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senescence 4

Bushenkangshuai Tang 1

Caenorhabditis elegans 1

CBX3 1

ECRG4 1

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Twist 1

UV irradiation 1

cancer 1

cell senescence 1

cervical cancer 1

cisplatin 1

diabetic nephropathy 1

drug resistance 1

epithelium homeostasis 1

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Reactive oxygen species generation is essential for cisplatin-induced accelerated senescence in hepatocellular

Kai Qu,Ting Lin,Zhixin Wang,Sinan Liu,Hulin Chang,Xinsen Xu,Fandi Meng,Lei Zhou,Jichao Wei,Minghui Tai,Yafeng Dong,Chang Liu

Frontiers of Medicine 2014, Volume 8, Issue 2,   Pages 227-235 doi: 10.1007/s11684-014-0327-1

Abstract:

Accelerated senescence is important because this process is involved in tumor suppression and hasHowever, the molecular mechanism of cisplatin-induced accelerated senescence in hepatocellular carcinomaCellular senescence was then assessed by β-galactosidase assay.Furthermore, cisplatin-induced accelerated senescence depended on intracellular ROS generation.The ROS scavenger N-acetyl-L-cysteine also significantly suppressed the cisplatin-induced senescence

Keywords： reactive oxygen species     senescence     cisplatin     hepatocellular carcinoma    

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Correlation of Twist upregulation and senescence bypass during the progression and metastasis of cervical

Tian Wang, Yan Li, Abidan Tuerhanjiang, Wenwen Wang, Zhangying Wu, Ming Yuan, Shixuan Wang

Frontiers of Medicine 2014, Volume 8, Issue 1,   Pages 106-112 doi: 10.1007/s11684-014-0307-5

Abstract: Cellular senescence has been proposed as the mechanism that protects an organism against cancer progressionThe strong positive expressions of the senescence marker CBX3 were 39.1%, 32%, and 15.6%, respectivelyof Twist with target siRNA in SiHa triggered the induction of the chromatin marker of the cellular senescenceCBX3 and senescence-associated β-galactosidase activity.Furthermore, Twist-induced senescence bypass is important in this process.

Keywords： cervical cancer     senescence     Twist     CBX3     lymph node metastasis    

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Preventive effect of Shenkang injection against high glucose-induced senescence of renal tubular cells

Biqiong Fu, Jie Yang, Jia Chen, Lirong Lin, Kehong Chen, Weiwei Zhang, Jianguo Zhang, Yani He

Frontiers of Medicine 2019, Volume 13, Issue 2,   Pages 267-276 doi: 10.1007/s11684-017-0586-8

Abstract: aimed to investigate the protective effect of SKI against high glucose (HG)-induced renal tubular cell senescenceHG-induced senescent cells showed the emergence of senescence associated heterochromatin foci, up-regulationof P16 and cyclin D1, increased senescence-associated β-galactosidase activity, and elevated expressionSKI treatment prevented HG-induced up-regulation of pro-senescence molecule mammalian target of rapamycinSKI may be a novel strategy for protecting against HG-induced renal tubular cell senescence in treatment

Keywords： Shenkang injection     senescence     renal tubular epithelial cells     diabetic nephropathy    

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Taking advantage of drug resistance, a new approach in the war on cancer

Liqin Wang, Rene Bernards

Frontiers of Medicine 2018, Volume 12, Issue 4,   Pages 490-495 doi: 10.1007/s11684-018-0647-7

Abstract:

Identification of the driver mutations in cancer has resulted in the development of a new category of molecularly targeted anti-cancer drugs. However, as was the case with conventional chemotherapies, the effectiveness of these drugs is limited by the emergence of drug-resistant variants. While most cancer therapies are given in combinations that are designed to avoid drug resistance, we discuss here therapeutic approaches that take advantage of the changes in cancer cells that arise upon development of drug resistance. This approach is based on notion that drug resistance comes at a fitness cost to the cancer cell that can be exploited for therapeutic benefit. We discuss the development of sequential drug therapies in which the first therapy is not given with curative intent, but to induce a major new sensitivity that can be targeted with a second drug that selectively targets the acquired vulnerability. This concept of collateral sensitivity has hitherto not been used on a large scale in the clinic and holds great promise for future cancer therapy.

