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期刊论文 4

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2020 2

2010 1

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三维视觉知识；三维参数模型；心脏病理诊断；数据增强 1

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Deep learning in digital pathology image analysis: a survey

Shujian Deng, Xin Zhang, Wen Yan, Eric I-Chao Chang, Yubo Fan, Maode Lai, Yan Xu

《医学前沿（英文）》 2020年 第14卷 第4期   页码 470-487 doi: 10.1007/s11684-020-0782-9

摘要： deep learning (DL) has achieved state-of-the-art performance in many digital pathology analysis tasks. Traditional methods usually require hand-crafted domain-specific features, and DL methods can learn representations without manually designed features. In terms of feature extraction, DL approaches are less labor intensive compared with conventional machine learning methods. In this paper, we comprehensively summarize recent DL-based image analysis studies in histopathology, including different tasks (e.g., classification, semantic segmentation, detection, and instance segmentation) and various applications (e.g., stain normalization, cell/gland/region structure analysis). DL methods can provide consistent and accurate outcomes. DL is a promising tool to assist pathologists in clinical diagnosis.

关键词： pathology     deep learning     segmentation     detection     classification    

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Hilar cholangiocarcinoma: Pathology and tumor biology

Dong KUANG, Guo-Ping WANG,

《医学前沿（英文）》 2010年 第4卷 第4期   页码 371-377 doi: 10.1007/s11684-010-0130-6

摘要： Hilar cholangiocarcinoma, first described by Klatskin in 1965, is a relatively rare tumor arising from the bile ducts. The histomorphological features of hilar cholangiocarcinoma are identical with other extra- and intra-hepatic bile duct carcinomas. The most common disease associated with cholangiocarcinoma is primary sclerosing cholangitis. The development of cholangiocarcinoma is a multistep process associated with several mutations in oncogenes and tumor-suppressor genes. Based on macroscopic appearance, three distinct subtypes have been described: sclerosing, nodular, and papillary. Microscopically, more than 95% of tumors are adenocarcinomas. Hilar cholangiocarcinoma is a slowly growing tumor and tends to spread longitudinally along the bile ducts with neural, perineural, and subepithelial extension. Lymph node invasion can be found in 30%–50% patients at the time of diagnosis, but blood-born metastases are rare and usually occur at late stages.

关键词： hilar cholangiocarcinoma     morphology     primary sclerosing cholangitis     metastasis     growth    

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Coronavirus disease 2019 (COVID-19): a clinical update

Min Zhou, Xinxin Zhang, Jieming Qu

《医学前沿（英文）》 2020年 第14卷 第2期   页码 126-135 doi: 10.1007/s11684-020-0767-8

摘要： Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has posed a significant threat to global health. It caused a total of 80 868 confirmed cases and 3101 deaths in Chinese mainland until March 8, 2020. This novel virus spread mainly through respiratory droplets and close contact. As disease progressed, a series of complications tend to develop, especially in critically ill patients. Pathological findings showed representative features of acute respiratory distress syndrome and involvement of multiple organs. Apart from supportive care, no specific treatment has been established for COVID-19. The efficacy of some promising antivirals, convalescent plasma transfusion, and tocilizumab needs to be investigated by ongoing clinical trials.

关键词： coronavirus disease 2019     epidemiology     pathology     radiology     clinical characteristics     treatment    

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基于三维参数模型重建的心脏病理视觉识别 Research Article

肖金肖1,李岩松1,田沄1,徐冬溶2,3,李鹏辉1,赵世凤1,潘云鹤3

《信息与电子工程前沿（英文）》 2022年 第23卷 第9期   页码 1324-1337 doi: 10.1631/FITEE.2200102

摘要： 心脏图像的视觉识别对于心脏病理诊断和治疗具有重要意义。由于可用标注数据集有限，传统方法通常基于三维心脏图像的二维切片对病理分类特征进行提取，难以确保心脏解剖结构的整体一致性。为此，本文提出一种基于三维参数模型重建的心脏病理分类方法。首先，基于收缩末期和舒张末期时相心脏图像的多个三维心脏成像数据重建三维心脏模型。其次，基于重建的三维心脏模型，通过统计形状模型方法构建三维参数模型。然后，基于三维统计形状模型及其视觉知识约束对心脏数据进行增强。最后，提取不同时相的三维心脏模型的形状和运动特征，对心脏病理进行分类。在STACOM公开挑战赛的ACDC数据集上的实验验证了所提方法的优越性和有效性。

关键词： 三维视觉知识；三维参数模型；心脏病理诊断；数据增强    

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标题 作者 时间 类型 操作

Deep learning in digital pathology image analysis: a survey

Shujian Deng, Xin Zhang, Wen Yan, Eric I-Chao Chang, Yubo Fan, Maode Lai, Yan Xu

期刊论文

Hilar cholangiocarcinoma: Pathology and tumor biology

Dong KUANG, Guo-Ping WANG,

期刊论文

Coronavirus disease 2019 (COVID-19): a clinical update

Min Zhou, Xinxin Zhang, Jieming Qu

期刊论文

基于三维参数模型重建的心脏病理视觉识别

肖金肖1,李岩松1,田沄1,徐冬溶2,3,李鹏辉1,赵世凤1,潘云鹤3

期刊论文