684-021-0827-8

摘要： Bevacizumab, an anti-VEGF monoclonal antibody, has significantly improved the clinical outcomes of patients with advanced non-squamous NSCLC (ns-NSCLC). However, the safety and efficacy of bevacizumab for elderly patients with advanced NSCLC require further investigation. Thus, 59 patients were included in the present retrospective study, 22 patients in the bevacizumab plus pemetrexed and platinum (B+PP) group, and 37 patients in the pemetrexed and platinum (PP) group. For the entire cohort of patients, the median OS was 33.3 months, and the 1-year and 2-year overall survival rates were 88.5% and 67.8%, respectively. The median OS and 1-year and 2-year OS rates were 20.5 months, 70.3% and 0%, respectively, in the B+PP group and 33.4 months, 97.0% and 89.4%, respectively, in the PP group (P <0.001). The incidence of grade≥3 adverse events was higher in the B+PP group than in the PP group (27.3% vs. 10.8%, respectively; P=0.204). Univariate and multivariate analyses suggested that the receipt of≥5 cycles of first-line chemotherapy was an independent favorable prognostic factor for OS, whereas the addition of bevacizumab was an unfavorable prognostic factor. With increased toxicities, the addition of bevacizumab to PP does not improve the overall survival of elderly patients with advanced ns-NSCLC.

关键词： bevacizumab     elderly patient     advanced non-small-cell lung cancer     overall survival     toxicity    

HTML PDF 收藏

Error analysis of the parameters for non-coaxial grazing X-ray microscope

ZHAO Lingling, HU Jiasheng, LI Xiang

《机械工程前沿（英文）》 2007年 第2卷 第3期   页码 323-329 doi: 10.1007/s11465-007-0057-z

摘要： A non-coaxial grazing X-ray microscope, consisting of four spherical mirrors, is designed for diagnosis of inertial confinement fusion (ICF). The aberrations and imaging quality of the microscope are analyzed. To acquire excellent imaging quality, suitable tolerances for manufacturing and assembling the microscope are necessary. This paper researches the changes of Gauss parameters and aberrations due to component and subsystem parameters (such as the radius of the mirror, angle between mirrors, grazing angle, object distance, etc.). Here, spot diagrams and modulation transfer function (MTF) are first adopted to quantitatively evaluate the imaging quality of the microscope. Suitable manufacturing tolerances of components and assembly tolerances of the system are established on the basis of the discussion and analysis. A set of non-coaxial grazing X-ray microscopes is manufactured based on the tolerances. In site tests of ICF, the images with high resolution are obtained by the microscope.

关键词： non-coaxial     spherical     manufacturing     necessary     diagnosis    

HTML PDF 收藏

Molecular classification of non-small-cell lung cancer: diagnosis, individualized treatment, and prognosis

null

《医学前沿（英文）》 2013年 第7卷 第2期   页码 157-171 doi: 10.1007/s11684-013-0272-4

摘要：

Non-small-cell lung cancer (NSCLC) is the most common cause of premature death among the malignant diseases worldwide. The current staging criteria do not fully capture the complexity of this disease. Molecular biology techniques, particularly gene expression microarrays, proteomics, and next-generation sequencing, have recently been developed to facilitate effectively its molecular classification. The underlying etiology, pathogenesis, therapeutics, and prognosis of NSCLC based on an improved molecular classification scheme may promote individualized treatment and improve clinical outcomes. This review focuses on the molecular classification of NSCLC based on gene expression microarray technology reported during the past decade, as well as their applications for improving the diagnosis, staging and treatment of NSCLC, including the discovery of prognostic markers or potential therapeutic targets. We highlight some of the recent studies that may refine the identification of NSCLC subtypes using novel techniques such as epigenetics, proteomics, or deep sequencing.

