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carcinoma progression by repressing translation through the interaction with eukaryotic initiation factor 4A-I

Frontiers of Medicine 2023, Volume 17, Issue 3,   Pages 476-492 doi: 10.1007/s11684-022-0966-6

Abstract: yielded opposite results. 5′-tiRNA-Gln exerted its function by binding eukaryotic initiation factor 4A-I(EIF4A1), which unwinds complex RNA secondary structures during translation initiation, causing theThe suppressed downregulated proteins include ARAF, MEK1/2 and STAT3, causing the impaired signalingsequence of forming intramolecular G-quadruplex structure is crucial for 5′-tiRNA-Gln to strongly bind EIF4A1Collectively, these findings reveal that 5′-tiRNA-Gln interacts with EIF4A1 to reduce related mRNA binding

Keywords： EIF4A1     G-quadruplex     hepatocellular carcinoma     tRNA-derived small RNA     translation initiation    

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Metabolic interventions combined with CTLA-4 and PD-1/PD-L1 blockade for the treatment of tumors: mechanisms

Frontiers of Medicine   Pages 805-822 doi: 10.1007/s11684-023-1025-7

Abstract: To date, immune checkpoint inhibitors (ICIs) of CTLA-4 and PD-1/PD-L1 represent the main class of immunotherapyBlockade of CTLA-4 and PD-1/PD-L1 has shown remarkable efficacy in several specific types of cancers,the generalized mechanism of targeting cancer metabolism at three crucial immune checkpoints (CTLA-4,PD-1, and PD-L1) to influence ICB therapy and propose potential combined immunotherapeutic strategies

Keywords： CTLA-4     PD-1     PD-L1     immune checkpoint blockade (ICB)     metabolic reprogramming     combined tumor therapeutic    

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Synthesis, insecticidal activities and DFT study of pyrimidin-4-amine derivatives containing the 1,2,4

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 7,   Pages 1090-1100 doi: 10.1007/s11705-021-2091-5

Abstract: Twenty six novel pyrimidin-4-amine derivatives containing the 1,2,4-oxadiazole motif were synthesizedTheir chemical structures were confirmed by 1H nuclear magnetic resonance (NMR), 13

Keywords： synthesis     pyrimidin-4-amine derivatives     1     2     4-oxadiazole     insecticidal activity     structure-activity    

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Wideband circular-polarized transmitarray for generating a high-purity vortex beam Correspondence

Liangjie QIU, Xiuping LI, Zihang QI, Wenyu ZHAO, Yuhan HUANG,xpli@bupt.edu.cn

Frontiers of Information Technology & Electronic Engineering 2023, Volume 24, Issue 6,   Pages 927-934 doi: 10.1631/FITEE.2200539

Abstract: structure and double-resonance characteristics ensure the stable phase shift of the element within the 1-Owing to the honeycomb arrangement of elements, the mode purity of l​​=​​−1 is >0.93 in a wide band from

Keywords： 轨道角动量；涡旋波束；透射阵；宽带；高纯度    

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Microwave-assisted synthesis and antimicrobial activities of 2-aryl-3-(naphthalene-1 or 2-yl)-1,3-thiazolidin-4-ones

Hua CHEN, Yanan LI, Jie BAI, Lian ZHAO, Xiangguo YUAN, Xiaoliu LI, Keqiang CAO

Frontiers of Chemical Science and Engineering 2009, Volume 3, Issue 2,   Pages 186-191 doi: 10.1007/s11705-009-0004-0

Abstract: 2-aryl-3-(naphthalene-1 or 2-yl)-1,3-thiazolidin-4-ones and were synthesized in 41%-67% yield by

Keywords： microwave-assisted synthesis     naphthyl     thiazolidin-4-one     antimicrobial    

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China in the eyes of news media: a case study under COVID-19 epidemic Research Article

Hong Huang, Zhexue Chen, Xuanhua Shi, Chenxu Wang, Zepeng He, Hai Jin, Mingxin Zhang, Zongya Li,honghuang@hust.edu.cn,chenzhexue@hust.edu.cn,xhshi@hust.edu.cn,wangchenxu@hust.edu.cn,hezepeng@hust.edu.cn,hjin@hust.edu.cn,mingxinzhang@hust.edu.cn,lzy901014@sina.com

Frontiers of Information Technology & Electronic Engineering 2021, Volume 22, Issue 11,   Pages 1443-1457 doi: 10.1631/FITEE.2000689

Abstract: We aim to answer three questions: (1) What has the international media focused on during the period?

