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R. Lyle Hood,Rudy T. Andriani,Tobias E. Ecker,John L. Robertson,Christopher G. Rylander
Engineering 2015, Volume 1, Issue 3, Pages 344-350 doi: 10.15302/J-ENG-2015077
Convection-enhanced delivery (CED) is a promising technique leveraging pressure-driven flow to increase penetration of infused drugs into interstitial spaces. We have developed a fiberoptic microneedle device for inducing local sub-lethal hyperthermia to further improve CED drug distribution volumes, and this study seeks to quantitatively characterize this approach in agarose tissue phantoms. Infusions of dye were conducted in 0.6% (w/w) agarose tissue phantoms with isothermal conditions at 15 °C, 20 °C, 25 °C, and 30 °C. Infusion metrics were quantified using a custom shadowgraphy setup and image-processing algorithm. These data were used to build an empirical predictive temporal model of distribution volume as a function of phantom temperature. A second set of proof-of-concept experiments was conducted to evaluate a novel fiberoptic device capable of generating local photothermal heating during fluid infusion. The isothermal infusions showed a positive correlation between temperature and distribution volume, with the volume at 30 °C showing a 7-fold increase at 100 min over the 15 °C isothermal case. Infusions during photothermal heating (1064 nm at 500 mW) showed a similar effect with a 3.5-fold increase at 4 h over the control (0 mW). These results and analyses serve to provide insight into and characterization of heat-mediated enhancement of volumetric dispersal.
Keywords: near-infrared laser thermochemotherapy agarose photothermal heating micro-catheter malignant glioma
Li Zhou, Lin Chen, Yang Yu, Tianlei Cui, Xiao Li, Ping Fu
Frontiers of Medicine 2017, Volume 11, Issue 3, Pages 445-448 doi: 10.1007/s11684-017-0520-0
Keywords: superior vena cava intervention vascular access exhaustion catheterization tunneled cuffed hemodialysis catheter
Frontiers of Medicine 2021, Volume 15, Issue 3, Pages 416-437 doi: 10.1007/s11684-021-0852-7
Keywords: surgical aortic valve replacement trans-catheter aortic valve implantation left ventricular hypertrophy
Flexible micro flow sensor for micro aerial vehicles
Rong ZHU, Ruiyi QUE, Peng LIU
Frontiers of Mechanical Engineering 2017, Volume 12, Issue 4, Pages 539-545 doi: 10.1007/s11465-017-0427-0
This article summarizes our studies on micro flow sensors fabricated on a flexible polyimide circuitThe micro flow sensor has merits of flexibility, structural simplicity, easy integrability with circuitsIn our study, we install the fabricated micro flow sensors on micro aerial vehicles (MAVs) to detect
Keywords: micro flow sensor flexible sensor surface flow sensing aerodynamic parameter micro aerial vehicle (MAV
Dependence of error sensitivity of frequency on bias voltage in force-balanced micro accelerometer
Lili CHEN, Wu ZHOU
Frontiers of Mechanical Engineering 2013, Volume 8, Issue 2, Pages 146-149 doi: 10.1007/s11465-013-0260-z
To predict more precisely the frequency of force-balanced micro accelerometer with different biasBased on the theoretical results, micro accelerometer is fabricated and tested to study the influences
Keywords: Micro-Electro-Mechanical Systems (MEMS) micro accelerometer force-balanced micro accelerometer frequency
Numerical simulation of micro scale flowing and boiling
Wen WANG, Rui ZHUAN,
Frontiers in Energy 2009, Volume 3, Issue 4, Pages 396-401 doi: 10.1007/s11708-009-0049-2
Keywords: volume-of-fluid (VOF) micro channel nucleate boiling bubble dynamics simulation
Dynamical research on spherical micro actuator with piezoelectric ceramic stacks drivers
ZHANG Ruihua, CHEN Haichu
Frontiers of Mechanical Engineering 2007, Volume 2, Issue 4, Pages 433-438 doi: 10.1007/s11465-007-0074-y
