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epigenetics 1

non-small-cell lung cancer 1

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Compound C620-0696, a new potent inhibitor targeting BPTF, the chromatin-remodeling factor in non-small-cell

Jiahui Xu, Qianqian Wang, Elaine Lai Han Leung, Ying Li, Xingxing Fan, Qibiao Wu, Xiaojun Yao, Liang Liu

Frontiers of Medicine 2020, Volume 14, Issue 1,   Pages 60-67 doi: 10.1007/s11684-019-0694-8

Abstract: Bromodomain PHD-finger transcription factor (BPTF) is the largest subunit of the nucleosome remodelingBPTF is also involved in oncogene transcription in diverse progressions of cancers.and extra-terminal family proteins in human cancers, no potent and selective inhibitor targeting the BPTFof biolayer interferometry revealed that compound C620-0696 exhibited high binding affinity to the BPTFMoreover, C620-0696 was cytotoxic in BPTF with a high expression of non-small-cell lung cancer (NSCLC

Keywords： BPTF     small molecule     epigenetics     non-small-cell lung cancer    

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Compound C620-0696, a new potent inhibitor targeting BPTF, the chromatin-remodeling factor in non-small-cell

Jiahui Xu, Qianqian Wang, Elaine Lai Han Leung, Ying Li, Xingxing Fan, Qibiao Wu, Xiaojun Yao, Liang Liu

Journal Article