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2018 1

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APL 2

PML/RARα 2

acute promyelocytic leukemia 2

ATRA 1

BRD4 1

CDKN2C 1

PML/RARα fusion protein 1

PU.1 1

S100A9 S100A9 1

annexin A2-S100A10 heterotetramer 1

cell cycle arrest 1

cell invasion 1

differentiation 1

interaction 1

plasmin 1

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BRD4 interacts with PML/RARα in acute promyelocytic leukemia

Qun Luo, Wanglong Deng, Haiwei Wang, Huiyong Fan, Ji Zhang

Frontiers of Medicine 2018, Volume 12, Issue 6, Pages 726-734 doi: 10.1007/s11684-017-0604-x

Abstract: /RARα) fusion protein to some extent./RARα in NB4 cells.Moreover, downregulation of PML/RARα at the mRNA and protein levels was observed upon JQ1 treatment.Furthermore, results from the RT-qPCR, ChIP-qPCR, and re-ChIP-qPCR assays showed that BRD4 and PML/RARαHence, we showed a new discovery of the interaction of BRD4 and PML/RARα, as well as the decline of PML

Keywords： BRD4 PML/RARα APL interaction

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Annexin A2-S100A10 heterotetramer is upregulated by PML/RARα fusion protein and promotes plasminogen-dependent

Dan Huang, Yan Yang, Jian Sun, Xiaorong Dong, Jiao Wang, Hongchen Liu, Chengquan Lu, Xueyu Chen, Jing Shao, Jinsong Yan

Frontiers of Medicine 2017, Volume 11, Issue 3, Pages 410-422 doi: 10.1007/s11684-017-0527-6

Abstract:

Aberrant expression of annexin A2-S100A10 heterotetramer (AIIt) associated with PML/RARα fusionZinc-induced U937/PR9 cells expressed PML/RARα fusion protein, and resultant increases in ANXA2The transactivation of ANXA2 promoter by PML/RARα fusion protein was 3.29±0.13 fold higherthan that by control pSG5 vector or wild-type RARα.Thus, PML/RARα fusion protein transactivated the ANXA2 promoter to upregulate ANXA2 and accumulate

Keywords： annexin A2-S100A10 heterotetramer PML/RARα fusion protein plasmin cell invasion acute promyelocytic leukemia

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Repression of CDKN2C caused by PML/RARα binding promotes the proliferation and differentiation block

Xiaoling Wang,Yun Tan,Yizhen Li,Jingming Li,Wen Jin,Kankan Wang

Frontiers of Medicine 2016, Volume 10, Issue 4, Pages 420-429 doi: 10.1007/s11684-016-0478-3

Abstract: kinase inhibitor 2C (CDKN2C) as a member of the cyclin-dependent kinase inhibitors is a target of the PML/RARα oncofusion protein in leukemogenesis of acute promyelocytic leukemia (APL)./RARα directly bound to the CDKN2C promoter in the APL patient-derived cell lineLuciferase assays indicated that PML/RARα inhibited the CDKN2C promoter activityFurthermore, all-trans retinoic acid treatment induced CDKN2C expression by releasing the PML/RAR&alpha

Keywords： CDKN2C acute promyelocytic leukemia cell cycle arrest differentiation

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Regulatory mechanism and functional analysis of

Yonglan Zhu,Fang Zhang,Shanzhen Zhang,Wanglong Deng,Huiyong Fan,Haiwei Wang,Ji Zhang

Frontiers of Medicine 2017, Volume 11, Issue 1, Pages 87-96 doi: 10.1007/s11684-016-0469-4

Abstract: We used real-time quantitative PCR to determine whether PML/RARα affects the expression of in NB4ChIP-based PCR and dual-luciferase reporter assay system were used to detect how PML/RARα and PUResults showed that was an ATRA-responsive gene, and PML/RARα was necessary for the ATRA-inducedCollectively, our data indicated that PML/RARα and PU.1 were necessary for the ATRA-induced expression

Keywords： S100A9 S100A9 PU.1 PML/RARα ATRA APL