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Changes of phenotype and function of human CD4 CD25 T cells induced by transfection of Foxp3

WU Kui, BI Yutian, WANG Yaoli, WANG Changzheng

Frontiers of Medicine 2008, Volume 2, Issue 4,   Pages 366-369 doi: 10.1007/s11684-008-0070-6

Abstract: paper is to explore the effects of transfection of Foxp3 gene on the phenotype and function of naive CD4The effect of transfected CD4 T cells on the proliferation and cytokine production of CD4CD25 T cellsFoxp3-gene transfected CD4 T cells could express Foxp3 and transfection of Foxp3 gene up-regulated theAfter transfection, the proliferation of CD4 T cells was eliminated.Transfected T cells inhibited the proliferation of CD4CD25 T cells.
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An 84-month observational study of the changes in CD4 T-lymphocyte cell count of 110 HIV/AIDS patients

Jian Wang,Biyan Liang,Xiaoping Zhang,Liran Xu,Xin Deng,Xiuhui Li,Lu Fang,Xinghua Tan,Yuxiang Mao,Guoliang Zhang,Yuguang Wang

Frontiers of Medicine 2014, Volume 8, Issue 3,   Pages 362-367 doi: 10.1007/s11684-014-0363-x

Abstract: The CD4 count between the two groups was not statistically significant.For CD4 count of≤200 cells/mm3, the mean CD4 count changes were 21 and 28 cells/mmFor CD4 count of 201–350 cells/mm3, the mean CD4 count changes were 6 and 25 cells/mmFor CD4 count of 351–500 cells/mm3, the mean CD4 count changes were -13 and -7 cellsFor CD4 count of>500 cells/mm3, the mean CD4 count changes were -34 and -17 cells/mm

Keywords： AIDS     HIV     CD4     traditional Chinese medicine     linear models    

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Innate and adaptive T cells in influenza disease

Simone Nüssing, Sneha Sant, Marios Koutsakos, Kanta Subbarao, Thi H.O. Nguyen, Katherine Kedzierska

Frontiers of Medicine 2018, Volume 12, Issue 1,   Pages 34-47 doi: 10.1007/s11684-017-0606-8

Abstract: summarize the current knowledge on influenza-specific innate MAIT and gd T cells as well as adaptive CD8+ and CD4+ T cells, and discuss how these responses can be harnessed by novel vaccine

Keywords： influenza     innate T cells     CD4+ and CD8+ T cells     vaccination    

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Clinical laboratory features of Meigs’ syndrome: a retrospective study from 2009 to 2018

Wenwen Shang, Lei Wu, Rui Xu, Xian Chen, Shasha Yao, Peijun Huang, Fang Wang

Frontiers of Medicine 2021, Volume 15, Issue 1,   Pages 116-124 doi: 10.1007/s11684-019-0732-6

Abstract: Serum carbohydrate antigen 125 and HE4 levels were higher in the MS group than in the ovarian thecoma-fibromaHowever, the serum HE4 levels were lower in the MS group than in the OC group ( <0.001).the glucose transporter 1, lactate dehydrogenase, and enolase 1 mRNA levels were lower in peripheral CD4

Keywords： Meigs’ syndrome     ovarian thecoma-fibroma     NLR (neutrophil to lymphocyte ratio)     CD4+ T cells    

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Biological features of intrahepatic CD4+CD25+ T cells in the naturally tolerance of rat liver transplantation

LU Ling, ZHANG Feng, PU Liyong, YAO Aihua, YU Yue, SUN Beicheng, LI Guoqiang, WANG Xuehao

Frontiers of Medicine 2007, Volume 1, Issue 4,   Pages 373-376 doi: 10.1007/s11684-007-0072-9