关键词： non-small-cell lung cancer     molecular typing     individualized medicine     molecular-targeted therapy     gene expression profiling    

HTML PDF 收藏

The world’s first offshore wind power non-desalination of seawater electrolysis for hydrogen production

《能源前沿（英文）》 2023年 第17卷 第3期   页码 317-319 doi: 10.1007/s11708-023-0888-2

摘要： The world’s first offshore wind power non-desalination of seawater electrolysis for hydrogen production successfully tested in Fujian, China

关键词： China     wind power non    

HTML PDF 收藏

Identify the contribution of vehicle non-exhaust emissions: a single particle aerosol mass spectrometer

《环境科学与工程前沿（英文）》 2023年 第17卷 第5期 doi: 10.1007/s11783-023-1662-8

摘要：

● A single particle observation was conducted in a high traffic flow road environment.

关键词： Non-exhaust emissions     SPAMS     PMF     Roadside environment    

HTML PDF 收藏

A conceptual methodology for simultaneous optimization of water and heat with non-isothermal mixing

Yanlong Hou, Wanni Xie, Zhenya Duan, Jingtao Wang

《化学科学与工程前沿（英文）》 2017年 第11卷 第2期   页码 154-165 doi: 10.1007/s11705-016-1593-z

摘要： A new conceptual methodology is proposed to simultaneously integrate water allocation and energy networks with non-isothermal mixing. This method employs a simultaneous model and includes two design steps. In the first step, the water allocation network (WAN), which could achieve the targets of saving water and energy, is obtained by taking account the temperature factor into the design procedure. The optimized targets of both freshwater and energy are reached at this step which ensures this approach is a simultaneous one. In the second step, based on the obtained WAN, the whole water allocation and heat exchange network (WAHEN) is combined with the non-isothermal mixing to reduce the number of heat exchangers. The thus obtained WAHEN can achieve three optimization targets (minimization of water, energy and the number of heat exchangers). Furthermore, the effectivity of our method has been demonstrated by solving two literature examples.

关键词： simultaneous integration     non-isothermal mixing     multi-target optimization     water and energy networks    

HTML PDF 收藏

FULL TIME-SPACE GOVERNANCE STRATEGY AND TECHNOLOGY FOR CROPLAND NON-POINT POLLUTION CONTROL IN CHINA

《农业科学与工程前沿（英文）》 2023年 第10卷 第4期   页码 593-606 doi: 10.15302/J-FASE-2023522

摘要：

Ensuring food safety while reducing agricultural non-point source pollution is quite challenging, especially in developing and underdeveloped countries. Effective systematic strategies and comprehensive technologies need to be developed for agricultural non-point source pollution control at the watershed scale to improve surface water quality. In this review, a proposal is made for a full time-space governance strategy that prioritizes source management followed by endpoint water pollution control. The 4R chain technology system is specifically reviewed, including source reduction, process retention, nutrient reuse and water restoration. The 4R chain technology system with the full time-space governance strategy was applied at the scale of an administrative village and proved to be a feasible solution for reducing agricultural non-point source pollution in China. In the future, a monitoring system needs to be established to trace N and P transport. Additionally, new smart fertilizer and intelligent equipment need to be developed, and relevant governance standards and supportive policies need to be set to enhance the efficacy of agricultural non-point source pollution control.

关键词： 4R chain technology system     agricultural non-point source pollution     case study     full time-space governance strategy    

HTML PDF 收藏

Effect of non-uniform illumination on performance of solar thermoelectric generators

Ershuai YIN, Qiang LI, Yimin XUAN

《能源前沿（英文）》 2018年 第12卷 第2期   页码 239-248 doi: 10.1007/s11708-018-0533-7

摘要： Solar thermoelectric generators (STEGs) are heat engines which can generate electricity from concentrated sunlight. The non-uniform illumination caused by the optical concentrator may affect the performance of solar thermoelectric generators. In this paper, a three-dimensional finite element model of solar thermoelectric generators is established. The two-dimensional Gaussian distribution is employed to modify the illumination profiles incident on the thermoelectric generator. Six non-uniformities of solar illumination are investigated while keeping the total energy constant. The influences of non-uniform illumination on the temperature distribution, the voltage distribution, and the maximum output power are respectively discussed. Three thermoelectric generators with 32, 18 and 8 pairs of thermocouples are compared to investigate their capability under non-uniform solar radiation. The result shows that the non-uniformity of the solar illumination has a great effect on the temperature distribution and the voltage distribution. Central thermoelectric legs can achieve a larger temperature difference and generate a larger voltage than peripheral ones. The non-uniform solar illumination will weaken the capability of the TE generator, and the maximum output power decrease by 1.4% among the range of non-uniformity studied in this paper. Reducing the number of the thermoelectric legs for non-uniform solar illumination can greatly increase the performance of the thermoelectric generator.

