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2022 1

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fluorescent probe 1

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lipoylation modification 1

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A dual-function chemical probe for detecting erasers of lysine lipoylation

Yusheng Xie, Jie Zhang, Liu Yang, Qingxin Chen, Quan Hao, Liang Zhang, Hongyan Sun

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 1,   Pages 121-127 doi: 10.1007/s11705-021-2051-0

Abstract: we have designed and synthesized a dual-function probe KTLlip for studying enzymatic delipoylation (eraser) activity and interaction of lysine lipoylation with the eraser at the same time.as a useful tool to detect delipoylation as demonstrated by its ability to fluorescently label the eraser

Keywords： dual-function     fluorescent probe     labeling     photo-cross-linker     lipoylation modification     eraser     sirtuin    

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A dual-function chemical probe for detecting erasers of lysine lipoylation

Yusheng Xie, Jie Zhang, Liu Yang, Qingxin Chen, Quan Hao, Liang Zhang, Hongyan Sun

Journal Article