Abstract: The biological features of intrahepatic CD4CD25 T regulatory cells in the naturally tolerance of ratThe proportion of intrahepatic CD4CD25 T cells from three groups was determined by flow cytometry (FCMThe purity of CD4CD25 T cells sorted by MACS was 86%–93%.The CD4CD25 T cells could specifically express the Foxp3 gene compared with CD4CD25 T cells. , the spleenCD4CD25 Tr cells could suppress the proliferation of CD4CD25 T cells, but the inhibition was reversed

Keywords： magnetic     LEW-to-DA     effector     MACS     cytometry    

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Exosomal CD44 Cooperates with Integrin α6β4 to Support Organotropic Metastasis via Regulating Tumor Cell Article

Wei Mu, Yajie Xu, Pengfei Gu, Wenbo Wang, Jingquan Li, Yang Ge, Hui Wang

Engineering 2021, Volume 7, Issue 10,   Pages 1415-1425 doi: 10.1016/j.eng.2020.08.013

Abstract: For the first time, our study has demonstrated that CD44, a transmembrane glycoprotein delivered by exosomesMoreover, CD44 was found to interact with integrin α6β4 to form a complex, thereby remodelingNotably, we also demonstrated that the CD44–α6β4 complex can be delivered to the targetThe selective uptake of CD44-competent tumor exosomes by liver cells activated fibrotic pathways andOur results suggest the potential application of exosomal CD44 as a biomarker for the clinical diagnosis

Keywords： Pancreatic cancer     Organotropic metastasis     Exosomes     Pre-metastatic niche     CD44    

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Preclinical characterization and comparison between CD3/CD19 bispecific and novel CD3/CD19/CD20 trispecific

Frontiers of Medicine 2022, Volume 16, Issue 1,   Pages 139-149 doi: 10.1007/s11684-021-0835-8

Abstract: The CD19-targeting bispecific T-cell engager blinatumomab has shown remarkable efficacy in patients withmultiple trials have shown that approximately 30% of blinatumomab-relapsed cases are characterized by CD19Blinatumomab and A-319 are CD3/CD19 bispecific antibodies with different molecular sizes and structures, and A-2019 is a novel CD3/CD19/CD20 trispecific antibody with an additional anti-CD20 function.in cells missing CD19, suggesting its potential function against CD19 weak or negative CD20 positive

Keywords： B-cell acute lymphoblastic leukemia     bispecific antibody     trispecific antibody     CD19     CD20    

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magnetic adsorbent based on salicylic acid-immobilized magnetite nano-particles for pre-concentration of Cd

Hossein Abdolmohammad-Zadeh, Arezu Salimi

Frontiers of Chemical Science and Engineering 2021, Volume 15, Issue 2,   Pages 450-459 doi: 10.1007/s11705-020-1930-0

Abstract: The nanocomposite was employed as a magnetic solid-phase extraction agent for separation of Cd(II) ions

Keywords： cadmium     magnetic solid-phase extraction     Fe3O4 nanoparticles     Fe3O4/salicylic acid nanocomposite     flame atomic absorption spectrometry    

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Single and joint effects of HHCB and cadmium on zebrafish (

Lei ZHANG, Jing AN, Qixing ZHOU

Frontiers of Environmental Science & Engineering 2012, Volume 6, Issue 3,   Pages 360-372 doi: 10.1007/s11783-011-0353-z

Abstract: Thus, single and joint toxic effects of 1,3,4,6,7,8-hexahydro-4,6,6,7,8,8- hexamethylcyclopenta-gamma-2-benzopyran (HHCB) as one of the most widely applied artificial musks and cadmium (Cd) as an toxiczebrafish ( ) were investigated by the exposure of zebrafish to various concentrations of HHCB or/and Cdperoxidase (POD), and malondialdehyde (MDA) were sensitive and induced in the zebrafish stressed by CdJoint effects on antioxidant enzymes depended more on the effect of single Cd in the first one or two

Keywords： 1     3     4     6     7     8-hexahydro-4     6     6     7     8     8-hexamethylcyclopenta-gamma-2-benzopyran (HHCB)     cadmium (Cd)     antioxidant    

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Clinical significance of CD34+CD117dim/CD34+CD117bri myeloblast-associated

