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非常规油气沉积学——研究非常规油气资源富集的“一把钥匙” Review
邹才能, 邱振, 张家强, 李志扬, 韦恒叶, 刘贝, 赵建华, 杨田, 朱世发, 陶辉飞, 张凤远, 王玉满, 张琴, 刘雯, 刘翰林, 冯子齐, 刘丹, 高金亮, 柳蓉, 李一凡
《工程（英文）》 2022年 第18卷 第11期 页码 62-78 doi: 10.1016/j.eng.2022.06.016
秦延文,韩超南,郑丙辉,张雷,曹伟
《中国工程科学》 2013年 第15卷 第3期 页码 19-25
采集辽河流域浑河、太子河干流及大伙房水库共56个站点的表层沉积物样品，根据相平衡分配法的修正模型建立辽河流域沉积物重金属质量基准（Cu、Pb、Zn、Cd的SQC（基于CCC）分别为75.26 μg/g、25.72 μg/g、255.96 μg/g、2.52 μg/g），依据重金属急、慢性生物毒性风险确定辽河流域沉积物重金属质量三级标准，并创建沉积物质量风险评估方法——沉积物污染指数法（SPI），对辽河流域水环境进行沉积物质量风险评估，评估结果显示：浑河干流中下游、太子河中上游及大伙房水库库中、库尾处的沉积物质量状况为中风险，此沉积物重金属污染状况使长期生活在其中的底栖生物受到轻微重金属慢性毒性影响，其中浑河中游红透山铜矿处和细河上游沈阳工业区的沉积物质量风险极高。
无溶剂气相制备用于可持续分离过程的膜材料 Perspective
赵俊杰, Karen K. Gleason
《工程（英文）》 2020年 第6卷 第12期 页码 1432-1442 doi: 10.1016/j.eng.2020.05.002
张英杰,范云鹰,董鹏,罗少林
《中国工程科学》 2008年 第10卷 第3期 页码 93-96
报告了电沉积Zn-Fe-SiO2复合镀层的研究结果，论述了电流密度、极间距、搅拌方式、阳极数量及排布方式、添加剂等对Zn-Fe-SiO2复合镀层的影响及试验所取得的技术指标
关键词： 电沉积 复合镀层 Zn-Fe-SiO2
用于材料探索与优化的高通量多羽流脉冲激光沉积 Article
Samuel S. Mao,Xiaojun Zhang
《工程（英文）》 2015年 第1卷 第3期 页码 367-371 doi: 10.15302/J-ENG-2015065
笔者设计并实现了高通量多羽流脉冲激光沉积 (MPPLD) 系统，而且与传统的高通量薄膜材料合成技术进行了比较。目前大多数组合式脉冲激光沉积 (PLD) 系统为了使沉积的薄膜厚度均匀而采用掩膜法多层薄膜沉积和沉积后退火的工艺，MPPLD则同时利用了多个PLD羽流的方向性和沉积速率的空间变化，在一个衬底上直接沉积不同成分的化合物以形成薄膜材料库
浅水富营养化湖泊巢湖汞的历史沉积记录——人类活动和气候变化的影响 Article
张含笑, 霍守亮, Kevin M. Yeager, 席北斗, 张靖天, 吴丰昌
《工程（英文）》 2019年 第5卷 第2期 页码 296-304 doi: 10.1016/j.eng.2018.11.022
赵高峰,周怀东, 付玉芹, 赵月前,蒋金杰,蔡伟伟,鲁晓红,杨小满
《中国工程科学》 2010年 第12卷 第6期 页码 41-47
采用GC-MS/MS技术对45个白洋淀表层沉积物（0～5 cm）样品中的三类（多溴联苯、 多溴联苯醚和多氯联苯）多卤代芳烃(PHAHs)进行分析20.57 ng·g-1 ·dw），PCB28,52, 66, 138, 156和170是被检出的主要同族体；多溴联苯(PBBs)和多溴联苯醚（PBDEs）在沉积物中的检出浓度相对较低实验结果与国内外最近的文献报道值相比较,显示这三类PHAHs在沉积物中的浓度处于低污染水平，引起的潜在风险也相对较低。
代谢组扩展生物学的“旁中心法则”——对理解基因组学-糖组学-代谢组学-表观基因组学互作的意义
Albert Stuart Reece
《工程（英文）》 2023年 第26卷 第7期 页码 16-16 doi: 10.1016/j.eng.2022.07.011
The central dogma of biology holds that the transcription of DNA into RNA and the translation of RNA into proteins forms the primary axis of biological activity [1]. Following major advances in the description of the complex glycan and lipid chains that are added onto these basic building blocks, the glycome and lipidome have recently been added to this doctrine as an exciting new extension named the ‘‘paracentral dogma” [2]. However, it has been pointed out that biological systems can include many layers, which are described in modern omics technology platforms relating to both cell-intrinsic and cell-extrinsic layers of control, including metabolomic, microbiomic, immunological, epigenomic, epitranscriptomic, proteomic and phosphoproteomic layers [3].
It is well known that stem and progenitor cells have a metabolism that is based on glycolysis and glutaminolysis [4]. Although this provides less energy to the cell than oxidative phosphorylation, it suffices for these cells’ needs, since such cells are generally relatively quiescent and normally suppress energy-intensive processes such as genome duplication and transcription. Moreover, it has been shown that the high intracellular lactate levels involved in such states not only inhibits the key gatekeeper enzymes of oxidative phosphorylation (i.e., pyruvate dehydrogenase and carnitine palmitoyl acyltransferase) but also actually covalently modifies them by lactylation in order to maintain this inhibited metabolic–epigenomic state [5]. In addition, intermediate metabolism and nutrients are the source of the very extensive library of post-translational modifications to DNA, RNA, and proteins, as well as supplying cellular energy for many of the required reactions. Hence, the metabolic state locks in and reinforces the epigenomic state, and the metabolome and epigenome thereby play mutually reinforcing roles. This self-reinforcing coordination explains why it is so difficult to generate induced pluripotent cells and is a contributory explanation for why the described protocols typically have such low cellular yields.
