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APL 3

PML/RARα 2

ATRA 1

BRD4 1

PU.1 1

S100A9 S100A9 1

arsenic trioxide 1

interaction 1

rhabdomyolysis 1

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Arsenic trioxide induced rhabdomyolysis, a rare but severe side effect, in an APL patient: a case report

Haiyan He, Ran An, Jian Hou, Weijun Fu

Frontiers of Medicine 2017, Volume 11, Issue 2, Pages 284-286 doi: 10.1007/s11684-017-0514-y

Abstract: acid (ATRA), ATO has become the first-line induction therapy in treating acute promyelocytic leukemia (APLIn this report, we present a rare side effect, rhabdomyolysis, in a 68-year-old female APL patient who

Keywords： arsenic trioxide APL rhabdomyolysis

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Regulatory mechanism and functional analysis of

Yonglan Zhu,Fang Zhang,Shanzhen Zhang,Wanglong Deng,Huiyong Fan,Haiwei Wang,Ji Zhang

Frontiers of Medicine 2017, Volume 11, Issue 1, Pages 87-96 doi: 10.1007/s11684-016-0469-4

Abstract: This study aimed to investigate the regulatory mechanism of and its function involvement in APL.was an ATRA-responsive gene, and PML/RARα was necessary for the ATRA-induced expression of in APLour data indicated that PML/RARα and PU.1 were necessary for the ATRA-induced expression of in APLFurthermore, promoted apoptosis in APL cells and affected cell growth.

Keywords： S100A9 S100A9 PU.1 PML/RARα ATRA APL

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BRD4 interacts with PML/RARα in acute promyelocytic leukemia

Qun Luo, Wanglong Deng, Haiwei Wang, Huiyong Fan, Ji Zhang

Frontiers of Medicine 2018, Volume 12, Issue 6, Pages 726-734 doi: 10.1007/s11684-017-0604-x

Abstract: However, few studies have investigated whether BRD4 influenced acute promyelocytic leukemia (APL), andcycle analysis, and Annexin-V/PI analysis indicated that JQ1 inhibited the growth of NB4 cells, an APL-derived

Keywords： BRD4 PML/RARα APL interaction