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Chidamide inhibits the NOTCH1-MYC signaling axis in T-cell acute lymphoblastic leukemia

Frontiers of Medicine 2022, Volume 16, Issue 3,   Pages 442-458 doi: 10.1007/s11684-021-0877-y

Abstract: More than 60% of T-ALL patients carry NOTCH1 gene mutations, leading to abnormal expression ofHDAC inhibitor, exerts an antitumor effect on T-ALL cell lines and primary cells including an anti-NOTCH1In particular, chidamide inhibits the NOTCH1-MYC signaling axis by down-regulating the level of the intracellularform of NOTCH1 (NICD1) as well as MYC, partly through their ubiquitination and degradation by the proteasomethe effectiveness and safety of chidamide in the treatment of T-ALL patients, including those with NOTCH1

Keywords: T-cell acute lymphoblastic leukemia     HDAC inhibitor     chidamide     NOTCH1     MYC     ubiquitination    

Role of Wnt and Notch signaling in regulating hair cell regeneration in the cochlea

Muhammad Waqas,Shasha Zhang,Zuhong He,Mingliang Tang,Renjie Chai

Frontiers of Medicine 2016, Volume 10, Issue 3,   Pages 237-249 doi: 10.1007/s11684-016-0464-9

Abstract: regenerative capacity because of the active participation of various signaling pathways, including Wnt and NotchThe Wnt and Notch pathways are highly sophisticated and conserved signaling pathways that control multipleIn this regard, Wnt and Notch signaling has gained increased research attention in hair cell regenerationThis review presents the current understanding of the Wnt and Notch signaling pathways in the auditory

Keywords: inner ear     cochlea     hair cell     regeneration     Wnt     Notch     signaling pathways    

Unidirectional and stage-dependent roles of Notch1 in Wnt-responsive Lgr5

Hui Jiang, Shan Zeng, Wenli Ni, Yan Chen, Wenyan Li

Frontiers of Medicine 2019, Volume 13, Issue 6,   Pages 705-712 doi: 10.1007/s11684-019-0703-y

Abstract: Wnt and Notch signaling play crucial roles in the determination of the prosensory domain and in the differentiationHere, we investigated the interactions between Notch and Wnt signaling on the basis of the bidirectionalregulation of Notch1 specifically in Wnt-responsive Lgr5 progenitors during different cochlear developmentWe found that the downregulation of Notch1 in Lgr5 cells from embryonic day (E) 14.5 to E18.5 can driveOur findings improved the understanding of the interactions between Notch and Wnt signaling in cochlear

Keywords: inner ear     cochlear     Wnt     Notch     Lgr5     auditory system    

Parametric equations for notch stress concentration factors of rib–deck welds under bending loading

Frontiers of Structural and Civil Engineering 2021, Volume 15, Issue 3,   Pages 595-608 doi: 10.1007/s11709-021-0720-1

Abstract: The effective notch stress approach for evaluating the fatigue strength of rib–deck welds requires notchFirst, we developed a model for investigating the effective notch stress in rib–deck welds.parametric analysis to investigate the effects of multiple geometric parameters of a rib–deck weld on the notchstepwise regression analysis was performed to obtain the optimal regression functions for predicting the notchThe notch stress concentration factors estimated from the developed formulas show agree well with the

Keywords: notch stress concentration factor     rib–deck weld     parametric analysis     regression analysis     parametric    

The Notch Signaling Pathway: Mechanistic Insights in Health and Disease Review

Yao Meng, Zhihan Bo, Xinyi Feng, Xinyi Yang, Penny A. Handford

Engineering 2024, Volume 34, Issue 3,   Pages 212-232 doi: 10.1016/j.eng.2023.11.011

Abstract:

The Notch signaling pathway is evolutionarily conserved across metazoan species and plays key rolesThe Notch receptor is activated by two families of canonical ligands (Delta and Serrate/Jagged) whereligand complex initiates force-mediated proteolysis, ultimately releasing the transcriptionally-active Notch

Keywords: Notch signaling pathway     Structural biology     Glycosylation     Genetic disorders     Cancer     Pharmacological    

Crack propagation with different radius local random damage based on peridynamic theory

Frontiers of Structural and Civil Engineering 2021, Volume 15, Issue 5,   Pages 1238-1248 doi: 10.1007/s11709-021-0695-y

Abstract: This study implements the peridynamic theory by subjecting bilateral notch cracked specimens to the conditions

Keywords: peridynamics     stochastic damage     bilateral notch crack    

Regeneration of hair cells in the mammalian vestibular system

Wenyan Li,Dan You,Yan Chen,Renjie Chai,Huawei Li

Frontiers of Medicine 2016, Volume 10, Issue 2,   Pages 143-151 doi: 10.1007/s11684-016-0451-1

