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Various brain-eating amoebae: the protozoa, the pathogenesis, and the disease

Frontiers of Medicine 2021, Volume 15, Issue 6,   Pages 842-866 doi: 10.1007/s11684-021-0865-2

Abstract: The mechanisms of pathogenesis, immunology, pathophysiology, clinical manifestations, epidemiology, diagnosis

Keywords： free-living amoebae     central nervous system infection     primary amoebic meningoencephalitis     granulomatous amoebic encephalitis    

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Obesity-related glomerulopathy: pathogenesis, pathologic, clinical characteristics and treatment

Tianhua Xu, Zitong Sheng, Li Yao

Frontiers of Medicine 2017, Volume 11, Issue 3,   Pages 340-348 doi: 10.1007/s11684-017-0570-3

Abstract:

In light of the rapid increase in the number of obesity incidences worldwide, obesity has become an independent risk factor for chronic kidney disease. Obesity-related glomerulopathy (ORG) is characterized by glomerulomegaly in the presence or absence of focal and segmental glomerulosclerosis lesions. IgM and complement 3 (C3) nonspecifically deposit in lesions without immune-complex-type deposits during ORG immunofluorescence. ORG-associated glomerulomegaly and focal and segmental glomerulosclerosis can superimpose on other renal pathologies. The mechanisms under ORG are complex, especially hemodynamic changes, inflammation, oxidative stress, apoptosis, and reduced functioning nephrons. These mechanisms synergize with obesity to induce end-stage renal disease. A slow increase of subnephrotic proteinuria (<3.5 g/d) is the most common clinical manifestation of ORG. Several treatment methods for ORG have been developed. Of these methods, renin–angiotensin–aldosterone system blockade and weight loss are proven effective. Targeting mitochondria may offer a novel strategy for ORG therapy. Nevertheless, more research is needed to further understand ORG.

Keywords： obesity-related glomerulopathy     pathogenesis     pathologic     clinical characteristics    

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MicroRNAs and lung cancers: from pathogenesis to clinical implications

Ji Qi, David Mu

Frontiers of Medicine 2012, Volume 6, Issue 2,   Pages 134-155 doi: 10.1007/s11684-012-0188-4

Abstract: summarize the functions of small-RNA-based, posttranscriptional gene regulators, i.e. microRNAs, in the pathogenesis

Keywords： lung biology     lung cancer     microRNA    

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Advances in COVID-19: the virus, the pathogenesis, and evidence-based control and therapeutic strategies

Guangbiao Zhou, Saijuan Chen, Zhu Chen

Frontiers of Medicine 2020, Volume 14, Issue 2,   Pages 117-125 doi: 10.1007/s11684-020-0773-x

Abstract: By sharing knowledge and deepening our understanding of the virus and the disease pathogenesis, we believe

Keywords： COVID-19     SARS-CoV-2     pathogenesis     evidence-based medicine     control and therapeutic strategies    

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Molecular pathogenesis of acute myeloid leukemia: A diverse disease with new perspectives

Felicitas THOL, Arnold GANSER

Frontiers of Medicine 2010, Volume 4, Issue 4,   Pages 356-362 doi: 10.1007/s11684-010-0220-5

Abstract: Understanding the pathogenesis of AML better is crucial for finding new treatment approaches.

Keywords： acute myeloid leukemia     mutations     risk stratification    

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Pathogenesis, diagnosis, and treatment of recurrent spontaneous abortion with immune type

Qi-De LIN, Li-Hua QIU

Frontiers of Medicine 2010, Volume 4, Issue 3,   Pages 275-279 doi: 10.1007/s11684-010-0101-y

Abstract: The pathogenesis of autoimmune RSA was mainly associated with antiphospholipid antibody (APA), while

Keywords： spontaneous abortion     recurrent     autoimmune     alloimmune     pathogenesis     diagnosis     immunotherapy    

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Toll-like receptor signaling in hematopoietic homeostasis and the pathogenesis of hematologic diseases

Joseph Cannova,Peter Breslin S.J.,Jiwang Zhang

Frontiers of Medicine 2015, Volume 9, Issue 3,   Pages 288-303 doi: 10.1007/s11684-015-0412-0

Abstract: Dysregulated TLR signaling contributes to the pathogenesis of many hematopoietic disorders, including

