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New definition of metabolic dysfunction-associated fatty liver disease with elevated brachial-ankle pulse wave velocity and albuminuria: a prospective cohort study

Frontiers of Medicine 2022, Volume 16, Issue 5,   Pages 714-722 doi: 10.1007/s11684-021-0888-8

Abstract: Patients with MAFLD with high value of hepamet fibrosis score or poor-controlled diabetes had higher

Keywords： metabolic dysfunction-associated fatty liver disease     non-alcoholic fatty liver disease     fibrosis score    

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Autophagy in hepatic progenitor cells modulates exosomal miRNAs to inhibit liver fibrosis in schistosomiasis

Frontiers of Medicine 2024, Volume 18, Issue 3,   Pages 538-557 doi: 10.1007/s11684-024-1079-1

Abstract: Schistosoma infection is one of the major causes of liver fibrosis.Emerging roles of hepatic progenitor cells (HPCs) in the pathogenesis of liver fibrosis have been identifiedNevertheless, the precise mechanism underlying the role of HPCs in liver fibrosis in schistosomiasisThis study examined how autophagy in HPCs affects schistosomiasis-induced liver fibrosis by modulatingBlocking autophagy by the autophagy inhibitor chloroquine (CQ) significantly diminished liver fibrosis

Keywords： schistosomiasis     hepatic progenitor cell     autophagy     extracellular vesicle     fibrosis     miRNA    

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mA reader YTHDF1 promotes cardiac fibrosis by enhancing AXL translation

Frontiers of Medicine 2024, Volume 18, Issue 3,   Pages 499-515 doi: 10.1007/s11684-023-1052-4

Abstract: Cardiac fibrosis caused by ventricular remodeling and dysfunction such as post-myocardial infarctionIn investigating the biological function of the m6A reader YTHDF1 in cardiac fibrosis, adeno-associated(TGF-β)-activated cardiac fibroblasts in vitro were performed to establish fibrosisYTHDF1 in mouse hearts can significantly restore impaired cardiac function and attenuate myocardial fibrosisOur results revealed that YTHDF1 could serve as a potential therapeutic target for myocardial fibrosis

Keywords： cardiac fibrosis     YTHDF1     AXL     ZBED6     heart failure    

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Chronic inhibition of cyclic guanosine monophosphate-specific phosphodiesterase 5 prevented cardiac fibrosis

Wei Gong,Mengwen Yan,Junxiong Chen,Sandip Chaugai,Chen Chen,Daowen Wang

Frontiers of Medicine 2014, Volume 8, Issue 4,   Pages 445-455 doi: 10.1007/s11684-014-0378-3

Abstract: Whether and how it ameliorates cardiac fibrosis, a major cause of diastolic dysfunction and heart failureThe purpose of this study was to investigate the effects of PDE5 inhibitor on cardiac fibrosis.We assessed cardiac fibrosis and pathology in mice subjected to transverse aortic constriction (TAC).In control mice, 4 weeks of TAC induced significant cardiac dysfunction, cardiac fibrosis, and cardiacSildenafil treatment markedly prevented TAC-induced cardiac dysfunction, cardiac fibrosis and cardiac

Keywords： PDE5     cardiac fibrosis     TGF-β     CREB    

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Strategies for preventing peritoneal fibrosis in peritoneal dialysis patients: new insights based on

Zhen Zhang, Na Jiang, Zhaohui Ni

Frontiers of Medicine 2017, Volume 11, Issue 3,   Pages 349-358 doi: 10.1007/s11684-017-0571-2

Abstract: morphologic and functional changes to the peritoneal membrane (PM), which is defined as peritoneal fibrosisInflammation and angiogenesis are key events during the pathogenesis of peritoneal fibrosis.This review discusses the pathophysiology of peritoneal fibrosis and recent research progress on key

Keywords： peritoneal dialysis     peritoneal fibrosis     inflammation     angiogenesis    

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Expression of integrin in hepatic fibrosis and intervention of resveratrol

Jianye WU, Chuanyong GUO, Jun LIU, Xuanfu XUAN

Frontiers of Medicine 2009, Volume 3, Issue 1,   Pages 100-107 doi: 10.1007/s11684-009-0013-x

Abstract: The aim of this study was to explore the expression of integrin-β1 in different stages of hepatic fibrosisand intervention of resveratrol as well as the way by which integrin-β1 promoted hepatic fibrosis.Hepatic fibrosis models of male Sprague Dawley (SD) rats were created and intragastric administrationLiver function and pathological sections of each group in different stages of hepatic fibrosis was testedas the development of hepatic fibrosis.