Abstract: regeneration and subsequent functional recovery of the vestibular system, including manipulating the Wnt, Notch

Keywords: utricle     hair cell     regeneration     Atoh1     Notch     Wnt    

Structural parameter design method for a fast-steering mirror based on a closed-loop bandwidth

Guozhen CHEN, Pinkuan LIU, Han DING

Frontiers of Mechanical Engineering 2020, Volume 15, Issue 1,   Pages 55-65 doi: 10.1007/s11465-019-0545-y

Abstract: In accordance with the transfer function, the notch filter and proportional-integral (PI) feedback controller

Keywords: fast-steering mirror     structural parameter     PI controller     bandwidth     notch filter    

The Analyzing Method for Fatigue Life of Aircraft Structures Under Corrosive Environment

Mu Zhitao

Strategic Study of CAE 2002, Volume 4, Issue 3,   Pages 68-72

Abstract: environment characteristics and corrosion depth distribution law of the naval aircraft structures fatigue notch

Keywords: aircraft structure     fatigue life     corrosive environment     fatigue notch factor    

Mechanical responses of pristine and defective hexagonal boron-nitride nanosheets: A molecular dynamics investigation

Mohammad SALAVATI, Arvin MOJAHEDIN, Ali Hossein Nezhad SHIRAZI

Frontiers of Structural and Civil Engineering 2020, Volume 14, Issue 3,   Pages 623-631 doi: 10.1007/s11709-020-0616-5

Abstract: In this work we conducted classical molecular dynamics (MD) simulation to investigate the mechanical characteristics and failure mechanism of hexagonal boron-nitride (h-BN) nanosheets. Pristine and defective structure of h-BN nanosheets were considered under the uniaxial tensile loadings at various temperatures. The defective structure contains three types of the most common initial defects in engineering materials that are known as cracks, notches (with various length/size), and point vacancy defects (with a wide range of concentration). MD simulation results demonstrate a high load-bearing capacity of extremely defective (amorphized) h-BN nanosheets. Our results also reveal that the tensile strength decline by increasing the defect content and temperature as well. Our MD results provide a comprehensive and useful vision concerning the mechanical properties of h-BN nanosheets with/without defects, which is very critical for the designing of nanodevices exploiting the exceptional physics of h-BN.

Keywords: hexagonal boron-nitride     mechanical properties     crack     notch     point defects     molecular dynamics    

Numerical simulation of the rockburst processes of a circular tunnel at different dilation angles

Wang Xuebin,Pan Yishan,Zhang Zhihui

Strategic Study of CAE 2010, Volume 12, Issue 2,   Pages 40-46

Abstract: an increase of the dilation angle, the shear band becomes wider; the dog-ear or V-shaped rockburst notch

Keywords: dilation angle     circular tunnel     rockburst     shear band     V-shaped notch     shear strain     volumetric strain    

Title Author Date Type Operation

Chidamide inhibits the NOTCH1-MYC signaling axis in T-cell acute lymphoblastic leukemia

Journal Article

Role of Wnt and Notch signaling in regulating hair cell regeneration in the cochlea

Muhammad Waqas,Shasha Zhang,Zuhong He,Mingliang Tang,Renjie Chai

Journal Article

Unidirectional and stage-dependent roles of Notch1 in Wnt-responsive Lgr5

Hui Jiang, Shan Zeng, Wenli Ni, Yan Chen, Wenyan Li

Journal Article

Parametric equations for notch stress concentration factors of rib–deck welds under bending loading

Journal Article

The Notch Signaling Pathway: Mechanistic Insights in Health and Disease

Yao Meng, Zhihan Bo, Xinyi Feng, Xinyi Yang, Penny A. Handford

Journal Article

Crack propagation with different radius local random damage based on peridynamic theory

Journal Article

Regeneration of hair cells in the mammalian vestibular system

Wenyan Li,Dan You,Yan Chen,Renjie Chai,Huawei Li

Journal Article

Structural parameter design method for a fast-steering mirror based on a closed-loop bandwidth

Guozhen CHEN, Pinkuan LIU, Han DING

Journal Article

The Analyzing Method for Fatigue Life of Aircraft Structures Under Corrosive Environment

Mu Zhitao

Journal Article

Mechanical responses of pristine and defective hexagonal boron-nitride nanosheets: A molecular dynamics investigation

Mohammad SALAVATI, Arvin MOJAHEDIN, Ali Hossein Nezhad SHIRAZI

Journal Article

Numerical simulation of the rockburst processes of a circular tunnel at different dilation angles

Wang Xuebin,Pan Yishan,Zhang Zhihui

Journal Article