Keywords： TLR     MyD88     hematopoiesis     bone marrow failure     leukemia     myelodysplastic syndrome    

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Increased expression of coronin-1a in amyotrophic lateral sclerosis: a potential diagnostic biomarker and therapeutic target

Frontiers of Medicine 2022, Volume 16, Issue 5,   Pages 723-735 doi: 10.1007/s11684-021-0905-y

Abstract: In conclusion, the role of CORO1A in ALS pathogenesis was discovered, potentially affecting the disease

Keywords： amyotrophic lateral sclerosis     coronin-1a     autophagy     pathogenesis    

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AML1-ETO driven acute leukemia: insights into pathogenesis and potential therapeutic approaches

Megan A. Hatlen, Lan Wang, Stephen D. Nimer

Frontiers of Medicine 2012, Volume 6, Issue 3,   Pages 248-262 doi: 10.1007/s11684-012-0206-6

Abstract:

The AML1-ETO fusion transcription factor is generated by the t(8;21) translocation, which is present in approximately 4%–12% of adult and 12%–30% of pediatric acute myeloid leukemia (AML) patients. Both human and mouse models of AML have demonstrated that AML1-ETO is insufficient for leukemogenesis in the absence of secondary events. In this review, we discuss the pathogenetic insights that have been gained from identifying the various events that can cooperate with AML1-ETO to induce AML in vivo. We also discuss potential therapeutic strategies for t(8;21) positive AML that involve targeting the fusion protein itself, the proteins that bind to it, or the genes that it regulates. Recently published studies suggest that a targeted therapy for t(8;21) positive AML is feasible and may be coming sometime soon.

Keywords： AML1-ETO     mouse model     leukemia     t(8     21)     pathway hits     mutation     hematopoiesis     Kasumi-1     CD34+    

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Reconsideration of endometriosis and its clinical significance

Lang Jinghe

Strategic Study of CAE 2009, Volume 11, Issue 10,   Pages 137-142

Abstract: Our series of conceptions about EM pathogenesis could be summarized as "3A"  model, "

Keywords： Endometriosis     pathogenesis     diagnosis     treatment    

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Review of hand, foot and mouth disease

Lan-Juan LI MD,

Frontiers of Medicine 2010, Volume 4, Issue 2,   Pages 139-146 doi: 10.1007/s11684-010-0033-6

Abstract: It is time to step up efforts to understand the molecular epidemics and pathogenesis so that we can develop

Keywords： hand     foot and mouth disease     epidemiology     pathogenesis     management     surveillance    

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Pathogenesis of pandemic H1N1 2009 influenza virus infection and the implication on management

Kelvin Kai-Wang TO FRCPath, Iris Wai-Sum LI FRCP, Ivan Fan-Ngai HUNG FRCP, Vincent Chi-Chung CHENG FRCPath, Kwok-Yung YUEN MD,

Frontiers of Medicine 2010, Volume 4, Issue 2,   Pages 147-156 doi: 10.1007/s11684-010-0030-9

Abstract: The pandemic H1N1 2009 influenza virus has caused the first influenza pandemic of the 21st century, leading to disproportionate fatalities in the low-risk population despite the generally mild nature of the illness. Advances in sci

Keywords： influenza A virus     H1N1 subtype     pandemic     pathogenesis     virulence factors     immunity     management     antiviral    

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Pathogenesis sequences in Gejiu miners with lung cancer: an introduction

Li Bian,Yonghua Ruan,Liju Ma,Hairong Hua,Li Zhou,Xiaoyu Tuo,Zheyan Zhou,Ting Li,Shiyue Liu,Kewei Jin

Frontiers of Medicine 2015, Volume 9, Issue 3,   Pages 344-349 doi: 10.1007/s11684-015-0399-6

Abstract:

Tin miners in Gejiu, Yunnan Province, China are at high risk of developing lung cancer with significant occupational characteristics. Tissue samples from these miners presented pathological characteristics, such as fibroplasia in carcinomas, peri-cancerous tissue in lung cancers, and hyperplasia and dysplasia of epithelial cells in peri-cancerous tissue. Carcinomas induced by Yunnan tin mine dust in the animal experiment underwent inflammation, fibroplasia, hyperplasia, dysplasia, and carcinogenesis of epithelial cells. A correlated and synergistic relationship was observed between bronchial epithelial cell transformation and fibroblast activation in vitro induced by mine dust. Fibroblast hyperplasia and activation are important factors that promote the transformation and carcinogenesis of epithelial cells. Our findings suggested that pulmonary fibrosis may increase the risk and promote the occurrence of lung cancer, which can lead to lung fiber hyperplasia.

