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Targeting apoptosis to manage acquired resistance to third generation EGFR inhibitors

Frontiers of Medicine 2022, Volume 16, Issue 5,   Pages 701-713 doi: 10.1007/s11684-022-0951-0

Abstract: A significant clinical challenge in lung cancer treatment is management of the inevitable acquired resistancekey hallmark of cancer and acquisition of apoptosis resistance is accordingly a key mechanism of drug acquiredefficacies and the development of resistance to apoptosis is tightly associated with the emergence of acquiredsensitivity to undergo apoptosis using various means promises an effective strategy for the management of acquired

Keywords： acquired resistance     EGFR inhibitor     apoptosis     lung cancer    

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lung microbiota and important taxa predicting clinical prognosis in patients with severe community-acquired

Frontiers of Medicine 2022, Volume 16, Issue 3,   Pages 389-402 doi: 10.1007/s11684-021-0856-3

Abstract: described the key features and prognostic roles of lung microbiota in patients with severe community-acquired

Keywords： severe community-acquired pneumonia     lung microbiota     clinical improvements     7-category ordinal scale    

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bone marrow transplantation in patients with severe aplastic anemia-II that progressed from non-severe acquired

Frontiers of Medicine 2021, Volume 15, Issue 5,   Pages 718-727 doi: 10.1007/s11684-020-0807-4

Abstract: Severe aplastic anemia II (SAA-II) progresses from non-severe aplastic anemia (NSAA). The unavailability of efficacious treatment has prompted the need for haploidentical bone marrow transplantation (haplo-BMT) in patients lacking a human leukocyte antigen (HLA)-matched donor. This study aimed to investigate the efficacy of haplo-BMT for patients with SAA-II. Twenty-two patients were included and followed up, and FLU/BU/CY/ATG was used as conditioning regimen. Among these patients, 21 were successfully engrafted, 19 of whom survived after haplo-BMT. Four patients experienced grade II–IV aGvHD, including two with grade III–IV aGvHD. Six patients experienced chronic GvHD, among whom four were mild and two were moderate. Twelve patients experienced infections during BMT. One was diagnosed with post-transplant lymphoproliferative disorder and one with probable EBV disease, and both recovered after rituximab infusion. Haplo-BMT achieved 3-year overall survival and disease-free survival rate of 86.4%±0.73% after a median follow-up of 42 months, indicating its effectiveness as a salvage therapy. These promising outcomes may support haplo-BMT as an alternative treatment strategy for patients with SAA-II lacking HLA-matched donors.

Keywords： severe aplastic anemia     non-severe acquired aplastic anemia     haploidentical bone marrow transplantation    

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Analysis of antibiotic usage for viral community-acquired pneumonia in adults

Rongmeng Jiang, Bing Han, Chang Dou, Fei Zhou, Bin Cao, Xingwang Li

Frontiers of Medicine 2021, Volume 15, Issue 1,   Pages 139-143 doi: 10.1007/s11684-019-0736-2

Abstract: The rationale for the antibiotic treatment of viral community-acquired pneumonia (CAP) in adults was

Keywords： adult     antibiotic     viral pneumonia    

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Diagnosis and management of acquired thrombotic thrombocytopenic purpura in southeast China: a single

Xinping Zhou,Xingnong Ye,Yanling Ren,Chen Mei,Liya Ma,Jiansong Huang,Weilai Xu,Juying Wei,Li Ye,Wenyuan Mai,Wenbin Qian,Haitao Meng,Jie Jin,Hongyan Tong

Frontiers of Medicine 2016, Volume 10, Issue 4,   Pages 430-436 doi: 10.1007/s11684-016-0492-5

Abstract:

Acquired thrombotic thrombocytopenic purpura (TTP) is a rare life-threatening thrombotic microangiopathyThis study aimed to provide a profile of the diagnosis and management of patients with acquired TTP collectedA total of 60 patients diagnosed with acute acquired TTP from March 2005 to August 2015 were enrolled

Keywords： thrombotic thrombocytopenic purpura     ADAMTS 13     plasma exchange    

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Sudden death due to arrhythmogenic right ventricular cardiomyopathy: Two case reports

CHEN Xinshan, ZHANG Yigu, RAO Guangxun, HUANG Guangzhao

Frontiers of Medicine 2007, Volume 1, Issue 3,   Pages 338-342 doi: 10.1007/s11684-007-0065-8

Abstract: not be explained by a single cause or factor and they are probably related to various congenital and acquired

Keywords： sarcoplasmic coagulation     acquired     ventricular myocardium     sino-atrial     autopsied    

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Study on factors affecting TB/HIV co-infection in four counties of China

Shi-Ming CHENG MD, Yu-Ji LAI MS, Er-Yong LIU MS, Lin ZHOU MD, Xue-Jing WANG MS, Qiu-Lan CHEN MS, Dong-Ming LI MS, Ning WANG MD,

Frontiers of Medicine 2010, Volume 4, Issue 2,   Pages 185-191 doi: 10.1007/s11684-010-0040-7