Keywords： 国家形象；新冠肺炎；主题挖掘；实体；新闻立场；情感    

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4-1BBL expressed by eukaryotic cells activates immune cells and suppresses the progression of murine

Hui QIU, Hui ZHANG, Zuohua FENG

Frontiers of Medicine 2009, Volume 3, Issue 1,   Pages 20-25 doi: 10.1007/s11684-009-0006-9

Abstract: The interaction by co-stimulatory molecules 4-1BB and 4-1BB ligand (4-1BBL) plays an important role inThe function of 4-1BB/4-1BBL expressed by the immune cells has been the focus for many tumor immunotherapyIn this study, 4-1BBL was expressed in non-immune cells and non-tumor cells, and the role of 4-1BBL inThe plasmid p4-1BBL containing the full length of mouse 4-1BBL cDNA sequence was constructed, and theThe study demonstrated that the molecule 4-1BBL expressed by BHK cells could enhance the proliferation

Keywords： 4-1BB ligand     tumor immunotherapy     tumor microenvironment    

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Synaptic devices based on semiconductor nanocrystals Review

Mingxuan BU, Yue WANG, Lei YIN, Zhouyu TONG, Yiqiang ZHANG, Deren YANG, Xiaodong PI

Frontiers of Information Technology & Electronic Engineering 2022, Volume 23, Issue 11,   Pages 1579-1601 doi: 10.1631/FITEE.2100551

Abstract:

To meet a growing demand for information processing, brain-inspired neuromorphic devices have been intensively studied in recent years. As an important type of neuromorphic device, have attracted strong attention. Among all the kinds of materials explored for the fabrication of , s (NCs) have become one of the preferred choices due to their excellent electronic and optical properties. In this review, we first introduce the research background of based on semiconductor NCs and briefly present the basic properties of semiconductor NCs. Recent developments in the field of based on semiconductor NCs are then discussed according to the materials employed in the active layers of the devices. Finally, we discuss existing problems and challenges of based on semiconductor NCs.

Keywords： Semiconductor nanocrystal     Synaptic devices     Neuromorphic computing    

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Passive mode-locked Er-doped fiber laser pulse generation based on titanium disulfide saturable absorber Research Articles

Xinxin Shang, Linguang Guo, Huanian Zhang, Dengwang Li, Qingyang Yue,huanian_zhang@163.com,qingyangyue@sdnu.edu.cn

Frontiers of Information Technology & Electronic Engineering 2021, Volume 22, Issue 5,   Pages 615-766 doi: 10.1631/FITEE.2000341

Abstract: In this study, (TiS) polyvinyl alcohol (PVA) film-type (SA) is synthesized with a modulation depth of 5.08% and a saturable intensity of 10.62 MW/cm by liquid-phase exfoliation and spin-coating methods. Since TiS-based SA has a strong nonlinear saturable absorption property, two types of optical soliton were observed in a mode-locked Er-doped . When the pump power was raised to 67.3 mW, a conventional mode-locked pulse train with a repetition rate of 1.716 MHz and a pulse width of 6.57 ps was generated, and the output spectrum centered at 1556.98 nm and 0.466 nm spectral width with obvious Kelly sidebands was obtained. Another type of mode-locked pulse train with the maximum output power of 3.92 mW and pulse energy of 2.28 nJ at the pump power of 517.2 mW was achieved when the polarization controllers were adjusted. Since TiS-based SA has excellent nonlinear saturable absorption characteristics, broad applications in ultrafast photonic are expected.

Keywords： 光纤激光器；被动锁模；可饱和吸收体；二硫化钛    

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Development of space-based diffractive telescopes Review Article

Wei Zhao, Xin Wang, Hua Liu, Zi-feng Lu, Zhen-wu Lu,wangxin971241@163.com,liuhua_rain@aliyun.com

Frontiers of Information Technology & Electronic Engineering 2020, Volume 21, Issue 6,   Pages 809-962 doi: 10.1631/FITEE.1900529

Abstract: formed by fabricating microstructures on the substrates have two important characteristics, ultra-light mass (surface mass density < 0.1 kg/m2) and loose surface shape tolerances (surface accuracy requirements are on the order of magnitude of centimeter). Large-aperture telescopes using a membrane diffractive optical element as the primary lens have , light weight, and low cost at launch. In this paper, the research and development on space-based s are classified and summarized. First, the imaging theory and the configuration of diffractive-optics telescopes are discussed. Then, the developments in s are introduced. Finally, the development prospects for this technology used as a high-resolution space reconnaissance system in the future are summarized, and the critical and relevant work that China should carry out is put forward.