Keywords： liver fibrosis     integrin-β1     resveratrol     tumor growth factor-β     tissue inhibitor of metalloproteinase-1    

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rice genotypes in stress environments: fine-tuning a selection method using production and resilience score RESEARCH ARTICLE

Frontiers of Agricultural Science and Engineering 2024, Volume 11, Issue 1,   Pages 169-185 doi: 10.15302/J-FASE-2023521

Abstract: It is hypothesized that applying a new quantitative selection method (the score index selection methodApplying the score index to previously published rice yield data for 39 genotypes grown in no-stressImportantly, the score index selection method offers improved precision than the conventional breeding

Keywords： breeding selection     drought resilience     production capacity index     resilience capacity index     stress score    

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Clinical characterization and diagnosis of cystic fibrosis through exome sequencing in Chinese infants

Liru Qiu, Fengjie Yang, Yonghua He, Huiqing Yuan, Jianhua Zhou

Frontiers of Medicine 2018, Volume 12, Issue 5,   Pages 550-558 doi: 10.1007/s11684-017-0567-y

Abstract:

Cystic fibrosis (CF) is a fatal autosomal-recessive disease caused by mutations in the CF transmembrane

Keywords： cystic fibrosis     pseudo-Bartter syndrome     hypokalemic alkalosis     CFTR gene     mutations     infants     diagnosis    

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Paeoniflorin prevents hepatic fibrosis of by inhibiting TGF-β1 production from macrophages in mice

CHU Deyong, LI Conglei, SHEN Jilong, WU Qiang

Frontiers of Medicine 2008, Volume 2, Issue 2,   Pages 154-165 doi: 10.1007/s11684-008-0029-7

Abstract: In order to investigate the effect of paeoniflorin (PAE) on hepatic fibrosis of mice with and , a modelof hepatic fibrosis caused by schistosomiasis was established in mice infected with cercariae of .Hepatic granuloma and fibrosis were evaluated via HE and Masson staining. The expression of ?significantly reduce the concentration of serum HA, the size of egg granuloma, the severity of hepatic fibrosisIn a word, PAE can prevent hepatic granuloma and fibrosis caused by schistosomiasis japonica through

Keywords： cercariae     collagen     hyaluronic     OPMCM     soluble    

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mutation c.1210-3C>G in with a poly-T tract of 5T affects mRNA splicing in a Chinese patient with cystic fibrosis

Frontiers of Medicine 2022, Volume 16, Issue 1,   Pages 150-155 doi: 10.1007/s11684-021-0846-5

Abstract: Cystic fibrosis (CF) is a rare autosomal recessive disease with only one pathogenic gene cystic fibrosis

Keywords： cystic fibrosis     CFTR     splicing mutation     minigene    

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Activation of the Macrophage-Associated Inflammasome Exacerbates Myocardial Fibrosis Through the 15-HETE-Mediated

Xu Chen,Zhiyong Du,Dongqing Guo,Jincheng Guo,Qianbin Sun,Tiantian Liu,Kun Hua,Chun Li,Yong Wang,Wei Wang,

Engineering doi: 10.1016/j.eng.2024.05.015

Abstract: To elucidate the nexus between macrophage-associated NLRP3 inflammasome activation and myocardial fibrosissignificant advancement toward precise MI prevention and treatment strategies, particularly early myocardial fibrosis

Keywords： Myocardial infarction     Macrophage inflammasome     NOD-like receptor family pyrin domain containing 3     Myocardial fibrosis    

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Fuzzy Comprehensive Performance Evaluation Method for Chained Operation Based on Balanced Score Card

Cao Jie,Cao Guo,He Jianmin

Strategic Study of CAE 2008, Volume 10, Issue 4,   Pages 90-96

Abstract:

From the views of balanced score card,a series of indexes and a fuzzy

Keywords： chained operation     balanced score card     performance evaluation     fuzzy comprehensive evaluation    

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Effect of Feixian Recipe on laminin, collagen I and III in rats with pulmonary fibrosis induced by bleomycin

ZHANG Xiaomei, JIANG Liangduo, ZHANG Wei, WU Jianjun, LU Xiangfeng

Frontiers of Medicine 2008, Volume 2, Issue 3,   Pages 314-316 doi: 10.1007/s11684-008-0060-8

Abstract: The aim of this paper is to observe the effect of the Feixian Recipe on pulmonary fibrosis in rats.A rat model with pulmonary fibrosis was established by intratracheal injection of bleomycin.Feixian Recipe has a significant therapeutic effect on bleomycin-induced pulmonary fibrosis in rats.

