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Engineering doi: 10.1016/j.eng.2023.09.017
Artificial Bear Bile: A Novel Approach to Balancing Medical Requirements and Animal Welfare
a State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
b The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300250, China
c Zhongshan Belling Biotechnology Co., Ltd., Zhongshan 528437, China
d Zhongshan Anshi Biopharmaceutical Co., Ltd., Zhongshan 528437, China
e WestChina-Frontier Pharma Tech Co., Ltd., Chengdu 610041, China
f Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Abstract
Keywords
Artificial bear bile ; Chemical profile ; Formula optimization ; Pharmacodynamic consistency ; Preclinical toxicological assessment
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