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Astrocytes in depression and Alzheimer’s disease
Frontiers of Medicine 2021, Volume 15, Issue 6, Pages 829-841 doi: 10.1007/s11684-021-0875-0
Keywords： astrocytes depression Alzheimer’s disease roles mechanisms
Protein phosphatase 2A, a key player in Alzheimer’s disease
Rong LIU, Qing TIAN
Frontiers of Medicine 2009, Volume 3, Issue 1, Pages 8-12 doi: 10.1007/s11684-009-0017-6
Keywords： protein phosphatase 2A Alzheimer’s disease holoenzyme composition protein phosphatase 2A inhibitors Leu309
Medical applications of phytoestrogens from the Thai herb
Suchinda Malaivijitnond
Frontiers of Medicine 2012, Volume 6, Issue 1, Pages 8-21 doi: 10.1007/s11684-012-0184-8
Pueraria mirifica Airy Shaw et Suvatabandhu is a medicinal plant endemic to Thailand. It has been used in Thai folklore medicine for its rejuvenating qualities in aged women and men for nearly one hundred years. Indeed, it has been claimed that P. mirifica contains active phytoestrogens (plant substances with estrogen-like activity). Using high performance liquid chromatography, at least 17 phytoestrogens, mainly isoflavones, have been isolated. Thus, fairly considerable scientific researches, both in vitro in cell lines and in vivo in various species of animals including humans, have been conducted to date to address its estrogenic activity on the reproductive organs, bones, cardiovascular diseases and other climacteric related symptoms. The antioxidative capacity and antiproliferative effect on tumor cell lines have also been assessed. In general, P. mirifica could be applicable for preventing, or as a therapeutic for, the symptoms related to estrogen deficiency in menopausal women as well as in andropausal men. However, the optimal doses for each desirable effect and the balance to avoid undesired side effects need to be calculated before use.
Keywords： white Kwao Krua miroestrol estrogenic activity reproduction osteoporosis breast cancer Alzheimer
Effect of ambient polycyclic aromatic hydrocarbons and nicotine on the structure of Aβ protein
Frontiers of Environmental Science & Engineering 2023, Volume 17, Issue 2, doi: 10.1007/s11783-023-1615-2
● B[a]P, nicotine and phenanthrene molecules altered the secondary structure of Aβ42.
Keywords： Polycyclic aromatic hydrocarbons Nicotine toxicology Aβ42 peptide Alzheimer’s disease
Atomistic characterization of binding modes and affinity of peptide inhibitors to amyloid-
Fufeng LIU,Wenjie DU,Yan SUN,Jie ZHENG,Xiaoyan DONG
Frontiers of Chemical Science and Engineering 2014, Volume 8, Issue 4, Pages 433-444 doi: 10.1007/s11705-014-1454-6
Keywords： Alzheimer’s disease amyloid β-protein peptide inhibitors protein-protein interaction molecular
Shuai Ma, Huan Zhang, Xiaoyan Dong, Linling Yu, Jie Zheng, Yan Sun
Frontiers of Chemical Science and Engineering 2018, Volume 12, Issue 2, Pages 283-295 doi: 10.1007/s11705-017-1687-2
Keywords： Alzheimer’s disease amyloid β-protein cyclic peptide inhibition protein aggregation
Title Author Date Type Operation
Effect of ambient polycyclic aromatic hydrocarbons and nicotine on the structure of Aβ protein
Journal Article
Atomistic characterization of binding modes and affinity of peptide inhibitors to amyloid-
Fufeng LIU,Wenjie DU,Yan SUN,Jie ZHENG,Xiaoyan DONG
Journal Article
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