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Engineering >> 2022, Volume 16, Issue 9 doi: 10.1016/j.eng.2022.07.006

First Pig-to-Live Human Xenotransplant Produces Mixed Results

Senior Technology Writer

Available online: 2022-07-28

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References

[ 1 ] University of Maryland School of Medicine faculty scientists and clinicians perform historic transplant of porcine heart into adult human with end-stage heart disease [Internet]. Baltimore: University of Maryland Medical Center; 2022 Jan 10 [cited 2022 Jun 10]. Available from: https://www.umms.org/ ummc/news/2022/pioneering-transplant-of-porcine-heart-into-adult-humanheart. link1

[ 2 ] Regalado A. The gene-edited pig heart given to a dying patient was infected with a pig virus [Internet]. Cambridge: MIT Technology Review; 2022 May 4 [cited 2022 Jun 10]. Available from: https://www.technologyreview.com/ 2022/05/04/1051725/xenotransplant-patient-died-received-heart-infectedwith-pig-virus/. link1

[ 3 ] Hryhorowicz M, Zeyland J, Slomski R, Lipin´ ski D. Genetically modified pigs as organ donors for xenotransplantation. Mol Biotechnol 2017;59(9):435–44. link1

[ 4 ] Weiss P. CRISPR use in humans shows promise while experts weigh ethical concerns. Engineering 2020;6(7):719–22. link1

[ 5 ] Wolf E, Kemter E, Klymiuk N, Reichart B. Genetically modified pigs as donors of cells, tissues, and organs for xenotransplantation. Anim Front 2019;9 (3):13–20. link1

[ 6 ] Goerlich CE, Griffith B, Hanna P, Hong SN, Ayares D, Singh AK, et al. The growth of xenotransplanted hearts can be reduced with growth hormone receptor knockout pig donors. J Thorac Cardiovasc Surg. In press. link1

[ 7 ] Servick K. Here’s how scientists pulled off the first pig-to-human heart transplant [Internet]. Washington, DC: Science Insider; 2022 Jan 12 [cited 2022 Jun 10]. Available from: https://www.science.org/content/article/here-s-howscientists-pulled-first-pig-human-heart-transplant. link1

[ 8 ] Mohiuddin MM, Singh AK, Corcoran PC, Thomas III ML, Clark T, Lewis BG, et al. Chimeric 2C10R4 anti-CD40 antibody therapy is critical for long-term survival of GTKO.hCD46.hTBM pig-to-primate cardiac xenograft. Nat Commun 2016;7:11138. link1

[ 9 ] Greer T. UAB announces first clinical-grade transplant of gene-edited pig kidneys into brain-dead human [Internet]. Birmingham: University of Alabama; 2022 Jan 20 [cited 2022 Jun 10]. Available from: https://www.uab. edu/news/campus/item/12566-uab-announces-first-clinical-grade-transplantof-gene-edited-pig-kidneys-into-brain-dead-human. link1

[10] Montgomery RA, Stern JM, Lonze BE, Tatapudi VS, Mangiola M, Wu M, et al. Results of two cases of pig-to-human kidney xenotransplantation. N Engl J Med 2022;386:1889–98. link1

[11] Yue Y, Xu W, Kan Y, Zhao HY, Zhou Y, Song X, et al. Extensive germline genome engineering in pigs. Nat Biomed Eng 2021;5:134–43. link1

[12] First heart transplant performed 35 years ago [Internet]. Washington, DC: Organ Procurement and Transplantation Network; 2002 Dec 3 [cited 2022 Jun 10]. Available from: https://optn.transplant.hrsa.gov/news/first-hearttransplant-performed-35-years-ago/. link1

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