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resistin 2

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Effects of resistin on insulin signaling in endothelial cells

Zhizhen LI, Fangping LI, Jianhong YE, Li YAN, Zuzhi FU

Frontiers of Medicine 2009, Volume 3, Issue 2, Pages 136-140 doi: 10.1007/s11684-009-0029-2

Abstract: The objective of this study was to investigate the effects of resistin on insulin signaling in humanHUVECs were incubated with recombinant human resistin (0-100 ng/mL) for 24 h.The results showed that resistin could significantly inhibit Akt and eNOS phosphorylation and NO productionBut under basal conditions, treatment with resistin could result in a decrease in eNOS phosphorylationThese findings suggested that resistin exerted an inhibitory effect on NO production by inhibiting insulin

Keywords： resistin endothelium nitric oxide endothelial nitric oxide synthase Akt-binding protein mouse

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Effects of resistin on skeletal glucose metabolism

Fang-Ping LI, Zhi-Zhen LI, Miao ZHANG, Li YAN, Zu-Zhi FU

Frontiers of Medicine 2010, Volume 4, Issue 3, Pages 329-335 doi: 10.1007/s11684-010-0091-9

Abstract: Resistin is an adipokine highly related to insulin resistance (IR).The purpose of our research was to investigate how resistin influences skeletal glucose metabolism andWe constructed the recombinant plasmid pcDNA3.1 expressing resistin and then transfected it into C2C12The expression of resistin in C2C12 myocytes was detected by Western blotting.We observed that resistin was expressed in transfected myocytes, and resistin decreased insulin induced

Keywords： resistin insulin resistance skeletal muscle

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Study on the action of resistin-induced human umbilical vein endothelial cell dysfunction

LI Zhizhen, LI Fangping, YAN Li, LI Feng, LI Yan, CHENG Hua, FU Zuzhi

Frontiers of Medicine 2007, Volume 1, Issue 2, Pages 196-199 doi: 10.1007/s11684-007-0037-z

Abstract: The aim of this paper was to investigate the effects of resistin on human umbilical vein endothelialHUVECs were incubated with recombinant human resistin (0, 50, 100 ng/mL) for 24 h.Incubation of HUVECs with resistin resulted in an increase in ICAM-1 expression and ET-1 mRNA expressionnot altered by resistin stimulation.Adipokine resistin exerted a direct effect in promoting HUVEC dysfunction by promoting ICAM-1 and ET-

Keywords： endothelial resistin stimulation Incubation pathogenesis dysfunction