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Targeting “undruggable” c-Myc protein by synthetic lethality

Chen Wang, Hui Fang, Jiawei Zhang, Ying Gu

Frontiers of Medicine 2021, Volume 15, Issue 4, Pages 541-550 doi: 10.1007/s11684-020-0780-y

Abstract: This method provides a new avenue for targeting “undruggable” proteins, such as c-Myc.Here, we revisit current methods used to target c-Myc and discuss the important functional nodes relatedto c-Myc in non-oncogene addicted network, whose inhibition may cause a catastrophe for tumor cell destiny

Keywords： synthetic lethality undruggable transcription factor c-Myc

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Abnormal expression of c-Myc in human bronchial epithelial cells malignantly transformed by anti-BPDE

FU Juan, JIANG Yiguo, CHEN Xuemin

Frontiers of Medicine 2008, Volume 2, Issue 4, Pages 380-385 doi: 10.1007/s11684-008-0073-3

Abstract: Here, we investigated the expression of proto-oncogene c- in human bronchial epithelial cells (16HBE-TThe levels of mRNA and protein of c-Myc were examined in the 16HBE-T and vehicle-treated control cellsLikewise, the expression of c-Myc protein was significantly enhanced as compared with those of the controlMoreover, the localization of c-Myc protein shows mainly nuclear staining in 16HBE-T.In conclusion, the abnormal expression of c-Myc was present in anti-BPDE malignantly transformed 16HBE

Keywords： transcriptase-polymerase vehicle-treated understood molecular mechanism different

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Chidamide inhibits the NOTCH1-MYC signaling axis in T-cell acute lymphoblastic leukemia

Frontiers of Medicine 2022, Volume 16, Issue 3, Pages 442-458 doi: 10.1007/s11684-021-0877-y

Abstract: In particular, chidamide inhibits the NOTCH1-MYC signaling axis by down-regulating the level of the intracellularform of NOTCH1 (NICD1) as well as MYC, partly through their ubiquitination and degradation by the proteasome

Keywords： T-cell acute lymphoblastic leukemia HDAC inhibitor chidamide NOTCH1 MYC ubiquitination

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The MYC transcription factor network: balancing metabolism, proliferation and oncogenesis

Patrick A. Carroll, Brian W. Freie, Haritha Mathsyaraja, Robert N. Eisenman

Frontiers of Medicine 2018, Volume 12, Issue 4, Pages 412-425 doi: 10.1007/s11684-018-0650-z

Abstract: In this review we focus on the MYC network (also known as the MAX-MLX Network), a highly conserved super-familyImportantly the MYC network has been shown to be deeply involved in a broad spectrum of human and otherMoreover, oncogenic activation of MYC and/or loss of a MYC antagonist, results in an imbalance in the

Keywords： network transcription cancer MYC MAX MLX

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Valveless pumping using a two-stage impedance pump

C.-C. LEE, Y. A. ABAKR, K.-C. WOO

Frontiers of Mechanical Engineering 2013, Volume 8, Issue 3, Pages 311-318 doi: 10.1007/s11465-013-0270-x

Abstract:

Impedance pump is defined as a type of valveless pumping mechanism, where an elastic tube is joined with a tube of different impedance, a periodic asymmetrical compression on part of the elastic tube will produce a unidirectional flow. Numerical and experimental studies had been conducted in the past, but little experimental work was found to exploit the principle of multi-stage impedance pumping for fluid transportation. This paper concentrates on the fluid behavior for an open-loop two-stage system experimentally. The aim of this work is to have an insight on the deliverable head and pumping rate of an open-loop two-stage impedance pumping system. This paper generally investigates the effect of different parameters towards the generation of unidirectional flows and composite flow of two opposite directions. Results obtained are of significant values.

Keywords： valveless pumping open-loop two-stage unidirectional composite

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Design of GPRS Data Terminal Based on S3C2410

Sun Xueyong

Strategic Study of CAE 2007, Volume 9, Issue 12, Pages 94-96

Abstract: hardware structure and working process of the embedded Internetconnected platform, which regards S3C2410

Keywords： GPRS；embedded Internet；S3C2410；SIM100-E

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Bioinspired C/TiO

Jian LI, Likun GAO, Wentao GAN

Frontiers of Agricultural Science and Engineering 2017, Volume 4, Issue 4, Pages 459-464 doi: 10.15302/J-FASE-2017178

Abstract: Hierarchical structures of -carbon-TiO (PP-C-TiO ) were confirmed by SEM observations.Furthermore, the conduction and valence bands of the PP-C-TiO are more negative than the correspondingThat is, the presence of C originating from wings in the PP-C-TiO could extend the photoresponsiveness

Keywords： bioinspired butterfly wings C/TiO₂ photocatalyst visible light

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Antithrombin deficiency and decreased protein C activity in a young man with venous thromboembolism:

Dong Wang, Min Tian, Guanglin Cui, Dao Wen Wang

Frontiers of Medicine 2018, Volume 12, Issue 3, Pages 319-323 doi: 10.1007/s11684-017-0553-4

Abstract:

Antithrombin and protein C are two crucial members in the anticoagulant system and play importantrevealed that the patient presented type I antithrombin deficiency combined with decreased protein Cactivity resulting from a small insertion mutation c.848_849insGATGT in and a short deletion variantc.572_574delAGA in .This study demonstrates that the combination of antithrombin deficiency and decreased protein C activity

Keywords： antithrombin deficiency protein C activity mutation variant venous thromboembolism anticoagulants

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Atomistic simulations of plasma catalytic processes

Erik C. Neyts

Frontiers of Chemical Science and Engineering 2018, Volume 12, Issue 1, Pages 145-154 doi: 10.1007/s11705-017-1674-7

Abstract: There is currently a growing interest in the realisation and optimization of hybrid plasma/catalyst systems for a multitude of applications, ranging from nanotechnology to environmental chemistry. In spite of this interest, there is, however, a lack in fundamental understanding of the underlying processes in such systems. While a lot of experimental research is already being carried out to gain this understanding, only recently the first simulations have appeared in the literature. In this contribution, an overview is presented on atomic scale simulations of plasma catalytic processes as carried out in our group. In particular, this contribution focusses on plasma-assisted catalyzed carbon nanostructure growth, and plasma catalysis for greenhouse gas conversion. Attention is paid to what can routinely be done, and where challenges persist.

Keywords： atomic scale simulation plasma-catalyst

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Elevated C-reactive protein levels predict worsening prognosis in Chinese patients with first-onset stroke

Jiangtao YAN, Rutai HUI, Daowen WANG

Frontiers of Medicine 2009, Volume 3, Issue 1, Pages 30-35 doi: 10.1007/s11684-009-0005-x

Abstract: The role of high sensitivity C-reactive protein (hsCRP) in predicting prognosis after stroke in the Asian

Keywords： C-reactive protein inflammation stroke

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A simple, azulene-based colorimetric probe for the detection of nitrite in water

Lloyd C. Murfin, Carlos M. López-Alled, Adam C. Sedgwick, Jannis Wenk, Tony D. James, Simon E. Lewis

Frontiers of Chemical Science and Engineering 2020, Volume 14, Issue 1, Pages 90-96 doi: 10.1007/s11705-019-1790-7

Abstract: We describe the synthesis and evaluation of an azulene-based chemodosimeter for nitrite. The probe was found to undergo two distinct color changes upon introduction aqueous nitrite ion. A near-instant formation of a grey color provides a qualitative indication of the presence of nitrite, followed by the formation of a deep-yellow/orange color, the endpoint from which quantitative data can be derived. The azulene probe exhibits 1:1 stoichiometry of reaction with nitrite in water, and is selective for nitrite over other anions. The azulene probe was applied to determine nitrite content in cured meat, and compared with the British Standard testing procedure (Griess test). The value obtained from the azulene-based probe agreed closely with the standard test. Our procedure only requires the preparation of one standard solution, instead of the three required for the standard Griess test.

Keywords： azulene nitrite diazoquinone

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Comments on the special issue of

Neil C. TURNER

Frontiers of Agricultural Science and Engineering 2017, Volume 4, Issue 2, Pages 254-255 doi: 10.15302/J-FASE-2017156

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Comments on the special issue on tropical crops of

Luiz J C B CARVALHO

Frontiers of Agricultural Science and Engineering 2016, Volume 3, Issue 4, Pages 375-376 doi: 10.15302/J-FASE-2016129

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Enhancing the efficiency of nitrogen removing bacterial population to a wide range of C:N ratio (1.5:1 to 14:1) for simultaneous C & N removal

Frontiers of Environmental Science & Engineering 2022, Volume 16, Issue 8, doi: 10.1007/s11783-022-1522-y

Abstract:

• Simultaneous C & N removal in Methammox occurs at wide C:N ratio.

Keywords： Methanogens Biological Nitrogen Removal (BNR) Simultaneous Methammox C:N ratio

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Uncertainty propagation analysis by an extended sparse grid technique

JIA, C. JIANG, C. M. FU, B. Y. NI, C. S. WANG, M. H. PING

Frontiers of Mechanical Engineering 2019, Volume 14, Issue 1, Pages 33-46 doi: 10.1007/s11465-018-0514-x

Abstract: In this paper, an uncertainty propagation analysis method is developed based on an extended sparse grid technique and maximum entropy principle, aiming at improving the solving accuracy of the high-order moments and hence the fitting accuracy of the probability density function (PDF) of the system response. The proposed method incorporates the extended Gauss integration into the uncertainty propagation analysis. Moreover, assisted by the Rosenblatt transformation, the various types of extended integration points are transformed into the extended Gauss-Hermite integration points, which makes the method suitable for any type of continuous distribution. Subsequently, within the sparse grid numerical integration framework, the statistical moments of the system response are obtained based on the transformed points. Furthermore, based on the maximum entropy principle, the obtained first four-order statistical moments are used to fit the PDF of the system response. Finally, three numerical examples are investigated to demonstrate the effectiveness of the proposed method, which includes two mathematical problems with explicit expressions and an engineering application with a black-box model.

Keywords： uncertainty propagation analysis extended sparse grid maximum entropy principle extended Gauss integration Rosenblatt transformation high-order moments analysis