Keywords： 薄膜衍射光学元件；衍射望远系统；超大口径    

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Transcription Factors HNF1A, HNF4A, and FOXA2 Regulate Hepatic Cell Protein N-Glycosylation Article

Vedrana Vičić Bočkor,Nika Foglar,Goran Josipović,Marija Klasić,Ana Vujić,Branimir Plavša,Toma Keser,Samira Smajlović,Aleksandar Vojta,Vlatka Zoldoš

Engineering 2024, Volume 32, Issue 1,   Pages 58-69 doi: 10.1016/j.eng.2023.09.019

Abstract:

Hepatocyte nuclear factor 1 alpha (HNF1A), hepatocyte nuclear factor 4 alpha (HNF4A), and forkheadOur in silico analysis of HNF1A, HNF4A, and FOXA2 binding to the 10 candidate glyco-genes studiedshort palindromic repeats/dead Cas9 (CRISPR/dCas9) molecular tool for the downregulation of the HNF1A, HNF4A, and FOXA2 genes in HepG2 cells—a human liver cancer cell line.We also propose a model showing feedback loops with the mutual activation of HNF1A–FOXA2 and HNF4A

Keywords： interspaced short palindromic repeats/dead Cas9 (CRISPR/dCas9)     Epigenetics     Hepatocyte nuclear factor 1alpha (HNF1A)     Hepatocyte nuclear factor 4 alpha (HNF4A)     Forkhead box protein A2 (FOXA2)     N-glycosylation    

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Design, synthesis, and antiviral properties of 2-aryl-1H-benzimidazole-4-carboxamide derivatives

Xianjin LUO, Zhonglü ZHANG, Yutian YANG, Fei XUE, Naiyun XIU, Yuanbin SHE

Frontiers of Chemical Science and Engineering 2009, Volume 3, Issue 3,   Pages 305-309 doi: 10.1007/s11705-009-0021-z

Abstract: A series of new benzimidazole derivatives were designed and synthesized. Their chemical structures were testified by H NMR, infrared spectroscopy (IR), mass spectrography (MS), and elemental analysis. Their potent antiviral properties indicated the prospect of new drugs. Compound , , , , , , and were identified as novel antivirus with much better selective activity and inhibitory activity than the comparable ribavirin against Coxsackie virus B in VERO cells.

Keywords： benzimidazole     coxsackie virus B3     antiviral properties    

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and Tracking the Process of Liver-Specific Injury by the Residual Tissue Activity of Carboxylesterase 1Liver-Specific Injury by the Residual Tissue Activity of Carboxylesterase 1 and Dipeptidyl Peptidase 4 Article

Qiusha Pan, Peifang Song, Zhenhua Ni, Xingkai Qian, Anqi Wang, Liwei Zou, Yong Liu, Ping Wang, Weidong Zhang, Hong Ma, Ling Yang

Engineering 2022, Volume 19, Issue 12,   Pages 153-165 doi: 10.1016/j.eng.2021.09.014

Abstract: We found that carboxylesterase 1 (CES1), as an intrahepatic marker, and dipeptidyl peptidase 4 (DPP-IVLevels of CES1 and DPP-IV can be used to identify liver damage itself and the inflammatory state, respectivelyTherefore, among the abovementioned biomarkers, only CES1 made it possible to specifically determineCES1 also enabled accurate assessment of the anti-cholestasis effects of ursodeoxycholic acid (UDCA;Our data highlights the potential of the combined use of CES1 (as an intrahepatic marker of liver damage

Keywords： Carboxylesterase 1     Dipeptidyl peptidase 4     Liver injury     Validation tracking    

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Evaluation of 1,4-naphthoquinone derivatives as antibacterial agents: activity and mechanistic studies

Frontiers of Environmental Science & Engineering 2023, Volume 17, Issue 3, doi: 10.1007/s11783-023-1631-2

Abstract:

● All 1,4-naphthoquinone hybrids exhibited significant antimicrobial

Keywords： 1     4-naphthoquinone derivatives     Antibacterial     Action mechanism     RecA    

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Experimental and computational assessment of 1,4-Dioxane degradation in a photo-Fenton reactive ceramic

Frontiers of Environmental Science & Engineering 2021, Volume 15, Issue 5, doi: 10.1007/s11783-020-1341-y

Abstract:

• 1,4-Dioxane was degraded via the photo-Fenton reactive membrane filtration

Keywords： Photo-Fenton     Ceramic membrane     1     4-Dioxane     Goethite    

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Title Author Date Type Operation

carcinoma progression by repressing translation through the interaction with eukaryotic initiation factor 4A-I

Journal Article

Metabolic interventions combined with CTLA-4 and PD-1/PD-L1 blockade for the treatment of tumors: mechanisms

Journal Article

Synthesis, insecticidal activities and DFT study of pyrimidin-4-amine derivatives containing the 1,2,4

Journal Article

Wideband circular-polarized transmitarray for generating a high-purity vortex beam

Liangjie QIU, Xiuping LI, Zihang QI, Wenyu ZHAO, Yuhan HUANG,xpli@bupt.edu.cn

Journal Article

Microwave-assisted synthesis and antimicrobial activities of 2-aryl-3-(naphthalene-1 or 2-yl)-1,3-thiazolidin-4-ones

Hua CHEN, Yanan LI, Jie BAI, Lian ZHAO, Xiangguo YUAN, Xiaoliu LI, Keqiang CAO

Journal Article

China in the eyes of news media: a case study under COVID-19 epidemic

Hong Huang, Zhexue Chen, Xuanhua Shi, Chenxu Wang, Zepeng He, Hai Jin, Mingxin Zhang, Zongya Li,honghuang@hust.edu.cn,chenzhexue@hust.edu.cn,xhshi@hust.edu.cn,wangchenxu@hust.edu.cn,hezepeng@hust.edu.cn,hjin@hust.edu.cn,mingxinzhang@hust.edu.cn,lzy901014@sina.com

Journal Article

4-1BBL expressed by eukaryotic cells activates immune cells and suppresses the progression of murine

Hui QIU, Hui ZHANG, Zuohua FENG

Journal Article

Synaptic devices based on semiconductor nanocrystals

Mingxuan BU, Yue WANG, Lei YIN, Zhouyu TONG, Yiqiang ZHANG, Deren YANG, Xiaodong PI

Journal Article

Passive mode-locked Er-doped fiber laser pulse generation based on titanium disulfide saturable absorber

Xinxin Shang, Linguang Guo, Huanian Zhang, Dengwang Li, Qingyang Yue,huanian_zhang@163.com,qingyangyue@sdnu.edu.cn

Journal Article

Development of space-based diffractive telescopes

Wei Zhao, Xin Wang, Hua Liu, Zi-feng Lu, Zhen-wu Lu,wangxin971241@163.com,liuhua_rain@aliyun.com

Journal Article

Transcription Factors HNF1A, HNF4A, and FOXA2 Regulate Hepatic Cell Protein N-Glycosylation

Vedrana Vičić Bočkor,Nika Foglar,Goran Josipović,Marija Klasić,Ana Vujić,Branimir Plavša,Toma Keser,Samira Smajlović,Aleksandar Vojta,Vlatka Zoldoš

Journal Article

Design, synthesis, and antiviral properties of 2-aryl-1H-benzimidazole-4-carboxamide derivatives

Xianjin LUO, Zhonglü ZHANG, Yutian YANG, Fei XUE, Naiyun XIU, Yuanbin SHE

Journal Article

and Tracking the Process of Liver-Specific Injury by the Residual Tissue Activity of Carboxylesterase 1Liver-Specific Injury by the Residual Tissue Activity of Carboxylesterase 1 and Dipeptidyl Peptidase 4

Qiusha Pan, Peifang Song, Zhenhua Ni, Xingkai Qian, Anqi Wang, Liwei Zou, Yong Liu, Ping Wang, Weidong Zhang, Hong Ma, Ling Yang

Journal Article

Evaluation of 1,4-naphthoquinone derivatives as antibacterial agents: activity and mechanistic studies

Journal Article

Experimental and computational assessment of 1,4-Dioxane degradation in a photo-Fenton reactive ceramic

Journal Article