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Expression of integrin in hepatic fibrosis and intervention of resveratrol
Jianye WU, Chuanyong GUO, Jun LIU, Xuanfu XUAN
Frontiers of Medicine 2009, Volume 3, Issue 1, Pages 100-107 doi: 10.1007/s11684-009-0013-x
Keywords: liver fibrosis integrin-β1 resveratrol tumor growth factor-β tissue inhibitor of metalloproteinase-1
Jiansong Huang,Yulan Zhou,Xiaoyu Su,Yuanjing Lyu,Lanlan Tao,Xiaofeng Shi,Ping Liu,Zhangbiao Long,Zheng Ruan,Bing Xiao,Wenda Xi,Quansheng Zhou,Jianhua Mao,Xiaodong Xi
Frontiers of Medicine 2016, Volume 10, Issue 3, Pages 311-319 doi: 10.1007/s11684-016-0460-0
We evaluated the roles of calpain cleavage-related mutations of the integrin β3 cytoplasmic tailin integrin αIIbβ3 bidirectional signaling using a trans-dominant inhibition model.consisting of the extracellular and transmembrane domains of human IL-2 receptor (Tac) and the human integrindomain were stably expressed in the 123 CHO cells harboring human glycoprotein Ib-IX and wild-type integrinIn conclusion, the calpain cleavage of integrin β3 resulted in the regulatory effects on signaling
Keywords: integrin β3 signal transduction trans-dominant inhibition model
Talin and kindlin: the one-two punch in integrin activation
Feng Ye, Adam K. Snider, Mark H. Ginsberg
Frontiers of Medicine 2014, Volume 8, Issue 1, Pages 6-16 doi: 10.1007/s11684-014-0317-3
Proper cell-cell and cell-matrix contacts mediated by integrin adhesion receptors are important forHere, we review how talin-integrin and kindlin-integrin interactions, in cooperation with talin-lipidand kindlin-lipid interactions, regulate integrin affinities and how the progress in these areas helpsus understand integrin-related diseases.
Keywords: signal transduction transmembrane domain nanodisc integrin talin kindling cell adhesion
Coronary leukocyte activation in relation to progression of coronary artery disease
Marijke A. de Vries,Arash Alipour,Erwin Birnie,Andrew Westzaan,Selvetta van Santen,Ellen van der Zwan,Anho H. Liem,Noëlle van der Meulen,Manuel Castro Cabezas
Frontiers of Medicine 2016, Volume 10, Issue 1, Pages 85-90 doi: 10.1007/s11684-016-0435-1
Leukocyte activation has been linked to atherogenesis, but there is little in vivo evidence for its role in the progression of atherosclerosis. We evaluated the predictive value for progression of coronary artery disease (CAD) of leukocyte activation markers in the coronary circulation. Monocyte and neutrophil CD11b, neutrophil CD66b expression and intracellular neutrophil myeloperoxidase (MPO) in the coronary arteries were determined by flow cytometry in patients undergoing coronary angiography. The primary outcome included fatal and nonfatal myocardial infarction or arterial vascular intervention due to unstable angina pectoris. In total 99 subjects who were included, 70 had CAD at inclusion (26 patients had single-vessel disease, 18 patients had two-vessel disease and 26 patients had three-vessel disease). The median follow-up duration was 2242 days (interquartile range: 2142–2358). During follow-up, 13 patients (13%) developed progression of CAD. Monocyte CD11b, neutrophil CD11b and CD66b expression and intracellular MPO measured in blood obtained from the coronary arteries were not associated with the progression of CAD. These data indicate that coronary monocyte CD11b, neutrophil CD11b and CD66b expression and intracellular MPO do not predict the risk of progression of CAD.
Keywords: coronary artery disease inflammation integrin myeloperoxidase leukocyte activation
Analysis of GM(1,1)Model and Its Application in Fire Risk Prediction
Chen Zijin,Wang Fuliang,Lu Shouxiang
Strategic Study of CAE 2007, Volume 9, Issue 5, Pages 91-94
Theoretical analysis of grey prediction model GM(1, 1) is present inMonotonicity of predicted value and its variation tendency predicted by GM(1, 1)model is proved.the monotonicity of predicted value and its variation tendency, applicability criterion of GM(1,1) is brought forward.
