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immune mapped protein 1 (NcIMP1) is a novel vaccine candidate against neosporosis

Xia CUI,Daoyu YANG,Tao LEI,Hui WANG,Pan HAO,Qun LIU

Frontiers of Agricultural Science and Engineering 2015, Volume 2, Issue 1,   Pages 66-72 doi: 10.15302/J-FASE-2015047

Abstract: The immune mapped protein 1 (NcIMP1) was identified as a membrane protein, and a previous study indicatedIn this study, the immune response and protection efficacy of NcIMP1 were evaluated.in the recombination plasmid pcDNA-IMP1, which was used for the intramuscular immunization of BALB/cThe parasite burden was significantly reduced in the pcDNA-IMP1-vaccinated mice.These data suggest that IMP1 is a promising vaccine candidate against neosporosis.

Keywords： Neospora caninum     immune mapped protein 1 (IMP1)     vaccine candidate     BALB/c mice    

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Molecular classification and precision therapy of cancer: immune checkpoint inhibitors

Yingyan Yu

Frontiers of Medicine 2018, Volume 12, Issue 2,   Pages 229-235 doi: 10.1007/s11684-017-0581-0

Abstract: refractory Hodgkin lymphoma, and urothelial carcinoma, all of which carry positive programmed death-1/programmed death-ligand 1 biomarkers.MSI-H status due to dMMR and characterized by increased neoantigen load, which elicits intense host immune

Keywords： molecular classification     precision medicine     pembrolizumab     PD-1/PD-L1     MSI-H    

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Influence of retinoic acid on TBX1 expression in myocardial cells induced by Shh and Fgf8

Miao LIU, Xiaoyan WU, Jiawei XU, Runming JIN

Frontiers of Medicine 2009, Volume 3, Issue 1,   Pages 61-66 doi: 10.1007/s11684-009-0007-8

Abstract: The aim of this study was to explore the regulatory mechanism of retinoic acid (RA) on the TBX1 geneThe expression of Shh and Fgf8 at mRNA and protein levels in neonatal rat myocardial cells were measuredWhen treated with 3×10 mol/L RA, we observed that the expression of Shh mRNA and protein in neonatalMeanwhile, we could detect that the expression of Fgf8 mRNA and protein were up-regulated by 2.50 timesAt the same time, it has shown that Shh and Fgf8 were involved in the regulation process of RA on TBX1

Keywords： retinoic acid     Tbx1 protein     Shh protein     Fgf8 protein    

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Activation of phagocytosis by immune checkpoint blockade

Chia-Wei Li, Yun-Ju Lai, Jennifer L. Hsu, Mien-Chie Hung

Frontiers of Medicine 2018, Volume 12, Issue 4,   Pages 473-480 doi: 10.1007/s11684-018-0657-5

Abstract:

Inhibition of macrophage-mediated phagocytosis has emerged as an essential mechanism for tumor immuneinhibiting the innate response is the presence of the macrophage inhibitory molecule, signal regulatory proteinOn the basis of a recently discovered programmed death protein 1 (PD-1) in TAMs, we discuss the potentialAs more and more immune receptors are found to be expressed on TAMs, the corresponding therapies may

Keywords： CD47     PD-1     PD-L1     immunotherapy     TAM     phagocytosis     macrophage    

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Metabolic interventions combined with CTLA-4 and PD-1/PD-L1 blockade for the treatment of tumors: mechanisms

Frontiers of Medicine 2023, Volume 17, Issue 5,   Pages 805-822 doi: 10.1007/s11684-023-1025-7

Abstract: Immunotherapies based on immune checkpoint blockade (ICB) have significantly improved patient outcomesTo date, immune checkpoint inhibitors (ICIs) of CTLA-4 and PD-1/PD-L1 represent the main class of immunotherapyBlockade of CTLA-4 and PD-1/PD-L1 has shown remarkable efficacy in several specific types of cancers,checkpoints (CTLA-4, PD-1, and PD-L1) to influence ICB therapy and propose potential combined immunotherapeuticstrategies co-targeting tumor metabolic pathways and immune checkpoints.

