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Yi Cao
Frontiers of Medicine 2015, Volume 9, Issue 3, Pages 261-274 doi: 10.1007/s11684-015-0406-y
Keywords： environmental pollution DNA methylation cancer biomarker diagnosis therapy prevention
Stem cell research in hepatocellular carcinoma
SUN Chengyi, ZUO Shi
Frontiers of Medicine 2008, Volume 2, Issue 1, Pages 1-4 doi: 10.1007/s11684-008-0001-6
Keywords： lineage hepato-pancreas differentiation block carcinogenesis current status
Mechanisms and impacts of chromosomal translocations in cancers
Jing H. Wang
Frontiers of Medicine 2012, Volume 6, Issue 3, Pages 263-274 doi: 10.1007/s11684-012-0215-5
Chromosomal aberrations have been associated with cancer development since their discovery more than a hundred years ago. Chromosomal translocations, a type of particular structural changes involving heterologous chromosomes, have made a critical impact on diagnosis, prognosis and treatment of cancers. For example, the discovery of translocation between chromosomes 9 and 22 and the subsequent success of targeting the fusion product BCR-ABL transformed the therapy for chronic myelogenous leukemia. In the past few decades, tremendous progress has been achieved towards elucidating the mechanism causing chromosomal translocations. This review focuses on the basic mechanisms underlying the generation of chromosomal translocations. In particular, the contribution of frequency of DNA double strand breaks and spatial proximity of translocating loci is discussed.
Keywords： DNA double strand breaks chromosomal translocations genomic instability spatial proximity carcinogenesis
Title Author Date Type Operation
Environmental pollution and DNA methylation: carcinogenesis, clinical significance, and practical applications
Yi Cao
Journal Article
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