Keywords: fire forecast GM(1 1) rate of the fire injured
Frontiers of Medicine Pages 805-822 doi: 10.1007/s11684-023-1025-7
Keywords: CTLA-4 PD-1 PD-L1 immune checkpoint blockade (ICB) metabolic reprogramming combined tumor therapeutic
Deng Yunhua
Strategic Study of CAE 2011, Volume 13, Issue 10, Pages 13-18
Keywords: Bohai Liaodong zone JX1-1 geological recognition large oilfield
Federated unsupervised representation learning Research Article
Fengda ZHANG, Kun KUANG, Long CHEN, Zhaoyang YOU, Tao SHEN, Jun XIAO, Yin ZHANG, Chao WU, Fei WU, Yueting ZHUANG, Xiaolin LI,fdzhang@zju.edu.cn,kunkuang@zju.edu.cn
Frontiers of Information Technology & Electronic Engineering 2023, Volume 24, Issue 8, Pages 1181-1193 doi: 10.1631/FITEE.2200268
Keywords: Federated learning Unsupervised learning Representation learning Contrastive learning
Non-equidistant GM(1,1) power model and its application in engineering
Wang Zhengxin,Dang Yaoguo,Liu Sifeng
Strategic Study of CAE 2012, Volume 14, Issue 7, Pages 98-102
Keywords: grey system non-equidistant sequence GM(1 1) power model parameter optimization
Band-gap tunable (GaxIn1−x)2O3 layer Research Articles
Fabi Zhang, Jinyu Sun, Haiou Li, Juan Zhou, Rong Wang, Tangyou Sun, Tao Fu, Gongli Xiao, Qi Li, Xingpeng Liu, Xiuyun Zhang, Daoyou Guo, Xianghu Wang, Zujun Qin,zhangfabi@outlook.com,qinzj@guet.edu.cn
Frontiers of Information Technology & Electronic Engineering 2021, Volume 22, Issue 10, Pages 1370-1378 doi: 10.1631/FITEE.2000330
Keywords: (GaxIn1−x)2O3薄膜;带隙可调谐;磁控溅射
Changlin Cao, Jingxian Gu, Jingyao Zhang
Frontiers of Medicine 2017, Volume 11, Issue 2, Pages 169-177 doi: 10.1007/s11684-017-0505-z
Keywords: soluble triggering receptor expressed on myeloid cells-1 infectious diseases diagnosis and prognosis
Molecular characterization of two suppressor of cytokine signaling 1 genes (
Xue XU,Jiannan ZHANG,Juan LI,Yajun WANG
Frontiers of Agricultural Science and Engineering 2015, Volume 2, Issue 1, Pages 73-83 doi: 10.15302/J-FASE-2015044
Keywords: chicken SOCS1a SOCS1b growth hormone prolactin
Visual knowledge guided intelligent generation of Chinese seal carving Research Article
Kejun ZHANG, Rui ZHANG, Yehang YIN, Yifei LI, Wenqi WU, Lingyun SUN, Fei WU, Huanghuang DENG, Yunhe PAN
Frontiers of Information Technology & Electronic Engineering 2022, Volume 23, Issue 10, Pages 1479-1493 doi: 10.1631/FITEE.2100094
We digitally reproduce the process of resource collaboration, design creation, and visual presentation of Chinese art. We develop an intelligent art-generation system (Zhejiang University Intelligent System, http://www.next.zju.edu.cn/seal/; the website of the search and layout system is http://www.next.zju.edu.cn/seal/search_app/) to deal with the difficulty in using a visual knowledge guided approach. The knowledge base in this study is the Qiushi Database, which consists of open datasets of images of seal characters and seal stamps. We propose a seal character generation method based on visual knowledge, guided by the database and expertise. Furthermore, to create the layout of the seal, we propose a deformation algorithm to adjust the seal characters and calculate layout parameters from the database and knowledge to achieve an intelligent structure. Experimental results show that this method and system can effectively deal with the difficulties in the generation of seal carving. Our work provides theoretical and applied references for the rebirth and innovation of art.