Abstract: HIV test among TB patients and TB examination among people living with HIV/acquired immunodeficiency

Keywords： tuberculosis/acquired immunodeficiency syndrome     dual infection     prevention and control     case detection    

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Co-infection of HIV and parasites in China: Results from an epidemiological survey in rural areas of Fuyang city, Anhui province, China

Li-Guang TIAN MPH, Jia-Xu CHEN PhD, Yu-Chun CAI BM, Jian GUO MPH, Xiao-Mei TONG, Qin LIU DVM, Xiao-Nong ZHOU PhD, Tian-Ping WANG PhD, Xiao-Mei YIN, Wei-Duo WU, Li ZHOU, Feng-Feng WANG, Zhen-Li WANG MSc, Guo-Jin CHENG, Peter STEINMANN PhD, Lan-Hua LI MSc,

Frontiers of Medicine 2010, Volume 4, Issue 2,   Pages 192-198 doi: 10.1007/s11684-010-0039-0

Abstract: The aim of this study was to investigate epidemiological characteristics of co-infection of HIV and intestinal parasites in a HIV/AIDS highly endemic area in China. A cross-sectional survey was carried out in two villages where HIV/AIDS prevalence in residents was over 1%. Stool samples of all residents in the two targeted villages were examined for the presence of intestinal parasites. Blood examination was performed for the HIV infection detection and anemia test. A questionnaire survey was carried out in all residents participating in the study. A total of 769 individuals were enrolled in the investigation, 720 of whom were involved in stool examination of intestinal parasites. The infection rates of parasites in the residents of the targeted villages were as follows: 0.56% for , 4.03% for Hookworm, 0.28% for , 0.42% for , 21.39% for , 3.89% for , 1.67% for spp., 4.44% for spp., and no infection for . The overall infection rate of intestinal worms was 4.72%, intestinal parasite infection rate was 24.31%, the anemia prevalence rate was 34.68%, the co-infection rate of HIV and intestinal helminthes 2.17%, the co-infection rate of HIV and intestinal protozoa 28.26%, of which the co-infection rates of HIV and , and HIV and spp. were 19.57% and 13.04%, respectively. A significant difference of spp. infection rate was found between HIV-positive group (13.04%) and HIV-negative group (4.70%) (<0.05). Higher prevalence of anemia (34.68%) occurred in the study villages, particularly in children (>50%) and women (>39%). It was concluded that the infection rate of intestinal protozoa in the residents was higher than that of intestinal helminthes in the local setting, and a same pattern appeared in the co-infection rate of HIV and parasites. An interesting finding is that the infection rate of spp. among the HIV-positives was significantly higher than that in the HIV-negatives, and children and women had higher anemia prevalence.

Keywords： human immunodeficiency virus (HIV)     acquired immunodeficiency syndrome (AIDS)     co-infection     intestinal    

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Title Author Date Type Operation

Targeting apoptosis to manage acquired resistance to third generation EGFR inhibitors

Journal Article

lung microbiota and important taxa predicting clinical prognosis in patients with severe community-acquired

Journal Article

bone marrow transplantation in patients with severe aplastic anemia-II that progressed from non-severe acquired

Journal Article

Analysis of antibiotic usage for viral community-acquired pneumonia in adults

Rongmeng Jiang, Bing Han, Chang Dou, Fei Zhou, Bin Cao, Xingwang Li

Journal Article

Diagnosis and management of acquired thrombotic thrombocytopenic purpura in southeast China: a single

Xinping Zhou,Xingnong Ye,Yanling Ren,Chen Mei,Liya Ma,Jiansong Huang,Weilai Xu,Juying Wei,Li Ye,Wenyuan Mai,Wenbin Qian,Haitao Meng,Jie Jin,Hongyan Tong

Journal Article

Sudden death due to arrhythmogenic right ventricular cardiomyopathy: Two case reports

CHEN Xinshan, ZHANG Yigu, RAO Guangxun, HUANG Guangzhao

Journal Article

Study on factors affecting TB/HIV co-infection in four counties of China

Shi-Ming CHENG MD, Yu-Ji LAI MS, Er-Yong LIU MS, Lin ZHOU MD, Xue-Jing WANG MS, Qiu-Lan CHEN MS, Dong-Ming LI MS, Ning WANG MD,

Journal Article

Co-infection of HIV and parasites in China: Results from an epidemiological survey in rural areas of Fuyang city, Anhui province, China

Li-Guang TIAN MPH, Jia-Xu CHEN PhD, Yu-Chun CAI BM, Jian GUO MPH, Xiao-Mei TONG, Qin LIU DVM, Xiao-Nong ZHOU PhD, Tian-Ping WANG PhD, Xiao-Mei YIN, Wei-Duo WU, Li ZHOU, Feng-Feng WANG, Zhen-Li WANG MSc, Guo-Jin CHENG, Peter STEINMANN PhD, Lan-Hua LI MSc,

Journal Article