Keywords： cancer     drug resistance     genetic screens     senescence     targeted therapy    

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ECRG4: a new potential target in precision medicine

Xin Qin, Ping Zhang

Frontiers of Medicine 2019, Volume 13, Issue 5,   Pages 540-546 doi: 10.1007/s11684-018-0637-9

Abstract: Given the rapid development in precision medicine, tremendous efforts have been devoted to discovering new biomarkers for disease diagnosis and treatment. Esophageal cancer-related gene-4 ( ), which is initially known as a new candidate tumor suppressor gene, is emerging as a sentinel molecule for gauging tissue homeostasis. ECRG4 is unique in its cytokine-like functional pattern and epigenetically-regulated gene expression pattern. The gene can be released from the cell membrane upon activation and detected in liquid biopsy, thus offering considerable potential in precision medicine. This review provides an updated summary on the biology of ECRG4, with emphasis on its important roles in cancer diagnosis and therapy. The future perspectives of ECRG4 as a potential molecular marker in precision medicine are also discussed in detail.

Keywords： ECRG4     tumor suppressor gene     sentinel molecule     precision medicine     cell senescence     epithelium homeostasis    

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Administration with

Qi RUI, Qin LU, Dayong WANG

Frontiers of Medicine 2009, Volume 3, Issue 1,   Pages 76-90 doi: 10.1007/s11684-009-0002-0

Abstract: During normal metabolism, oxidative byproducts will inevitably generate and damage molecules thereby impairing their biological functions, including the aging process. (补肾抗衰方, ) is a traditional Chinese medicine widely used for clinically treating premature ovarian failure. In the present study, administration at high concentrations significantly increased lifespan, slowed aging-related decline, and delayed accumulation of aging-related cellular damage in wild-type . administration could further largely alleviate the aging defects induced by UV and oxidative stresses, and administration at different concentrations could largely rescue the aging defects in mutant animals. The protective effects of administration on aging process were at least partially dependent on the Ins/IGF-like signaling pathway. Moreover, administration at different concentrations obviously altered the expression patterns of antioxidant genes and suppressed the severe stress responses induced by UV and oxidative stresses, suggesting that -induced tolerance to UV or oxidative stress might result from reactive oxygen species scavenging. administration during development was not necessarily a requirement for UV and oxidative stress resistance, and the concentrations of administrated examined were not toxic for nematodes. Therefore, administration could effectively retrieve the aging defects induced by UV irradiation and oxidative stress in .

Keywords： Bushenkangshuai Tang     UV irradiation     oxidative stress     tissue senescence     lifespan        

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Title Author Date Type Operation

Reactive oxygen species generation is essential for cisplatin-induced accelerated senescence in hepatocellular

Kai Qu,Ting Lin,Zhixin Wang,Sinan Liu,Hulin Chang,Xinsen Xu,Fandi Meng,Lei Zhou,Jichao Wei,Minghui Tai,Yafeng Dong,Chang Liu

Journal Article

Correlation of Twist upregulation and senescence bypass during the progression and metastasis of cervical

Tian Wang, Yan Li, Abidan Tuerhanjiang, Wenwen Wang, Zhangying Wu, Ming Yuan, Shixuan Wang

Journal Article

Preventive effect of Shenkang injection against high glucose-induced senescence of renal tubular cells

Biqiong Fu, Jie Yang, Jia Chen, Lirong Lin, Kehong Chen, Weiwei Zhang, Jianguo Zhang, Yani He

Journal Article

Taking advantage of drug resistance, a new approach in the war on cancer

Liqin Wang, Rene Bernards

Journal Article

ECRG4: a new potential target in precision medicine

Xin Qin, Ping Zhang

Journal Article

Administration with

Qi RUI, Qin LU, Dayong WANG

Journal Article