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2022 1

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ABC-F family proteins 1

Antibiotic resistance 1

Ribosome 1

SrpA 1

Streptococcus suis 1

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Characterization of a Novel Gene, srpA, Conferring Resistance to Streptogramin A, Pleuromutilins Article

Chaoyang Zhang, Lu Liu, Peng Zhang, Jingpo Cui, Xiaoxia Qin, Lichao Ma, Kun Han, Zhanhui Wang, Shaolin Wang, Shuangyang Ding, Zhangqi Shen

Engineering 2022, Volume 9, Issue 2,   Pages 85-94 doi: 10.1016/j.eng.2020.12.015

Abstract: study, we identified a new adenosine triphosphate (ATP)-binding cassete (ABC)-F family determinant, srpAA sequence alignment revealed that SrpA shares the highest amino acid identity with Vga(E) (36%) andIn SrpA-ribosome docked compounds, the extended loop region of SrpA approaches the valnemulinbindingA detailed mutational analysis of the loop residues confirmed that this domain is crucial for SrpA activitybinding assay supported the protective effects of SrpA on the ribosome by preventing antibiotic binding

Keywords： SrpA     Streptococcus suis     Antibiotic resistance     Ribosome     ABC-F family proteins    

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Characterization of a Novel Gene, srpA, Conferring Resistance to Streptogramin A, Pleuromutilins

Chaoyang Zhang, Lu Liu, Peng Zhang, Jingpo Cui, Xiaoxia Qin, Lichao Ma, Kun Han, Zhanhui Wang, Shaolin Wang, Shuangyang Ding, Zhangqi Shen

Journal Article