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Role of Wnt and Notch signaling in regulating hair cell regeneration in the cochlea
Muhammad Waqas,Shasha Zhang,Zuhong He,Mingliang Tang,Renjie Chai
Frontiers of Medicine 2016, Volume 10, Issue 3, Pages 237-249 doi: 10.1007/s11684-016-0464-9
Keywords: inner ear cochlea hair cell regeneration Wnt Notch signaling pathways
Acetyl salicylic acid attenuates cardiac hypertrophy through Wnt signaling
Samuel Chege Gitau,Xuelian Li,Dandan Zhao,Zhenfeng Guo,Haihai Liang,Ming Qian,Lifang Lv,Tianshi Li,Bozhi Xu,Zhiguo Wang,Yong Zhang,Chaoqian Xu,Yanjie Lu,Zhiming Du,Hongli Shan,Baofeng Yang
Frontiers of Medicine 2015, Volume 9, Issue 4, Pages 444-456 doi: 10.1007/s11684-015-0421-z
Ventricular hypertrophy is a powerful and independent predictor of cardiovascular morbid events. The vascular properties of low-dose acetyl salicylic acid (aspirin) provide cardiovascular benefits through the irreversible inhibition of platelet cyclooxygenase 1; however, the possible anti-hypertrophic properties and potential mechanism of aspirin have not been investigated in detail. In this study, healthy wild-type male mice were randomly divided into three groups and subjected to transverse aortic constriction (TAC) or sham operation. The TAC-operated mice were treated with the human equivalent of low-dose aspirin (10 mg·kg−1·d−1); the remaining mice received an equal amount of phosphate buffered saline with 0.65% ethanol, which was used as a vehicle. A cardiomyocyte hypertrophy model induced by angiotensin II (10 nmol·L−1) was treated with the human equivalent of low (10 or 100 µmol·L−1) and high (1000 µmol·L−1) aspirin concentrations in plasma. Changes in the cardiac structure and function were assessed through echocardiography and transmission electron microscopy. Gene expression was determined through RT-PCR and western blot analysis. Results indicated that aspirin treatment abrogated the increased thickness of the left ventricular anterior and posterior walls, the swelling of mitochondria, and the increased surface area in in vivo and in vitro hypertrophy models. Aspirin also normalized the upregulated hypertrophic biomarkers, β-myosin heavy chain (β-MHC), atrial natriuretic peptide (ANP), and b-type natriuretic peptide (BNP). Aspirin efficiently reversed the upregulation of β-catenin and P-Akt expression and the TAC- or ANG II-induced downregulation of GSK-3β. Therefore, low-dose aspirin possesses significant anti-hypertrophic properties at clinically relevant concentrations for anti-thrombotic therapy. The downregulation of β-catenin and Akt may be the underlying signaling mechanism of the effects of aspirin.
Keywords: aspirin Akt cardiac hypertrophy GSK-3β Wnt/β-catenin
Frontiers of Medicine 2023, Volume 17, Issue 4, Pages 685-698 doi: 10.1007/s11684-022-0942-1
Keywords: acute myeloid leukemia acyl-CoA synthetase long chain family member 5 Wnt3a palmitoylation ABT-199
Unidirectional and stage-dependent roles of Notch1 in Wnt-responsive Lgr5
Hui Jiang, Shan Zeng, Wenli Ni, Yan Chen, Wenyan Li
Frontiers of Medicine 2019, Volume 13, Issue 6, Pages 705-712 doi: 10.1007/s11684-019-0703-y
Wnt/β-catenin signaling pathway and its role in hepatocellular carcinoma
ZHANG Xufeng, YU Liang, LU Yi
Frontiers of Medicine 2008, Volume 2, Issue 3, Pages 216-228 doi: 10.1007/s11684-008-0042-x
Keywords: interacting complicated understanding embryogenesis activation organism development
Regeneration of hair cells in the mammalian vestibular system
Wenyan Li,Dan You,Yan Chen,Renjie Chai,Huawei Li
Frontiers of Medicine 2016, Volume 10, Issue 2, Pages 143-151 doi: 10.1007/s11684-016-0451-1
MicroRNA-148b promotes proliferation of hair follicle cells by targeting
Wanbao YANG,Qinqun LI,Bo SU,Mei YU
Frontiers of Agricultural Science and Engineering 2016, Volume 3, Issue 1, Pages 72-80 doi: 10.15302/J-FASE-2016089
Keywords: miR-148b hair follicle proliferation NFAT5 Wnt10b
Intestinal Epithelial Axin1 Deficiency Protects Against Colitis via Altered Gut Microbiota
Shari Garrett,Yongguo Zhang,Yinglin Xia,Jun Sun,
Engineering doi: 10.1016/j.eng.2023.06.007
Keywords: Microbiome inflammation Inflammatory bowel disease Immunity Microbiome Paneth cells Akkermansia muciniphila Wnt
Title Author Date Type Operation
Role of Wnt and Notch signaling in regulating hair cell regeneration in the cochlea
Muhammad Waqas,Shasha Zhang,Zuhong He,Mingliang Tang,Renjie Chai
Journal Article
Acetyl salicylic acid attenuates cardiac hypertrophy through Wnt signaling
Samuel Chege Gitau,Xuelian Li,Dandan Zhao,Zhenfeng Guo,Haihai Liang,Ming Qian,Lifang Lv,Tianshi Li,Bozhi Xu,Zhiguo Wang,Yong Zhang,Chaoqian Xu,Yanjie Lu,Zhiming Du,Hongli Shan,Baofeng Yang
Journal Article
ACSL5, a prognostic factor in acute myeloid leukemia, modulates the activity of Wnt/-catenin signaling
Journal Article
Unidirectional and stage-dependent roles of Notch1 in Wnt-responsive Lgr5
Hui Jiang, Shan Zeng, Wenli Ni, Yan Chen, Wenyan Li
Journal Article
Wnt/β-catenin signaling pathway and its role in hepatocellular carcinoma
ZHANG Xufeng, YU Liang, LU Yi
Journal Article
Regeneration of hair cells in the mammalian vestibular system
Wenyan Li,Dan You,Yan Chen,Renjie Chai,Huawei Li
Journal Article
MicroRNA-148b promotes proliferation of hair follicle cells by targeting
Wanbao YANG,Qinqun LI,Bo SU,Mei YU
Journal Article