Xueping Li, Yuting Dai, Bing Chen, Jinyan Huang, Saijuan Chen, Lu Jiang

Frontiers of Medicine 2021, Volume 15, Issue 4,   Pages 608-620 doi: 10.1007/s11684-021-0836-7

Abstract: Two leukemic myeloblast populations (CD34 CD117 and CD34 CD117 ) were previously identified in t(8;21Here, we examined the impact of CD34 CD117 /CD34 CD117 myeloblast-associated gene expression on t(8;The mRNA expression levels of CD34 CD117 -associated genes ( , , and ) and CD34 CD117 -associated genesUnivariate analysis revealed that CD19, CD34 CD117 proportion, mutation, minimal residual diseaseIdentifying the clinical relevance of CD34 CD117 /CD34 CD117 myeloblast-associated gene expression may

Keywords： t(8     21)(q22     q22) AML     CD34+CD117dim/ CD34+CD117bri cell population    

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Comparisons in subcellular and biochemical behaviors of cadmium between low-Cd and high-Cd accumulation

Meng XUE, Yihui ZHOU, Zhongyi YANG, Biyun LIN, Jiangang YUAN, Shanshan WU

Frontiers of Environmental Science & Engineering 2014, Volume 8, Issue 2,   Pages 226-238 doi: 10.1007/s11783-013-0582-4

Abstract: in low-Cd accumulation cultivars and high-Cd accumulation cultivars of pakchoi ( L.).low-Cd cultivars.The high-Cd cultivars had significantly higher leaf and stem Cd concentrations than the low-Cd cultivarsthan high-Cd cultivars, leaf vacuole sequestrated higher proportions of Cd.Cd in the form of pectate/protein complexes (extracted by 1 mol·L NaCl) played a decisive role in Cd

Keywords： cadmium (Cd)     low-Cd cultivar     pakchoi (Brassica chinensis L.)    

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Cultivars and oil extraction techniques affect Cd/Pb contents and health risks in oil of rapeseed grownon Cd/Pb-contaminated farmland

Frontiers of Environmental Science & Engineering 2023, Volume 17, Issue 7, doi: 10.1007/s11783-023-1687-z

Abstract:

● Organic solvent extracted fewer Cd/Pb in rapeseed oil than physical

Keywords： Rapeseed oil     Oil extraction technologies     Human health risk assessment     Cd/Pb-contaminated farmland    

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Celecoxib in combination with retinoid CD437 inhibits melanoma A375 cell

Jianwen REN, Zhenhui PENG, Birong GUO, Min PAN

Frontiers of Medicine 2009, Volume 3, Issue 1,   Pages 108-112 doi: 10.1007/s11684-009-0015-8

Abstract: This study aimed to investigate the effects of celecoxib, synthetic retinoid 6-[3-(1-adamantyl)-4-hydroxyphenyl]-2-naphthalenecarboxylic acid (CD437) and the combination of the two on cell proliferation, apoptosis, and cycle arrest of human malignant melanoma A375 cells. 3-(4,5-dimethylthiazol-2-yl)-2,5-di-phenyltetrazoliumbromideCelecoxib in combination with CD437 could significantly enhance the effects of inhibiting proliferationCD437 could inhibit the growth of human malignant melanoma A375 cells by inducing apoptosis and G /G

Keywords： celecoxib     CD437     melanoma A375 cell     apoptosis     cycle arrest    

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Growth responses of the newly-discovered Cd-hyperaccumulator Rorippa globosa and its accumulation characteristicsof Cd and As under joint stress of Cd and As

SUN Yuebing, ZHOU Qixing, WEI Shuhe, REN Liping

Frontiers of Environmental Science & Engineering 2007, Volume 1, Issue 1,   Pages 107-113 doi: 10.1007/s11783-007-0020-6

Abstract: has been identified as a newly-found Cd-hyperaccumulating species.under joint stress of Cd and As.The results showed that Cd and As had an antagonistic effect on enhancing the growth of plants and Cdlevel under single Cd pollution.from a high concentration of Cd and As.