These concepts become even more important when it is considered that cancer cells are de-differentiated, similarly rely on glycolysis and glutaminolysis, and are similarly metabolically–epigenomically–genomically synchronized. The disruption of this metabolic system is a key focus of mechanistic cancer research.
These important considerations imply that the descriptive and predictive power of the newly described ‘‘paracentral dogma” of biology may be usefully and meaningfully extended by including the metabolome, along with the genome, transcriptome, proteome, glycome, and lipidome, to describe cell-intrinsic regulation—not only in terms of another omics analytical layer but also as a fully predictive and interactive partner in the symphonic-like multilayer coordination that evidently comprises cellular regulatory layering.
新孢子虫病——分子流行病学及发病机制综述 Review
Asis Khan, Jahangheer S. Shaik, Patricia Sikorski, Jitender P. Dubey, Michael E. Grigg
《工程（英文）》 2020年 第6卷 第1期 页码 10-19 doi: 10.1016/j.eng.2019.02.010
工业5.0——仿生学和合成生物学的关联及内涵 Artical
Peter Sachsenmeier
《工程（英文）》 2016年 第2卷 第2期 页码 225-229 doi: 10.1016/J.ENG.2016.02.015
仿生学(模仿生物特殊本领的学科) 以及合成生物学，将和过去50年的硅芯片一样与工程开发、工业发展产生紧密联系。化学工业已经将白色生物技术应用于新工艺、新材料和资源的可持续利用中。合成生物学也已经应用到第二代生物燃料的发展中，并利用特制的微生物或生物制催化剂获取太阳能。而仿生学在制药、处理工程以及DNA存储领域的市场潜力是巨大的。这些研究将给生物学带来新思考。生物工程将和今天的数字化技术一样驱动创新。本文讨论了生物工程，特别是碳基生物燃料的应用和细胞饰变的技术与风险。大数据、分析学和海量存储将是未来的发展方向。虽然合成生物学在未来50年将和当今的数字化一样普遍且具有革新能力，但是目前它的应用和影响力还处在初级阶段。本文采用了将生物工程发展分为五个阶段(DNA分析、生物回路、最小基因组、原始细胞、异源生物学)的普遍分类方法，阐述了其对安全与保障、工业发展以及生物工程和生物技术作为跨学科领域发展的影响，同时讨论了伦理问题及公众对仿生学和合成生物学结果的公众讨论的重要性
关键词： 仿生学 合成生物学 生物工程 生物传感器 生物燃料 生物武器 虚拟进化 原始细胞 异种细胞 经济意义 工业5.0 德国 中国
人类蛋白质N-糖基化的十二年全基因组关联研究 Review
Anna Timoshchuk, Sodbo Sharapov, Yurii S. Aulchenko
《工程（英文）》 2023年 第26卷 第7期 页码 17-31 doi: 10.1016/j.eng.2023.03.013
Most human-secreted and membrane-bound proteins have covalently attached oligosaccharide chains, or glycans. Glycosylation influences the physical and chemical properties of proteins, as well as their biological functions. Unsurprisingly, alterations in protein glycosylation have been implicated in a growing number of human diseases, and glycans are increasingly being considered as potential therapeutic targets, an essential part of therapeutics, and biomarkers. Although glycosylation pathways are biochemically well-studied, little is known about the networks of genes that guide the cell- and tissue-specific regulation of these biochemical reactions in humans in vivo. The lack of a detailed understanding of the mechanisms regulating glycome variation and linking the glycome to human health and disease is slowing progress in clinical applications of human glycobiology. Two of the tools that can provide much sought-after knowledge of human in vivo glycobiology are human genetics and genomics, which offer a powerful data-driven agnostic approach for dissecting the biology of complex traits. This review summarizes the current state of human populational glycogenomics. In Section 1, we provide a brief overview of the N-glycan's structural organization, and in Section 2, we give a description of the major blood plasma glycoproteins. Next, in Section 3, we summarize, systemize, and generalize the results from current N-glycosylation genome-wide association studies (GWASs) that provide novel knowledge of the genetic regulation of the populational variation of glycosylation. Until now, such studies have been limited to an analysis of the human blood plasma N-glycome and the N-glycosylation of immunoglobulin G and transferrin. While these three glycomes make up a rather limited set compared with the enormous multitude of glycomes of different tissues and glycoproteins, the study of these three does allow for powerful analysis and generalization. Finally, in Section 4, we turn to genes in the established loci, paying particular attention to genes with strong support in Section 5. At the end of the review, in Sections 6 and 7, we describe special cases of interest in light of new discoveries, focusing on possible mechanisms of action and biological targets of genetic variation that have been implicated in human protein N-glycosylation.
标题 作者 时间 类型 操作
非常规油气沉积学——研究非常规油气资源富集的“一把钥匙”
邹才能, 邱振, 张家强, 李志扬, 韦恒叶, 刘贝, 赵建华, 杨田, 朱世发, 陶辉飞, 张凤远, 王玉满, 张琴, 刘雯, 刘翰林, 冯子齐, 刘丹, 高金亮, 柳蓉, 李一凡
期刊论文
新孢子虫病——分子流行病学及发病机制综述
Asis Khan, Jahangheer S. Shaik, Patricia Sikorski, Jitender P. Dubey, Michael E. Grigg
期刊论文
陈蓉：原子层沉积制造方法与应用（2020年1月10日）
陈蓉(高级职称)
2020年03月13日
会议视频
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