Keywords： CTLA-4     PD-1     PD-L1     immune checkpoint blockade (ICB)     metabolic reprogramming     combined tumor therapeutic    

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4-1BBL expressed by eukaryotic cells activates immune cells and suppresses the progression of murine

Hui QIU, Hui ZHANG, Zuohua FENG

Frontiers of Medicine 2009, Volume 3, Issue 1,   Pages 20-25 doi: 10.1007/s11684-009-0006-9

Abstract: The interaction by co-stimulatory molecules 4-1BB and 4-1BB ligand (4-1BBL) plays an important role inThe function of 4-1BB/4-1BBL expressed by the immune cells has been the focus for many tumor immunotherapyIn this study, 4-1BBL was expressed in non-immune cells and non-tumor cells, and the role of 4-1BBL inThe plasmid p4-1BBL containing the full length of mouse 4-1BBL cDNA sequence was constructed, and theThe study demonstrated that the molecule 4-1BBL expressed by BHK cells could enhance the proliferation

Keywords： 4-1BB ligand     tumor immunotherapy     tumor microenvironment    

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PROTECTIVE ROLES OF D1 PROTEIN TURNOVER AND THE XANTHOPHYLL CYCLE IN TOMATO (

Tao LU, Jiazhi LU, Mingfang QI, Zhouping SUN, Yufeng LIU, Tianlai LI

Frontiers of Agricultural Science and Engineering   Pages 262-279 doi: 10.15302/J-FASE-2021383

Abstract: D1 protein turnover and the xanthophyll cycle (XC) are important photoprotective mechanisms in plantsHere, streptomycin sulfate (SM) and dithiothreitol (DTT) were used in tomato plants as inhibitors of D1protein turnover and XC to elucidate their photoprotective impacts under sub-high temperature and highprotein production at both transcriptional and translational levels.Overall, inhibition of D1 turnover caused greater photoinhibition than XC inhibition.

Keywords： D1 turnover     photoinhibition     photoprotection     photosynthesis     tomato     xanthophyll cycle    

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PD-1/PD-L1 blockade in cervical cancer: current studies and perspectives

Yumeng Wang, Guiling Li

Frontiers of Medicine 2019, Volume 13, Issue 4,   Pages 438-450 doi: 10.1007/s11684-018-0674-4

Abstract: recent years, exciting progress has been made in immunotherapies, including the rapid development of immuneCheckpoint blockades targeting the PD-1/PD-L1 axis have achieved effective clinical responses with acceptableIn this review, we summarize recent advances in our understanding of the PD-1/PD-L1 signaling pathway, including the expression patterns of PD-1/PD-L1 and potential PD-1/PD-L1-related therapeutic strategies

Keywords： PD-1     PD-L1     immune checkpoint blockade antibody     immunotherapy     cervical cancer    

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PROTECTIVE ROLES OF D1 PROTEIN TURNOVER AND THE XANTHOPHYLL CYCLE IN TOMATO (SOLANUM LYCOPERSICUM) UNDER

Frontiers of Agricultural Science and Engineering 2021, Volume 8, Issue 2,

Abstract:

D1 protein turnover and the xanthophyll cycle (XC) are important photoprotective mechanisms in plantsHere, streptomycin sulfate (SM) and dithiothreitol (DTT) were used in tomato plants as inhibitors of D1protein turnover and XC to elucidate their photoprotective impacts under sub-high temperature and highprotein production at both transcriptional and translational levels.Overall, inhibition of D1 turnover caused greater photoinhibition than XC inhibition.

