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Astrocytes in depression and Alzheimer’s disease
《医学前沿(英文)》 2021年 第15卷 第6期 页码 829-841 doi: 10.1007/s11684-021-0875-0
关键词: astrocytes depression Alzheimer’s disease roles mechanisms
Protein phosphatase 2A, a key player in Alzheimer’s disease
Rong LIU, Qing TIAN
《医学前沿(英文)》 2009年 第3卷 第1期 页码 8-12 doi: 10.1007/s11684-009-0017-6
关键词: protein phosphatase 2A Alzheimer’s disease holoenzyme composition protein phosphatase 2A inhibitors Leu309 demethylation Tyr307 phosphorylation
Medical applications of phytoestrogens from the Thai herb
null
《医学前沿(英文)》 2012年 第6卷 第1期 页码 8-21 doi: 10.1007/s11684-012-0184-8
Pueraria mirifica Airy Shaw et Suvatabandhu is a medicinal plant endemic to Thailand. It has been used in Thai folklore medicine for its rejuvenating qualities in aged women and men for nearly one hundred years. Indeed, it has been claimed that P. mirifica contains active phytoestrogens (plant substances with estrogen-like activity). Using high performance liquid chromatography, at least 17 phytoestrogens, mainly isoflavones, have been isolated. Thus, fairly considerable scientific researches, both in vitro in cell lines and in vivo in various species of animals including humans, have been conducted to date to address its estrogenic activity on the reproductive organs, bones, cardiovascular diseases and other climacteric related symptoms. The antioxidative capacity and antiproliferative effect on tumor cell lines have also been assessed. In general, P. mirifica could be applicable for preventing, or as a therapeutic for, the symptoms related to estrogen deficiency in menopausal women as well as in andropausal men. However, the optimal doses for each desirable effect and the balance to avoid undesired side effects need to be calculated before use.
关键词: white Kwao Krua miroestrol estrogenic activity reproduction osteoporosis breast cancer Alzheimer
Effect of ambient polycyclic aromatic hydrocarbons and nicotine on the structure of Aβ protein
《环境科学与工程前沿(英文)》 2023年 第17卷 第2期 doi: 10.1007/s11783-023-1615-2
● B[a]P, nicotine and phenanthrene molecules altered the secondary structure of Aβ42.
关键词: Polycyclic aromatic hydrocarbons Nicotine toxicology Aβ42 peptide Alzheimer’s disease Molecular dynamics simulations Environmental pollution
Atomistic characterization of binding modes and affinity of peptide inhibitors to amyloid-
Fufeng LIU,Wenjie DU,Yan SUN,Jie ZHENG,Xiaoyan DONG
《化学科学与工程前沿(英文)》 2014年 第8卷 第4期 页码 433-444 doi: 10.1007/s11705-014-1454-6
关键词: Alzheimer’s disease amyloid β-protein peptide inhibitors protein-protein interaction molecular dynamics simulation
Shuai Ma, Huan Zhang, Xiaoyan Dong, Linling Yu, Jie Zheng, Yan Sun
《化学科学与工程前沿(英文)》 2018年 第12卷 第2期 页码 283-295 doi: 10.1007/s11705-017-1687-2
关键词: Alzheimer’s disease amyloid β-protein cyclic peptide inhibition protein aggregation
标题 作者 时间 类型 操作
Atomistic characterization of binding modes and affinity of peptide inhibitors to amyloid-
Fufeng LIU,Wenjie DU,Yan SUN,Jie ZHENG,Xiaoyan DONG
期刊论文