Keywords: Seal-carving Intelligent generation Deep learning Parametric modeling Computational art
A review of optically induced rotation Review Article
Qi ZHU, Nan LI, Heming SU, Wenqiang LI, Huizhu HU,huhuizhu2000@zju.edu.cn
Frontiers of Information Technology & Electronic Engineering 2022, Volume 23, Issue 2, Pages 171-185 doi: 10.1631/FITEE.2000338
Keywords: Optical tweezer Optically induced rotation Angular momentum Micro-rotor
PD-1/PD-L1 blockade in cervical cancer: current studies and perspectives
Yumeng Wang, Guiling Li
Frontiers of Medicine 2019, Volume 13, Issue 4, Pages 438-450 doi: 10.1007/s11684-018-0674-4
Keywords: PD-1 PD-L1 immune checkpoint blockade antibody immunotherapy cervical cancer
Title Author Date Type Operation
Expression of integrin in hepatic fibrosis and intervention of resveratrol
Jianye WU, Chuanyong GUO, Jun LIU, Xuanfu XUAN
Journal Article
Roles of integrin β3 cytoplasmic tail in bidirectional signal transduction in a trans-dominant inhibition
Jiansong Huang,Yulan Zhou,Xiaoyu Su,Yuanjing Lyu,Lanlan Tao,Xiaofeng Shi,Ping Liu,Zhangbiao Long,Zheng Ruan,Bing Xiao,Wenda Xi,Quansheng Zhou,Jianhua Mao,Xiaodong Xi
Journal Article
Talin and kindlin: the one-two punch in integrin activation
Feng Ye, Adam K. Snider, Mark H. Ginsberg
Journal Article
Coronary leukocyte activation in relation to progression of coronary artery disease
Marijke A. de Vries,Arash Alipour,Erwin Birnie,Andrew Westzaan,Selvetta van Santen,Ellen van der Zwan,Anho H. Liem,Noëlle van der Meulen,Manuel Castro Cabezas
Journal Article
Analysis of GM(1,1)Model and Its Application in Fire Risk Prediction
Chen Zijin,Wang Fuliang,Lu Shouxiang
Journal Article
Metabolic interventions combined with CTLA-4 and PD-1/PD-L1 blockade for the treatment of tumors: mechanisms
Journal Article
geological recognition breakthrough in Liaodong zone, which leading to the discovery of the large oilfield JX1-recognition breakthrough in Liaodong zone, which leading to the discovery of the large oilfield JX1-1
Deng Yunhua
Journal Article
Federated unsupervised representation learning
Fengda ZHANG, Kun KUANG, Long CHEN, Zhaoyang YOU, Tao SHEN, Jun XIAO, Yin ZHANG, Chao WU, Fei WU, Yueting ZHUANG, Xiaolin LI,fdzhang@zju.edu.cn,kunkuang@zju.edu.cn
Journal Article
Non-equidistant GM(1,1) power model and its application in engineering
Wang Zhengxin,Dang Yaoguo,Liu Sifeng
Journal Article
Band-gap tunable (GaxIn1−x)2O3 layer
Fabi Zhang, Jinyu Sun, Haiou Li, Juan Zhou, Rong Wang, Tangyou Sun, Tao Fu, Gongli Xiao, Qi Li, Xingpeng Liu, Xiuyun Zhang, Daoyou Guo, Xianghu Wang, Zujun Qin,zhangfabi@outlook.com,qinzj@guet.edu.cn
Journal Article
Soluble triggering receptor expressed on myeloid cell-1 (sTREM-1): a potential biomarker for the diagnosis
Changlin Cao, Jingxian Gu, Jingyao Zhang
Journal Article
Molecular characterization of two suppressor of cytokine signaling 1 genes (
Xue XU,Jiannan ZHANG,Juan LI,Yajun WANG
Journal Article
Visual knowledge guided intelligent generation of Chinese seal carving
Kejun ZHANG, Rui ZHANG, Yehang YIN, Yifei LI, Wenqi WU, Lingyun SUN, Fei WU, Huanghuang DENG, Yunhe PAN
Journal Article
A review of optically induced rotation
Qi ZHU, Nan LI, Heming SU, Wenqiang LI, Huizhu HU,huhuizhu2000@zju.edu.cn
Journal Article