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Toll-like receptor signaling in hematopoietic homeostasis and the pathogenesis of hematologic diseases

Joseph Cannova,Peter Breslin S.J.,Jiwang Zhang

Frontiers of Medicine 2015, Volume 9, Issue 3, Pages 288-303 doi: 10.1007/s11684-015-0412-0

Abstract: Accumulating evidence suggests that TLR signaling is involved in normal hematopoiesis and specific hematologicSterile activation of TLR signaling is required to generate early embryonic hematopoietic progenitorIn adult animals, TLR signaling directly or indirectly promotes differentiation of myeloid cells at theActivating mutations of the MyD88 gene, which codes for a key adaptor involved in TLRDysregulated TLR signaling contributes to the pathogenesis of many hematopoietic disorders, including

Keywords： TLR MyD88 hematopoiesis bone marrow failure leukemia myelodysplastic syndrome

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Effects of the

Yi FANG,Xiangwei FU,Junjie LI,Ming DU,Baoyu JIA,Jinlong ZHANG,Xiaosheng ZHANG,Shien ZHU

Frontiers of Agricultural Science and Engineering 2014, Volume 1, Issue 4, Pages 314-320 doi: 10.15302/J-FASE-2014038

Abstract: This study was conducted to systematically assess the reproductive performance of transgenic ewes. In the transgenic founders (F ) and their positive offspring (F ), hematological and reproductive parameters and the global DNA methylation level in oocytes at various stages were analyzed. The values of the physiological and biochemical parameters determined from the blood samples did not differ significantly between the transgenic and wild-type ewes. Moreover, the transgenic ewes showed reproductive traits similar to the wild-type ewes. These traits included characteristics of puberty, the estrus cycle, estrus duration, gestation, the pregnancy rate and the superovulation response. Additionally, no significant differences were found between transgenic and wild-type ewes in the DNA methylation level of the oocytes at various stages. In summary, the preliminary evidence presented in this paper demonstrates that the presence of the transgene did not affect the reproductive performance in sheep.

Keywords： TLR4 transgenic ewe safety assessment reproductive trait oocyte DNA methylation

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Bioactive hyaluronic acid fragments inhibit lipopolysaccharide-induced inflammatory responses via the Toll-like receptor 4 signaling pathway

Na You, Sasa Chu, Binggang Cai, Youfang Gao, Mizhou Hui, Jin Zhu, Maorong Wang

Frontiers of Medicine 2021, Volume 15, Issue 2, Pages 292-301 doi: 10.1007/s11684-020-0806-5

Abstract: B-HA significantly suppressed the phosphorylation of the TLR4 signaling pathway proteins p65, IKKα/β,that the B-HA attenuated the LPS-stimulated inflammatory response by inhibiting the activation of the TLR4

Keywords： bioactive hyaluronan lipopolysaccharide inflammatory cytokines TLR4 human macrophages