Keywords： bleomycin     intratracheal injection     prednisone     collagen     bleomycin-induced pulmonary    

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Therapeutic Targeting of PKM2 Ameliorates NASH Fibrosis Progression in A Macrophage-Specific and Liver-Specific

Hengdong Qu,Di Zhang,Junli Liu,Jieping Deng,Ruoyan Xie,Keke Zhang,Hongmei Li,Ping Tao,Genshu Wang,Jian Sun,Oscar Junhong Luo,Chen Qu,Wencai Ye,Jian Hong,

Engineering doi: 10.1016/j.eng.2024.05.005

Abstract: Liver fibrosis, which is driven by chronic inflammation and hepatic stellate cell (HSC) activation, criticallyactivation and inflammatory liver diseases; however, its role and therapeutic potential in NASH-related fibrosisMacrophage-specific PKM2 knockout (PKM2FL/FLLysM-Cre) significantly ameliorated hepatic inflammation and fibrosisoligonucleotide drug that preferentially accumulates in the liver, dose-dependently reversed NASH-related fibrosisa macrophage-specific or liver-specific manner may serve as a novel strategy to combat NASH-related fibrosis

Keywords： M2     Macrophages     nonparenchymal cells     heteroduplex oligonucleotide     Nonalcoholic steatohepatitis     Liver fibrosis    

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Clinical risk score for invasive fungal diseases in patients with hematological malignancies undergoing

Ling Wang, Ying Wang, Jiong Hu, Yuqian Sun, He Huang, Jing Chen, Jianyong Li, Jun Ma, Juan Li, Yingmin Liang, Jianmin Wang, Yan Li, Kang Yu, Jianda Hu, Jie Jin, Chun Wang, Depei Wu, Yang Xiao, Xiaojun Huang

Frontiers of Medicine 2019, Volume 13, Issue 3,   Pages 365-377 doi: 10.1007/s11684-018-0641-0

Abstract: diseases to establish a training dataset ( =3500) by simple random sampling to develop a weighted risk scoreTo make the risk score applicable for clinical settings, a pre-chemo risk score that deleted all unpredictableIn conclusion, an objective, weighted risk score for IFD was developed, and it may be useful in guiding

Keywords： invasive fungal diseases     hematological malignancies     chemotherapy     risk score     prophylaxis    

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Title Author Date Type Operation

New definition of metabolic dysfunction-associated fatty liver disease with elevated brachial-ankle pulse wave velocity and albuminuria: a prospective cohort study

Journal Article

Autophagy in hepatic progenitor cells modulates exosomal miRNAs to inhibit liver fibrosis in schistosomiasis

Journal Article

mA reader YTHDF1 promotes cardiac fibrosis by enhancing AXL translation

Journal Article

Chronic inhibition of cyclic guanosine monophosphate-specific phosphodiesterase 5 prevented cardiac fibrosis

Wei Gong,Mengwen Yan,Junxiong Chen,Sandip Chaugai,Chen Chen,Daowen Wang

Journal Article

Strategies for preventing peritoneal fibrosis in peritoneal dialysis patients: new insights based on

Zhen Zhang, Na Jiang, Zhaohui Ni

Journal Article

Expression of integrin in hepatic fibrosis and intervention of resveratrol

Jianye WU, Chuanyong GUO, Jun LIU, Xuanfu XUAN

Journal Article

rice genotypes in stress environments: fine-tuning a selection method using production and resilience score

Journal Article

Clinical characterization and diagnosis of cystic fibrosis through exome sequencing in Chinese infants

Liru Qiu, Fengjie Yang, Yonghua He, Huiqing Yuan, Jianhua Zhou

Journal Article

Paeoniflorin prevents hepatic fibrosis of by inhibiting TGF-β1 production from macrophages in mice

CHU Deyong, LI Conglei, SHEN Jilong, WU Qiang

Journal Article

mutation c.1210-3C>G in with a poly-T tract of 5T affects mRNA splicing in a Chinese patient with cystic fibrosis

Journal Article

Activation of the Macrophage-Associated Inflammasome Exacerbates Myocardial Fibrosis Through the 15-HETE-Mediated

Xu Chen,Zhiyong Du,Dongqing Guo,Jincheng Guo,Qianbin Sun,Tiantian Liu,Kun Hua,Chun Li,Yong Wang,Wei Wang,

Journal Article

Fuzzy Comprehensive Performance Evaluation Method for Chained Operation Based on Balanced Score Card

Cao Jie,Cao Guo,He Jianmin

Journal Article

Effect of Feixian Recipe on laminin, collagen I and III in rats with pulmonary fibrosis induced by bleomycin

ZHANG Xiaomei, JIANG Liangduo, ZHANG Wei, WU Jianjun, LU Xiangfeng

Journal Article

Therapeutic Targeting of PKM2 Ameliorates NASH Fibrosis Progression in A Macrophage-Specific and Liver-Specific

Hengdong Qu,Di Zhang,Junli Liu,Jieping Deng,Ruoyan Xie,Keke Zhang,Hongmei Li,Ping Tao,Genshu Wang,Jian Sun,Oscar Junhong Luo,Chen Qu,Wencai Ye,Jian Hong,

Journal Article

Clinical risk score for invasive fungal diseases in patients with hematological malignancies undergoing

Ling Wang, Ying Wang, Jiong Hu, Yuqian Sun, He Huang, Jing Chen, Jianyong Li, Jun Ma, Juan Li, Yingmin Liang, Jianmin Wang, Yan Li, Kang Yu, Jianda Hu, Jie Jin, Chun Wang, Depei Wu, Yang Xiao, Xiaojun Huang

Journal Article