Keywords: spherical micro-gripper friction coefficient dynamic frequency
Laboratory assessment of Alaska aggregates using Micro-Deval test
Jenny LIU,Sheng ZHAO,Anthony MULLIN
Frontiers of Structural and Civil Engineering 2017, Volume 11, Issue 1, Pages 27-34 doi: 10.1007/s11709-016-0359-5
Keywords: aggregate durability Washington degradation test Micro-Deval test
Characterization of micro-mixing in a novel impinging streams reactor
Hui HU, Zhiming CHEN, Zhen JIAO
Frontiers of Chemical Science and Engineering 2009, Volume 3, Issue 1, Pages 58-64 doi: 10.1007/s11705-009-0106-8
Keywords: micro-mixing impinging streams reactor turbulent mixing mass transfer
Recent advances in micro- and nano-machining technologies
Shang GAO, Han HUANG
Frontiers of Mechanical Engineering 2017, Volume 12, Issue 1, Pages 18-32 doi: 10.1007/s11465-017-0410-9
Keywords: micro machining cutting electro discharge machining (EDM) laser machining focused ion beam (FIB)
Special issue: Micro-electromechanical systems (MEMS)
Zhuangde JIANG
Frontiers of Mechanical Engineering 2017, Volume 12, Issue 4, Pages 457-458 doi: 10.1007/s11465-017-0492-4
Frontiers of Environmental Science & Engineering 2021, Volume 15, Issue 6, doi: 10.1007/s11783-021-1409-3
• MFC promoted the nitrogen removal of anammox with Fe-C micro-electrolysis
Keywords: Waste tire MFCs Micro-electrolysis Anammox Feammox
Boiling heat transfer correlations for refrigerant mixtures flowing inside micro-fin tubes
ZHANG Xiaoyan, ZHANG Xingqun, CHEN Yunguang, YUAN Xiuling
Frontiers in Energy 2008, Volume 2, Issue 4, Pages 489-493 doi: 10.1007/s11708-008-0110-6
Keywords: comparison micro-fin calculation transfer prediction
Machinability of ultrasonic vibration-assisted micro-grinding in biological bone using nanolubricant
Frontiers of Mechanical Engineering 2023, Volume 18, Issue 1, doi: 10.1007/s11465-022-0717-z
Keywords: micro-grinding biological bone ultrasonic vibration (UV) nanoparticle jet mist cooling (NJMC) grinding
Hybrid optimization algorithm for modeling and management of micro grid connected system
Kallol ROY,Kamal Krishna MANDAL
Frontiers in Energy 2014, Volume 8, Issue 3, Pages 305-314 doi: 10.1007/s11708-014-0308-8
Keywords: micro grid (MG) multi-objective function artificial bee colony (ABC) fuel cost operation and maintenance
Title Author Date Type Operation
Characterizing Thermal Augmentation of Convection-Enhanced Drug Delivery with the Fiberoptic Microneedle Device
R. Lyle Hood,Rudy T. Andriani,Tobias E. Ecker,John L. Robertson,Christopher G. Rylander
Journal Article
direct cannulation of superior vena cava for a hemodialysis patient with an original dysfunctional catheter
Li Zhou, Lin Chen, Yang Yu, Tianlei Cui, Xiao Li, Ping Fu
Journal Article
opportunities in improving left ventricular remodelling and clinical outcome following surgical and trans-catheter
Journal Article
Dependence of error sensitivity of frequency on bias voltage in force-balanced micro accelerometer
Lili CHEN, Wu ZHOU
Journal Article
Dynamical research on spherical micro actuator with piezoelectric ceramic stacks drivers
ZHANG Ruihua, CHEN Haichu
Journal Article
Laboratory assessment of Alaska aggregates using Micro-Deval test
Jenny LIU,Sheng ZHAO,Anthony MULLIN
Journal Article
Characterization of micro-mixing in a novel impinging streams reactor
Hui HU, Zhiming CHEN, Zhen JIAO
Journal Article
microbial fuel cell for enhancing the nitrogen removal of the anammox process coupled with iron-carbon micro-electrolysis
Journal Article
Boiling heat transfer correlations for refrigerant mixtures flowing inside micro-fin tubes
ZHANG Xiaoyan, ZHANG Xingqun, CHEN Yunguang, YUAN Xiuling
Journal Article
Machinability of ultrasonic vibration-assisted micro-grinding in biological bone using nanolubricant
Journal Article