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P50 auditory sensory gating in first onset schizophrenics and normal healthy adults

WANG Hongxing, ZHANG Mingdao, CHEN Xingshi, LOU Feiying, LIANG Jianhua, CHEN Chong, SHI Tiantao, LU Qiulin

Frontiers of Medicine 2007, Volume 1, Issue 4,   Pages 429-432 doi: 10.1007/s11684-007-0084-5

Abstract: The aim of this research was to investigate the variations of P50 auditory sensory gating (P50) in normal

Keywords： anterior     Positive     S2-P50     schizophrenic     EMG/EP    

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Behavioral methods for the functional assessment of hair cells in zebrafish

Qin Yang, Peng Sun, Shi Chen, Hongzhe Li, Fangyi Chen

Frontiers of Medicine 2017, Volume 11, Issue 2,   Pages 178-190 doi: 10.1007/s11684-017-0507-x

Abstract:

Zebrafish is an emerging animal model for studies on auditory system.Zebrafish displays a series of innate and robust behavior related to its auditory function.Here, we reviewed the advantage of using zebrafish in auditory research and then introduced three behavioral

Keywords： zebrafish (Danio rerio)     behavior     auditory     startle response     vestibular-ocular reflex     rheotaxis    

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Unidirectional and stage-dependent roles of Notch1 in Wnt-responsive Lgr5

Hui Jiang, Shan Zeng, Wenli Ni, Yan Chen, Wenyan Li

Frontiers of Medicine 2019, Volume 13, Issue 6,   Pages 705-712 doi: 10.1007/s11684-019-0703-y

Abstract: Wnt and Notch signaling play crucial roles in the determination of the prosensory domain and in the differentiation of hair cells (HCs) and supporting cells during mouse inner ear development; however, the relationship between the two signaling pathways in the mouse cochlea remains largely unknown. Here, we investigated the interactions between Notch and Wnt signaling on the basis of the bidirectional regulation of Notch1 specifically in Wnt-responsive Lgr5 progenitors during different cochlear development stages. We found that the downregulation of Notch1 in Lgr5 cells from embryonic day (E) 14.5 to E18.5 can drive the quiescent Lgr5 cells to re-enter the cell cycle and differentiate into extra HCs, whereas the upregulation of Notch1 expression did not affect the proliferation or differentiation of otic progenitor cells. No effect was observed on the upregulation or downregulation of Notch1 in Lgr5 cells from E10.5 to E14.5. We concluded that the roles of Notch1 in Wnt-responsive Lgr5 cells are unidirectional and stage dependent and Notch1 serves as a negative regulator for Lgr5 progenitor activation during cochlear differentiation. Our findings improved the understanding of the interactions between Notch and Wnt signaling in cochlear development.

Keywords： inner ear     cochlear     Wnt     Notch     Lgr5     auditory system    

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Past review, current progress, and challenges ahead on the cocktail party problem Review

Yan-min QIAN, Chao WENG, Xuan-kai CHANG, Shuai WANG, Dong YU

Frontiers of Information Technology & Electronic Engineering 2018, Volume 19, Issue 1,   Pages 40-63 doi: 10.1631/FITEE.1700814

Abstract: cocktail party environment, and describe the conventional single-channel techniques such as computational auditory

Keywords： Cocktail party problem     Computational auditory scene analysis     Non-negative matrix factorization     Permutation    

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Towards human-like and transhuman perception in AI 2.0: a review Review

Yong-hong TIAN,Xi-lin CHEN,Hong-kai XIONG,Hong-liang LI,Li-rong DAI,Jing CHEN,Jun-liang XING,Jing CHEN,Xi-hong WU,Wei-min HU,Yu HU,Tie-jun HUANG,Wen GAO

Frontiers of Information Technology & Electronic Engineering 2017, Volume 18, Issue 1,   Pages 58-67 doi: 10.1631/FITEE.1601804

Abstract: review the state-of-the-art advances across different areas of perception, including visual perception, auditoryperception for the forthcoming era of AI 2.0, including: (1) human-like and transhuman active vision; (2) auditoryperception and computation in an actual auditory setting; (3) speech perception and computation in a

Keywords： Intelligent perception     Active vision     Auditory perception     Speech perception     Autonomous learning    

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Title Author Date Type Operation

P50 auditory sensory gating in first onset schizophrenics and normal healthy adults

WANG Hongxing, ZHANG Mingdao, CHEN Xingshi, LOU Feiying, LIANG Jianhua, CHEN Chong, SHI Tiantao, LU Qiulin

Journal Article

Behavioral methods for the functional assessment of hair cells in zebrafish

Qin Yang, Peng Sun, Shi Chen, Hongzhe Li, Fangyi Chen

Journal Article

Unidirectional and stage-dependent roles of Notch1 in Wnt-responsive Lgr5

Hui Jiang, Shan Zeng, Wenli Ni, Yan Chen, Wenyan Li

Journal Article

Past review, current progress, and challenges ahead on the cocktail party problem

Yan-min QIAN, Chao WENG, Xuan-kai CHANG, Shuai WANG, Dong YU

Journal Article

Towards human-like and transhuman perception in AI 2.0: a review

Yong-hong TIAN,Xi-lin CHEN,Hong-kai XIONG,Hong-liang LI,Li-rong DAI,Jing CHEN,Jun-liang XING,Jing CHEN,Xi-hong WU,Wei-min HU,Yu HU,Tie-jun HUANG,Wen GAO

Journal Article