Keywords： Yunnan tin mine     miners     lung cancer    

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Study on the action of resistin-induced human umbilical vein endothelial cell dysfunction

LI Zhizhen, LI Fangping, YAN Li, LI Feng, LI Yan, CHENG Hua, FU Zuzhi

Frontiers of Medicine 2007, Volume 1, Issue 2,   Pages 196-199 doi: 10.1007/s11684-007-0037-z

Abstract: These data suggest that adipocyteendothelium cross-talk might play an important role in the pathogenesis

Keywords： endothelial     resistin stimulation     Incubation     pathogenesis     dysfunction    

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Avian influenza A: an avian influenza virus from low pathogenic to highly pathogenic

William J. Liu, Haixia Xiao, Lianpan Dai, Di Liu, Jianjun Chen, Xiaopeng Qi, Yuhai Bi, Yi Shi, George F. Gao, Yingxia Liu

Frontiers of Medicine 2021, Volume 15, Issue 4,   Pages 507-527 doi: 10.1007/s11684-020-0814-5

Abstract: summarized and discussed from the perspectives of molecular epidemiology, clinical features, virulence and pathogenesis

Keywords： H7N9     HPAIV     epidemiology     clinical features     pathogenesis     hemagglutinin     immunity     vaccine    

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Title Author Date Type Operation

Various brain-eating amoebae: the protozoa, the pathogenesis, and the disease

Journal Article

Obesity-related glomerulopathy: pathogenesis, pathologic, clinical characteristics and treatment

Tianhua Xu, Zitong Sheng, Li Yao

Journal Article

MicroRNAs and lung cancers: from pathogenesis to clinical implications

Ji Qi, David Mu

Journal Article

Advances in COVID-19: the virus, the pathogenesis, and evidence-based control and therapeutic strategies

Guangbiao Zhou, Saijuan Chen, Zhu Chen

Journal Article

Molecular pathogenesis of acute myeloid leukemia: A diverse disease with new perspectives

Felicitas THOL, Arnold GANSER

Journal Article

Pathogenesis, diagnosis, and treatment of recurrent spontaneous abortion with immune type

Qi-De LIN, Li-Hua QIU

Journal Article

Toll-like receptor signaling in hematopoietic homeostasis and the pathogenesis of hematologic diseases

Joseph Cannova,Peter Breslin S.J.,Jiwang Zhang

Journal Article

Increased expression of coronin-1a in amyotrophic lateral sclerosis: a potential diagnostic biomarker and therapeutic target

Journal Article

AML1-ETO driven acute leukemia: insights into pathogenesis and potential therapeutic approaches

Megan A. Hatlen, Lan Wang, Stephen D. Nimer

Journal Article

Reconsideration of endometriosis and its clinical significance

Lang Jinghe

Journal Article

Review of hand, foot and mouth disease

Lan-Juan LI MD,

Journal Article

Pathogenesis of pandemic H1N1 2009 influenza virus infection and the implication on management

Kelvin Kai-Wang TO FRCPath, Iris Wai-Sum LI FRCP, Ivan Fan-Ngai HUNG FRCP, Vincent Chi-Chung CHENG FRCPath, Kwok-Yung YUEN MD,

Journal Article

Pathogenesis sequences in Gejiu miners with lung cancer: an introduction

Li Bian,Yonghua Ruan,Liju Ma,Hairong Hua,Li Zhou,Xiaoyu Tuo,Zheyan Zhou,Ting Li,Shiyue Liu,Kewei Jin

Journal Article

Study on the action of resistin-induced human umbilical vein endothelial cell dysfunction

LI Zhizhen, LI Fangping, YAN Li, LI Feng, LI Yan, CHENG Hua, FU Zuzhi

Journal Article

Avian influenza A: an avian influenza virus from low pathogenic to highly pathogenic

William J. Liu, Haixia Xiao, Lianpan Dai, Di Liu, Jianjun Chen, Xiaopeng Qi, Yuhai Bi, Yi Shi, George F. Gao, Yingxia Liu

Journal Article