关键词： solar thermoelectric generators     non-uniform solar illumination     performance evaluation     solar energy    

HTML PDF 收藏

Research progress in pathogenic genes of hereditary non-syndromic mid-frequency deafness

null

《医学前沿（英文）》 2016年 第10卷 第2期   页码 137-142 doi: 10.1007/s11684-016-0449-8

摘要：

Hearing impairment is considered as the most prevalent impairment worldwide. Almost 600 million people in the world suffer from mild or moderate hearing impairment, an estimated 10% of the human population. Genetic factors play an important role in the pathogenesis of this disorder. Hereditary hearing loss is divided into syndromic hearing loss (associated with other anomalies) and non-syndromic hearing loss (not associated with other anomalies). Approximately 80% of genetic deafness is non-syndromic. On the basis of the frequency of hearing loss, hereditary non-syndromic hearing loss can be divided into high-, mid-, low-, and total-frequency hearing loss. An audiometric finding of mid-frequency sensorineural hearing loss, or a “bowl-shaped” audiogram, is uncommon. Up to now, merely 7 loci have been linked to mid-frequency hearing loss. Only four genetic mid-frequency deafness genes, namely, DFNA10 (EYA4), DFNA8/12 (TECTA), DFNA13 (COL11A2), DFNA44 (CCDC50), have been reported to date. This review summarizes the research progress of the four genes to draw attention to mid-frequency deafness genes.

关键词： hereditary non-syndromic hearing loss     mid-frequency hearing loss     deafness genes    

HTML PDF 收藏

系统非优分析理论及方法

何平

《中国工程科学》 2003年 第5卷 第7期   页码 40-46

摘要：

对系统非优分析理论做了较为详细的论述。指出寻求不确定系统优化的主要问题，关键是缺少对系统的非优分析。在系统非优范畴的基础上建立了征兆群与经验分析，提出了系统非优度量以及从非优追踪到系统自组织等问题。

关键词： 系统非优范畴     非优征兆群     非优度量     系统自组织    

HTML PDF 收藏

Seismic fragility curves for structures using non-parametric representations

Chu MAI, Katerina KONAKLI, Bruno SUDRET

《结构与土木工程前沿（英文）》 2017年 第11卷 第2期   页码 169-186 doi: 10.1007/s11709-017-0385-y

摘要： Fragility curves are commonly used in civil engineering to assess the vulnerability of structures to earthquakes. The probability of failure associated with a prescribed criterion (e.g., the maximal inter-storey drift of a building exceeding a certain threshold) is represented as a function of the intensity of the earthquake ground motion (e.g., peak ground acceleration or spectral acceleration). The classical approach relies on assuming a lognormal shape of the fragility curves; it is thus parametric. In this paper, we introduce two non-parametric approaches to establish the fragility curves without employing the above assumption, namely binned Monte Carlo simulation and kernel density estimation. As an illustration, we compute the fragility curves for a three-storey steel frame using a large number of synthetic ground motions. The curves obtained with the non-parametric approaches are compared with respective curves based on the lognormal assumption. A similar comparison is presented for a case when a limited number of recorded ground motions is available. It is found that the accuracy of the lognormal curves depends on the ground motion intensity measure, the failure criterion and most importantly, on the employed method for estimating the parameters of the lognormal shape.

