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Engineering >> 2022, Volume 13, Issue 6 doi: 10.1016/j.eng.2021.06.013

Tissue Engineering to Restore Cardiac Function

Toronto General Research Institute, Toronto General Hospital, University Health Network & Department of Surgery, Division of Cardiac Surgery, University of Toronto, Toronto, ON M5G 2C4, Canada

Received: 2021-04-08 Revised: 2021-05-19 Accepted: 2021-07-22 Available online: 2021-07-28

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References

[ 1 ] Vunjak-Novakovic G. Tissue engineering of the heart: an evolving paradigm. J Thorac Cardiovasc Surg 2017;153(3):593–5. link1

[ 2 ] Li SH, Sun Z, Brunt KR, Shi X, Chen MS, Weisel RD, et al. Reconstitution of aged bone marrow with young cells repopulates cardiac-resident bone marrowderived progenitor cells and prevents cardiac dysfunction after a myocardial infarction. Eur Heart J 2013;34(15):1157–67. link1

[ 3 ] Wu J, Zeng F, Huang XP, Chung JY, Konecny F, Weisel RD, et al. Infarct stabilization and cardiac repair with a VEGF-conjugated, injectable hydrogel. Biomaterials 2011;32(2):579–86. link1

[ 4 ] Kang K, Sun Lu, Xiao Y, Li SH, Wu J, Guo J, et al. Aged human cells rejuvenated by cytokine enhancement of biomaterials for surgical ventricular restoration. J Am Coll Cardiol 2012;60(21):2237–49. link1

[ 5 ] Alibhai FJ, Tobin SW, Yeganeh A, Weisel RD, Li RK. Emerging roles of extracellular vesicles in cardiac repair and rejuvenation. Am J Physiol Heart Circ Physiol 2018;315(4):H733–44. link1

[ 6 ] Noiseux N, Mansour S, Weisel R, Stevens LM, Der Sarkissian S, Tsang K, et al. The IMPACT-CABG trial: a multicenter, randomized clinical trial of CD133+ stem cell therapy during coronary artery bypass grafting for ischemic cardiomyopathy. J Thorac Cardiovasc Surg 2016;152(6):1582–8.e2. link1

[ 7 ] Yau TM, Pagani FD, Mancini DM, Chang HL, Lala A, Woo YJ, et al; the Cardiothoracic Surgical Trials Network. Intramyocardial injection of mesenchymal precursor cells and successful temporary weaning from left ventricular assist device support in patients with advanced heart failure: a randomized clinical trial. JAMA 2019;321(12):1176. link1

[ 8 ] Li RK, Mickle DAG, Weisel RD, Zhang Ji, Mohabeer MK. In vivo survival and function of transplanted rat cardiomyocytes. Circ Res 1996;78(2):283–8. link1

[ 9 ] Romagnuolo R, Masoudpour H, Porta-Sánchez A, Qiang B, Barry J, Laskary A, et al. Human embryonic stem cell-derived cardiomyocytes regenerate the infarcted pig heart but induce ventricular tachyarrhythmias. Stem Cell Rep 2019;12(5):967–81. link1

[10] Brunt KR, Zhang Y, Mihic A, Li M, Li SH, Xue P, et al. Role of WNT/b-catenin signaling in rejuvenating myogenic differentiation of aged mesenchymal stem cells from cardiac patients. Am J Pathol 2012;181(6):2067–78. link1

[11] Nasseri BA, Ebell W, Dandel M, Kukucka M, Gebker R, Doltra A, et al. Autologous CD133+ bone marrow cells and bypass grafting for regeneration of ischaemic myocardium: the Cardio133 trial. Eur Heart J 2014;35(19):1263–74. link1

[12] See F, Seki T, Psaltis PJ, Sondermeijer HP, Gronthos S, Zannettino AC, et al. Therapeutic effects of human STRO-3-selected mesenchymal precursor cells and their soluble factors in experimental myocardial ischemia. J Cell Mol Med 2011;15(10):2117–29. link1

[13] Rogers JG, Pagani FD, Tatooles AJ, Bhat G, Slaughter MS, Birks EJ, et al. Intrapericardial left ventricular assist device for advanced heart failure. N Engl J Med 2017;376(5):451–60. link1

[14] Kelley ST, Malekan R, Gorman JH, Jackson BM, Gorman RC, Suzuki Y, et al. Restraining infarct expansion preserves left ventricular geometry and function after acute anteroapical infarction. Circulation 1999;99(1):135–42. link1

[15] Wassenaar JW, Gaetani R, Garcia JJ, Braden RL, Luo CG, Huang D, et al. Evidence for mechanisms underlying the functional benefits of a myocardial matrix hydrogel for post-MI treatment. J Am Coll Cardiol 2016;67(9):1074–86. link1

[16] He X, Wang Q, Zhao Y, Zhang H, Wang B, Pan J, et al. Effect of intramyocardial grafting collagen scaffold with mesenchymal stromal cells in patients with chronic ischemic heart disease: a randomized clinical trial. JAMA Netw Open 2020;3(9):e2016236. link1

[17] Davis ME, Motion JPM, Narmoneva DA, Takahashi T, Hakuno D, Kamm RD, et al. Injectable self-assembling peptide nanofibers create intramyocardial microenvironments for endothelial cells. Circulation 2005;111(4):442–50. link1

[18] Jones RH, Velazquez EJ, Michler RE, Sopko G, Oh JK, O’Connor CM, et al.; the STICH Hypothesis 2 Investigators. Coronary bypass surgery with or without surgical ventricular reconstruction. N Engl J Med 2009;360(17):1705–17. link1

[19] Miyagi Y, Zeng F, Huang XP, Foltz WD, Wu J, Mihic A, et al. Surgical ventricular restoration with a cell- and cytokine-seeded biodegradable scaffold. Biomaterials 2010;31(30):7684–94. link1

[20] Mihic A, Cui Z, Wu J, Vlacic G, Miyagi Y, Li SH, et al. A conductive polymer hydrogel supports cell electrical signaling and improves cardiac function after implantation into myocardial infarct. Circulation 2015;132(8):772–84. link1

[21] Zhang C, Hsieh MH, Wu SY, Li SH, Wu J, Liu SM, et al. A self-doping conductive polymer hydrogel that can restore electrical impulse propagation at myocardial infarct to prevent cardiac arrhythmia and preserve ventricular function. Biomaterials 2020;231:119672. link1

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