Micronization of curcumin with biodegradable polymer by supercritical anti-solvent using micro swirl
Kimthet Chhouk, Wahyudiono, Hideki Kanda, Shin-Ichro Kawasaki, Motonobu Goto
Frontiers of Chemical Science and Engineering
2018,
Volume 12,
Issue 1,
Pages 184-193
doi:
10.1007/s11705-017-1678-3
Abstract:
Curcumin is a hydrophobic polyphenol compound exhibiting a wide range of biological activities such as anti-inflammatory, anti-bacterial, anti-fungal, anti-carcinogenic, anti-human immunodeficiency virus, and anti-microbial activity. In this work, a swirl mixer was employed to produce the micronized curcumin with polyvinylpyrrolidone (PVP) by the supercritical anti-solvent process to improve the bioavailability of curcumin. The effects of operating parameters such as curcumin/PVP ratio, feed concentration, temperature, pressure, and CO flow rate were investigated. The characterization and solubility of particles were determined by using scanning electron microscopy, Fourier Transform Infrared spectroscopy, and ultra-violet-visible spectroscopy. The result shows that the optimal condition for the production of curcumin/PVP particles is at curcumin/PVP ratio of 1:30, feed concentration of 5 mg·mL , temperature of 40 °C, pressure of 15 MPa, and CO flow rate of 15 mL·min . Moreover, the dissolution of curcumin/PVP particles is faster than that of raw curcumin.
Keywords：
micronization
curcumin
polyvinylpyrrolidone
supercritical anti-solvent
swirl mixer
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