Keywords： D1 turnover / photoinhibition / photoprotection / photosynthesis / tomato / xanthophyll cycle    

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Glycosylation of dentin matrix protein 1 is critical for fracture healing via promoting chondrogenesis

Hui Xue, Dike Tao, Yuteng Weng, Qiqi Fan, Shuang Zhou, Ruilin Zhang, Han Zhang, Rui Yue, Xiaogang Wang, Zuolin Wang, Yao Sun

Frontiers of Medicine 2019, Volume 13, Issue 5,   Pages 575-589 doi: 10.1007/s11684-019-0693-9

Abstract: The PG form of dentin matrix protein 1 (DMP1-PG) is involved in maintaining the health of articular cartilageOur previous data have shown that DMP1-PG is richly expressed in the cartilaginous calluses of fractureHowever, the possible significant role of DMP1-PG in chondrogenesis and fracture healing is unknown.by using a glycosylation site mutant DMP1 mouse (S89G-DMP1 mouse).Given the deficiency of DMP1-PG, the impaired IL-6/JAK/STAT signaling pathway was observed to affect

Keywords： fracture     extracellular matrix     dentin matrix protein 1     proteoglycan     cartilage    

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Immunological and virological characteristics of human immunodeficiency virus type 1 superinfection:

Yang Gao, Wen Tian, Xiaoxu Han, Feng Gao

Frontiers of Medicine 2017, Volume 11, Issue 4,   Pages 480-489 doi: 10.1007/s11684-017-0594-8

Abstract: Superinfection is frequently detected among individuals infected by human immunodeficiency virus type I (HIV-1)This observation indicates that the immune responses elicited by natural HIV-1 infection may play a roleThus, a successful HIV-1 vaccine likely needs to induce more potent and broader immune responses thanimmunity induced by primary infection is insufficient and if superinfection can lead to cross-reactive immuneresponses will be highly informative for HIV-1 vaccine design.

Keywords： human immunodeficiency virus type I     superinfection     incidence     immune response    

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Gene and protein expression of proteinase-activated receptor-1, 2 in a murine model of acute graft host

Quan LI MD , Weiming LI MD , Ping ZOU MD , Jian ZHANG BM ,

Frontiers of Medicine 2009, Volume 3, Issue 3,   Pages 309-315 doi: 10.1007/s11684-009-0043-4

Abstract: Proteinase-activated receptors (PARs) are a novel subclass of seven transmembrane-spanning, G protein-coupledand pathological processes including inflammation and immune response.In the present study, we first detected the expression of PAR-1, 2 protein and mRNA in a murine modelPAR-1, 2 protein expression was in accordance with the mRNA expression, as shown by Western blot.PAR-1 and PAR-2 may play an important role in the pathogenesis of acute GVHD.

Keywords： graft vs host disease     proteinase-activated receptor     murine model     hematopoietic stem cell transplantation    

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Monitoring checkpoint inhibitors: predictive biomarkers in immunotherapy

Min Zhang, Jingwen Yang, Wenjing Hua, Zhong Li, Zenghui Xu, Qijun Qian

Frontiers of Medicine 2019, Volume 13, Issue 1,   Pages 32-44 doi: 10.1007/s11684-018-0678-0

Abstract: In particular, immune checkpoint inhibitors are proved to be unprecedentedly in increasing the overallHere, we review the biomarkers that can serve as potential predictors of the outcomes of immune checkpoint

Keywords： immune checkpoint     companion diagnosis     PD-L1     tumor mutation burden     immune score    

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Construction and humoral immune response of Epstein-Barr virus latent membrane protein 2 DNA vaccine

Jianqing PAN PhD, Qin ZHANG MD, Daowen WANG MD, PhD,

Frontiers of Medicine 2009, Volume 3, Issue 4,   Pages 390-395 doi: 10.1007/s11684-009-0087-5

Abstract: We constructed a eukaryotic expression plasmid encoding Epstein-Barr virus latent membrane protein 2It was employed to evaluate immune response of the mice inoculated doubly with the DNA vaccine.IgG antibody against LMP2 epitope in the mice immunized with the DNA vaccine encoding LMP2 was up to 1&In conclusion, the EBV DNA vaccine can induce a strong humoral immune response in mice.