关键词： earthquake engineering     fragility curves     lognormal assumption     non-parametric approach     kernel density estimation     epistemic uncertainty    

HTML PDF 收藏

DITCHES AND PONDS CAN BE THE SOURCES OR SINKS OF NON-POINT SOURCE POLLUTION: OBSERVATIONS IN AN UPLAND

《农业科学与工程前沿（英文）》 2023年 第10卷 第4期   页码 607-626 doi: 10.15302/J-FASE-2023517

摘要：

As the common features of agroecosystems, ditches and ponds benefit the irrigation and drainage, as well as intercepting non-point source pollutants. However, most ditch-pond studies have been conducted in lowland areas. To test this source-sink assumption in upland areas, this study made observations on the ecological function of the ditch and pond system in a typical catchment in China. First, the changes in ponds in the catchment were analyzed using high-resolution remote sensing data. Then, the migration of agricultural pollutants in ditches and ponds were analyzed by field sampling and laboratory detection. The results showed that over the past 15 years the length of ditches in the catchment and the number of small ponds (< 500 m2) have increased by 32% and 75%, respectively. The rate of change in nutrient concentrations in the ditches and ponds were mostly from −20% to 20%, indicating ditches and ponds can be both sources and sinks for agricultural pollutants. Lastly, the contributing factors were explored and it was found that ditches and ponds are important sinks in dry season. However, during the rainy season, ditches and ponds become sources of pollutants, with the rapid drainage of ditches and the overflow of ponds in upland areas. The results of this study revealed that the ditches and ponds could be used for ecological engineering in upland catchments to balance drainage and intercept pollutants.

关键词： ditches     ponds     non-point source pollution     mountainous areas     nitrogen     phosphorus    

HTML PDF 收藏

标题 作者 时间 类型 操作

Primary spinal epidural non-Hodgkin’s lymphoma presented with spinal cord compression syndrome

Chunquan CAI MD, PhD, Qingjiang ZHANG BM, Changhong SHEN MD, PhD,

期刊论文

Different sites of extranodal involvement may affect the survival of patients with relapsed or refractory non-Hodgkin

Lili Zhou, Ping Li, Shiguang Ye, Xiaochen Tang, Junbang Wang, Jie Liu, Aibin Liang

期刊论文

thyroid-stimulating hormone during radiotherapy to prevent primary hypothyroidism in medulloblastoma/PNET and Hodgkin

Maura Massimino, Marta Podda, Lorenza Gandola, Emanuele Pignoli, Ettore Seregni, Carlo Morosi, Filippo Spreafico, Andrea Ferrari, Emilia Pecori, Monica Terenziani

期刊论文

Bevacizumab in combination with pemetrexed and platinum for elderly patients with advanced non-squamousnon-small-cell lung cancer: a retrospective analysis

期刊论文

Error analysis of the parameters for non-coaxial grazing X-ray microscope

ZHAO Lingling, HU Jiasheng, LI Xiang

期刊论文

Molecular classification of non-small-cell lung cancer: diagnosis, individualized treatment, and prognosis

null

期刊论文

The world’s first offshore wind power non-desalination of seawater electrolysis for hydrogen production

期刊论文

Identify the contribution of vehicle non-exhaust emissions: a single particle aerosol mass spectrometer

期刊论文

A conceptual methodology for simultaneous optimization of water and heat with non-isothermal mixing

Yanlong Hou, Wanni Xie, Zhenya Duan, Jingtao Wang

期刊论文

FULL TIME-SPACE GOVERNANCE STRATEGY AND TECHNOLOGY FOR CROPLAND NON-POINT POLLUTION CONTROL IN CHINA

期刊论文

Effect of non-uniform illumination on performance of solar thermoelectric generators

Ershuai YIN, Qiang LI, Yimin XUAN

期刊论文

Research progress in pathogenic genes of hereditary non-syndromic mid-frequency deafness

null

期刊论文

系统非优分析理论及方法

何平

期刊论文

Seismic fragility curves for structures using non-parametric representations

Chu MAI, Katerina KONAKLI, Bruno SUDRET

期刊论文

DITCHES AND PONDS CAN BE THE SOURCES OR SINKS OF NON-POINT SOURCE POLLUTION: OBSERVATIONS IN AN UPLAND

期刊论文