Keywords： synergic adverse     stress     present study     potential     weight    

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Tumor-derived exosomes induce initial activation by exosomal CD19 antigen but impair the function ofCD19-specific CAR T-cells via TGF-β signaling

Frontiers of Medicine doi: 10.1007/s11684-023-1010-1

Abstract: Tumor-derived exosomes induce initial activation by exosomal CD19 antigen but impair the function ofCD19-specific CAR T-cells via TGF-β signaling

Keywords： exosomes induce activation     impair function CD19     exosomal CD19 antigen    

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Title Author Date Type Operation

Changes of phenotype and function of human CD4 CD25 T cells induced by transfection of Foxp3

WU Kui, BI Yutian, WANG Yaoli, WANG Changzheng

Journal Article

An 84-month observational study of the changes in CD4 T-lymphocyte cell count of 110 HIV/AIDS patients

Jian Wang,Biyan Liang,Xiaoping Zhang,Liran Xu,Xin Deng,Xiuhui Li,Lu Fang,Xinghua Tan,Yuxiang Mao,Guoliang Zhang,Yuguang Wang

Journal Article

Innate and adaptive T cells in influenza disease

Simone Nüssing, Sneha Sant, Marios Koutsakos, Kanta Subbarao, Thi H.O. Nguyen, Katherine Kedzierska

Journal Article

Clinical laboratory features of Meigs’ syndrome: a retrospective study from 2009 to 2018

Wenwen Shang, Lei Wu, Rui Xu, Xian Chen, Shasha Yao, Peijun Huang, Fang Wang

Journal Article

Biological features of intrahepatic CD4+CD25+ T cells in the naturally tolerance of rat liver transplantation

LU Ling, ZHANG Feng, PU Liyong, YAO Aihua, YU Yue, SUN Beicheng, LI Guoqiang, WANG Xuehao

Journal Article

Exosomal CD44 Cooperates with Integrin α6β4 to Support Organotropic Metastasis via Regulating Tumor Cell

Wei Mu, Yajie Xu, Pengfei Gu, Wenbo Wang, Jingquan Li, Yang Ge, Hui Wang

Journal Article

Preclinical characterization and comparison between CD3/CD19 bispecific and novel CD3/CD19/CD20 trispecific

Journal Article

magnetic adsorbent based on salicylic acid-immobilized magnetite nano-particles for pre-concentration of Cd

Hossein Abdolmohammad-Zadeh, Arezu Salimi

Journal Article

Single and joint effects of HHCB and cadmium on zebrafish (

Lei ZHANG, Jing AN, Qixing ZHOU

Journal Article

Clinical significance of CD34+CD117dim/CD34+CD117bri myeloblast-associated

Xueping Li, Yuting Dai, Bing Chen, Jinyan Huang, Saijuan Chen, Lu Jiang

Journal Article

Comparisons in subcellular and biochemical behaviors of cadmium between low-Cd and high-Cd accumulation

Meng XUE, Yihui ZHOU, Zhongyi YANG, Biyun LIN, Jiangang YUAN, Shanshan WU

Journal Article

Cultivars and oil extraction techniques affect Cd/Pb contents and health risks in oil of rapeseed grownon Cd/Pb-contaminated farmland

Journal Article

Celecoxib in combination with retinoid CD437 inhibits melanoma A375 cell

Jianwen REN, Zhenhui PENG, Birong GUO, Min PAN

Journal Article

Growth responses of the newly-discovered Cd-hyperaccumulator Rorippa globosa and its accumulation characteristicsof Cd and As under joint stress of Cd and As

SUN Yuebing, ZHOU Qixing, WEI Shuhe, REN Liping

Journal Article

Tumor-derived exosomes induce initial activation by exosomal CD19 antigen but impair the function ofCD19-specific CAR T-cells via TGF-β signaling

Journal Article