Keywords： Epstein-Barr virus     latent membrane protein 2     nasopharyngeal carcinoma     humoral immunity    

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Dysregulated N-methyladenosine modification in peripheral immune cells contributes to the pathogenesis

Frontiers of Medicine 2024, Volume 18, Issue 2,   Pages 285-302 doi: 10.1007/s11684-023-1035-5

Abstract: and liquid chromatography–mass spectrometry were utilized for m6A profiling in peripheral immunedifferential m6A modification and expression, including C-X3-C motif chemokine receptor 1(CX3CR1).In RAW264.7 macrophages, disrupted CX3CR1 signaling affected chemotaxis, potentially influencing immuneSerum proteome analysis demonstrated the role of dysregulated immune cell migration in ALS.

Keywords： sup>6-methyladenosine     epi-transcriptome     proteome     single cell RNA sequencing analysis     CX3CR1    

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Title Author Date Type Operation

immune mapped protein 1 (NcIMP1) is a novel vaccine candidate against neosporosis

Xia CUI,Daoyu YANG,Tao LEI,Hui WANG,Pan HAO,Qun LIU

Journal Article

Molecular classification and precision therapy of cancer: immune checkpoint inhibitors

Yingyan Yu

Journal Article

Influence of retinoic acid on TBX1 expression in myocardial cells induced by Shh and Fgf8

Miao LIU, Xiaoyan WU, Jiawei XU, Runming JIN

Journal Article

Activation of phagocytosis by immune checkpoint blockade

Chia-Wei Li, Yun-Ju Lai, Jennifer L. Hsu, Mien-Chie Hung

Journal Article

Metabolic interventions combined with CTLA-4 and PD-1/PD-L1 blockade for the treatment of tumors: mechanisms

Journal Article

4-1BBL expressed by eukaryotic cells activates immune cells and suppresses the progression of murine

Hui QIU, Hui ZHANG, Zuohua FENG

Journal Article

PROTECTIVE ROLES OF D1 PROTEIN TURNOVER AND THE XANTHOPHYLL CYCLE IN TOMATO (

Tao LU, Jiazhi LU, Mingfang QI, Zhouping SUN, Yufeng LIU, Tianlai LI

Journal Article

PD-1/PD-L1 blockade in cervical cancer: current studies and perspectives

Yumeng Wang, Guiling Li

Journal Article

PROTECTIVE ROLES OF D1 PROTEIN TURNOVER AND THE XANTHOPHYLL CYCLE IN TOMATO (SOLANUM LYCOPERSICUM) UNDER

Journal Article

Glycosylation of dentin matrix protein 1 is critical for fracture healing via promoting chondrogenesis

Hui Xue, Dike Tao, Yuteng Weng, Qiqi Fan, Shuang Zhou, Ruilin Zhang, Han Zhang, Rui Yue, Xiaogang Wang, Zuolin Wang, Yao Sun

Journal Article

Immunological and virological characteristics of human immunodeficiency virus type 1 superinfection:

Yang Gao, Wen Tian, Xiaoxu Han, Feng Gao

Journal Article

Gene and protein expression of proteinase-activated receptor-1, 2 in a murine model of acute graft host

Quan LI MD , Weiming LI MD , Ping ZOU MD , Jian ZHANG BM ,

Journal Article

Monitoring checkpoint inhibitors: predictive biomarkers in immunotherapy

Min Zhang, Jingwen Yang, Wenjing Hua, Zhong Li, Zenghui Xu, Qijun Qian

Journal Article

Construction and humoral immune response of Epstein-Barr virus latent membrane protein 2 DNA vaccine

Jianqing PAN PhD, Qin ZHANG MD, Daowen WANG MD, PhD,

Journal Article

Dysregulated N-methyladenosine modification in peripheral immune cells contributes to the pathogenesis

Journal Article